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Two New Triterpenoid Acids from Kadsura coccinea
Yan Song,Qing-Jie Zhao,Yong-Sheng Jin,Chuan-Wei Feng,Hai-Sheng Chen 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.12
An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC50 values ranging from 3.01 to 18.08 μg/mL.
Design and Self-Assembly of Amphiphilic Block Copolymers for Drug Delivery
Yi Yan Yang,Chuan Yang,Jeremy P. K. Tan,Nikken Wiradharma,Shrinivas Venkataraman,Amalina Bte Ebrahim Attia,Zhan Yuin Ong,Wei Cheng,Ashlynn Lee,Lin Kin Yong,Kazuki Fukushima,Sung Ho Kim,Daniel J. Coady 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.1
NURBS Interpolator with Adaptive Smooth Feedrate Scheduling and Minimal Feedrate Fluctuation
Taiyong Wang,Yong-Bin Zhang,Jing-Chuan Dong,Run-Ji Ke,Yan-Yu Ding 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.2
For an effective NURBS interpolator, generating the smooth feedrate profile and minimizing the feedrate fluctuation are two main tasks, which have a great influence on the machining quality. In this paper, a NURBS interpolator is proposed to solve the problem with offline-online two stages, which contain curving splitting, feedrate scheduling, and real-time interpolation modules. At first, in offline module, the limited feedrate of the curve is calculated with consideration of geometric characteristics and dynamic constraints, and the curve is split into several segments according to the key regions. Thus the necessary information is stored. Then the feedrate scheduling algorithm is applied with constant feedrate scheduling method at each segment, where tangential acceleration and jerk are taken into consideration to generate an adaptive smooth S-type feedrate profile. Moreover, in real-time interpolation module, an average feedrate calculation method is proposed to determine the sampling step size. And to minimize the feedrate fluctuation, a double interpolation algorithm based on the cosine theorem is presented, which use the second-order Taylor’s expansion method two times in one interpolation period. Finally, simulations and experiments are conducted to verify the performance of the proposed interpolator.
Optimal Conditions for Hepatitis B Core Antigen Production in Shaked Flask Fermentation
Beng Ti Tey,Tau Chuan Ling,Yan Peng Tan,Swee Tin Ong,Arbakariya Ariff,Wen Siang Tan,Hong Puay Ong,Kok Hoe Yong 한국생물공학회 2004 Biotechnology and Bioprocess Engineering Vol.9 No.5
The effects of various environmental factors such as pH (5, 6, 7, 8 and 9), temperature (30, 37 and 40C) and rotational speed (150, 200 and 250 rpm) on the growth and the hepatitis B core antigen (HBcAg) production of Escherichia coli W3110IQ were examined in the present study. The highest growth rate is achieved at pH 7, 37C and at a rotational speed of 250 rpm which is 0.927 h-1. The effect of pH on cell growth is more substantial compared to other parameters; it recorded a 123% different between the highest growth rate (0.927 h-1) at pH 7 and lowest growth at pH 5. The highest protein yield is achieved at pH 9, rotational speed of 250 rpm and 40C. The yield of protein at pH 7 is 154% higher compared to the lowest yield achieved at pH 5. There is about 28% different of the protein yield for the E. coli cultivated at 250 rpm compared to that at 150 rpm which has the lowest HBcAg yield. The yield of protein at 40C is 38% higher compared to the lowest yield achieved at 30C.
Optimal Conditions for Hepatitis B Cove Antigen Production in Shaked Flask Fermentation
Tey Beng Ti,Yong Kok Hoe,Ong Hong Puay,Ling Tau Chuan,Ong Swee Tin,Tan Yan Peng,Ariff Avbakariya,Tan Wen Siang The Korean Society for Biotechnology and Bioengine 2004 Biotechnology and Bioprocess Engineering Vol.9 No.5
The effects of various environmental factors such as pH (5, 6, 7, 8 and 9), temperature (30, 37 and $40^{\circ}C$) and rotational speed (150, 200 and 250 rpm) on the growth and the hepatitis B core antigen (HBcAg) production of Escherichia coli W3110IQ were examined in the present Study. The highest growth rate is achieved at pH 7, $37^{\circ}C$ and at a rotational Speed of 250 rpm which is 0.927 $h^{-1}$. The effect of pH on cell growth is more substantial compared to other parameters; it recorded a $123\%$ different between the highest growth rate (0.927 $h^{-1}$) at pH 7 and lowest growth at pH 5. The highest protein yield is achieved at pH 9, rotational speed of 250 rpm and $40^{\circ}C$. The yield of protein at pH 7 is $154\%$ higher compared to the lowest yield achieved at pH 5. There is about $28\%$ different of the protein yield for the E. coli cultivated at 250 rpm compared to that at 150 rpm which has the lowest HBcAg yield. The yield of protein at $40^{\circ}C$ is $38\%$ higher compared to the lowest yield achieved at $30^{\circ}C$.
Quan-Xi Zheng,Chuan-Yong Yan,Mu-Wei Zhu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
The specificity and conversion of supercritical methanolysis of wheat straw (WS) and rice straw (RS) canbe enhanced by Pretreatment using Trichoderma sp. AH, particularly the esters of the methanol-solubleportion (MSP) of WS and RS in supercritical methanolysis. However, only about 100 organic compoundsof lower volatility and polarity could be detected in MSP by gas chromatography-mass spectrometry. Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry was used to determinethe organic nitrogen compounds (ONCs) in the MSPs from supercritical methanolysis of raw andpretreated WS with Trichoderma sp. AH. The most prevalent ONCs in the MSPs of native and pretreatedWSs in the positive ion mode would be N2On (n = 1–9) species having twin-bonding equivalence values(2–25) together with carbon-atom numbers of 4–35. Peak prevalent ONC within prior-treated WS MSPs isN2O4, with the most abundant ONC in raw WS MSPs is N2O5. These results help to understand the impactof Trichoderma sp. AH pretreatment upon converting ability/specificity for ONCs within WS methanolysisand employing MSP in producing jet fuel.
ODV-Associated Proteins of the <i>Pieris rapae</i> Granulovirus
Wang, Xiao-Feng,Zhang, Bao-Qin,Xu, Hai-Jun,Cui, Ying-Jun,Xu, Yi-Peng,Zhang, Min-Juan,Han, Yeon Soo,Lee, Yong Seok,Bao, Yan-Yuan,Zhang, Chuan-Xi American Chemical Society 2011 JOURNAL OF PROTEOME RESEARCH Vol.10 No.6
<P><I>Alphabaculovirus</I> (lepidopteran-specific nucleopolyhedroviruses, NPV) and <I>Betabaculovirus</I> (granuloviruses, GV) are two main genera of the family Baculoviridae. The virion proteomes of <I>Alphabaculovirus</I> have been well studied; however, the <I>Betabaculovirus</I> virion compositions remain unclear. <I>Pieris rapae</I> granulovirus (PrGV) can kill larvae of <I>P. rapae</I>, a worldwide and important pest of mustard family crops. In this study, the occlusion-derived virus (ODV)-associated proteins of PrGV were identified using three mass spectrometry (MS) approaches. The MS analyses demonstrated that 47 proteins were present in PrGV-ODV. Of the 47 PrGV-ODV proteins, 33 have homologues identified previously in other baculovirus ODV/BVs, whereas 14 (P10, Pr21, Pr29, Pr35, Pr42, Pr54, P45/48, Pr83, Pr84, Pr89, Pr92, Pr111, Pr114 and FGF3) were newly identified ODV proteins. Seven of the 14 newly identified ODV proteins are specific to <I>Betabaculovirus</I>, including Pr35, Pr42, Pr54, Pr83, Pr84, Pr111 and Pr114. Furthermore, the data derived from these MS approaches were validated by immunoblotting analysis using antisera prepared from 11 randomly selected recombinant PrGV-ODV proteins (including 5 <I>Betabaculovirus</I>-unique proteins). Comparison analyses revealed the similar and different compositions between <I>Betabaculovirus</I> and <I>Alphabaculovirus</I> virions, which deepen our understanding of the baculovirus virion structure and provide helpful information on <I>Betabaculovirus</I>–host interaction studies.</P><P>We used three mass spectrometry (MS) approaches to identify the occlusion-derived virus (ODV)-associated proteins of the <I>Pieris rapae</I> Granulovirus. A total of 47 proteins were identified; 14 of them were first identified in the ODV, and 7 are specific to Granulovirus.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2011/jprobs.2011.10.issue-6/pr2000804/production/images/medium/pr-2011-000804_0002.gif'></P>