A multi-country study of the economic burden of dengue fever: Vietnam, Thailand, and Colombia

Lee, Jung-Seok,Mogasale, Vittal,Lim, Jacqueline K.,Carabali, Mabel,Lee, Kang-Sung,Sirivichayakul, Chukiat,Dang, Duc Anh,Palencia-Florez, Diana Cristina,Nguyen, Thi Hien Anh,Riewpaiboon, Arthorn,Chanth Public Library of Science 2017 PLoS neglected tropical diseases Vol.11 No.10

<▼1><P><B>Background</B></P><P>Dengue fever is a major public health concern in many parts of the tropics and subtropics. The first dengue vaccine has already been licensed in six countries. Given the growing interests in the effective use of the vaccine, it is critical to understand the economic burden of dengue fever to guide decision-makers in setting health policy priorities.</P><P><B>Methods/Principal findings</B></P><P>A standardized cost-of-illness study was conducted in three dengue endemic countries: Vietnam, Thailand, and Colombia. In order to capture all costs during the entire period of illness, patients were tested with rapid diagnostic tests on the first day of their clinical visits, and multiple interviews were scheduled until the patients recovered from the current illness. Various cost items were collected such as direct medical and non-medical costs, indirect costs, and non-out-of-pocket costs. In addition, socio-economic factors affecting disease severity were also identified by adopting a logit model. We found that total cost per episode ranges from $141 to $385 for inpatient and from $40 to $158 outpatient, with Colombia having the highest and Thailand having the lowest. The percentage of the private economic burden of dengue fever was highest in the low-income group and lowest in the high-income group. The logit analyses showed that early treatment, higher education, and better knowledge of dengue disease would reduce the probability of developing more severe illness.</P><P><B>Conclusions/Significance</B></P><P>The cost of dengue fever is substantial in the three dengue endemic countries. Our study findings can be used to consider accelerated introduction of vaccines into the public and private sector programs and prioritize alternative health interventions among competing health problems. In addition, a community would be better off by propagating the socio-economic factors identified in this study, which may prevent its members from developing severe illness in the long run.</P></▼1><▼2><P><B>Author summary</B></P><P>Dengue fever has been prevalent in South-East Asia and South America. Despite the increase of dengue fever cases, there continues to be a lack of economic assessment partly due to the absence of vaccines until recent times. Many of the previous economic burden studies for dengue fever were not standardized, making them difficult to compare. We implemented the standardized economic burden survey for dengue fever in a multi-country setting: Vietnam, Thailand, and Colombia. We found that the economic burden of dengue fever is substantial in all three dengue endemic countries. Our study also identified socio-economic factors which are related to the probability of experiencing severe illness. The first live attenuated, tetravalent dengue vaccine (CYD-TDV) has been already licensed in some dengue-endemic countries. As three countries will soon face decisions on whether and how to incorporate current and future vaccine candidates within their budget constraints, the updated economic burden estimates can be used to develop sustainable financing plans.</P></▼2>

Preliminary study of AR navigation-guided core-needle breast biopsy

Nova Eka Diana,Jegyeong Ryu,Hee Ryung Lee,Youngseok O,Deukhee Lee 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

Accurate tumor localization has remained to be one of the biggest challenges in core-needle biopsy due to the malleability and texture-heterogeneity of tissues surrounding a tumor. To overcome these limitations, we explored the effectiveness of augmented reality (AR)-guidance to navigate the core-needle insertion in breast biopsy thanks to the enhanced technology of AR. Our proposed framework consists of two independent functions: tumor localization and needle pose tracking in real-time. First, tumor localization was achieved by employing the two-front environmental sensors of HoloLens 2 (HL2) for tracking the passive-reflective markers. Given the geometrical information of the reference markers, the stereo-correspondences and the marker pose can be calculated efficiently for overlaying the corresponding virtual models in HL2. Second, an external RGB camera was used to track the pose of a needle. A You-Only-Look-Once (YOLO) model with a customized training set of 200 images was employed to detect the collinear pinkt-ape points attached to the needle. The interpoint-distance between these points will be utilized to estimate the pose of a needle that will be sent to HL2 using TCP/IP communication. Finally, real-time navigation of needle insertion can be rendered in HL2 using a more accurate transformation to assist the breast biopsy. Overall, the preliminary results demonstrate that the whole process can be executed in a reasonable running time of less than two seconds.

Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy

Pae, Chi-Un,Serretti, Alessandro,Mandelli, Laura,De Ronchi, Diana,Patkar, Ashwin A.,Jun, Tae-Youn,Kim, Jung-Jin,Lee, Chang-Uk,Lee, Soo-Jung,Lee, Chul,Paik, In-Ho Lippincott Williams Wilkins, Inc. 2007 PHARMACOGENETICS AND GENOMICS Vol.17 No.1

OBJECTIVE: Antidepressant drug efficacy is partially under genetic control and a number of gene variants have been associated with antidepressants efficacy over the last few years. In the search for further genes influencing antidepressant response we focused on the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1). BASIC METHODS: One hundred and four Korean inpatients affected by major depressive disorder were treated with various antidepressants at standard therapeutic daily doses and rated with the 10-items Montgomery–Åsberg Depression rating scale (MADRS) at baseline and discharge. Five DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C) were analysed for all patients. RESULTS: Rs2005976 was found to be significantly associated with final MADRS scores, with the rarest A allele associated with higher final scores (P=0.00055), rs760761 also showed a significant association (P=0.0058) and rs2619522 showed a positive trend (P=0.025). Markers were not significantly associated with Clinical Global Impression Scale scores. Five marker haplotypes were mildly associated with MADRS final scores but when considering the block composed of the three single nucleotide polymorphisms individually associated with response (rs2005976, rs760761 and rs2619522), results were more marked (P=0.0096), with the more frequent G–C–A haplotype associated with a positive outcome. CONCLUSIONS: Despite limitations due to the sample size and the mild antidepressant response, we observed a significant association between DTNBP1 variants and antidepressant response.

Use of Portable Global Positioning System (GPS) Devices in Exposure Analysis for Time-location Measurement

Lee, Ki-Young,Kim, Joung-Yoon,Putti, Kiran,Bennett, Deborah H.,Cassady, Diana,Hertz-Picciotto, Irva Korean Society of Environmental Health 2009 한국환경보건학회지 Vol.35 No.6

Exposure analysis is a critical component of determining the health impact of pollutants. Global positioning systems (GPS) could be useful in developing time-location information for use in exposure analysis. This study compares four low cost GPS receivers with data logging capability (Garmin 60, Garmin Forerunner 201, GeoStats GeoLogger and Skytrx minitracker MT4100) in terms of accuracy, precision, and ease of use. The accuracy of the devices was determined at two known National Geodetic Survey points. The coordinates logged by the devices were compared when the devices were carried while walking and driving. The Garmin 60 showed better accuracy and precision than the GeoLogger when they were placed at the geodetic points. The Forerunner and Skytrx did not record when they were kept stationary. When the subject wore the devices while walking, the location of the devices differed by about 8 m on average between any two device combinations involving the four devices. The distance between the coordinates logged by the devices decreased when the devices were carried with their antennas facing the sky. All the devices showed similar routes when they were used in a car. All the devices except the Forerunner had satisfactory signal reception when they were worn and when they were carried in the car. The GeoLogger is less comfortable for the subject because of specific wearing requirements. This evaluation found that the Garmin 60 and the Skytrx may be useful in personal exposure analysis studies to record time-location data.

Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein–Induced Retinal Angiogenesis

Lee, Heon-Woo,Chong, Diana C.,Ola, Roxana,Dunworth, William P.,Meadows, Stryder,Ka, Jun,Kaartinen, Vesa M.,Qyang, Yibing,Cleaver, Ondine,Bautch, Victoria L.,Eichmann, Anne,Jin, Suk-Won American Heart Association 2017 Arteriosclerosis, thrombosis, and vascular biology Vol.37 No.4

<P>Conclusions-Our data identify BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A, and BMPR2 as an essential proangiogenic cue for retinal vessels.</P>

Impact of Surveillance Mammography Intervals Less Than One Year on Performance Measures in Women With a Personal History of Breast Cancer

Lee Janie M.,Ichikawa Laura E.,Wernli Karen J.,Bowles Erin J. A.,Specht Jennifer M.,Kerlikowske Karla,Miglioretti Diana L.,Lowry Kathryn P.,Tosteson Anna N. A.,Stout Natasha K.,Houssami Nehmat,Onega T 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.8

Objective: When multiple surveillance mammograms are performed within an annual interval, the current guidance for oneyear follow-up to determine breast cancer status results in shared follow-up periods in which a single breast cancer diagnosis can be attributed to multiple preceding examinations, posing a challenge for standardized performance assessment. We assessed the impact of using follow-up periods that eliminate the artifactual inflation of second breast cancer diagnoses. Materials and Methods: We evaluated surveillance mammograms from 2007–2016 in women with treated breast cancer linked with tumor registry and pathology outcomes. Second breast cancers included ductal carcinoma in situ or invasive breast cancer diagnosed during one-year follow-up. The cancer detection rate, interval cancer rate, sensitivity, and specificity were compared using different follow-up periods: standard one-year follow-up per the American College of Radiology versus follow-up that was shortened at the next surveillance mammogram if less than one year (truncated follow-up). Performance measures were calculated overall and by indication (screening, evaluation for breast problem, and short interval follow-up). Results: Of 117971 surveillance mammograms, 20% (n = 23533) were followed by another surveillance mammogram within one year. Standard follow-up identified 1597 mammograms that were associated with second breast cancers. With truncated follow-up, the breast cancer status of 179 mammograms (11.2%) was revised, resulting in 1418 mammograms associated with unique second breast cancers. The interval cancer rate decreased with truncated versus standard follow-up (3.6 versus 4.9 per 1000 mammograms, respectively), with a difference (95% confidence interval [CI]) of -1.3 (-1.6, -1.1). The overall sensitivity increased to 70.4% from 63.7%, for the truncated versus standard follow-up, with a difference (95% CI) of 6.6% (5.6%, 7.7%). The specificity remained stable at 98.1%. Conclusion: Truncated follow-up, if less than one year to the next surveillance mammogram, enabled second breast cancers to be associated with a single preceding mammogram and resulted in more accurate estimates of diagnostic performance for national benchmarks.

Lamina Cribrosa Changes after Laser In Situ Keratomileusis in Myopic Eyes

Soomin Lee,Da-Ye Diana Choi,Dong Hui Lim,Tae Young Chung,Jong Chul Han,Changwon Kee 대한안과학회 2018 Korean Journal of Ophthalmology Vol.32 No.2

Purpose: To determine deep optic nerve head structure changes after transient intraocular pressure elevation during laser in situ keratomileusis (LASIK) for myopia Methods: Enhanced depth imaging-optical coherence tomography was performed in each myopic eye that underwent LASIK surgery. Enhanced depth imaging-optical coherence tomography images were created at postoperative 1 day, 1 week, 2 weeks, and 1 month. Lamina cribrosa (LC) thickness, LC depth and prelaminar thickness at the superior, middle and inferior portions of the optic nerve head were measured by two investigators. Results: Forty eyes in 40 patients were included in the present study. During follow-up, there were no significant differences in prelaminar thickness or LC depth. The LC demonstrated increased thickness at postoperative 1 day at all three locations (superior, middle, and inferior) (p < 0.001, p < 0.001, p < 0.001, respectively). However, no significant changes were observed at postoperative 1 week, 2 weeks, and 1 month. Conclusions: The LC thickness could increase at 1 day after LASIK surgery. However, the thickness will gradually return to baseline morphology. Temporary intraocular pressure increase during LASIK does not appear to induce irreversible LC thickness changes.

Risk of Cardiovascular and Cerebrovascular Events in Hepatitis C Patients Following Completion of Direct-Acting Antiviral Therapy: A Retrospective Cohort Study

( Sooji Lee ),( Amanda W. Singer ),( Anu Osinusi ),( Diana M. Brainard ),( Anand P. Chokkalingam ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic hepatitis C virus (HCV) infection has been associated with adverse cardiovascular and cerebrovascular outcomes. Viral eradication with direct-acting antiviral (DAA) therapy may decrease the risk of these events among HCV patients. We aimed to characterize the risk of cardiovascular and cerebrovascular events among HCV patients treated with DAA regimens compared to untreated patients in US claims data. Methods: 322,276 adults with chronic HCV were enrolled in the database between January 2006 and September 2015. We identified 8,342 HCV patients dispensed at least 12 weeks of DAA therapy (excluding boceprevir and telaprevir) and, for comparison, 76,423 untreated HCV patients who had follow-up time in the DAA era. Events were identified by diagnostic claims for acute and chronic ischemic heart disease, angina pectoris, cardiomyopathy, heart failure, subarachnoid hemorrhage, occlusion and stenosis of precerebral or cerebral arteries, cerebrovascular disease, cerebral atherosclerosis, intracerebral hemorrhage, and transient cerebral ischemia. Hazard ratios (HRs) estimating risk of incident cardiovascular and cerebrovascular events associated with completion of DAA therapy were calculated with adjustment for covariates using Cox proportional hazards methods. Results: HCV patients dispensed a full course of DAA therapy were more likely to be male, over 55 years-old, with baseline diagnoses of cirrhosis, diabetes, or hypertension, and on cardiovascular medications. After adjustment for covariates, there was a reduced risk of total cardiovascular and cerebrovascular events in patients completing DAA therapy compared to untreated patients (HR=0.86, 95% confidence interval [CI]: 0.74-0.99). Adjusted HRs were similar for cardiovascular disease (HR=0.90, 95%CI: 0.76-1.05) and cerebrovascular disease (HR=0.89, 95%CI: 0.74-1.08). Conclusions: In this real-world cohort, DAA therapy appeared to reduce the risk of cardiovascular and cerebrovascular events in HCV patients even within a short period following therapy. The benefits of curative DAA therapy in reducing extrahepatic complications of HCV may be even greater with longer follow-up.

류마티스 관절염 환자의 치료행위 모형 검증을 위한 횡문화적 비교연구

은영,이은옥,이인숙,Wilkie, Diana J.,Belza, Basia 대한류마티스 건강전문학회 1999 근관절건강학회지 Vol.6 No.2

Patients with chronic disease have various treatment patterns because it shows a progressive degenerative feature. Especially various physical and emotional problems of the rheumatoid arthritis patients leave them shopping around various types of treatment. According to previous studies, over 70% of patients with arthritis experienced the traditional oriental medicine or folk remedies simultaneously with medical treatment within one year after the onset of disease. The purposes of this study are 1) to compare the patterns of treatment-seeking behaviors between Korean arthritis patients and Americans : and 2) test two models of treatment-seeking behaviors by path analysis, one for early treatment-seeking behavior model(ETBM) and the other is chronic treatment-seeking behavior model (CTBM) in Korean sample. The interview survey was performed to 133 RA patients with structured questionnaire at out-patient clinic or public health center. Patients characteristics such as age, duration of disease were similar two countries except higher educational background in Americans. There were no patients using only alternative therapies or no medical treatment in the US. Most of the American patients have chosen both medical treatment and alternative therapy, while the Koreans less than American. In Korea, combined treatment group usually consists of the people who are younger, more educated and higher economic status than the characters of other groups in early or chronic stages. In early stage, they tend to have strong belief of curing from the disease, satisfy the relationship with their physicians and comply with direction of the medical professional. The paths of two model were explained by 70% in ETBM and 33% in CTBM When the models were modified, almost all paths of the CTBM were the same as the previous one, but direct determinant factor was changed from the relationship with physicians to the lay referral system in chronic model. These two models' explanation powers became 94% and 88%, respectively. The attitude or perception of disease, lay referral system and the relationship with medical personnel are the main determinants of treatment seeking behaviors.

Этногенез вепсского народа и особенности его праздников, связанных с почитанием природы, как феномен «синей культуры»

КапарушкинаДианаИгоревна ( Kaparushkina Diana Igorevna ),ЛиКёнХи ( Lee Kyung Hee ),КимТэЧжин ( Kim Tae Jin ) 배재대학교 한국-시베리아센터 2021 한국시베리아연구 Vol.25 No.2

В настоящей статье для первого рассмотрения темы кратк о затрагиваются вопросы происхождения вепсского народа, ареалов его расселения в древности и в настоящее время. О бобщенно рассматриваются аспекты, повлиявшие на праздни ки этнических меньшинств российского заполярья, и более п одробно традиционные представления вепсов о мире как фе номен «синей культуры». В связи с этим проводится краткий анализ вепсских праздников как неотъемлемой части вепсск ого быта и культа почитания природы. В контексте рассмот рения традиционных вепсских праздников затрагиваются не только этнолокальные особенности праздников, но и те черт ы, которые отражают основные характеристики миропониман ия и мировосприятия вепсов, указывают на архетипы древне й вепсской культуры, доказывают значительную сохранность ее рудиментов в жизни современных вепсов. In this article, for the first consideration of the topic, the issues of the origin of the Vepsian people, the areas of their settlement in antiquity and at the present time, are briefly touched upon. The aspects that influenced the festivals of ethnic minorities of the Russian Arctic are considered in general, and in more detail the traditional ideas of the Vepsians about the world as a phenomenon of "blue culture" are considered. In this regard, a short analysis of Vepsian festivals as an integral part of Vepsian life and the worship of nature. In the context of considering traditional Vepsian festivals, not only the ethnolocal features of the festivals are touched upon, but also those features that reflect the main characteristics of the worldview. The ideas and perceptions of the Vepsians indicate the archetypes of the ancient Vepsian culture, and prove the significant preservation of its rudiments in the life of modern Vepsians.