Diphenyl derivatives from coastal saline soil fungus Aspergillus iizukae

Desheng Liu,Ling Yan,Liying Ma,Yuling Huang,Xiaohong Pan,Weizhong Liu,Zhihua Lv 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

Two new diphenyl derivatives, named iizukinesA (1) and B (2), along with nine known compounds wereisolated from coastal saline soil derived fungus Aspergillusiizukae. The structures were determined by extensivespectroscopic analysis. Their cytotoxicities were preliminarilyevaluated on HL-60, BEL-7402 and A-549 cell linesby the MTT assay.

Carpooling Service for Large-Scale Taxicab Networks

Zhang, Desheng,He, Tian,Zhang, Fan,Lu, Mingming,Liu, Yunhuai,Lee, Haengju,Son, Sang H. Association for Computing Machinery 2016 ACM transactions on sensor networks Vol.12 No.3

<P>Carpooling has long held the promise of reducing gas consumption by decreasing mileage to deliver coriders. Although ad hoc carpools already exist in the real world through private arrangements, little research on the topic has been done. In this article, we present the first systematic work to design, implement, and evaluate a carpool service, called coRide, in a large-scale taxicab network intended to reduce total mileage for less gas consumption. Our coRide system consists of three components, a dispatching cloud server, passenger clients, and an onboard customized device, called TaxiBox. In the coRide design, in response to the delivery requests of passengers, dispatching cloud servers calculate cost-efficient carpool routes for taxicab drivers and thus lower fares for the individual passengers. To improve coRide's efficiency in mileage reduction, we formulate an NP-hard route calculation problem under different practical constraints. We then provide (1) an optimal algorithm using Linear Programming, (2) a 2-approximation algorithm with a polynomial complexity, and (3) its corresponding online version with a linear complexity. To encourage coRide's adoption, we present a win-win fare model as the incentive mechanism for passengers and drivers to participate. We test the performance of coRide by a comprehensive evaluation with a real-world trial implementation and a data-driven simulation with 14,000 taxi data from the Chinese city Shenzhen. The results show that compared with the ground truth, our service can reduce 33% of total mileage; with our win-win fare model, we can lower passenger fares by 49% and simultaneously increase driver profit by 76%.</P>

Alternative Biological Material for Tissue Engineering of the Vagina: Porcine-Derived Acellular Vaginal Matrix

Tian Yanpeng,Liu Yibin,Xiao Yanlai,Li Zhongkang,Zhang Mingle,Chen Liang,Li Zhen,Zhang Wangchao,Zhang Zhiqiang,Kong Desheng,Meng Li,Du Yanfang,Zhang Jingkun,Gao Jingui,Huang Xianghua 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.2

Background: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a severe congenital disorder characterized by vaginal hypoplasia caused by dysplasia of the Müllerian duct. Patients with MRKH syndrome often require nonsurgical or surgical treatment to achieve satisfactory vaginal length and sexual outcomes. The extracellular matrix has been successfully used for vaginal reconstruction. Methods: In this study, we developed a new biological material derived from porcine vagina (acellular vaginal matrix, AVM) to reconstruct the vagina in Bama miniature pigs. The histological characteristics and efficacy of acellularization of AVM were evaluated, and AVM was subsequently transplanted into Bama miniature pigs to reconstruct the vaginas. Results: Macroscopic analysis showed that the neovaginas functioned well in all Bama miniature pigs with AVM implants. Histological analysis and electrophysiological evidence indicated that morphological and functional recovery was restored in normal vaginal tissues. Scanning electron microscopy showed that the neovaginas had mucosal folds characteristics of normal vagina. No significant differences were observed in the expression of CK14, HSP47, and α-actin between the neovaginas and normal vaginal tissues. However, the expression of estrogen receptor (ER) was significantly lower in the neovaginas than in normal vaginal tissues. In addition, AVM promoted the expression of β-catenin, c-Myc, and cyclin D1. These results suggest that AVM might promotes vaginal regeneration by activating the β-catenin/c-Myc/cyclin D1 pathway. Conclusion: This study reveals that porcine-derived AVM has potential application for vaginal regeneration. Background: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a severe congenital disorder characterized by vaginal hypoplasia caused by dysplasia of the Müllerian duct. Patients with MRKH syndrome often require nonsurgical or surgical treatment to achieve satisfactory vaginal length and sexual outcomes. The extracellular matrix has been successfully used for vaginal reconstruction. Methods: In this study, we developed a new biological material derived from porcine vagina (acellular vaginal matrix, AVM) to reconstruct the vagina in Bama miniature pigs. The histological characteristics and efficacy of acellularization of AVM were evaluated, and AVM was subsequently transplanted into Bama miniature pigs to reconstruct the vaginas. Results: Macroscopic analysis showed that the neovaginas functioned well in all Bama miniature pigs with AVM implants. Histological analysis and electrophysiological evidence indicated that morphological and functional recovery was restored in normal vaginal tissues. Scanning electron microscopy showed that the neovaginas had mucosal folds characteristics of normal vagina. No significant differences were observed in the expression of CK14, HSP47, and α-actin between the neovaginas and normal vaginal tissues. However, the expression of estrogen receptor (ER) was significantly lower in the neovaginas than in normal vaginal tissues. In addition, AVM promoted the expression of β-catenin, c-Myc, and cyclin D1. These results suggest that AVM might promotes vaginal regeneration by activating the β-catenin/c-Myc/cyclin D1 pathway. Conclusion: This study reveals that porcine-derived AVM has potential application for vaginal regeneration.

Small Base Station Association and Cooperative Receiver Design for HetNets via Distributed SOCP

( Li Lu ),( Desheng Wang ),( Hongyi Zhao ),( Yingzhuang Liu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12

How to determine the right number of small base stations to activate in multi-cell uplinks to match traffic from a fixed quantity of K users is an open question. This paper analyses the uplink cooperative that jointly receives base stations activation to explore this question. This paper is different from existing works only consider transmitting power as optimization objective function. The global objective function is formulated as a summation of two terms: transmitting power for data and coordinated overhead for control. Then, the joint base stations activation and beamforming problem is formulated as a mixed integer second order cone optimization. To solve this problem, we develop two polynomial-time distributed methods. Method one is a two-stage solution which activates no more than K small base stations (SBSs). Method two is a heuristic algorithm by dual decomposition to MI-SOCP that activates more SBSs to obtain multiple-antennae diversity gains. Thanks to the parallel computation for each node, our methods are more computationally efficient. The strengths and weaknesses of these two proposed two algorithms are also compared using numerical results.

DESIGN AND BRAKING STABILITY ANALYSIS OF A NOVEL INTERNAL PUMP-HYDRAULIC RETARDER AXLE FOR HEAVY ARTICULATED VEHICLE

Zhiwei Gao,Desheng Li,Zongqiang Liu,Lezhi Ye 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.5

The retarder is widely used to ensure braking safety in heavy vehicles due to its noncontact braking characteristics. Currently, retarders are generally mounted on tractors, but semi-trailers have greater inertia and are prone to accidents. Therefore, the semi-trailer’s brakes have to work frequently to maintain stability during downhill braking, which causes the brakes to generate high temperatures or even failure. Based on the above problems, a novel internal pump-hydraulic retarder axle (IP-HRA) is proposed, which integrates the pump and hydraulic retarder (HR) into the support axle. The prototype of the IP-HRA was made and a bench test was conducted. In the experiment, the single-side braking power of the IP-HRA reaches 300 kW and its torque can be controlled by adjusting the outlet pressure. A co-simulation model of articulated vehicles is established to predict the braking state by computer solutions. Based on the experimental data, the methods of IP-HRA braking semi-trailer and traditional HR braking tractor are compared. The results of co-simulation show that the IP-HRA is more conducive to the braking stability of the articulated vehicle than the traditional HR when only retarder is used. Finally, the braking time and braking deceleration of IP-HRA are verified by road experiments.

Catalytic synthesis and enhanced Curie temperature of ε-Fe₃N@C nanostructure synthesized in a tetraethylenepentamine solution

Li, Yong,Pan, Desheng,Li, Da,Feng, Yang,Choi, C.J.,Liu, Wei,Zhang, Zhidong Elsevier 2018 Journal of magnetism and magnetic materials Vol.465 No.-

<P><B>Abstract</B></P> <P>ε-Fe<SUB>3</SUB>N@C nanocrystals without oxidation are one-pot synthesized by using the iron(II) acetylacetonate and tetraethylenepentamine (TEPA) as Fe and N precursors under a low temperature (533 K) in the presence of a small quantity of Pt atoms as the co-catalyst. The ε-Fe<SUB>3</SUB>N@C nanoparticles with a core-shell structure are nearly spherical and have a wide particle size distribution of 100–500 nm in diameter. Fe nanoparticles obtained by reduction of Fe<SUP>2+</SUP> with TEPA are an effective catalyzer for decomposing TEPA to produce N and C atoms at a temperature much lower than the boiling point of TEPA. The diffusion of N atoms into Fe nanoparticles for the formation of ε-Fe<SUB>3</SUB>N@C is proposed, based on the results obtained by kinetically controlling the synthetic temperature and surfactants. The ε-Fe<SUB>3</SUB>N@C nanoparticles have an excellent saturation magnetization of 135.5 emu/g at room temperature. A significantly enhanced Curie temperature (T<SUB>C</SUB>) of 614 K is reached in the present ε-Fe<SUB>3</SUB>N@C nanoparticles, which is much higher than the T<SUB>C</SUB> values in the previously reported ε-Fe<SUB>3</SUB>N<SUB>x</SUB>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Tetraethylenepentamine is proposed as a new N source to synthesize Fe nitride. </LI> <LI> Core-shelled ε-Fe<SUB>3</SUB>N@C nanoparticles are one-pot synthesized at 260 °C. </LI> <LI> Curie temperature of ε-Fe<SUB>3</SUB>N is significantly enhanced to 614 K. </LI> <LI> ε-Fe<SUB>3</SUB>N@C shows a high saturation magnetization of 135.5 emu/g at 300 K. </LI> </UL> </P>

Small Base Station Association and Cooperative Receiver Design for HetNets via Distributed SOCP

Lu, Li,Wang, Desheng,Zhao, Hongyi,Liu, Yingzhuang Korean Society for Internet Information 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12

How to determine the right number of small base stations to activate in multi-cell uplinks to match traffic from a fixed quantity of K users is an open question. This paper analyses the uplink cooperative that jointly receives base stations activation to explore this question. This paper is different from existing works only consider transmitting power as optimization objective function. The global objective function is formulated as a summation of two terms: transmitting power for data and coordinated overhead for control. Then, the joint base stations activation and beamforming problem is formulated as a mixed integer second order cone optimization. To solve this problem, we develop two polynomial-time distributed methods. Method one is a two-stage solution which activates no more than K small base stations (SBSs). Method two is a heuristic algorithm by dual decomposition to MI-SOCP that activates more SBSs to obtain multiple-antennae diversity gains. Thanks to the parallel computation for each node, our methods are more computationally efficient. The strengths and weaknesses of these two proposed two algorithms are also compared using numerical results.

Polyamidoamine Immobilized TEMPO Mediated Oxidation of Cellulose: Effect of Macromolecular Catalyst Structure on the Reaction Rate, Oxidation Degree and Degradation Degree

Huazhe Liang,Meng Cao,Desheng Yang,Tingting Sun,Xiaomeng Chu,Shaojie Liu 한국섬유공학회 2020 Fibers and polymers Vol.21 No.6

A series of polyamidoamine (PAMAM) immobilized TEMPO macromolecular catalysts were prepared by condensation reduction reactions between carbonyl groups in 4-O-TEMPO and primary amines in PAMAM. The macromolecular catalyst and NaBr/NaClO were used as catalytic system for selective oxidation of cellulose in aqueous medium. Effects of various factors, such as TEMPO loading ratios and PAMAM generations, were studied on the catalytic performances. Compared with free TEMPO, the macromolecular catalyst with less than 50 % TEMPO loading ratio had a higher reaction rate in the initial stage of the reaction. Especially, the reaction rate of G1.0 PAMAM with 30 % TEMPO loading ratio was comparable to free TEMPO in the whole reaction process. Its cellulose oxidation degree (or catalytic activity) was also equivalent to the level of free TEMPO. Interestingly, the cellulose depolymerization degree of macromolecular catalyst was not affected by the cellulose oxidation degree and was lower than that of free TEMPO. The macromolecular catalyst could be recycled efficiently by the combination of supernatant circulation and salting-out extraction, and the recycling performance was excellent.

First-principles study of the field-induced current-switch by dithiocarboxylate anchoring group in molecular junction

Caijuan Xia,Changfeng Fang,Peng Zhao,Desheng Liu 한국물리학회 2010 Current Applied Physics Vol.10 No.3

Based on non-equilibrium Green’s function and first-principles calculations, we investigate the electronic transport properties of 4,40-biphenyl bis (dithiocarboxylate) (BDCT) molecular junction with the fieldinduced geometry relaxation. The results indicate that the external field has noticeable effects on the molecular structure, coupling strengths and bonding distances. More importantly, it is found that the inclusion of field-induced molecular geometry relaxation can predict a current-switch behavior, which may have some potential applications in future molecular circuit.

Increased Expression of EMMPRIN and VEGF in the Rat Brain after Gamma Irradiation

Ming Wei,Hong Li,Huiling Huang,Desheng Xu,Dashi Zhi,Dong Liu,Yipei Zhang 대한의학회 2012 Journal of Korean medical science Vol.27 No.3

The extracellular matrix metalloproteinase inducer (EMMPRIN) has been known to play a key regulatory role in pathological angiogenesis. A elevated activation of vascular endothelial growth factor (VEGF) following radiation injury has been shown to mediate blood-brain barrier (BBB) breakdown. However, the roles of EMMPRIN and VEGF in radiation-induced brain injury after gamma knife surgery (GKS) are not clearly understood. In this study, we investigated EMMPRIN changes in a rat model of radiation injury following GKS and examined potential associations between EMMPRIN and VEGF expression. Adult male rats were subjected to cerebral radiation injury by GKS under anesthesia. We found that EMMPRIN and VEGF expression were markedly upregulated in the target area at 8-12 weeks after GKS compared with the control group by western blot,immunohistochemistry, and RT-PCR analysis. Immunofluorescent double staining demonstrated that EMMPRIN signals colocalized with caspase-3 and VEGF-positive cells. Our data also demonstrated that increased EMMPRIN expression was correlated with increased VEGF levels in a temporal manner. This is the first study to show that EMMPRIN and VEGF may play a role in radiation injuries of the central nervous system after GKS.