http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Dachuan Zhang (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Allergen-Dependent Differences in ILC2s Frequencies in Patients With Allergic Rhinitis
Dachuan Fan,Xiangdong Wang,Min Wang,Yang Wang,Liang Zhang,Ying Li,Erzhong Fan,Feifei Cao,Koen Van Crombruggen,Luo Zhang 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.3
Purpose: Group 2 innate lymphoid cells (ILC2s) are a novel population of lineage-negative cells that induce innate type 2 responses by producing the critical Th2-type cytokines IL-5 and IL-13 in response to IL-25 and IL-33 stimulation. ILC2s accumulation in the peripheral blood of patients with allergic rhinitis (AR) is controversial; the precise role of ILC2s in the immunopathogenesis of AR is still not clear. We investigated the role of ILC2s in phenotypic AR sensitized to distinct allergens. Methods: Flow cytometric analysis of the peripheral blood of 7 healthy controls (HCs), 9 patients monosensitized to house dust mite (HDM), and 8 patients monosensitized to mugwort was performed to quantify ILC2s frequency. Peripheral blood mononuclear cells (PBMCs) were isolated from HDM-AR and mugwort-AR patients, and Lineage- and Lineage+ cells were separated using a fluorescence-activated cell sorter (FACS). IL-5 and IL-13 levels in the supernatants of PBMCs, and Lineage- and Lineage+ cells stimulated with IL-25 and/or IL-33 combined with IL-2 in vitro were assessed using the Milliplex magnetic bead kit. Results: The percentage of ILC2s was significantly elevated in HDM-AR patients compared to mugwort-AR patients and HCs, while no significant difference was found between mugwort-AR patients and HCs. IL-33±IL-25 plus IL-2 induced a significantly greater release of IL-5 and IL-13 in the PBMCs of HDM-AR patients compared to PBMCs of mugwort-AR patients. IL-25 plus IL-2 also induced a significantly greater release of IL-13 in the PBMCs of HDM-AR patients compared to PBMCs of mugwort-AR patients. Stimulation with IL-33 and/or IL-25 combined with IL-2 also induced a significantly greater IL-5 and IL-13 release from Lineage- cells compared to Lineage+ cells. Conclusions: AR patients sensitized to HDM or mugwort allergen have distinct phenotypic and functional profiles in ILC2s frequencies. ILC2s mediate major type 2 immunity in the development of HDM-AR and may be a potential therapeutic target.
-
Xiangshan Li,Yong Zhu,Dachuan Xia,Zhanke Wang,Guangxu Zhang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
A novel amino-anchored sulfonic acid functional heteropolyacid ionic liquid ([NHSO]3PW12O40) wasdesigned, synthesized and used as a catalyst in the Baeyer-Villiger (BV) oxidation of cyclohexanone tosynthetic e-caprolactone (e-CL). The catalyst was well characterized by FT-IR, XRD, 1H NMR, XPS, TGDTAand SEM analysis methods, which showed that the tungsten phosphate anion (PW12O403) was successfullymodified from the sulphonate-functionalised IL precursor NHSO and formed a new hydrogenbond between the introduced –NH2 group and PW12O403. The combined effect of ionic bonds and hydrogenbonds contributed to the good stability of the catalyst. Catalyst activity evaluation experiments confirmedthat [NHSO]3PW12O40 exhibited superior performances such as a cyclohexanone conversion of86% and e-CL yield and selectivity of 82% and 95%, respectively. Furthermore, [NHSO]3PW12O40 couldbe recovered by simple treatment and the activity of the catalyst did not decrease significantly after fivereplicae experiments. In addition, the reaction kinetics and mechanism of the catalyst were investigatedand a simple validation was given in conjunction with the bond energy changes of the catalyst during thereaction. The innovative of the green, stable and high-performance functionalised heteropolyacid IL catalystprovides a new solution for the efficient production of e-CL.
-
Candida J. Rebello,William D. Johnson,Yang Pan,Sandra Larrivee,Dachuan Zhang,Mark Nisbet,Jodee Johnson,YiFang Chu,Frank L. Greenway 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.1
This study compared the effect of a snack with ingredients to slow carbohydrate digestion (Test-snack) on postprandial blood glucose and insulin concentrations and subjective appetite ratings. We hypothesized that Test-snack would lower glucose and insulin responses and reduce appetite compared with a Control-snack. Overweight or obese subjects (n = 17) completed a randomized crossover study. Glucose, insulin, and appetite ratings were measured before consuming each snack or white bread (Bread) and over a period of 4 h. Subjects received Test-snack, Control-snack, or Bread in random order at least a week apart. The a priori primary outcome was the glucose response, and the secondary outcomes were appetite ratings and insulin responses. Mixed effects statistical models were used to perform analysis of variance in terms of the area under curve (AUC) and at specific time points. The 2-h AUC for glucose was significantly lower with Test-snack compared to Control-snack and Bread (AUC and 95% confidence intervals: Test = 2186.43 [1783.36–2589.51]; Control = 3293.75 [2893.97–3693.54]; Bread = 2800.28 [2405.79–3194.77] mg/dL · min). Four-hour AUC for glucose, and insulin, followed a similar pattern except that Test-snack did not differ from Bread. The glucose concentrations peaked at 45 min under all three conditions, but Test-snack elicited a lower response than Control-snack and Bread (P < .01). Test increased fullness and satisfaction and reduced hunger and prospective intake compared to Bread (P < .02), but was not significantly different from Control-snack. Ingredients that slow carbohydrate digestion in a snack reduce the postprandial glucose and insulin responses compared to a product without these ingredients.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
