http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Deepali (검색결과 25 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
Cross domain analyzer to acquire review proficiency in big data
Deepali Virmani,Preeti Arora,Pradnya Satish Kulkarni 한국통신학회 2017 ICT Express Vol.3 No.3
Sentiment analysis is the pre-eminent technology for extracting relevant information in the data domain. In this paper, a cross-domain sentimental classification approach, the cross-domain analyzer (CDA), is proposed, which will extract positive words and replace their synonyms to escalate polarity. Additionally, the approach blends two different domains and detects all self-sufficient words. This is executed on Amazon datasets, in which two different domains are trained to analyze the sentiments of the reviews in the other domain. The proposed approach contributes promising results in the cross-domain analysis, and an accuracy of 92% is achieved. In BOMEST, the CDA improves precision and recall by 16% and 7%, respectively.
-
-
-
Thyroid Cytology in India: Contemporary Review and Meta-analysis
Shipra Agarwal,Deepali Jain 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.6
Fine-needle aspiration cytology (FNAC) is a screening test for triaging thyroid nodules, aiding in subsequent clinical management. However, the advantages have been overshadowed by the multiplicity of reporting systems and a wide range of nomenclature used. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was formulated in 2007, to give the world a uniform thyroid cytology reporting system, facilitating easy interpretation by the clinicians. Here, we review the status of thyroid FNAC in India in terms of various reporting systems used including a meta-analysis of the previously published data. An extensive literature search was performed using internet search engines. The reports with detailed classification system used in thyroid cytology were included. The meta-analysis of published data was compared with the implied risk of malignancy by TBSRTC. More than 50 studies were retrieved and evaluated. TBSRTC is currently the most widely used reporting system with different studies showing good efficacy and interobserver concordance. Ancillary techniques have, as of now, limited applicability and acceptability in thyroid cytology in India. Twenty-eight published articles met the criteria for inclusion in the meta-analysis. When compared with TBSRTC recommendations, the meta-analysis showed a higher risk of malignancy for categories I and III. Thyroid FNAC is practiced all over India. TBSRTC has found widespread acceptance, with most institutions using this system for routine thyroid cytology reporting. However, reasons for a high malignancy risk for categories I and III need to be looked into. Various possible contributing factors are discussed in the review.
-
Acid-Fastness of Histoplasma in Surgical Pathology Practice
Madhu Rajeshwari,Deepali Jain,Immaculata Xess,Mehar Chand Sharma 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.5
Background: Histoplasmosis (HP) is diagnosed by visualizing intracellular microorganisms in biopsy and/or culture. Periodic-acid Schiff (PAS) and Gomori methenamine silver (GMS) staining methods are routinely used for identification. The acid-fast property of Histoplasma was identified decades ago, but acid-fast staining has not been practiced in current surgical pathology. Awareness of the acid-fast property of Histoplasma, which is due to mycolic acid in the cell wall, is important in distinguishing Histoplasma from other infective microorganisms. Here, we examined acid-fastness in previously diagnosed cases of Histoplasma using the Ziehl-Neelsen (ZN) stain and correlated those findings with other known fungal stains. Methods: All cases diagnosed as HP were retrieved and reviewed along with ZN staining and other fungal stains. We also stained cases diagnosed with Cryptococcus and Leishmania as controls for comparison. Results: A total of 54 patients ranging in age from 11 to 69 years were examined. The most common sites of infection were the skin, adrenal tissue, and respiratory tract. Of the total 43 tissue samples, 20 (46.5%) stained positive with the ZN stain. In viable cases, a significant proportion of microorganisms were positive while necrotic cases showed only rare ZN-positive yeasts. In comparison to PAS and GMS stains, there was a low burden of ZN-positive yeasts. Cryptococcus showed characteristic ZN staining and all cases of Leishmania were negative. Conclusions: Although the morphology of fungal organisms is the foundation of identification, surgical pathologists should be aware of the acid-fast property of fungi, particularly when there is the potential for confusion with other infective organisms.
-
Analysis of Immunoexpression of BRCA1-Associated Protein 1 (BAP1) in Pleural Mesotheliomas
( Rimlee Dutta ),( Deepali Jain ),( Aruna Nambirajan ),( Prabhat Mallick ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Malignant mesotheliomas have an aggressive clinical course and are usually diagnosed at advanced stage. The gold standard of diagnosis is histological demonstration of invasion into adjacent organs, however in routine pleural biopsies, ancillary tests are often required to distinguish mesothelioma from florid reactive mesothelial proliferation. In this regard, demonstration of immunohistochemical loss of BRCA1-associated protein 1 (BAP1) has been found to be highly specific. Purpose Herein, we tried to study the immunoexpression of BAP1 in cases of pleural mesotheliomas and tried to analyse its usefulness as a diagnostic marker. We retrospectively searched our computerised database for cases of pleural mesotheliomas. Data regarding clinical semiology and imaging details of these cases were retrieved. Paraffin embedded blocks of all available cases with adequate tissues (including biopsies and resections) were recovered and immunohistochemistry for BAP1 was performed, as per established protocol. Results A total of twenty-five cases were identified, however only twenty-one of the cases had adequate tissue in the retrieved blocks. Majority of the cases were elderly males, non-smokers, who presented with symptoms of cough, dyspnoea and chest pain and on imaging were found to harbour pleural based mass lesions. Only three of the cases showed a biphasic pattern on histomorphology with presence of sarcomatoid component, while the other cases showed an exclusive epithelioid pattern. The tumor cells were diffusely immunopositive for calretinin, p53, CK5/6, WT1 and were immunonegative for TTF1, napsin-A and desmin. BAP1 immunoexpression was lost in eleven cases (52.3%) out of total. Results In the absence of demonstrable evidence of invasion, distinguishing florid reactive mesothelial proliferation from malignant mesothelioma is often problematic and more so in trucut biopsies and malignant effusion cytology. In this regard, BAP1 has been found to be highly specific in confirming the malignant nature of mesothelial cells, thereby facilitating the diagnosis of malignant mesothelioma.
-
Mohit Rajput,Deepali Mishra,Kunal Kumar,Rana P. Singh 대한암예방학회 2022 Journal of cancer prevention Vol.27 No.3
Emergence of radioresistance in prostate cancer (PCa) cells is a major obstacle in cancer therapy and contributes to the relapse of the disease. EGF receptor (EGFR) signaling plays an important role in the development of radioresistance. Herein, we have assessed the modulatory effects of silibinin on radiation-induced resistance via DNA repair pathways in EGFR-knockdown DU145 cells. shRNA-based silencing of EGFR was done in radioresistant human PCa DU145 cells and effects of ionizing radiation (IR) and silibinin were assessed using clonogenic and trypan blue assays. Furthermore, radiosensitizing effects of silibinin on PCa in context with EGFR were analyzed using flow cytometry, comet assay, and immunoblotting. Silibinin decreased the colony formation ability with an increased death of DU145 cells exposed to IR (5 Gray), with a concomitant decrease in Rad51 protein expression. Silibinin (25 μM) augmented the IR-induced cytotoxic effect in EGFR-knockdown PCa cells, along with induction of G2/M phase cell cycle arrest. Further, we studied homologous recombination (HR) and non-homologous end joining (NHEJ) pathways in silibinin-induced DNA double-strand breaks in EGFR-knockdown DU145 cells. Silibinin down-regulated the expression of Rad51 and DNA-dependent protein kinase proteins without any considerable effect on Ku70 and Ku80 in IR-exposed EGFR-knockdown PCa cells. The pro-survival signaling proteins, phospho-extracellular signal-regulated kinases (ERK)1/2, phospho-Akt and phospho-STAT3 were decreased by silibinin in EGFR-deficient PCa cells. These findings suggest a novel mechanism of silibinin-induced radiosensitization of PCa cells by targeting DNA repair pathways, HR and NHEJ, and suppressing the pro-survival signaling pathways, ERK1/2, Akt and STAT3, in EGFR-knockdown PCa cells.
-
Meghana Prabhu,Deepali Jain,Siddhartha Datta Gupta,Chandrasekhar Bal,Rakesh Kumar 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.5
Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Metastases to axillary lymph nodes (ALN) are very rare. As perliterature, only 25 cases have been reported. We report an unusual case of 47-year-old male with Hürthle cell carcinoma of thethyroid presenting with a solitary axillary lymph node metastasis 17 years after thyroidectomy, along with review of literature.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
