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      • Phase, Structure, and Dynamics of the Hydration Layer Probed by Atomic Force Microscopy

        Bai, Liyi,Zhang, Zhengqing,Jang, Joonkyung American Chemical Society 2019 The Journal of Physical Chemistry Part C Vol.123 No.35

        <P>Using the molecular dynamics method we simulate the hydration layer probed by an atomic force microscope (AFM) tip. We investigate how the AFM tip affects the phase, structure, and dynamics of the intrinsic hydration layer formed on a hydrophobic carbon plate. Without the AFM tip the molecular packing and orientation of the hydration layer are ordered up to the second molecular layer. With approaching the tip, the hydration layer is perturbed and eventually evaporates. The force-distance curve in AFM lacks an oscillation typically found for the hydration layer formed on a hydrophilic surface. The molecular diffusions parallel and perpendicular to the plate are, respectively, enhanced and restricted by the tip. The molecular reorientation is significantly slowed down by the tip and plate, which disrupt the hydrogen-bond network present in the bulk water.</P> [FIG OMISSION]</BR>

      • Dewetting transition of water confined between atomically rough surfaces: A lattice gas Monte Carlo simulation study

        Bai, Liyi,Jang, Jihye,Zhang, Zhengqing,Jang, Joonkyung Elsevier 2018 Chemical physics letters Vol.694 No.-

        <P><B>Abstract</B></P> <P>Using lattice gas Monte Carlo simulations, we studied the dewetting transition of water confined between a spherical tip and a plate, which is relevant to atomic force microscopy measurements conducted in water. The dewetting transition was investigated by varying the tip-plate distance, tip size, and the pressure of water. With introduction of an atomic scale roughness (1 < nm) in the tip and the plate, the dewetting transition significantly increased in range and yielded an enhanced hydrophobic force between the tip and the plate. This finding is in agreement with the experimental results previously reported by Singh et al.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Water confined between a spherical tip and a plate was theoretically studied. </LI> <LI> Lattice gas Monte Carlo simulation on the dewetting transition of confined water. </LI> <LI> Atomic scale roughness significantly affects the dewetting transition. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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        Does Early Endoscopy Affect the Clinical Outcomes of Patients with Acute Nonvariceal Upper Gastrointestinal Bleeding? A Systematic Review and Meta-Analysis

        Bai Liyi,Jiang Wei,Cheng Rui,Dang Yan,Min Li,Zhang Shutian 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.4

        Background/Aims: In patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB), the optimal timing of endoscopy is still a matter of dispute. We conducted a systematic review and meta-analysis to determine the clinical benefit of early endoscopy. Methods: A literature search of the MEDLINE, Embase, and Cochrane databases was conducted to identify publications from inception to March 1, 2022. Eligible studies included observational cohort studies and randomized controlled trials that reported clinical outcomes of endoscopy in patients with ANVUGIB. ANVUGIB patients who underwent endoscopy within 24 hours of admission were considered to have had an early endoscopy. The primary outcome was the mortality rate in ANVUGIB patients who had early or nonearly endoscopy. Results: The final analysis included five randomized controlled studies (RCTs) and 20 observational studies from the 1,206 identified articles. The mortality rate was not significantly reduced among patients who received endoscopy performed within 24 hours, whether in cohort studies nor in RCTs. For subgroup analysis, a higher mortality rate was found only among patients who received very early endoscopy within 12 hours (odds ratio, 1.66; p<0.001, I2=0) in cohort studies. No significant difference in mortality rates was found among patients at high risk of bleeding who received early versus nonearly endoscopy. Conclusions: Early endoscopy within 24 hours does not appear to significantly reduce the mortality rates of patients with ANVUGIB. Further well-designed studies are warranted to address if very early endoscopy within 12 hours can provide a clinical benefit for patients at high risk of bleeding.

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