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Yan Jin,Hong Wang,Jing Li,Minyan Dang,Wenzhi Zhang,Yan Lei,Hao Zhao 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.4
In the present experimental study, cecal ligation and puncture significantly increased the myocardial injury assessed in terms of excess release of creative kinase-MB (CK-MB), cardiac troponin I (cTnI), interleukin (IL)-6 and decrease of IL-10 in the blood following 12 h of laparotomy procedure as compared to normal control. Also, a significant increase in protein expression levels of high-mobility group box 1 (HMGB1) and decreased phosphorylation of glycogen synthase kinase-3β (GSK-3β) was observed in the myocardial tissue as compared to normal control. A single independent administration of telmisartan (2 and 4 mg/kg) and AR-A014418 (1 and 2 mg/kg) substantially reduced sepsis-induced myocardial injury in terms of decrease levels of CK-MB, cTnI and IL-6, HMGB1, GSK-3β and increase in IL-10 and p-GSK-3β in the blood in sepsis- subjected rats. The effects of telmisartan at dose 4 mg/kg and AR-A014418 at a dose of 2 mg/kg were significantly higher than the telmisartan at a dose of 2 mg/kg and AR-A014418 1 mg/kg respectively. Further, no significant effects on different parameters were observed in the sham control group in comparison to normal. Therefore it is plausible to suggest that sepsis may increase the levels of angiotensin II to trigger GSK-3β-dependent signaling to activate the HMGB1/receptors for advanced glycation end products, which may promote inflammation and myocardial injury in sepsis-subjected rats.
A STRONGLY CONVERGENT PARALLEL PROJECTION ALGORITHM FOR CONVEX FEASIBILITY PROBLEM
Dang, Ya-Zheng,Gao, Yan The Korean Society for Computational and Applied M 2012 Journal of applied mathematics & informatics Vol.30 No.1
In this paper, we present a strongly convergent parallel projection algorithm by introducing some parameter sequences for convex feasibility problem. To prove the strong convergence in a simple way, we transmit the parallel algorithm in the original space to an alternating one in a newly constructed product space. Thus, the strong convergence of the parallel projection algorithm is derived with the help of the alternating one under some parametric controlling conditions.
Inter-Vehicle Cooperation Channel Estimation for IEEE802.11p V2I Communications
Yan Yang,Fei Dan,Shuping Dang 한국통신학회 2017 Journal of communications and networks Vol.19 No.3
The impact of imperfect channel state information (CSI) is particularly serious in vehicle-to-infrastructure (V2I) and vehicle-to-vehicle (V2V) communications.~Considering the sparse characteristics of V2I channels, this paper proposes an inter-vehicle cooperation channel estimation (IVC-CE) method at the IEEE 802.11p physical layer, and the effects of outdated CSI can be mitigated by single or multiple vehicle measurements.~With these assisted measurements, we can develop an interpolation-assisted channel estimation technique to obtain accurate CSI.~To select optimum measurements from a group of channel estimates, we utilize the position and velocity of a vehicle as a priori information.~We investigate the validity of the IVC-CE technique with the traditional linear minimum mean-squared error algorithm and present a scalable data transmission scheme at the physical layer.~The performance of IVC-CE is analyzed by its mean squared error and bit error rate in a fast fading channel environment. Simulations and numerical results show the merits of the proposed techniques, which can significantly enhance estimation performance and support safety related data transmissions for vehicular ad hoc networks.
Nannan Dang,Wei Wang,Jiazhong Zhang,Yan Liu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.8
The bifurcation analysis of nonlinear combustion instability in a Rijke burner is studied numerically. First, a saturated flame model and a third-order saturated flame model are proposed, and the mode truncation effects are investigated by studying their influences on system eigenvalues. Then, bifurcation analysis on the flame location, average flame intensity, damping, and time delay in the flame model is conducted with the new flame models. Results show that the burner driven by the saturated model loses stability via supercritical Hopf bifurcations, whereas the system driven by the third-order saturated model shows the characteristic of subcritical Hopf bifurcations, accompanied by bistable regimes emerging in the bifurcation diagrams. Finally, the effects of velocity perturbations are analyzed further, and the results show that a given system may oscillates with different frequencies if the disturbance is imposed to different Galerkin modes. This study reveals that the process of the combustion system’s transition to instability depends strongly on the nonlinear term in the flame model.
A STRONGLY CONVERGENT PARALLEL PROJECTION ALGORITHM FOR CONVEX FEASIBILITY PROBLEM
Ya-zheng Dang,Yan Gao 한국전산응용수학회 2012 Journal of applied mathematics & informatics Vol.30 No.1
In this paper, we present a strongly convergent parallel projection algorithm by introducing some parameter sequences for convex feasibility problem. To prove the strong convergence in a simple way, we transmit the parallel algorithm in the original space to an alternating one in a newly constructed product space. Thus, the strong convergence of the parallel projection algorithm is derived with the help of the alternating one under some parametric controlling conditions.
Effect of Sophora flavescens on the pharmacokinetics of carbamazepine in rats
Lei Shi,Xue-Liang Dang,Xin-You Liu,Hua-Mei Wei,Meng-Meng Yang,Yan Zhang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12
Carbamazepine (CBZ), an antiepilepticwith narrow therapeutic window, is a substrate ofCYP 3A4 which metabolizes CBZ to carbamazepine-10,11-epoxide (CBZE). CBZE is an active and toxicitymetabolite, and it is a substrate of MRP-2. UsingCBZ for a long time can cause hepatic injury. Sophora flavescens (SF) is a medicinal herb used forthe protected hepatic injury. This study investigatedthe acute and chronic effects of SF on the pharmacokineticsof CBZ in rats. The concentrations of CBZand CBZE in plasma and tissues were determined byHPLC method. The results showed that SF whichsignificantly decreased the AUC0-t of CBZ, increasedCBZE conversely. Tissue analysis showed that theconcentrations of CBZ and CBZE in brain and liverwere decreased by SF. In addition, the distribution ofCBZE in kidney was reduced significantly, whichinfluenced the CBZE excretion and increased the drugtoxic potentially. Results in the current study suggestthat patients using CBZ might be cautioned in the useof SF extract or Sophora-derived products. Meanwhile,patients receiving drugs which are substrates ofCYP 3A4 and/or MRP-2 should be advised of thepotential herb–drug interaction to reduce the risk oftherapeutic failure or increased toxicity of conventionaldrug therapy.
The Prediction Research of Population Density Based on Deep Learning in Grain Stored Insects
Wu Jian-Jun,Dang Hao,Li Miao,Sun Fu-Yan,Zhu Yu-Hua,Zhen Tong,Zou Bing-Qiang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.10
Precision of pests, in stored grain insect population density, has been a hot and difficult research in pest detection and control system. The accuracy of prediction of pest density will directly affect to warehouse grain temperature and the food quality etc. In order to improve the accuracy, the paper which using the depth study method, established an insects density prediction mode with the depth of the belief network as the core. The model is applied to the algorithm of deep learning predictive control. According to the temperature and humidity of the grain obtained from the actual measurement and the initial density of the pest, we predicted the pest density. Simulation results show that the root mean square error is small between the predictive value and actual value, high prediction accuracy. The deep learning algorithm is applied to the population density of pests is effective.
Bai Liyi,Jiang Wei,Cheng Rui,Dang Yan,Min Li,Zhang Shutian 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.4
Background/Aims: In patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB), the optimal timing of endoscopy is still a matter of dispute. We conducted a systematic review and meta-analysis to determine the clinical benefit of early endoscopy. Methods: A literature search of the MEDLINE, Embase, and Cochrane databases was conducted to identify publications from inception to March 1, 2022. Eligible studies included observational cohort studies and randomized controlled trials that reported clinical outcomes of endoscopy in patients with ANVUGIB. ANVUGIB patients who underwent endoscopy within 24 hours of admission were considered to have had an early endoscopy. The primary outcome was the mortality rate in ANVUGIB patients who had early or nonearly endoscopy. Results: The final analysis included five randomized controlled studies (RCTs) and 20 observational studies from the 1,206 identified articles. The mortality rate was not significantly reduced among patients who received endoscopy performed within 24 hours, whether in cohort studies nor in RCTs. For subgroup analysis, a higher mortality rate was found only among patients who received very early endoscopy within 12 hours (odds ratio, 1.66; p<0.001, I2=0) in cohort studies. No significant difference in mortality rates was found among patients at high risk of bleeding who received early versus nonearly endoscopy. Conclusions: Early endoscopy within 24 hours does not appear to significantly reduce the mortality rates of patients with ANVUGIB. Further well-designed studies are warranted to address if very early endoscopy within 12 hours can provide a clinical benefit for patients at high risk of bleeding.