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Interleukin-17 is Increased In the Urine of Patients With Lupus Nephritis
( Chong Hyeon Yoon ),( Mi La Cho ),( So Youn Min ),( Kyung Soo Park ),( Jin Jung Choi ),( Wan Uk Kim ),( Do June Min ),( Jun Ki Min ),( Yeon Sik Hong ),( Sung Hwan Park ),( Chul Soo Cho ),( Ho Youn Ki 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-
Comparison of performances of AnypJex 2 HPV HR, Cobas 4800 HPV Test, and the Hybrid Capture 2
( Do Hoom Lee ),( Myong Chaol Lim ),( Chong Woo Yoo ),( Jung Nam Joo ),( Joo Young Kim ),( Sang Yoon Park ),( Sang Hyun Hwang ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Background: The Anyplcx 1I1-IIlV I-m (Seegcnc, Seoul, Korea) is a new multiplex real-time peR assay for screening cervical cancer and is designed to detect 14 high-risk hum:m papillomaviruses (hrHPVs) along with all the genotypeinformation in a single tube. The aim of this st ud)· is to evaluate the performance of An}``plex II HPV HR (A nyplex_HR) in comparison to that of Cob as 4800 HPV (Cobas_ 4BOO) and Hybrid capture 2 (i-IC2). Methods: The performance of Anyplex_HR for hrH!>\`` genotype detection was retrospectively evaluated against HC2 and Cobas, at the National Cancer Center using 400 cervical swab samples. All discrepant samples were confirmed by peR with type specific primers followed by SCi:jucncing. Results: Overall agreement and kappa value of Anyplex_IIR with Cobas_ 4Boo were 98.0 % and 0.96, respectively.Agreement between two the assays and the corresponding kappa values for HPV 16, HPV IB, and other hrHPVs were 99.5%. 99.8%, and 9B.8%. and 0.98, 0.96. and 0.97. respectively. Agreement and kappa values of I-IC2 with Cobas_ 4800 were 95.25% and 0.91. HI``V positivity of Anyplex_HR and Cobas_ 4800 in low-grade squamous intra epilheliallesion (LS IL)Jhigh-grade squamous inlraepithcliallesion (HSIL) samples m:ltchcd. Both HPV _I-IR and Cobas_ 4800 showed excellent results in the precision test Conclusions: AI1)``Plex_HR is comparative to Cobas_ 4800 and IIC2 for cervical cancer screening. II may prove more useful for follow-up testing and patient management by providing genotyping information beyond HPV 16 and HPV 18.
Park, Chong Jin,Choi, Yoon Jin,Kim, Jeong Gyun,Han, In-bo,Do Han, Kyung,Choi, Jung Min,Sohn, Seil Elsevier 2018 JOURNAL OF CLINICAL NEUROSCIENCE Vol.56 No.-
<P><B>Abstract</B></P> <P>Pertaining to an association between Acute Myocardial Infarction (AMI) and Ankylosing Spondylitis (AS) is sparse. The purpose of this nationwide longitudinal study was to investigate the prevalence of AMI in newly diagnosed AS patients.</P> <P>A total of 12,988 patients were enrolled in the AS group from January 1, 2010 to December 31, 2014 from the Korean National Health Insurance Service (NHIS). The control group consisted of 64,940 subjects according to 1:5 age-sex stratified matching. The AMI incidence rates in AS and control group were compared using the Kaplan-Meier method. The hazard ratio of AMI and the control group was estimated by Cox proportional hazards regression analyses.</P> <P>During a 6 year follow up, 62 patients (0.48%) in the AS group and 157 persons (0.24%) in the control group developed AMI. The hazard ratio of AMI in the AS group was 1.99 (95% confidence interval [95% CI], 1.48–2.67) after adjusting for sex and age. The hazard ratio of AMI in the AS group was 1.81 (95% CI, 1.34–2.43) after adjusting for demographics and comorbid medical disorders.</P> <P>The incidence rate of AMI increases in newly diagnosed AS patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A total of 12,988 patients were enrolled in the AS group from January 1, 2010 to December 31, 2014. </LI> <LI> The control group consisted of 64,940 subjects according to 1:5 age-sex stratified matching. </LI> <LI> 62 patients (0.48%) in the AS group and 157 persons (0.24%) in the control group developed AMI. </LI> <LI> The hazard ratio of AMI in the AS group was 1.81 (95% CI, 1.34–2.43) after adjusting for demographics and comorbid disorders. </LI> <LI> This is the largest and longest nationwide study to investigate increased risk of AMI in AS patients. </LI> </UL> </P>
Park, Thae-Yeong,Rhee, Sang-Hoon,Kim, Han-Do,Kim, Chong-Rak,Kang, Ho-Sung,Yoo, Mi-Ae The Korean Society for Integrative Biology 1997 Korean journal of biological sciences Vol.1 No.1
Promoter of the Drosophila proliferating cell nuclear antigen (PCNA) gene contains DRE (Drosophila DNA replication-related element) required for the high level expression of replication-related genes. Recently, we found that promoter region of the D-raf (a Drosophila homolog of the human c-raf-1) contains two sequences homologous to the DRE and demonstrated the DRE/DREF (DRE-binding factor) involvement in regulation of the D-raf gene. In this study, using ursolic acid (UA), a pentacyclic triterpene acid reported to possess antitumor activities, we examined effects of UA on proliferation of the Drosophila cultured Kc cells and on expression of the PCNA and D-raf genes. UA showed an inhibitory effect on proliferation of the Kc cells in a concentration-dependent manner in DNA content assays and [3H]thymidine incorporation assays. The IC50 value of anti-proliferative effects of UA in DNA content assays was about 7.5uM. UA showed inhibitory effects on expression of the PCNA as well as on that of the D-raf, which were examined with the reporter plasmic p5'-168DPCNACAT or p5'-878DrafCAT, respectively. The results obtained in the present study suggest that expression of the PCNA and D-raf genes is coordinately regulated in at least UA-treated Kc cells and that down-regulation of expression of the PCNA and D-raf genes might be related with the antitumor activities of UA.
Do, Kyoung-Tag,Jung, Soon-Woo,Park, Kyung-Do,Na, Chong-Sam Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.5
Objective: To determine the effects of genomic breeding values (GBV) and single nucleotide polymorphisms (SNP) on the total number of piglets born (TNB) in 3 pig breeds (Berkshire, Landrace, and Yorkshire). Methods: After collecting genomic information (Porcine SNP BeadChip) and phenotypic TNB records for each breed, the effects of GBV and SNP were estimated by using single step best linear unbiased prediction (ssBLUP) method. Results: The heritability estimates for TNB in Berkshire, Landrace, and Yorkshire breeds were 0.078, 0.107, and 0.121, respectively. The breeding value estimates for TNB in Berkshire, Landrace, and Yorkshire breeds were in the range of -1.34 to 1.47 heads, -1.79 to 1.87 heads, and -2.60 to 2.94 heads, respectively. Of sows having records for TNB, the reliability of breeding value for individuals with SNP information was higher than that for individuals without SNP information. Distributions of the SNP effects on TNB did not follow gamma distribution. Most SNP effects were near zero. Only a few SNPs had large effects. The numbers of SNPs with absolute value of more than 4 standard deviations in Berkshire, Landrace, and Yorkshire breeds were 11, 8, and 19, respectively. There was no SNP with absolute value of more than 5 standard deviations in Berkshire or Landrace. However, in Yorkshire, four SNPs (ASGA 0089457, ASGA0103374, ALGA0111816, and ALGA0098882) had absolute values of more than 5 standard deviations. Conclusion: There was no common SNP with large effect among breeds. This might be due to the large genetic composition differences and the small size of reference population. For the precise evaluation of genetic performance of individuals using a genomic selection method, it may be necessary to establish the appropriate size of reference population.
Park, Su-Jung,Kim, Ji-Hee,Ko, Han-Suk,Kim, Chong-Rak,Kim, Han-Do,Kang, Ho-Sung 대한의생명과학회 2001 Journal of biomedical laboratory sciences Vol.7 No.4
Nebulin is an approximately 700 kDa filamentous protein in vertebrate skeletal muscle. It binds to the Z line and also binds side-by-side to the entire thin actin filament in a sarcomere. The correlation of nebulin size with thin filament length have led to the suggestion that nebulin acts as a molecular ruler for the length of thin filaments. The C-terminal part of human nebulin is anchored in the sarcomeric Z-disk and contains an SH3 domain. SH3 domains have been identified in an ever-increasing number of proteins important for a wide range of cellular processes, from signal transduction to cytoskeleton assembly and membrane localization. However, the exact physiological role of SH3 domains remains, in many cases, unclear. To explore the role of nebulin SH3 in the cytoskeletal rearrangement that accompanies myoblast differentiation, we transfected sense and antisense nebulin SH3 domain fused to enhanced green fluorescent protein in myoblast. Cells expressing nebulin SH3 fragment showed decrease of cell-cell adhesion, and cells transfected with antisense nebulin SH3 gene showed a rounded cell morphology and loss of cell-matrix adhesion. No alteration in cell shape and differentiation were observed in control cells expressing enhanced green fluorescent protein. Perturbation of nebulin altered the cell shape and disrupted cell adhesion in myoblast, demonstrating that nebulin can affect cytoskeleton rearrangement.