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- 저자 : Da Ke Xu (검색결과 4 건)
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Da-Hong Li,Ping Hu,Sheng-tao Xu,Chun-yan Fang,Shuang Tang,Xin-yu Wang,Xing-yan Sun,He Lian,Ying Xu,Xiao-ke Gu,Jin-yi Xu 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.7
Herein, a series of lasiokaurin derivatives were designed and synthesized. All the derivatives together with lasiokaurin and oridonin were tested for their antimicrobial and antiproliferative activity. Compound 16 showed the most promising antimicrobial activity with MICs of 2.0 and 1.0 lg/mL against Gram-Positive bacteria S. aureus and B. subtilis, respectively. All the synthetic lasiokaurin derivatives showed better antiproliferative activity than parent compound lasiokaurin 1. Compound 10 exhibited the strongest cytotoxicity with IC50 values of 0.47 and 0.20 lM against MGC-803 and CaEs-17 cells, accordingly. Moreover, it was shown to have potent antitumor activity in vivo in a murine model of MGC-803 gastric cancer. Preliminary SARs were also concluded based on obtained data. The apoptosis-inducing effects of 10 were further investigated using CaEs-17 cells. The results showed that lasiokaurin derivative 10 could induce apoptosis via mitochondria related pathway and arrest CaEs-17 cell cycle at S phase. Compound 10 could also affect apoptosisrelated proteins that was up-regulation of CDK2 and downregulation of ATM and cyclin A1.
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Flow Velocity Deviation of Spinning Solution Under Multi-field Coupling
Zhiming Zhang,Da Hong,Xinyu Huang,Kang Liu,Qiao Xu,Zhen Chen,Qiaoling Ji,Changjin Ke 한국섬유공학회 2023 Fibers and polymers Vol.24 No.10
Rotating jet spinning uses the centrifugal force generated by the high-speed rotation of the motor to keep the spinning solution ejected from the nozzle to form nanofibers. At present, the research work on rotating jet spinning mainly involves the materials, properties and applications of fibers, parameter influence and jet trajectory, while there are few studies on the optimization of spinning core components. In this paper, by analyzing the force and flow state of spinning solution in the flow channel of spinning nozzle, it is found that the maximum velocity region of spinning solution will be offset. The reason for this phenomenon is that the spinning solution is subjected to Coriolis force in the rotating system, resulting in the secondary flow of solution. The relationship between nozzle parameters, solution parameters as well as process parameters, and the outlet velocity of solution was sought, and the structure of spinning nozzle was optimized. The factors affecting velocity offset in straight-tube nozzles and bent-tube nozzles are simulated. High-speed centrifugal spinning experiments were conducted using both unoptimized and optimized nozzles.
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Xiu Ying Xia,Na Xu,Da Ke Xu,Jun Yang,Yu Shi Luan 한국유전학회 2008 Genes & Genomics Vol.30 No.1
The genetic relationships among 17 clones of Vaccinium (Vaccinium spp.), including 2 Northeast Chinese wild species and 15 commercial cultivars were evaluated through a Random Amplified Polymorphic DNA(RAPD)analysis of young leaves. The Rapids generated a total of 115 markers with 15 random primers, of which 98.26% were found to be polymorphic. These RAPD markers could successfully separate individuals from the 17 samples and detect variations in the Vaccinium species. Genetic similarity and genetic distance were measured by Nei`s unbiased measurement. Using arithmetic averages (UPGMA) dendrogram, the unweighted pair-group method indicated that 17 samples were classified into three major groups: two groups of each wild species, and one group of 15 cultivars. The 15 cultivars could be clearly assigned into two subgroups of which the only lowbush sample (Blomidon) was clustered in one subgroup and the other 14 cultivars were clustered in one subgroup. The cluster results had some relativity with the pedigree of cultivars. These indicated that the polymorphic RAPD markers developed in this study should have general utility for identification of the varieties and examination of genetic relationships in blueberry.
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Physical properties and chemical composition of the cores in the California molecular cloud
Zhang, Guo-Yin,Xu, Jin-Long,Vasyunin, A. I.,Semenov, D. A.,Wang, Jun-Jie,Dib, Sami,Liu, Tie,Liu, Sheng-Yuan,Zhang, Chuan-Peng,Liu, Xiao-Lan,Wang, Ke,Li, Di,Wu, Zhong-Zu,Yuan, Jing-Hua,Li, Da-Lei,Gao, Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P><I>Aims.</I> We aim to reveal the physical properties and chemical composition of the cores in the California molecular cloud (CMC), so as to better understand the initial conditions of star formation.</P><P><I>Methods.</I> We made a high-resolution column density map (18.2′′) with <I>Herschel</I> data, and extracted a complete sample of the cores in the CMC with the fellwalker algorithm. We performed new single-pointing observations of molecular lines near 90 GHz with the IRAM 30m telescope along the main filament of the CMC. In addition, we also performed a numerical modeling of chemical evolution for the cores under the physical conditions.</P><P><I>Results.</I> We extracted 300 cores, of which 33 are protostellar and 267 are starless cores. About 51% (137 of 267) of the starless cores are prestellar cores. Three cores have the potential to evolve into high-mass stars. The prestellar core mass function (CMF) can be well fit by a log-normal form. The high-mass end of the prestellar CMF shows a power-law form with an index <I>α</I> = −0.9 ± 0.1 that is shallower than that of the Galactic field stellar mass function. Combining the mass transformation efficiency (<I>ε</I>) from the prestellar core to the star of 15 ± 1% and the core formation efficiency (CFE) of 5.5%, we suggest an overall star formation efficiency of about 1% in the CMC. In the single-pointing observations with the IRAM 30m telescope, we find that 6 cores show blue-skewed profile, while 4 cores show red-skewed profile. [HCO<SUP>+</SUP>]/[HNC] and [HCO<SUP>+</SUP>]/[N2H<SUP>+</SUP>] in protostellar cores are higher than those in prestellar cores; this can be used as chemical clocks. The best-fit chemical age of the cores with line observations is ~5 × 10<SUP>4</SUP> yr.</P>
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