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박순도(SD Park),홍용하(YH Hong),정희식(HS Chung),이동구(DK Lee) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.9
Uterus duplex unicollis is the term that could be applied to that congenital anomaly where there is complete external separation of the uteri low up to the level of the internal os but have one cervix. Mrs. M.O.S. had normal full term delivery at home in a small town when she was 22 years old. At the age of 24, she was under full term condition and had dystocia, and the fetus was dead in the uterus . In the small town the classic cesarean section was performed by a physician. The patient, aged 27, visited us on May 7, 1964 and the complaints were dysmenorrhea since last operation and sterility condition. On examination the cervix was usual shaped and only one. An adulrfist sized, nontender, ovoid, firm mass was palpated at the right adbexal region, appearing a right ovarian tumor. On May 11, 1964 under general anesthesia laparotomy was performed. The right lower abdominal mass was firmly adherent to the pelvic organs and the mass was difficult to do orientation. It was the right uterus of a double uterus with right tube and ovary. The mass was removed with some difficulty subtotally and the bleeding was not remarkable. Incidenrtal apperdectomy was performed. After the third postop- erative day, the patient was febrile and the right lower abdomen was getting tender and blood clots were removed exteaperitoneally. One week later she was discharged in good condit- ion. Operative Specimen: The specimen was a cystic and incompleteoy removed uterus with a retort shaped tude and ovary attached. The hemisecteds shows completely cystic with dark old blood content and the wall is uniform in thickness. The lower part of the cavity was completely closed. On the anterior surface and wall of the uterus several silk stich materials wee seen. The right tube was enlarged and retort shaped with old blood and the ovary was not remarkable(Fig.1) Postoperative Diagnosis: Hematometra, Uterus, Right Duplex Unicollis. Hematosalpinx, Right. Ovary, Right. In 1966 and 1968, she had two full termpregnancies and labors in her home.
대장암환자에서 Capecitabine (XelodaⓇ) 단독요법에 의한 수족증후군
박순도,이길연,박선진,이석환,이상목 대한대장항문학회 2009 Annals of Coloproctolgy Vol.25 No.4
Purpose: Capecitabine (XelodaⓇ), which is a systemic prodrug of 5-fluorouracil, can be used in oral formulation for treatment of advanced colorectal cancer as a 1st line or an alternative modality to I.V. 5-fluorouracil-based chemotherapy. One of the most common side effects of this drug is hand-foot syndrome (HFS), palmar-plantar erythrodysesthesia syndrome. We planned this study to clarify the incidence and the clinical course of severe hand-foot syndrome (WHO classification, grade 3 or 4) following capecitabine monotherapy for adjuvant treatment of colorectal cancer. Methods: From August 2006 to August 2008, 45 colorectal cancer patients were treated with capecitabine, 1,250 mg/m2, orally administered twice daily for 2 wk, followed by 1 wk of rest, given as 3-wk cycles. Seven of them discontinued the drug within 3rd cycle due to poor performance status, gastrointestinal troubles, or other causes. We retrospectively analyzed the remaining 38 patients’ medical records and defined the incidence and the clinical course of HFS. Results: Of the 38 patients, 17 (44.7%) suffered severe HFS after capecitabine monotherapy. Of those 17, 5 (29.4%) had severe symptoms after the 1st chemotherapy cycle, and 14 patients (82.4%) had severe symptoms within the 4th cycle. Three of the 14 female and 14 of the 24 male patients complained of severe HFS, showing a statistical male predominance (P= 0.043). Eventually, we had to decrease capecitabine to 75% of the daily dose in 12 patients and to 50% in one patient, and to discontinue its use in 4 patients. Conclusion: Capecitabine monotherapy very frequently provokes severe HFS, especially in the early cycles of chemotherapy and in males. Purpose: Capecitabine (XelodaⓇ), which is a systemic prodrug of 5-fluorouracil, can be used in oral formulation for treatment of advanced colorectal cancer as a 1st line or an alternative modality to I.V. 5-fluorouracil-based chemotherapy. One of the most common side effects of this drug is hand-foot syndrome (HFS), palmar-plantar erythrodysesthesia syndrome. We planned this study to clarify the incidence and the clinical course of severe hand-foot syndrome (WHO classification, grade 3 or 4) following capecitabine monotherapy for adjuvant treatment of colorectal cancer. Methods: From August 2006 to August 2008, 45 colorectal cancer patients were treated with capecitabine, 1,250 mg/m2, orally administered twice daily for 2 wk, followed by 1 wk of rest, given as 3-wk cycles. Seven of them discontinued the drug within 3rd cycle due to poor performance status, gastrointestinal troubles, or other causes. We retrospectively analyzed the remaining 38 patients’ medical records and defined the incidence and the clinical course of HFS. Results: Of the 38 patients, 17 (44.7%) suffered severe HFS after capecitabine monotherapy. Of those 17, 5 (29.4%) had severe symptoms after the 1st chemotherapy cycle, and 14 patients (82.4%) had severe symptoms within the 4th cycle. Three of the 14 female and 14 of the 24 male patients complained of severe HFS, showing a statistical male predominance (P= 0.043). Eventually, we had to decrease capecitabine to 75% of the daily dose in 12 patients and to 50% in one patient, and to discontinue its use in 4 patients. Conclusion: Capecitabine monotherapy very frequently provokes severe HFS, especially in the early cycles of chemotherapy and in males.
박순도(SD Park),홍용하(YH Hong),윤진규(CK Yoon),송민자(MZ Song) 대한산부인과학회 1970 Obstetrics & Gynecology Science Vol.13 No.2
Two cases of the extrauterine displacement of Lippes loop are presentd in this paper. Case 1 is a 28year old Korean Women, para 2, gravida 2. This patient had undergone Lippes loop and the extrauterine displaced loop was found on X-ray film one year and seven months later after the insertion. Laparotomy revealed Lippes loop subserosaly at the posterior wall of the uterus and the loop was removed. Case 2 is a 34 year old Korean women, Para 3 gravida 3. The patient had undergone Lippes loop and the extrauterine displaced loop ws found four years and three months later, abdominal total hysterectomy was performed. Also the occurence, morbility, mechanism, diagnosis and treatment were discussed and briefly the current literatures were review here.