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( Laura Alonso Guardo ),( Carlos Cano Gala ),( David Sanchez Poveda ),( Pablo Rueda Juan ),( Francisco Jose Sanchez Montero ),( Jose Carlos Garzon Sanchez ),( Juan Ignacio Santos Lamas ),( Miguel Vice 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode (InterStimⓡ, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal. (Korean J Pain 2016; 29: 23-28)
Guardo, Laura Alonso,Gala, Carlos Cano,Poveda, David Sanchez,Juan, Pablo Rueda,Sanchez Montero, Francisco Jose,Garzon Sanchez, Jose Carlos,Lamas, Juan Ignacio Santos,Sanchez Hernandez, Miguel Vicente The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode ($Interstim^{(R)}$, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal.
Ignacio Iglesias-Garriz,David Alonso,Carmen Garrote,Victoria Casares,Javier Vara,Jose Maria De la Torre,Miguel A. Rodriguez,Felipe Fernandez-Vazquez 한국심초음파학회 2020 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.28 No.1
BACKGROUND: Proper scaling of cardiac dimensions is of paramount importance in making correct decisions in clinical cardiology. The usual normalization of cardiac dimensions to overall body size assumes an isometric relationship. We sought to investigate these relationships to obtain the best allometric coefficient (AC) for scaling. METHODS: Ninety-seven healthy volunteers were included. The dimensions to be scaled were the left atrial volume, the end-diastolic and end-systolic left ventricular volumes, and the diameter of the tricuspid annulus. A Bayesian statistical analysis was applied with isometric coefficients as priors. RESULTS: The linear correlations between cardiac dimensions and body size were modest, ranging from 0.12 (-0.10–0.32) for the left atrial volume and height to 0.70 (0.58–0.80) for the end-diastolic volume and height. The ACs varied across the different cardiac dimensions and body size measurements. For the best linear relationships, the isometric coefficients were outside the 95% highest density interval of the posterior distribution for the left atrial volume-weight (AC: 0.7; 0.4–0.9) and end-diastolic volume-height (AC: 2.3; 1.7–2.9), whereas they were different from 1 for the left atrial volume-weight, end-diastolic volume, and diameter of the tricuspid annulus-body surface area (AC: 0.6; 0.3–0.8). Not scaling the cardiac dimensions to their corresponding ACs can lead to important errors in size estimations of cardiac structure. CONCLUSIONS: The ACs found in this study are somewhat different from the corresponding isometric coefficients and often different from 1. This finding should be considered when normalizing cardiac structures to body size when making clinical decisions.
Han, Jeehoon,Luterbacher, Jeremy S.,Alonso, David Martin,Dumesic, James A.,Maravelias, Christos T. Elsevier 2015 Bioresource technology Vol.182 No.-
<P><B>Abstract</B></P> <P>The work develops a strategy for the production of ethanol from lignocellulosic biomass. In this strategy, the cellulose and hemicellulose fractions are simultaneously converted to sugars using a γ-valerolactone (GVL) solvent containing a dilute acid catalyst. To effectively recover GVL for reuse as solvent and biomass-derived lignin for heat and power generation, separation subsystems, including a novel CO<SUB>2</SUB>-based extraction for the separation of sugars from GVL, lignin and humins have been designed. The sugars are co-fermented by yeast to produce ethanol. Furthermore, heat integration to reduce utility requirements is performed. It is shown that this strategy leads to high ethanol yields and the total energy requirements could be satisfied by burning the lignin. The integrated strategy using corn stover feedstock leads to a minimum selling price of $5 per gallon of gasoline equivalent, which suggests that it is a promising alternative to current biofuels production approaches.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A process based on a new GVL-based biomass hydrolysis technology is studied. </LI> <LI> New separations for recovery of sugars, GVL, and lignin are developed. </LI> <LI> Separations are integrated with biomass-to-sugars and sugar-to-ethanol conversions. </LI> <LI> Proposed strategy is an attractive alternative to enzymatic lignocellulosic ethanol. </LI> <LI> Study identifies future research directions in conversions and separations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Development of a real-time SYBR Green PCR assay for the rapid detection of Dermatophilus congolensis
Alfredo García,Remigio Martínez,José Manuel Benitez-Medina,David Risco,Waldo Luis García,Joaquín Rey,Juan Manuel Alonso,Javier Hermoso de Mendoza 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.4
Methods such as real time (RT)-PCR have not been developed for the rapid detection and diagnosis of Dermatophilus (D.) congolensis infection. In the present study, a D. congolensis-specific SYBR Green RT-PCR assay was evaluated. The detection limit of the RT-PCR assay was 1 pg of DNA per PCR reaction. No cross-reaction with nucleic acids extracted from Pseudomonas aeruginosa,Mycobacterium tuberculosis, Staphylococcus aureus, or Austwickia chelonae was observed. Finally, the RT-PCR assay was used to evaluate clinical samples collected from naturally infected animals with D. congolensis. The results showed that this assay is a fast and reliable method for diagnosing dermatophilosis.
LSST: From Science Drivers to Reference Design and Anticipated Data Products
Ivezić,, d,eljko,Kahn, Steven M.,Tyson, J. Anthony,Abel, Bob,Acosta, Emily,Allsman, Robyn,Alonso, David,AlSayyad, Yusra,Anderson, Scott F.,Andrew, John,P. Angel, James Roger,Angeli, George Z American Astronomical Society 2019 The Astrophysical journal Vol.873 No.2