http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Influence of Human Factor in the AACMM Performance: a New Evaluation Methodology
González-Madruga Daniel,Cuesta Eduardo,Barreiro Joaquín,Martínez-Pellitero Susana 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
One of the main principles of metrology, when talking about instrument calibration, concern to the idea of reproducing the actualmeasurement process during calibration (same instrument handling, environment, measurement parameters, etc.) in order to obtainsuitable information. In spite of that, this principle is being currently neglected in Articulated Arm Coordinate Measuring Machine(AACMM) evaluation and/or calibration procedures. These procedures are carried out in manufacturer facilities under unknownconditions and measurement parameters instead of “in-situ” procedures with similar measurement parameters. Thereby, reportedaccuracy has little to do with AACMM common use and, therefore, with its reliability. This work presents a new evaluationmethodology for both AACMM and operator performance. To do so, a survey of main measurement parameters (operator, contactforce, type of feature) is carried out by mean of contact force sensor on the AACMM probe and geometric gauges. ANOVA have beenused for the study of these parameters and its impact on AACMM performance. Additionally, a new evaluation methodology capableof quantifying AACMM, operator and its measuring technique contribution to measurement uncertainty has been developed. It issupported by a feature-base gauge that has been specifically designed for this task.
Renan Rodrigues de Oliveira Silva,Paulo Victor Cuesta Calvo,Christian Adrian Merfels,Mikael Vitor Rodrigues Lima,Harrson S. Santana,Attilio Converti,Mauri Sergio Alves Palma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Continuous flow synthesis in microreactors has been integrated into chemical-pharmaceutical industryin recent years as an alternative to the batch process due to its advantages, especially process intensification,which can reduce the time for a new drug to be placed on the market on a large scale. This workaimed to transpose the synthesis of Lobeglitazone, a drug employed in the treatment of diabetes mellitustype 2, from batch to flow process in a microreactor as well as to determine the reaction kinetics of eachstep. The synthesis was carried out in five-steps, being synthesized intermediates 4-chloro-6-(4-methoxyphenoxy)pyrimidine (I1), 2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethanol (I2), 4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzaldehyde (I3), 5-[4-(2-{[6-(4-methoxyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzylidene]thiazolidine-2,4-dione (I4) andLobeglitazone. Intermediates I1 and I4 were synthesized in flow, while I4 was synthesized either in a continuousflow multistep synthesis or in a one-pot batch process. The flow syntheses of I1, I2 and I4 showed28.0 %, 61.8 % and 32.0 % yields at 25, 160 and 120 C, respectively, while the yield of I3 in batch processwas 73.3 % at 60 C. In one-pot batch process and continuous flow multistep synthesis, I2 was obtainedwith 13 and 16 % yields, respectively. These preliminary results constitute a starting point for the synthesisof this drug in flow on an industrial scale, with the aim of improving reaction performance using thisnew technology.
Michael A. Clores,Joward B. Bautista,Jason B. Fernandez,Michael A. Cuesta,Rafe M. Brown 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.1
We report for the first time the herpetological biodiversity (amphibians and reptiles) of the Caramoan Island Group (CIG), Maqueda Channel, southern Luzon Island, the Philippines. Herpetofaunal biodiversity assessment, using the standard field-based methodology for survey work, was conducted at nine sites in the CIG, off the northeast coast of the Bicol Peninsula of southern Luzon. The overall species richness (s) in the CIG is 22 (three amphibians, 12 lizards, and seven snakes) represent new island records for a variety of the native species, ten of which are endemic to the Philippines. Beta diversity (β-diversity) of the CIG is 0.84 reflecting a relatively high degree of local area turnover of species when among-site comparisons were quantified; this finding most likely reflects habitat variability which is consistent with our observation emphasizing how a high proportion of faunal diversity is associated with, or confined, to very specific microhabitats (limestone areas, lower-montane forests, mangroves, beach coastal forests, etc.). The overall community similarity index of the archipelago was 0.545 implying that CIG has moderate overlap of amphibian and reptilian species composition. Our findings provide baseline information on the unique composition of herpetofauna in the CIG, which highlights a general paucity of knowledge about the Peninsula’s herpetofaunal diversity.
Cárdaba Miguel A. M.,Fernández A.,Martinez L.,Cuesta U. 한국마케팅과학회 2023 Journal of Global Fashion Marketing Vol.14 No.2
Product placement is one of the most widely used marketing and advertising strategies. Although previous research has examined the role of different key variables in traditional media, the effect of prominence and integration in product placement strategies that appear in digital media such as fashion and beauty blogs has not been fully investigated. A 2 (Prominence: “low” vs. “high”) X 2 (Integration: “low” vs. “high”) between-subjects experiment was conducted to examine the impact of these variables on young digital natives consumers’ recall and attitudes towards the product, the brand, the blog- ger and the post. The results show that integrated placements are effective at eliciting brand and product recall and improv- ing attitudes towards the post and the blogger. Prominence, on the other hand, did not have the expected impact on brand or product recall. In addition, Prominent product placement did increase consumers’ suspicion of the persuasion attempt. Implications and recommendations for bloggers and marketers are discussed.
Hb Murcia (β118(G19)His>Gln): A New Hemoglobin Variant Found in a Spanish Woman
Fernández Beatriz González,Campuzano José Bartolomé Nieto,Rocamora Dolores García,Nieto Jorge M,Fernández Fernando Ataúlfo González,Villegas Ana,Cuesta Celina Benavente,Ropero Paloma 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.5
Observation of coherent elastic neutrino-nucleus scattering
Akimov, D.,Albert, J. B.,An, P.,Awe, C.,Barbeau, P. S.,Becker, B.,Belov, V.,Brown, A.,Bolozdynya, A.,Cabrera-Palmer, B.,Cervantes, M.,Collar, J. I.,Cooper, R. J.,Cooper, R. L.,Cuesta, C.,Dean, D. J.,D American Association for the Advancement of Scienc 2017 Science Vol.357 No.6356
<P>The coherent elastic scattering of neutrinos off nuclei has eluded detection for four decades, even though its predicted cross section is by far the largest of all low-energy neutrino couplings. This mode of interaction offers new opportunities to study neutrino properties and leads to a miniaturization of detector size, with potential technological applications. We observed this process at a 6.7s confidence level, using a low-background, 14.6-kilogram CsI[Na] scintillator exposed to the neutrino emissions from the Spallation Neutron Source at Oak Ridge National Laboratory. Characteristic signatures in energy and time, predicted by the standard model for this process, were observed in high signal-to-background conditions. Improved constraints on nonstandard neutrino interactions with quarks are derived from this initial data set.</P>