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RISS 인기검색어
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- 저자 : Rana P. Singh (검색결과 8 건)
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Incremental Software Version Release Planning For Adaptive Maintenance
Arti Rana,Dr. S.P Singh,Dr. Rachna Soni,Dr. Ashish Jolly 보안공학연구지원센터 2015 International Journal of Software Engineering and Vol.9 No.8
The core of the versioning is change management. Versioning is related to the creation and management of the software changes for the traceability of number of releases of software, all of which has the same general function but is enhanced or tailored. Version control gives you the option to expand your project in the future and engage in possible collaborations with others. Even after the software is delivered it is required for every successful software system continues to be improved and adapted over time to meet the changing needs of the market. In this paper the Markov model is then proposed, and market share of software according to optimal release version analysis for n versions is studied.
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Artificial Intelligence Inspired Intelligent Trust Based Routing Algorithm for IoT
Kajol Rana,Ajay Vikram Singh,P. Vijaya International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.11
Internet of Things (IoT) is a relatively new concept that has gained immense popularity in a short period of time due to its wide applicability in making human life more convenient and automated. As an illustration: the development of smart homes, smart cities, etc. However, it is also accompanied by a substantial number of risks and flaws. IoT makes use of low-powered devices, so secure, less time-consuming and energy-intensive transmission (routing) of messages due to the limited availability of energy is one of the many and most significant concerns for IoT developers. The following paper presents a trust-based routing scenario for the Internet of Things (IoT) that exploits the past transmission record from the cupcarbon simulator's log files. Artificial Neural Network is used to quantify knowledge of trust, calculate the value of trust, and share this information with other network devices. As a human behavioural pattern, trust provides a superior method for making routing decisions. If there is a tie in the trust values and no other path is available, the remaining battery power is used to break the tie and make a forwarding decision; this is also seen as a more efficient use of the available resources. The proposed algorithm is observed to have superior energy consumption and routing decisions compared to conventional routing algorithms, and it improves the communication pattern.
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Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide
Hahm Eun-Ryeong,Mathan Sivapar V.,Singh Rana P.,Singh Shivendra V. 대한암예방학회 2022 Journal of cancer prevention Vol.27 No.2
Diallyl trisulfide (DATS) is an attractive anti-cancer phytochemical with in vitro and in vivo growth inhibitory effects against different solid tumors including breast cancer. We have shown previously that an immortalized mammary epithelial cell line (MCF-10A) is resistant to growth inhibition by DATS. In this study, we performed RNA-seq analysis using a breast cancer cell line (SK-BR-3) and MCF-10A cells to gain insights into cancer selective effects of DATS. The Gene Ontology analysis revealed upregulation of genes associated with actin cytoskeleton but downregulation of mitochondria-related genes in the SK-BR-3 human breast cancer cell line but not in the non-oncogenic MCF-10A cell line upon treatment with DATS. Quantitative real-time reverse transcription polymerase chain reaction confirmed DATS-mediated upregulation of several actin cytoskeleton-related genes in the SK-BR-3 cell line. The DATS treatment dose-dependently disrupted actin cytoskeleton in the SK-BR-3 cell line, whereas the MCF-10A cell line was more resistant to this effect. The DATS treatment caused a marked increase in phosphorylation of dynamin-1-like (DRP1) protein in the SK-BR-3 cell line. However, the DATS-mediated apoptosis was not affected by genetic deletion of DRP1 protein. The Reactome pathway analysis showed downregulation of genes associated with citric acid cycle in the SK-BR-3 cell line but not in the MCF-10A cells. However, expression of aconitase 2 or dihydrolipoamide S-succinyltransferase was not affected by DATS treatment. In conclusion, this study reveals that actin cytoskeleton is a novel target of DATS in the SK-BR-3 cell line, which may explain its inhibitory effect on breast cancer cell migration.
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Mohit Rajput,Deepali Mishra,Kunal Kumar,Rana P. Singh 대한암예방학회 2022 Journal of cancer prevention Vol.27 No.3
Emergence of radioresistance in prostate cancer (PCa) cells is a major obstacle in cancer therapy and contributes to the relapse of the disease. EGF receptor (EGFR) signaling plays an important role in the development of radioresistance. Herein, we have assessed the modulatory effects of silibinin on radiation-induced resistance via DNA repair pathways in EGFR-knockdown DU145 cells. shRNA-based silencing of EGFR was done in radioresistant human PCa DU145 cells and effects of ionizing radiation (IR) and silibinin were assessed using clonogenic and trypan blue assays. Furthermore, radiosensitizing effects of silibinin on PCa in context with EGFR were analyzed using flow cytometry, comet assay, and immunoblotting. Silibinin decreased the colony formation ability with an increased death of DU145 cells exposed to IR (5 Gray), with a concomitant decrease in Rad51 protein expression. Silibinin (25 μM) augmented the IR-induced cytotoxic effect in EGFR-knockdown PCa cells, along with induction of G2/M phase cell cycle arrest. Further, we studied homologous recombination (HR) and non-homologous end joining (NHEJ) pathways in silibinin-induced DNA double-strand breaks in EGFR-knockdown DU145 cells. Silibinin down-regulated the expression of Rad51 and DNA-dependent protein kinase proteins without any considerable effect on Ku70 and Ku80 in IR-exposed EGFR-knockdown PCa cells. The pro-survival signaling proteins, phospho-extracellular signal-regulated kinases (ERK)1/2, phospho-Akt and phospho-STAT3 were decreased by silibinin in EGFR-deficient PCa cells. These findings suggest a novel mechanism of silibinin-induced radiosensitization of PCa cells by targeting DNA repair pathways, HR and NHEJ, and suppressing the pro-survival signaling pathways, ERK1/2, Akt and STAT3, in EGFR-knockdown PCa cells.
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Goel, Sonu,Kumar, Ravinder,Lal, Pranay,Tripathi, J.P.,Singh, Rana J.,Rathinam, Arul,Christian, Anant Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: Section 5 of India's tobacco control legislation "Cigarettes and Other Tobacco Products Act (COTPA), 2003"comprehensively prohibits all kinds of tobacco advertisement, promotion and sponsorship (TAPS), but permits advertisments at the point-of-sale (POS) under certain conditions. This provision has been exploited by the tobacco companies to promote their products. Objective: To measure compliance with the provisions of Section 5 of Indian tobacco control legislation (COTPA, 2003) at point of sale. Materials and Methods: A cross-sectional survey using an observation checklist was conducted in 1860 POS across three jurisdictions (Chennai city, District Vadodara and District Mohali) in India. Results: The most common mode of advertisement of tobacco products was product showcasing (51.1%), followed by dangles (49.6%), stickers (33.8%) and boards (27.1%). More than one fourth of POS were found violating legal provisions for displaying advertisement boards in one or other forms (oversized, extended to full body lenth of POS, displayed brandname/packshot and promotional messages). Advertisement boards (16.3%) without health warnings were also found and wherever found, more than 90% health warning were not as per the specification in respect to size, font and background color. Conclusions: Point of sale advertising is aggressively used by the tobacco industry to promote their products. There is an urgent need of effective implementation of a comprehensive ban on tobacco product advertisement, promotion and sponsorship at point of sale.
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Eun-Ryeong Hahm,Su-Hyeong Kim,Sivapar V. Mathan,Rana P. Singh,Shivendra V. Singh 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.2
Diallyl trisulfide (DATS), a metabolic by-product of processed garlic, is highly effective in inhibiting growth of human breast cancer cells in vitro and in vivo, but the underlying mechanisms are still not fully understood. In this study, we performed RNA-seq analyses using luminal-type (MCF-7) and basal-like (MDA-MB-231) human breast cancer cells to identify mechanistic targets of DATS. The Reactome Pathway Analysis revealed upregulation of genes associated with SLIT/ROBO tumor suppressor signaling following DATS treatment in both MCF-7 and MDA-MB-231 cells. However, the expression of SLIT2 and ROBO1 proteins or their downstream target C-X-C motif chemokine receptor 4 was not affected by DATS treatment in both cell lines. The Reactome as well as the Gene Ontology Pathways Analyses of the RNA-seq data from DATS-treated cells indicated downregulation of genes associated with G2/M phase cell cycle arrest in comparison with vehicle-treated control cells. Consistent with the RNA-seq data, DATS treatment caused a significant increase in the fraction of the G2/M population in both cell lines when compared to corresponding control cells. In addition, Ser10 phosphorylation of histone H3, a mitotic marker, was also increased significantly following DATS treatment in MCF-7 and MDA-MB-231 cells. These results indicate that while SLIT/ROBO signaling is not affected by DATS treatment, cell cycle arrest likely contributes to the antitumor effect of this phytochemical.
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