Adipose-Derived Stem Cells Enhance Burn Wound Healing and Neuropathic Pain Treatment

Hui-Min David WANG 한국생물공학회 2016 한국생물공학회 학술대회 Vol.2016 No.4

Frequency and Outcome of Neuroleptic Rotation in the Management of Delirium in Patients with Advanced Cancer

신성훈,David Hui,Gary Chisholm,강정훈,Julio Allo,Janet Williams,Eduardo Bruera 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3

Purpose The response to haloperidol as a first-line neuroleptic and the pattern of neuroleptic rotation after haloperidol failure have not been well defined in palliative care. The purpose of this study was to determine the efficacy of haloperidol as a first-line neuroleptic and the predictors associated with the need to rotate to a second neuroleptic. Materials and Methods We conducted a retrospective review of the charts of advanced cancer patients admitted to our acute palliative care unit between January 2012 and March 2013. Inclusion criteria were a diagnosis of delirium and first-line treatment with haloperidol. Results Among 167 patients with delirium, 128 (77%) received only haloperidol and 39 (23%) received a second neuroleptic. Ninety-one patients (71%) who received haloperidol alone improved and were discharged alive. The median initial haloperidol dose was 5 mg (interquartile ranges [IQR], 3 to 7 mg) and the median duration was 5 days (IQR, 3 to 7 days). The median final haloperidol dose was 6 mg (IQR, 5 to 7 mg). A lack of treatment efficacy was the most common reason for neuroleptic rotation (87%). Significant factors associated with neuroleptic rotation were inpatient mortality (59% vs. 29%, p=0.001), and being Caucasian (87% vs. 62%, p=0.014). Chlorpromazine was administered to 37 patients (95%) who were not treated successfully by haloperidol. The median initial chlorpromazine dose was 150 mg (IQR, 100 to 150 mg) and the median duration was 3 days (IQR, 2 to 6 days). Thirteen patients (33%) showed reduced symptoms after the second neuroleptic. Conclusion Neuroleptic rotation from haloperidol was only required in 23% of patients with delirium and was associated with inpatient mortality and white race.

FRAGMENTATION KINEMATICS IN COMET 332P/IKEYA-MURAKAMI

Jewitt, David,Mutchler, Max,Weaver, Harold,Hui, Man-To,Agarwal, Jessica,Ishiguro, Masateru,Kleyna, Jan,Li, Jing,Meech, Karen,Micheli, Marco,Wainscoat, Richard,Weryk, Robert American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.829 No.1

<P>We present initial time-resolved observations of the split comet 332P/Ikeya-Murakami taken using the Hubble Space Telescope. Our images reveal a dust-bathed cluster of fragments receding from their parent nucleus at projected speeds in the range 0.06-3.5 m s(-1) from which we estimate ejection times from 2015 October to December. The number of fragments with effective radii greater than or similar to 20 m follows a differential power law with index gamma = -3.6 +/- 0.6, while smaller fragments are less abundant than expected from an extrapolation of this power law. We argue that, in addition to losses due to observational selection, torques from anisotropic outgassing are capable of destroying the small fragments by driving them quickly to rotational instability. Specifically, the spin-up times of fragments. 20 m in radius are shorter than the time elapsed since ejection from the parent nucleus. The effective radius of the parent nucleus is re <= 275 m (geometric albedo 0.04 assumed). This is about seven times smaller than previous estimates and results in a nucleus mass at least 300 times smaller than previously thought. The mass in solid pieces, 2 x 10(9) kg, is about 4% of the mass of the parent nucleus. As a result of its small size, the parent nucleus also has a short spin-up time. Brightness variations in time-resolved nucleus photometry are consistent with rotational instability playing a role in the release of fragments.</P>

Load deformation characteristics of shallow suspension footbridge with reverse profiled pre-tensioned cables

Ming-Hui Huang,David P. Thambiratnam,Nimal J. Perera 국제구조공학회 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.21 No.4

Cable supported structures offer an elegant and economical solution for bridging over long spans with resultant low material content and ease of construction. In this paper, a model of shallow cable supported footbridge with reverse profiled pre-tensioned cables is treated and its load deformation characteristics under different quasi-static loads are investigated. Effects of important parameters such as cable sag and pre-tension are also studied. Numerical results performed on a 3D model show that structural stiffness of this bridge (model) depends not only on the cable sag and cross sectional areas of the cables, but also on the pre-tension in the reverse profiled cables. The tension in the top supporting cables can be adjusted to a high level by the pre-tension in the reverse profiled bottom cables, with the total horizontal force in the bridge structure remaining reasonably constant. It is also evident that pretensioned horizontally profiled cables can greatly increase the lateral horizontal stiffness and suppress the lateral horizontal deflection induced by eccentric vertical loads.

On the parametric instability of multilayered conical shells using the FOSDT

John Lair,David Hui,Abdullah H. Sofiyev,Viktor Gribniak,Ferruh Turan 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.3

This paper investigates the parametric instability (PI) of multilayered composite conical shells (MLCCSs) under axial load periodically varying the time, using the first order shear deformation theory (FOSDT). The basic equations for the MLCCSs are derived and then the Galerkin method is used to obtain the ordinary differential equation of the motion. The equation of motion converted to the Mathieu-Hill type differential equation, in which the DI is examined employing the Bolotin’s method. The expressions for left and right limits of dimensionless parametric instability regions (PIRs) of MLCCSs based on the FOSDT are obtained. Finally, the influence of various parameters; lay-up, shear deformations (SDs), aspect ratio, as well as loading factors on the borders of the PIRs are examined.

Optimally Fabricated Chitosan Particles Containing Ovalbumin Induced Cellular and Humoral Immunity in Immunized Mice

김승훈,류영채,Hui-Min David Wang,황병희 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.5

Subunit vaccines have been developed as promising vaccines with safety. However, subunit vaccines have difficulties in commercialization due to low efficiencies of delivery and immune response. As a result, studies of adjuvants that improve the immune-inducing ability of vaccines have been conducted globally. Aluminum salts (alum) have been extensively used as vaccine adjuvants, but they cannot induce potent cellular immunity. In this study, chitosan particles were fabricated by the precipitationcoacervation method on four different conditions. Ovalbumin (OVA), as a model antigen, was encapsulated in chitosan particles. The optimized fabrication conditions of chitosan particles were 8 mL/min drop rate of sodium sulfate and 0.5 mg/mL chitosan concentration in a sonication bath. Properties of the optimized chitosan particle were about 300 nm diameter, 0.1 polydispersity index, 16.2 mV zeta potential, and 90% loading efficiency. Chitosan particlecontaining OVA showed 76% uptake efficiency by mouse macrophage cells and suitable cell viability. Immunization of mice by chitosan particles exhibited IgG1 titer and Interleukin-4 production of a similar level with the alum. Moreover, chitosan particles showed significantly enhanced IgG2 titer and Interferon-gamma production related to Th1-mediated cellular immune response. These results indicated that chitosan particles could be expected to be a promising adjuvant inducing cellular and humoral immunity for subunit vaccine delivery.

Facile synthesis of N-doped graphene supported porous cobalt molybdenum oxynitride nanodendrites for the oxygen reduction reaction

Sharma, Kamaldeep,Hui, David,Kim, Nam Hoon,Lee, Joong Hee The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.3

<P>Exploring an inexpensive, active and stable electrocatalyst as an alternative to expensive Pt for the oxygen reduction reaction (ORR), porous Co-Mo-ON alloy nanodendrites supported on nitrogen-doped graphene (Co-Mo-ON/NG) have been synthesized by a two-step solid state heating method. The Co-Mo-ON/NG nanodendrites offer high ORR activity and superior electrochemical stability both in acidic and alkaline media. This superiority is due to the synergistic effect of NG, enhanced catalytic efficiency by Mo, highly active intrinsic surface area and exposure of catalytic facets of nanodendritic morphology towards the ORR. The Co-Mo-ON/NG nanodendrites show a 4e<SUP>−</SUP> ORR process with 0.710 V and 0.915 V onset potentials in 0.5 M H2SO4 and 0.1 M KOH, respectively. The Co-Mo-ON/NG nanodendrites show extreme electrochemical stability in terms of 96% and 97% current retention for 40 000 s in both acidic and alkaline media, respectively, long term durability for continuous 2000 cycles and greater resistance to methanol than the commercial Pt/C catalyst. Furthermore, Mo-ON/NG, Co-ON/NG, and Co-Mo-ON are also tested to evaluate the effect of Mo-doping and NG on the electrocatalytic activity of Co-Mo-ON/NG nanodendrites. Owing to their low cost, easy synthesis, outstanding ORR performance, and extreme durability, Co-Mo-ON/NG nanodendrites emerged as a promising non-precious and highly stable ORR electrocatalyst in fuel cell applications.</P>

Load deformation characteristics of shallow suspension footbridge with reverse profiled pre-tensioned cables

Huang, Ming-Hui,Thambiratnam, David P.,Perera, Nimal J. Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.21 No.4

Cable supported structures offer an elegant and economical solution for bridging over long spans with resultant low material content and ease of construction. In this paper, a model of shallow cable supported footbridge with reverse profiled pre-tensioned cables is treated and its load deformation characteristics under different quasi-static loads are investigated. Effects of important parameters such as cable sag and pre-tension are also studied. Numerical results performed on a 3D model show that structural stiffness of this bridge (model) depends not only on the cable sag and cross sectional areas of the cables, but also on the pre-tension in the reverse profiled cables. The tension in the top supporting cables can be adjusted to a high level by the pre-tension in the reverse profiled bottom cables, with the total horizontal force in the bridge structure remaining reasonably constant. It is also evident that pre-tensioned horizontally profiled cables can greatly increase the lateral horizontal stiffness and suppress the lateral horizontal deflection induced by eccentric vertical loads.

Spinal Dural Arteriovenous Fistula: Imaging Features and Its Mimics

Ying Jeng,David Yen-Ting Chen,Hui-Ling Hsu,Yen-Lin Huang,Chi-Jen Chen,Ying-Chi Tseng 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.5

Spinal dural arteriovenous fistula (SDAVF) is the most common spinal vascular malformation, however it is still rare and underdiagnosed. Magnetic resonance imaging findings such as spinal cord edema and dilated and tortuous perimedullary veins play a pivotal role in the confirmation of the diagnosis. However, spinal angiography remains the gold standard in the diagnosis of SDAVF. Classic angiographic findings of SDAVF are early filling of radicular veins, delayed venous return, and an extensive network of dilated perimedullary venous plexus. A series of angiograms of SDAVF at different locations along the spinal column, and mimics of serpentine perimedullary venous plexus on MR images, are demonstrated. Thorough knowledge of SDAVF aids correct diagnosis and prevents irreversible complications.

Accurate Backbone Curves for Large-Amplitude Vibrations of Imperfect Rectangular Plate with Viscous Damping

He Huang,David Hui 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.5

This paper deals with the solution of modified-Duffing ordinary differential equation for large-amplitude vibrations of imperfect rectangular plate with viscous damping. Lindstedt's perturbation technique and Runge-Kutta method are applied. The results for both methods are presented and compared for a validity check. It is proved that Lindstedt’s perturbation technique only works accurately for a small range of vibration amplitude. For a structure with a sufficiently large geometric imperfection, the well-known softenspring to harden-spring transforming backbone curve is confirmed and better developed. Although the softening to hardening behavior occurs twice in one backbone curve, the turning points share the same vibration frequency. Yet the amplitude for turning points varies due to the existence of imperfection. Moreover, the effect of damping ratio on vibration mode and vibration amplitude is studied. The usual nonlinear vibration tends to behave more linearly under the effect of large damping.