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The multiple merger assembly of a hyperluminous obscured quasar at redshift 4.6
Dí,az-Santos, T.,Assef, R. J.,Blain, A. W.,Aravena, M.,Stern, D.,Tsai, C.-W.,Eisenhardt, P.,Wu, J.,Jun, H. D.,Dibert, K.,Inami, H.,Lansbury, G.,Leclercq, F. American Association for the Advancement of Scienc 2018 Science Vol.362 No.6418
<P><B>Mergers drive a powerful dusty quasar</B></P><P>Massive galaxies in the early Universe host supermassive black holes at their centers. When material falls toward the black hole, it releases energy and is observed as a quasar. Astronomers found a population of powerful distant quasars that are obscured by dust, but it has been unclear how they are formed. Díaz-Santos <I>et al.</I> observed the dust-obscured quasar WISE J224607.56-052634.9 at submillimeter wavelengths, finding three small companion galaxies connected to the quasar by bridges of gas and dust. They inferred that galaxy mergers can provide both the raw material to power a quasar and large quantities of dust to obscure it.</P><P><I>Science</I>, this issue p. 1034</P><P>Galaxy mergers and gas accretion from the cosmic web drove the growth of galaxies and their central black holes at early epochs. We report spectroscopic imaging of a multiple merger event in the most luminous known galaxy, WISE J224607.56−052634.9 (W2246−0526), a dust-obscured quasar at redshift 4.6, 1.3 billion years after the Big Bang. Far-infrared dust continuum observations show three galaxy companions around W2246−0526 with disturbed morphologies, connected by streams of dust likely produced by the dynamical interaction. The detection of tidal dusty bridges shows that W2246−0526 is accreting its neighbors, suggesting that merger activity may be a dominant mechanism through which the most luminous galaxies simultaneously obscure and feed their central supermassive black holes.</P>
Sardinian honeys as sources of xanthine oxidase and tyrosinase inhibitors
Di Petrillo, Amalia,Santos-Buelga, Celestino,Era, Benedetta,Gonzalez-Paramas, Ana Maria,Tuberoso, Carlo Ignazio Giovanni,Medda, Rosaria,Pintus, Francesca,Fais, Antonella 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
Sardinian honeys obtained from different floral sources (Arbutus, Asphodelus, Eucalyptus, Thistle, and Sulla) were evaluated for their ability to inhibit tyrosinase and xanthine oxidase enzymes and for their antioxidant activity. Physicochemical parameters, total phenolic, and flavonoids content were also determined. Honey from Arbutus flowers had the highest antioxidant activity followed by Eucalyptus and Thistle ones. These three honeys showed good tyrosinase and xanthine oxidase inhibition properties. Thus, these Sardinian honeys could have a great potential as antioxidant sources for pharmaceutical and cosmetic applications.
Sardinian honeys as sources of xanthine oxidase and tyrosinase inhibitors
Amalia Di Petrillo,Celestino Santos-Buelga,Benedetta Era,Ana Maria Gonza´lez-Parama´s,Carlo Ignazio Giovanni Tuberoso,RosariaMedda,Francesca Pintus,Antonella Fais 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
Sardinian honeys obtained from different floral sources (Arbutus, Asphodelus, Eucalyptus, Thistle, and Sulla) were evaluated for their ability to inhibit tyrosinase and xanthine oxidase enzymes and for their antioxidant activity. Physicochemical parameters, total phenolic, and flavonoids content were also determined. Honey from Arbutus flowers had the highest antioxidant activity followed by Eucalyptus and Thistle ones. These three honeys showed good tyrosinase and xanthine oxidase inhibition properties. Thus, these Sardinian honeys could have a great potential as antioxidant sources for pharmaceutical and cosmetic applications.
Marielle Bazzo Di Domê,nico,Henrique Cesca,Thales Henrique Jincziwski Ponciano,Renan Brandenburg dos Santos,Ulysses Lenz,Viní,cius Picoli Antunes,Vinicius Webber Godinho,Kauê, Collares,Pedro Henrique 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: To evaluate the effectiveness of hydrogen peroxide (H2O2) in the form of mouthwash and nasal spray as an auxiliary treatment for coronavirus disease 2019 (COVID-19). METHODS: Forty hospitalized patients who tested positive for severe acute respiratory syndrome coronavirus 2 using a reverse-transcription polymerase chain reaction test were evaluated. They were randomly divided into an experimental group (n=20; gargling with 1.0% H2O2 and nasal wash with 0.5% H2O2) or a control group (n=20). The solutions were used for 7 days and the patients were monitored every 2 days, for a total of 8 days. At check-ups, patients were asked about their symptoms and possible adverse effects of the solutions. The presence and severity (mild, moderate, or severe) of symptoms were recorded. Data were compared using the Student test and the Fisher exact test (α=0.05). RESULTS: There was no significant difference between the 2 groups in the length of hospital stay (p=0.65). The most frequent symptom on day 0 was coughing (72.0% in the experimental group and 76.5% in the control group), which abated over time. There was no significant difference between the groups in the evaluated symptoms. Most (75.0%) of the patients in the experimental group presented a reduction in dyspnea between days 0 and 2. Few patients reported adverse effects from the use of the solutions. CONCLUSIONS: H2O2 as a mouthwash and nasal spray is safe to use. There is insufficient evidence to demonstrate that H2O2 is effective as an auxiliary treatment for hospitalized COVID-19 patients.
Marielle Bazzo Di Domê,nico,Kauê, Collares,Renan Brandenburg dos Santos,Ulysses Lenz,Viní,cius Picoli Antunes,Vinicius Webber Godinho,Henrique Cesca,Thales Henrique Jincziwski Ponciano,Pedro Henrique 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: This study evaluated the effectiveness of hydrogen peroxide (H2O2) as mouthwash and nasal spray on symptom relief in coronavirus disease 2019 (COVID-19) patients. METHODS: Patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), who were treated in a hos-pital or at home, and patients’ family members (not positive for SARS-CoV-2), were randomized into 2 groups: experimental (1% H2O2 for gargling, 0.5% H2O2 for nasal wash), and control. Patients gargled the solution 3 times a day, and applied the nasal spray twice a day, for a 7-day period. Family members received the same treatment as the treated COVID-19 patient. The re-searchers contacted patients every 2 days over an 8-day period. An average post-treatment interval of 8 days passed before test-ing family members. RESULTS: The most frequent symptoms on day 0 were cough, loss of taste, and hyposmia; there were no significant differences between groups, independent of the period. The symptom of dyspnea presented a significant difference between days 2 and 4 (p< 0.05). Among family members, 86.0% had no antibodies, 2.3% had antibodies, and 11.6% had active infections (4 in the ex-perimental group and 6 in the control group). The most frequent adverse effects in the H2O2 group were a burning throat and nose. CONCLUSIONS: H2O2 was not effective for the relief of COVID-19 symptoms and was associated with reports of transient adverse effects.
Claudio Terranova,Marianna Tucci,Laura Di Pietra,Santo Davide Ferrara 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.2
Objective: The genes encoding for gamma-aminobutyric acid (GABA) A and B receptors may be considered as candidatesfor alcoholism; genetic alterations at this level may produce structural and functional diversity and thus play a role in the responseto alcohol addiction treatment. To investigate these aspects further, we conducted a preliminary genetic association study ona population of Italian male alcohol addicts, focusing on GABA A and B receptors. Methods: A total of 186 alcohol-dependent subjects (in the first phase 139, then 47 more samples) and 182 controls were genotypedfor 25 single nucleotide polymorphisms (SNPs) of genes encoding the alpha-1 subunit of GABA A receptor (GABRA1) andsubunits 1 and 2 of GABA B receptor (GABBR1 and GABBR2). The chi-squared test for allele and genotype distributions andHardy-Weinberg equilibrium analysis of both subjects and controls were performed. Bonferroni’s correction for multiple comparisonswas applied. Results: Preliminary results comparing 139 alcohol-dependent subjects and 182 controls showed differences in genotype distributionin the former for SNP rs29253, located in the intron region of the GABBR1 gene. In order to clarify the meaning ofthis association, 47 more samples from alcohol-dependent subjects were tested for this SNP only: the previously found associationwas not confirmed. Conclusion: The lack of significant differences between the two groups does not provide evidence that GABRA 1 and GABBR1and 2 genes are candidates for alcoholism in this population. Further studies with larger samples are needed, together with investigation of other components of the GABA pathway.
Vahid Hajipour,Madjid Tavana,Francisco J. Santos-Arteaga,Alireza Alinezhad,Debora Di Caprio 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.4
Supplier selection and order allocation constitute vital strategic decisions that must be made by managers within supply chain management environments. In this paper, we propose a multi-objective fuzzy model for supplier selection and order allocation in a two-level supply chain with multi-period, multi-source, and multi-product characteristics. The supplier evaluation objectives considered in this model include cost, delay, and electronic-waste (e-waste) minimization, as well as coverage and weight maximization. A signal function is used to model the price discount offered by the suppliers. Triangular fuzzy numbers are used to deal with the uncertainty of delay and e-waste parameters while the fuzzy Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) is used to obtain the weights of the suppliers. The resulting NP-hard problem, a Pareto-based meta-heuristic algorithm called controlled elitism non-dominated sorting genetic algorithm (CENSGA), is developed. The Non-dominated Sorting Genetic Algorithm (NSGA-II) and Multi-Objective Particle Swarm Optimization (MOPSO) are used to validate the applicability of the CENSGA algorithm and the Taguchi technique to tune the parameters of the algorithms. The results are analysed using graphical and statistical comparisons illustrating how the proposed CENSGA dominates NSGA-II and MOPSO in terms of mean ideal solution distance (MID) and spacing metrics.
Phototactic guidance of a tissue-engineered soft-robotic ray
Park, Sung-Jin,Gazzola, Mattia,Park, Kyung Soo,Park, Shirley,Di Santo, Valentina,Blevins, Erin L.,Lind, Johan U.,Campbell, Patrick H.,Dauth, Stephanie,Capulli, Andrew K.,Pasqualini, Francesco S.,Ahn, American Association for the Advancement of Scienc 2016 Science Vol.353 No.6295
<P>Inspired by the relatively simple morphological blueprint provided by batoid fish such as stingrays and skates, we created a biohybrid system that enables an artificial animal-a tissue-engineered ray-to swim and phototactically follow a light cue. By patterning dissociated rat cardiomyocytes on an elastomeric body enclosing a microfabricated gold skeleton, we replicated fish morphology at 1/10 scale and captured basic fin deflection patterns of batoid fish. Optogenetics allows for phototactic guidance, steering, and turning maneuvers. Optical stimulation induced sequential muscle activation via serpentine-patterned muscle circuits, leading to coordinated undulatory swimming. The speed and direction of the ray was controlled by modulating light frequency and by independently eliciting right and left fins, allowing the biohybrid machine to maneuver through an obstacle course.</P>
Handray Fernandes de Souza,Giovana Felicio Monteiro,Victor Dédalo Di Próspero Gonçalves,João Vitor dos Santos,Amanda Cristina Dias de Oliveira,Karina Nascimento Pereira,Mariana Fronja Carosia,Marina V 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.7
Mead is a fermented alcoholic beverage produced by yeast action on a diluted solution of honey. In this study, for the first time, sensory acceptance, purchase intention and color parameters of potentially probiotic mead with Saccharomyces boulardii were evaluated. The mead with S. boulardii presented yeast counts higher than 106 CFU/mL, being considered potentially probiotic, and tended to be yellow in color. About 160 tasters participated in the sensory evaluation, and 69.38% knew mead, but only 35.62% had tried the beverage. In terms of acceptance, the mead were within the acceptable range (above 5), and F2 (with initial soluble solids of 30° Brix and S. boulardii concentration of 0.030 g/L) was the most accepted, with an overall average of 7.63 ± 1.42 on the nine-point hedonic scale. In addition, F2 presented the highest purchase intention. In conclusion, the mead showed a tendency towards the color yellow and good sensory acceptance.
Rosália Rubel,Herta S. Dalla Santa,Sandro J.R. Bonatto,Se´rgio Bello,Luiz Cla´udio Fernandes,Raffaello Di Bernardi,Juliana Gern,Cid Aimbire´ M. Santos,Carlos Ricardo Soccol 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
This study investigated the effect of Ganoderma lucidum supplementation on lymphocytes and peritoneal macrophages from mice. Our results show that G. lucidum in vivo was able to increase interferon-γ (IFN-γ) concentration but reduced CD3+ and CD8+ spleen lymphocytes. Ex vivo, IFN-γ; and interleukin-10 levels were increased and the tumor necrosis factor-α (TNF-α) level was reduced by peritoneal macrophages from mice fed with G. lucidum. In the absence of stimuli nitric oxide production was reduced in mice fed with G. lucidum, and with lipopolysaccharide stimulation nitric oxide production was increased but was lower than control values (P<.05). G. lucidum was grown by solid-state culture in wheat grain, and a chow containing 10% G. lucidum mycelium was formulated (G10). Swiss male mice were divided into two groups, termed G10 and control groups according to the diet, and were fed for 3 months. Peritoneal macrophages were obtained and investigated with regard to phagocytosis, lysosomal volume, hydrogen peroxide, superoxide anion, and cytokines ex vivo. In the plasma we investigated concentrations of cytokines, and in the spleen we determined subsets of CD3+, CD4+, CD8+, and CD19+ lymphocytes.