A Research of Hwang ji-young’s work - “Without people and people” performance

Ji-Young Hwang,Sung-ok Choi 한국콘텐츠학회 2019 한국콘텐츠학회 ICCC 논문집 Vol.2019 No.12

A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea

Yong Sung Choi,정성훈,김은선,Eun Sun Kim,Eunhee Lee,Euiseok Jung,So-Yeon Lee,이우령,Hye Sun Yoon,Yong Joo Kim,Ji Kyoung Park,Son Moon Shin,Ellen Ai-Rhan Kim 대한신생아학회 2022 Neonatal medicine Vol.29 No.1

Purpose: Pediatricians have a significant responsibility to educate mothers about the importance of breastfeeding. However, there have been minimal efforts in the courses of resident training in Korea. The purpose of this study is to evaluate the change in knowledge and attitude before and after a 4-week breastfeeding educational intervention among multicenter residents. Methods: Prospective interventional educational research was designed for residents at eight training hospitals in Korea. Institutional reviews were obtained in each hospital. The education curriculum consisted of 14 courses regarding breastfeeding theory and practice. These materials were used to teach pediatric residents for 4 weeks. Knowledge-based tests were administered before the course, and re-tests were administered after the course using different test items of similar levels. Test scores and survey responses were compared before and after the intervention. Results: A total of 73 residents (1st year 20, 2nd year 23, 3rd year 16, and 4th year residents 14) from eight training hospitals completed the intervention. Their average age was 30.3±2.9 years, 17 (23.3%) were male, 22 (30.1%) were married, and eight had more than one child of their own. The mean pre-test score was 61.8±13.4 and the mean post-test score was 78.3±7.5 (P<0.001). The inter-grade difference in the score was significant in the pre-test (P=0.005), but not significant in the post-test (P=0.155). There were more responses of obtaining confidence after the intervention (P<0.001). Conclusion: In our study, pediatric residents showed improvement in their knowledge and confidence level after 4 weeks of the breastfeeding curriculum. This will provide a basis for future policymaking in the training of pediatric residents regarding breastfeedReceived: 6 January 2022 Revised: 15 February 2022 Accepted: 15 February 2022 Correspondence to: Ellen Ai-Rhan Kim, MD Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-3390 Fax: +82-2-3010-6978 E-mail: arkim@amc.seoul.kr A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea Yong-Sung Choi, MD,PhD1, Sung-Hoon Chung, MD, PhD2, Eun Sun Kim, MD, PhD3, Eun Hee Lee, MD4, Euiseok Jung, MD5, So Yeon Lee, MD, PhD5, Wooryoung Lee, MD6, Hye Sun Yoon, MD, PhD7, Yong Joo Kim, MD, PhD8, Ji Kyoung Park, MD, PhD9, Son Moon Shin, MD, PhD9, and Ellen Ai-Rhan Kim, MD, PhD5 1Department of Pediatrics, Kyung Hee University Hospital, Seoul, Korea 2Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea 3Department of Pediatrics, Kangwon National University Hospital, Chuncheon, Korea 4Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea 5Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 6Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea 7Department of Pediatrics, Nowon Eulji Medical Center, Eulji University, Seoul, Korea 8Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Korea 9Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 pISSN 2287-9412 . eISSN 2287-9803 Copyright(c) 2022 By Korean Society of Neonatology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Original Article 29 Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 ing in Korea.

고속도로 IC 및 JCT 주변 유휴부지의 물류시설 활용가능성 분석 : 수도권 및 지방광역시를 중심으로

양현지(Yang, Hyun-Ji),최재성(Choi, Jae-Sung) 한국물류학회 2021 물류학회지 Vol.31 No.2

최근 코로나 19 등의 감염병으로 인한 비대면 활동 증가로 인터넷, 모바일 등을 통한 이커머스 택배 이용건수가 증가하며 택배업체 등의 물류시설 부지 확보 수요가 점점 증가하는 추세이다. 업체별로 필요한 부지를 연도별 임계치 수준에서 수급하며 적게는1천 평에서 많게는 1만 평 이상의 부지가 추가적으로 필요하므로 부족한 부지를 현재와 같이 부동산업체 등을 통해 사적영역에서확보하는 것은 지속가능성의 한계에 직면할 것으로 보인다. 본 연구에서는 수도권(서울, 인천, 경기도) 및 지방광역시(대전, 대구, 광주, 울산, 부산)를 중심으로 공공 부문의 도시계획시설 측면에서 가장 넓은 유휴부지의 확보가 가능한 고속도로 IC/JCT 교통광장 유휴부지의 부지현황⋅활용가능성을 분석하였다. 분석방법 및 내용으로 다음 카카오맵의 로드뷰, 스카이뷰 등을 활용해 연구대상지의 유휴부지를 전수조사 후 사업지 내 이면도로 등의 존재 유무에 따라 단기 및 중⋅장기적 사업 우선순위화 분류, 국가물류통합정보센터 내 물류단지 건립계획을 이용해 택배업체의 허브 및 서브터미널 건설 시 예상 사업비 분석, 한국은행의 산업연관표를 적용해 경제적 파급효과 등의 결과를 도출하였다. 도출된 유휴부지를 택배업체 등에서 활용하기 위해서는 IC/JCT 교통광장대부분의 지역이 현재 ｢국토계획법 시행령 제71조｣에 의해 생산⋅자연녹지 용도지역인 상황을 고려하면 ｢건축법 시행령 별표1｣ 의 ‘18.창고시설 중 물류터미널’을 추가하는 방안, ｢도로법｣내 교통광장의 설치 및 관리에 관한 규정을 신설하거나 박성중 의원등 10인이 제안하여 위원회 심사 중인 ｢도로공간의 입체개발에 관한 법률안｣의 본회의 통과를 통한 입법화를 완료해 법적 근거마련이 필요한 상황으로 보인다. 향후 법제도 개선을 통해 고속도로 IC/JCT의 유휴부지(총 183만평-수도권 140만평, 지방광역시43만평) 중 수도권은 약 12%, 지방광역시는 약 10% 정도만이라도 활용 가능하다면‘19년 한국통합물류협회의 18개 택배사업자가제시한 물류시설 구축을 위한 유휴부지 마련 수요를 충족시켜 부지확보의 어려움이 일정 부분 해소될 수 있을 것으로 추정한다. As contact-free activities have increased due to infectious diseases such as COVID-19, the number of delivery-related services has also increased through the rise of e-commerce. As such, the demand for securing sites for logistics facilities is rising as well. Each delivery company keeps supply and demand in balance at the annual threshold level, which means that they require additional land ranging from 3,300m2 (1,000 pyeong) to as much as 33,000m2 (10,000 pyeong). However, it is unreasonable to continuously secure land to meet demands from private areas through real estate companies, as is the current standard procedure done by delivery companies. This study analyzes the feasibility of securing unused land in its current state, focusing on unused sites in expressways IC/JCT, where the widest unused land, in terms of urban planning facilities can be found, mainly in the capital region (Seoul, Incheon, Gyeonggi-do) and provincial metropolitan cities (Daejeon, Daegu, Gwangju, Ulsan, Busan). Full-scale inspection of unused land near expressways is first conducted using Kakao Map’s Road View and Sky View, and the results, such as short-term or mid to long term business priorities, are derived depending on whether backside roads exist or not. Estimated business expenses are calculated using information of logistics center from the National Logistics Integrated Information Center, and economic effects of building hubs and sub-terminals for delivery companies in the unused land are also drawn, applying the Leontief input-output table from the Bank of Korea. Most unused land such as those surrounding roundabouts near expressways IC/JCT is considered as productive green areas and natural green areas in accordance with Article 71 of ｢Enforcement Decree of the National Land Planning and Utilization Act｣, so clause 18, which states “logistics terminal amongst storage facility field”, of schedule 1 in ｢Enforcement Decree of Building Act｣ should be added to the Article to loosen restriction on construction in areas surrounding roundabouts. Also, regulations on the installation and management of roundabouts in the ｢Road Act｣ should be established to allow delivery company to utilize the unused land derived through this analysis. Preparation of a legal basis is deemed necessary by passing legislation through the plenary session for ｢The Bill on the Development of Three-dimensional Road Space｣ under examination made by 10 lawmakers, including Park Sung-joong. If approximately 12% of the total unused land in expressways IC/JCT in the capital region and approximately 10% in provincial metropolitan cities are made available by improving the legal system in the future, demand of 18 delivery companies from Korea Logistics Association will be met. Through this, it is estimated that the difficulty of securing sites for logistics facility construction would be partially resolved.

Reducing sugar production from Laminaria japonica using the thermal acid hydrolysis and Bacillus sp. treatments

Ji-Suk JANG,YuKyenong CHO,Mi-Ran CHOI,Sung-Koo KIM 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

Influence of the Structural Characteristics of Amino Acids on Direct Methylation Behaviors by TMAH in Pyrolysis

Choi, Sung-Seen,Ko, Ji-Eun Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.11

Direct methylation behaviors of 20 amino acids with tetramethylammonium hydroxide (TMAH) were studied under diluted conditions with silica. Amino acid concentration was controlled by dilution with silica ($SiO_2$) and the molar ratios of amino acid/silica were 0.20, 0.50, and 2.0. The molar ratios of amino acid/TMAH (0.51 - 4.64) also varied. It was found that arginine, asparagine, aspartic acid, cysteine, glutamic acid, and glutamine did not generate any directly methylated pyrolysis products, whereas alanine, glycine, isoleucine, leucine, methionine, phenylanaline, valine, and proline generated all the directly methylated pyrolysis products. Tri- and tetra methylated products of lysine consisted of two types. Histidine and threonine hardly generated the partly methylated products. Mono- and dimethylated products of serine, tryptophan, and tyrosine were not observed. Relative intensities of the methylated products varied with the amino acid concentration, TMAH concentration, and pyrolysis temperature. Direct methylation behaviors of amino acids were explained by the structural characteristics of amino acids.

Enhanced Biological Production of L-Cysteine at Ultra-high Substrate Concentrations of D,L-2-amino-Δ2-thiazoline-4-carboxylic acid

Sung Hun Youn,Hyun Jung Kim,Eun Ji Lee,Ha Na Park,Soo Hyun Woo,Yea Hoon Choi,Chul Soo Shin 한국생물공학회 2007 한국생물공학회 학술대회 Vol.2007 No.4

Synthesis and biological evaluation of tricarbonyl technetium labeled 2-(4-chloro)phenyl-imidazo[1,2-a]pyridine analog (99mTcCB257) as a TSPO-binding ligand

Ji Young Choi,Byung Chul Lee,Sang Eun Kim,Jae Ho Jung,In Ho Song,문병석 대한방사성의약품학회 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.2

In our previous study, tricarbonyl 99mTc-labeled TSPO-binding ligand, named 99mTc-CB256, having positively charge (+1) was investigated but did not show promising results in in vivo environment despite of a nanomolar binding affinity for TSPO. Because the overall positively charge of 99mTc-CB256 would likely interrupt its target protein uptake, we herein designed the neutral tricarbonyl-99mTc labeled TSPO-binding ligand (99mTc-CB257, 1). 99mTc-CB257 was prepared by the facile incorporation of the [99mTc(CO)3]+ into a N-(hydroxycarbonylmethyl)2-picoly moiety in CB257. The radiochemical yield of 99mTc-CB257 after HPLC purification was 54.1 ± 2.4% (decay corrected, n = 3). The authentic Re-CB257 (2) was synthesized by using (NEt4)2[Re(CO)3Br3] in 69.0% yield. The binding affinity of 2 for TSPO was measured in leukocyte and showed approximately 280 times higher than that observed for the positively charged (+1) ligand, Re-CB256 ( K i = 0.57 ± 0.06 nM versus 159.3 ± 8.7 nM, respectively). Our results indicated that 1 can be considered potentially as a new SPECT radiotracer for TSPO-rich cancer and provides the foundation for further in vivo evaluation related with abnormal TSPOoverexpression environments

Synthesis and biological evaluation of tricarbonyl technetium labeled 2-(4-chloro)phenyl-imidazo[1,2-a]pyridine analog (^99mTc-CB257) as a TSPO-binding ligand

Choi, Ji Young,Jung, Jae Ho,Song, In Ho,Moon, Byung Seok,Lee, Byung Chul,Kim, Sang Eun 대한방사성의약품학회 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.2

In our previous study, tricarbonyl $^{99m}Tc$-labeled TSPO-binding ligand, named $^{99m}Tc$-CB256, having positively charge (+1) was investigated but did not show promising results in in vivo environment despite of a nanomolar binding affinity for TSPO. Because the overall positively charge of $^{99m}Tc$-CB256 would likely interrupt its target protein uptake, we herein designed the neutral tricarbonyl-$^{99m}Tc$ labeled TSPO-binding ligand ($^{99m}Tc$-CB257, 1). $^{99m}Tc$-CB257 was prepared by the facile incorporation of the $[^{99m}Tc(CO)_3]^+$ into a N-(hydroxycarbonylmethyl)-2-picoly moiety in CB257. The radiochemical yield of $^{99m}Tc$-CB257 after HPLC purification was $54.1{\pm}2.4%$ (decay corrected, n = 3). The authentic Re-CB257 (2) was synthesized by using $(NEt_4)_2[Re(CO)_3Br_3]$ in 69.0% yield. The binding affinity of 2 for TSPO was measured in leukocyte and showed approximately 280 times higher than that observed for the positively charged (+1) ligand, Re-CB256 ($K_i=0.57{\pm}0.06nM$ versus $159.3{\pm}8.7nM$, respectively). Our results indicated that 1 can be considered potentially as a new SPECT radiotracer for TSPO-rich cancer and provides the foundation for further in vivo evaluation related with abnormal TSPO-overexpression environments.

Differential Gene Expression Analysis in Human Leukemia Cell Line K562 Treated With Benzene :

Choi, Sulji,Kim, Ji-Young,Kim, Kee-Beom,Seol, Jin-Ee,Baek, Hee Jo,Kook, Hoon,Seo, Sang-Beom Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2011 Epidemiology Vol.22 No.-

The Effects of Electro-Acupuncture the Rat with Induced MCAO

Choi, Jung-Hyun,Kim, Ji-Sung,Kim, Dong-Il,Kim, Bo-Kyoung,Kim, Soon-Hee,Song, Chi-Won The Society of Korean Medicine 2009 대한한의학회지 Vol.30 No.3

Objectives : This study was aimed at examining the effects of the application of EA (electroacupuncture) at GV20 and LI4 in the early cerebral ischemia on the size of cerebral infarction, COX-2 and IL-6. Methods : For this experiment, 21, six-week-old male S-D (Sprague - Dawley) rats weighting 160g to 200g were selected and randomly classified into 3 groups, seven rats in each group. Brain ischemia was simulated using a modified Koizumi method which was performed on each rat. In the GV20 group, the GV20 of the SD rats was stimulated for thirty minutes with acupunctural electrode low frequency stimulator five hours after inducement of ischemia. For the LI4 group, the LI4 was stimulated as above, while for the Ischemia group, no stimulation was applied. Twenty-four hours after the experiment, stained cerebral tissues were examined and an immuno-histological test was done to examine inflammatory reaction Results : Out of the three groups, the LI4 group showed the smallest size of cerebral infarction and the Ischemia group showed the highest COX-2 (cyclooxygenase-2) expression value in the cortex of the cerebrum. In addition, the LI4 group showed the lowest COX-2 expression value in unknown putamen out of the three groups. Conclusions : We infer that EA, applied at LI4 and GV20 in early ischemia, is effective in delaying the expression of IL-6 (interleukin-6) and COX-2, the inflammatory agents manifested from stroke. In addition, application at LI4, rather than GV20, can lower the expression value of the inflammatory agents. Further, EA can be an effective way to block early inflammatory reaction in stroke.