성대마비환자를 대상으로 시행한 후두근전도검사의 임상적 유용성

최홍식,최영준,문상우,김태만,최홍식,최영준,문상우,김태만 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

하중스펙트럼을 이용한 고속도로 판형교의 피로해석에 관한 연구

최홍식,변근주,이기성,김영진 연세대학교 산업기술연구소 1987 논문집 Vol.19 No.1

The objective of this study is to propose effective stress ranges for a fatigue analysis and to develop a method estimating the fatigue life of existing plate girder bridge. The procedure for the effective stress range is consisted of three parts. In the first one, the external loading conditions are systematized by analyzing the actual traffic volumn from Taejeon to Taegu on the Seoul-Pusan Expressway. In the seconed one, the load spectrums for each loading case are elicited. Finally, the stress spectrums are derived from the dynamic analysis of the bridges. The single effective stress range is obtained using Rayleigh probability density function. The effective stress ranges obtained may give a realistic estimate of the life of existing bridges. The results of this study may provide the basic data for the fatigue test.

위장간 수술환자에서 겐타마이신의 임상약물동태

최준식,문홍섭,최인,범진필 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

The purpose of this investigation was to determine pharmacokinetic parameter of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korea normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were 0.226±0.032, 0.231±0.063 L/㎏ and 0.357± 0.024, 0.337±0.041 hr^-1 for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters. KS and VS were 0.00344±0.00049(hr·mL/min/1.73㎡)^-1 and 0.214±0.0502 L/㎏ for gastronintestinal surgical patients using NPEM method. The V and K were 0.216±0.048 L/㎏ and 0.336±0.043 hr^-1 for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetic between NLSR and Bayesian analysis in gastrointestinal surgical patient.

1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

鐵筋콘크리트 土留構造物의 最適化에 關한 硏究

崔洪植,邊根周,李相旻 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

A mathematical model is formulated for the minimum cost design of reinforced concrete earth structures. The design variables are selected to be the depth and steel ratio in the retaining wall, and the depth, steel ratio and footing sizes in the isolated column footings. An elastic analysis is performed and resulting designs are based on both the ultimate strength theory and the elastic theory of concrete design. Constraint requirements are imposed to insure structural strength and side constraints. The resulting mathematical model is a nonlinear constrained optimization problem. The modified Lagrange Multiplier method is suggested as a satisfactory algorithm for the optimum design of the R.C. earth structures.

인두 신경증과 위식도 역류의 상관관계에 대한 예비연구 : Preliminary Study

최홍식,이승문,김광문,홍원표 釜算慶南耳鼻咽喉科學會 1994 임상이비인후과 Vol.5 No.2

식도발성의 숙련 정도에 따른 모음의 음향학적 특징과 자음 산출에 대한 연구

최성희,최홍식,김한수,임성은,이성은,표화영 한국음성과학회 2003 음성과학 Vol.10 No.3

Esophageal Speech uses the esophageal air during phonation. Fluent esophageal speakers frequently intake air in oral communication, but unskilled esophageal speakers are difficult with swallowing lots of air. The purpose of this study was to investigate the different of acoustic characteristics of vowel and consonants production according to the speech proficiency level in esophageal speech. 13 normal male speakers and 13 male esophageal speakers (5 unskilled esophageal speakers, 8 skilled esophageal speakers) with age ranging from 50 to 70 years old. The stimuli were sustained /a/ vowel and 36 meaningless two syllable words. Used vowel is /a/ and consonants were 18 : /k, n, t, m, p, s, c, ch, kh, th, ph, h, I, k', t', p', s', c'/. Fundamental frequency (Fx), Jitter, shimmer, HNR, MPT were measured with by electroglottography using Lx speech studio (Laryngograph Ltd, London, UK). 36 meaningless words produced by esophageal speakers were presented to 3 speech-language pathologists who phonetically transcribed their responses. Fx, Jitter, HNR parameters is significant different between skilled esophageal speakers and unskilled esophageal speakers (P<.05). Considering manner of articulation, ANOVA showed that differences in two esophageal speech groups on speech proficiency were significant; Glide had the highest number of confusion with the other phoneme class, affricates are the most intelligible in the unskilled esophageal speech group, whereas in the skilled esophageal speech group fricatives resulted highest number of confusions, nasals are the most intelligible. In the place of articulation, glottal /h/ is the highest confusion consonant in both groups. Bilabials are the most intelligible in the skilled esophageal speech; velars are the most intelligible in the unskilled esophageal speech. In the structure of syllable, 'CV+V' is more confusion in the skilled esophageal group, unskilled esophageal speech group has similar confusion in both structures. In unskilled esophageal speech, significantly different Fx, Jitter, HNR acoustic parameters of vowel and the highest confusions of Liquid, Nasals consonants could be attributed to unstable, improper contact of neoglottis as vibratory source and insufficiency in the phonatory air supply, and higher motoric demand of remaining articulation due to morphological characteristics of vocal tract after laryngectomy.

철근 콘크리트 기둥의 최적화에 관한 연구

최홍식,변근주 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.1

This study is concerned with the optimum proportioning of R.C. sections for the optimum design of R.C. columns, using the Working Stress Design theory based on the AIK (the Architectural Institute of Korea) Code and the Ultimate Strength Design theory based on the ACI Code (318-77). In R.C. columns, since the strength and the steel ratio are usually considered at the preliminary stage, the design constraints used are strength constraints, and the side constraints(upper and lower limits of steel ratio). Cost objective function for the minimum cost design is obtained by considering the cost of concrete, steel bars, and forming. Section optimization of a column is achieved by using SUMT for the tension controls cases, and the heuristic method for the compression controls cases. It has been observed that the optimum proportioning of R.C. column results in significant saving in the construction cost, and that the minimum steel ratio of the Code, for the compression failure column, and the balanced steel ratio, for the tension failure columns, were the optimum solutions. The optimization algorithm developed may be recommended to achieve the minimum cost design of R.C. columns.

Van der Woude 증후군 1예

최홍식,임재열,박준호,남지인 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.11

골결손과 치주질환 유도 후 성견 절치의 실험적 함입이동시 치주조직의 반응

황현식,박양수,최홍란 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.3

치주질환에 이환된 성인환자에서 상악전치의 치간공간과 아울러 정출이 발생된 경우 기능 및 심미의 회복을 위해서는 함입이동이 필요하다. 본 연구는 골하치주낭 즉, 수직적 골결손이 있는 절치의 함입이동시 치주조직 반응을 살펴보기 위하여 시행되었다. 상악 좌우 측절치에 골결손과 함께 치주질환을 유발시킨 성견 4마리를 실험대상으로 하여 양측 모두에 치주수술을 시행하고 결손부 최하방 치근면에 notch를 형성한 2주후 우측 제2측절치는 4주간 함입이동 후 4주간 보정을 시행한 실험측으로, 좌측 제2측절치는 구강위생관리만 시행한 대조측으로 사용한 바 조직소견을 통하여 다음과 같은 결론을 얻었다. 1. 함입이동없이 치주수술만 시행한 대조측의 조직소견은 치주낭 깊이의 감소를 보였으나 notch 부위부터 치주낭 기저부까지 긴 접합상피 상태를 보였으며 신생백악질이 형성된 일부에서만 결합조직 부착의 양상이 보였다. 2. 함입이동을 시행한 실험측은 대조측에 비하여 상피부착이 줄어든 반면 보다 넓은 신생 결합조직 부착 소견을 나타내었다. 3. 대조측과는 달리 실험측 notch 근처의 결합조직내에는 다수의 세포가 관찰되었으며, 신생 백악질 생성 역시 대조측 보다 많이 관찰되었다. 이상의 결과는 치주질환으로 인하여 정출된 치아에서도 철저한 염증조절과 구강위생이 유지되고 적절한 크기의 힘에 의하여 순수한 함입이동이 적용된다면 바람직한 치료결과가 가능함을 시사하였다. While periodontal disease results in the extrusion of upper incisors with interdental spacing in adult patient, the intrusive movement should be executed for the rehabilitation in terms of esthetics and function. The present study was performed to investigate the periodontal response following orthodontic intrusion of teeth with infrabony pocket. Bone defect and periodontal disease were produced adjacent to the both maxillary second lateral incisors in four adult dogs. Four weeks later, a flap operation was performed to eliminate inflammation and a reference notch was made on the root surface at the level of bottom of each defect. Two weeks after periodontal surgery, 4 weeks of intrusion and subsequent another 4 weeks of retention was executed on the right side of incisors while left incisors served as the control. Through the histologic analysis, following results were obtained. 1. Histologic section of control side showed the reduction of pocket depth after flap operation. However, the status of long junctional epithelium was observed while new connective tissue attachment occurred in a small area adjacent newly formed cementum. 2. Epithelial attachment was less around the intruded incisor while new connective tissue attachment was much more compared to the control side. 3. Plenty of cells were observed in the connective tissue around the reference notch of the intruded incisor and the degree of the new cementum formation was higher in the intruded incisor than the control. The results of the present study suggested that an orthodontic intrusion of periodontally involved and extruded incisors could be carried out with a desirable periodontal response, provided that inflammation is under control.