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- 저자 : Guardo, Laura Alonso (검색결과 5 건)
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Guardo, Laura Alonso,Gala, Carlos Cano,Poveda, David Sanchez,Juan, Pablo Rueda,Sanchez Montero, Francisco Jose,Garzon Sanchez, Jose Carlos,Lamas, Juan Ignacio Santos,Sanchez Hernandez, Miguel Vicente The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode ($Interstim^{(R)}$, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal.
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( Laura Alonso Guardo ),( Carlos Cano Gala ),( David Sanchez Poveda ),( Pablo Rueda Juan ),( Francisco Jose Sanchez Montero ),( Jose Carlos Garzon Sanchez ),( Juan Ignacio Santos Lamas ),( Miguel Vice 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode (InterStimⓡ, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal. (Korean J Pain 2016; 29: 23-28)
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ON THE BETTI NUMBERS OF THREE FAT POINTS IN ℙ<sup>1</sup> × ℙ<sup>1</sup>
Favacchio, Giuseppe,Guardo, Elena Korean Mathematical Society 2019 대한수학회지 Vol.56 No.3
In these notes we introduce a numerical function which allows us to describe explicitly (and nonrecursively) the Betti numbers, and hence, the Hilbert function of a set Z of three fat points whose support is an almost complete intersection (ACI) in ${\mathbb{P}}^1{\times}{\mathbb{P}}^1$. A nonrecursively formula for the Betti numbers and the Hilbert function of these configurations is hard to give even for the corresponding set of five points on a special support in ${\mathbb{P}}^2$ and we did not find any kind of this result in the literature. Moreover, we also give a criterion that allows us to characterize the Hilbert functions of these special set of fat points.
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Alice Indini,Lorenza Di Guardo,Carolina Cimminiello,Domenica Lorusso,Francesco Raspagliesi,Michele Del Vecchio 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6
Objective: immunotherapy with immune checkpoint inhibitors has become one of thestandard therapeutic modalities for patients with advanced melanoma. Melanoma of thefemale lower genital tract is a rare and aggressive disease, with poor long-term clinicaloutcomes. To date, no study evaluated the role of immunotherapy in metastatic melanoma ofthe lower genital tract. Methods: Data of women with metastatic melanoma of the lower genital tract wereprospectively collected. Survival outcomes over time was assessed using Kaplan-Meier model. Results: Seven cases of metastatic melanoma of the lower genital tract (vulva [n=2], vagina[n=4], and uterine cervix [n=1]) treated with immune checkpoint inhibitors are reviewed. Two patients had metastatic disease at diagnosis, while 5 patients developed metastaticdisease at a mean (standard deviation) time of 9.9 (±3.0) months from primary diagnosis. Four patients received an anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA4)(ipilimumab) and 3 received an anti-programmed cell death 1 (PD-1) (pembrolizumab[n=2], nivolumab [n=1]) therapy. The response rate to immunotherapy was 28.5%. Patientsreceiving an anti-PD-1 experienced a better progression-free survival than patients treatedwith anti-CTLA4 (p=0.01, log-rank test). Although not reaching statistical significance,overall survival was better in patients having an anti-PD-1 therapy in comparison to anti-CTLA4 (p=0.15, log-rank test). Conclusion: Results from our series confirm the poor prognosis of women with metastaticmelanoma of the lower genital tract, thus supporting the need of exploring newtreatment modalities. Further studies are warranted to improve knowledge on the role ofimmunotherapy in metastatic melanoma of the lower genital tract.
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On the Betti numbers of three fat points in $\mathbb{P}^1 \times \mathbb{P}^1$
Giuseppe Favacchio,Elena Guardo 대한수학회 2019 대한수학회지 Vol.56 No.3
In these notes we introduce a numerical function which allows us to describe explicitly (and nonrecursively) the Betti numbers, and hence, the Hilbert function of a set $Z$ of three fat points whose support is an almost complete intersection (ACI) in $\mathbb{P}^1 \times \mathbb{P}^1.$ A nonrecursively formula for the Betti numbers and the Hilbert function of these configurations is hard to give even for the corresponding set of five points on a special support in $\mathbb P^2$ and we did not find any kind of this result in the literature. Moreover, we also give a criterion that allows us to characterize the Hilbert functions of these special set of fat points.
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