치매간호중재 프로그램이 경증 치매노인의 Na, K, Ca, Cl, P, Cholesterol의 혈중농도 및 17-KS, 17-OHCS의 뇨배설량에 미치는 영향

나현주,조명숙,임욱빈 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.2

This study was conducted for the evaluation of the effect of Dementia prevention nursing program on Urinary 17-KS, 17-OHCS, and Blood Na, Cl, K, Ca, P, cholesterol. The sample for the present study was composed of 16 demented elderly in D care center for the eldery in K city. The Dementia prevention nursing program consisted of concept memory training, music therapy, and art therapy. The program was performed twice a week and about ninety minutes was consumed for one session. The program had been administered for 8 weeks. We checked Urinary 17-KS, 17-OHCS, and Blood Na, Cl, K, Ca, P, cholesterol befor and after the program. Statistical analysis was performed by using descriptive statistics and Wlicoxon signed rank test of SAS system for window 6.12. The result were follows : 1. Urinary 17-KS 17-KS score increased significantly after intervention(p=0.005). 2. Urinary 17-OHCS 17-KS score increased significantly after intervention(p=0.00l). 3. Blood Na, Cl, K, Ca, P, cholesterol Na(p=0.0002), Cl(p=0.0001) K(p=0.0001), Ca(p=0.0028) decreased significantly after intervention. The results show that Dementia prevention nursing program increases Urinary 17-KS, the Dementia 17-OHCS, and decreases Blood Na, Cl, K, Ca, P, cholesterol. In conclusion, prevention nursing program can be used for the effective measure to decrease stress of the Demented elderly.

Verbal Suffix-Repetition Constructions in Korean: A Constraint-and Construction-based Approach

( Sae Youn Cho ),( Na Hyun Ku ) 경희대학교 언어연구소 2012 언어연구 Vol.29 No.1

Cho, Sae-Youn & Ku Na-Hyun 2012, Verbal Suffix-Repetition Constructions in Korean: A Constraint-and Construction-based Approach. Linguistic Research 29(1), 173-195. There are various Verbal Suffix-Repetition (VSR) constructions in Korean, where suffixes such as-na1 tun(ci)/ tun(ka) are attached to the repeated verbs. Calling the VSR Choice-denying Repeated Verbs construction, Lee (2011) claims that the following verb of the VSR, which can he replaced with ma!-, should contain a negative but the preceding verb should be affirmative in the VSR construction which disallows any NPI within it. Unlike Lee (2011), we claim that the verbs in the VSR can freely occur either in the preceding position or in the following one regardless of their Neg value so long as they share the same verbal suffix forms such as -tun(ka). Furthermore, NPIs may occur within the VSR construction if they occur with a negative predicate within the same clause. To implement the findings above into HPSG, we have proposed the two lexical entries for mal-, the VSR Construction Rule, and the NPI Clause-mate Constraint. These tools enable us to account for the idiosyncratic properties of the VSR constructions under this constraint- and construction-based approach.

Original Articles : Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer Lines

( Hyun Ju Lee ),( Ja Sung Rho ),( Shao Ran Gui ),( Mi Kyung Kim ),( Yu Kyoung Lee ),( Yeon Sook Lee ),( Jeong Eun Kim ),( Eu Na Cho ),( Mong Cho ),( Tae Ho Hwang ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma patients having high levels of aldosterone and virus amplification in JX-594 treatment, we investigated the association between virus amplification and aldosterone in human cancer cell lines. Methods: Cell proliferation was determined by a cell-counting-kit-based colorimetric assay, and vaccinia virus quantitation was performed by quantitative polymerase chain reaction (qPCR) and a viral plaque assay. Also, the intracellular pH was measured using a pH-sensitive dye. Results: Simultaneous treatment with JX-594 and aldosterone significantly increased viral replication in A2780, PC-3, and HepG2 cell lines, but not in U2OS cell lines. Furthermore, the aldosterone treatment time altered the JX-594 replication according to the cell line. The JX-594 replication peaked after 48 and 24 hours of treatment in PC-3 and HepG2 cells, respectively. qPCR showed that JX-594 entry across the plasma membrane was increased, however, the changes are not significant by the treatment. This was inhibited by treatment with spironolactone (an aldosterone-receptor inhibitor). JX-594 entry was significantly decreased by treatment with EIPA [5-(N-ethyl-N-isopropyl)amiloride; a Na+/H+-exchange inhibitor], but aldosterone significantly restored JX-594 entry even in the presence of EIPA. Intracellular alkalization was observed after aldosterone treatment but was acidified by EIPA treatment. Conclusions: Aldosterone stimulates JX-594 amplification via increased virus entry by affecting the H+ gradient. (Korean J Hepatol 2011;17:213-219)

Cloning, Purification, and Characterization of a New DNA Polymerase from a Hyperthermophilic Archaeon, Thermococcus sp. NA1

( Yun Jae Kim ),( Hyun Sook Lee ),( Seung Seob Bae ),( Jeong Ho Jeon ),( Jae Kyu Lim ),( Yo Na Cho ),( Ki Hoon Nam ),( Sung Gyun Kang ),( Sang Jin Kim ),( Suk Take Kwon ),( Jung Hyun Lee ) 한국미생물생명공학회 2007 Journal of microbiology and biotechnology Vol.17 No.7

Expression of the Na⁺-HCO₃⁻cotransporter and its role in pH_iregulation in guinea pig salivary glands

Li, Jingchao,Koo, Na-Youn,Cho, Ik-Hyun,Kwon, Tae-Hwan,Choi, Se-Young,Lee, Sung J.,Oh, Seog B.,Kim, Joong-Soo,Park, Kyungpyo American Physiological Society 2006 American journal of physiology, Gastrointestinal a Vol.291 No.6

<P>Patterns of salivary HCO3<SUP>−</SUP>secretion vary and depend on species and gland types. However, the identities of the transporters involved in HCO3<SUP>−</SUP>transport and the underlying mechanism of intracellular pH (pHi) regulation in salivary glands still remain unclear. In this study, we examined the expression of the Na<SUP>+</SUP>-HCO3<SUP>−</SUP>cotransporter (NBC) and its role in pHiregulation in guinea pig salivary glands, which can serve as an experimental model to study HCO3<SUP>−</SUP>transport in human salivary glands. RT-PCR, immunohistochemistry, and pHimeasurements from BCECF-AM-loaded cells were performed. The amiloride-sensitive Na<SUP>+</SUP>/H<SUP>+</SUP>exchanger (NHE) played a putative role in pHiregulation in salivary acinar cells and also appeared to be involved in regulation in salivary ducts. In addition to NHE, NBC also played a role in pHiregulation in both acini and ducts. In the parotid gland, NBC1 was functionally expressed in the basolateral membrane (BLM) of acinar cells and the luminal membrane (LM) of ducts. In the submandibular gland, NBC1 was expressed only in the BLM of ducts. NBC1 expressed in these two types of salivary glands takes up HCO3<SUP>−</SUP>and is involved in pHiregulation. Although NBC3 immunoreactivity was also detected in submandibular gland acinar cells and in the ducts of both glands, it is unlikely that NBC3 plays any role in pHiregulation. We conclude that NBC1 is functionally expressed and plays a role in pHiregulation in guinea pig salivary glands but that its localization and role are different depending on the type of salivary glands.</P>

배추 생육 중 토양 수용성 양이온의 경시적 변화 모니터링

김용국(Yong gook Kim),Khok Pros,김경영(Kyoung young Kim),조현종(Hyun Jong Cho),나홍식(Hong Sik Na),한광현(Gwang Hyun Han) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

토양의 치환성 이온 함량이 아닌 식물체에 직접 흡수되는 수용성 이온들을 모니터링 하는 것이 중요하다. 배추가 생육하면서 토양 중 수용성 양이온들의 함량이 어떻게 변하는지 확인하고, 각 이온의 농도에 따라 그에 알맞은 처방이 이루어져야 한다. 토양 시료는 경기도 이천시의 배추 밭에서 정식 이후 16, 35, 48, 70일에 처리구별 각 3반복씩 채취하였다. 처리구는 N 기준 무처리구(Nil), NPK 비료 표준 시비량의 50% 처리구(Con), 100% 처리구(Inf), 그리고 표준 시비량의 50% 처리구에 음폐퇴비가 100%(C100), 200%(C200), 300%(C300) 추가된 처리구가 있다. 채취한 토양은 풍건 후 2 mm 체에 거르고 1:5 비율로 증류수 추출하였으며, Whatman No.2 필터를 사용하여 여과한 후 0.45 μm 실린지 필터로 재 여과하였다. 토양 추출액의 분석은 (주)테크넬 POCT 분석 키트를 사용하였다. 화학비료 처리구의 토양 중 Na의 농도비율은 생육기간 중 꾸준히 증가하는 경향이 있었다. 하지만 K의 농도비율은 시간이 지남에 따라 경시적 감소가 명확하였다. 음폐퇴비 처리구의 경우 토양 중 Na의 농도비율은 생육기간 중 증가하는 경향이었으며, 특히 퇴비 처리수준에 비례하여 높아졌다. Mg의 농도비율은 모든 처리구에서 비슷한 수준을 유지하였다. 모든 처리구에서 토양 중 K의 농도비율 감소는 Na 농도비율의 증가와 상관관계가 높았다.

결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

갑상선 미세 유두상 암의 임상적 특징

나병곤,배학연,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

Purpose: Papillary thyroid microcarcinoma (PTMC) is increasing in incidence because of ultrasound-guided fine-needle aspiration cyology (FNA). According to WHO, PTMC is defined as a papillary thyroid cancer of 1 cm or less in diameter. Within the group of patients with PTMC, prognosis is known to be very favorable. This study was carried out to evaluate the clinicohistological characteristics of PTMC and to determine a reasonable extent of surgery for them. Methods: From Mar. 2002 to Dec. 2007, 610 patients with thyroid diseases underwent thyroidectomy at Chosun University hospital. Among these patients, 205 patients (33%) had a thyroid papillary carcinoma less than or equal to 1 cm in great diameter. The clinicopathologic features and treatment outcome of these patients were evaluated retrospectively. Results: In the period 2002-2007, PTMC incidence rate in our institution increased from 10% to 20%. There were 19 men and 186 women with a median age of 46 years (range; 16-74). PTMC diameter ranged from 0.1 to 1 cm. (mean 0.54 cm) 15.7% of patients with PTMC presented with preoperative symptoms (palpable mass, fatigue, pain, hoarseness). Preoperatively 84.3% of these 205 cases were diagnosed by ultrasonography. We performed unilateral lobectomy (41%), near total thyroidectomy (44%), and total thyroidectomy (11%) with or without central compartment neck node dissection. During a mean follow-up of 36 months, 5 patients (2.4%) developed locoregional recurrence with no distant metastasis. There were no significant difference on recurrence rate by size, capsular invasion. But multiplicity of primary tumor has a higher locoregional recurrence rate (p= 0.04). The detection rate of PTMC is increasing due to FNA technique in our hospital. This study shows that PTMC may have capsular invasion, lymph node involvement, multiplicity and locoregional recurrence likely to larger (>1 cm) papillary carcinoma. Conclusion: We suggest that total or near total thyroidectomy with central compartment neck dissection is proper therapeutic operation for PTMC and modified neck dissection shoud be performed if lateral neck lymph node are enlarged or diagnosed as metastatic tumor.

1997년 포항지역에서 유행한 소아 무균성 뇌막염의 임상상

조성민,김나연,정진화,김수근,임현술 동국대학교 의학연구소 1998 東國醫學 Vol.5 No.-

1997년 포항지역에서 유행한 소아 무균성뇌막염의 임상상을 고찰하고 이 질환의 발생과 환자가 당시에 사용하던 식수와의 관계를 알아보기 위하여 1997년 5월부터 1997년 10월까지 동국대학교 의료원 포항병원소아과에 내원하여 무균성뇌막염으로 진단 받은 78명의 환아들을 대상으로 의무기록의 후향적 분석 및 식수에 관한 전화 조사를 실시하였다. 환아의 남녀비는 1.23:1이었으며 5-6세군에서 가장 많았다. 월별 분포는 5월에 시작하여 10월까지 발생하였으나 6월과 9월에 점유율이 높았다. 임상 증상 및 증후로는 발열이 가장 많았고(96.2%), 구토(89.7%), 두통(84.6%), 경부강직(73.1%), 인두 발적(71.8%), 식욕부진(52.6%) 등의 순으로 나타났다. 혈액검사 소견으로 백혈구수가 10,000/㎣ 이상으로 증가한 경우가 54.5%였고, 혈침치가 20mm/h 이상인 경우가 29.0%였으며, C반응단백이 0.5mg/dl 이상인 경우가 84.1%였다. 뇌척수액 검사소견은 백혈구수가 13-860/㎣으로 평균 241.2/㎣였고, 단백량은 평균 78.4mg/dl, 당량은 평균 70.8mg/dl였다. 합병증이나 후유증이 발생한 경우는 없었다. 발병 당시의 식수에 관한 전화 조사는 46명에서 가능하였는데 생수를 끓이지 않고 먹는 경우가 13명(28.3%), 생수를 끊여 먹는 경우가 11명(23.9%), 상수를 끓이지 않고 먹는 경우는 2명(4.3%), 상수를 끓여 먹는 경우는 20명(43.5%)으로 전체적으로 보면 물을 끓여 먹는 경우가 31명(67.4%), 물을 끓이지 않고 먹는 경우는 15명(32.6%)으로 나타났다. 본 조사에서는 무균성뇌막염이 발생하지 않은 대조군의 설정이 되지 않았고, 표본의 크기가 매우 작으며, 식수 이외의 물을 통한 전파에 관한 조사가 이루어지지 않아 본 조사 자료만으로는 무균성뇌막염의 발생과 식수와의 관계를 밝히기 어려웠다. 이를 밝히기 위해서는 지역 주민을 대상으로 한 역학조사와 무균성뇌막염이 유행할 당시에 식수 및 식수 이외에 사용하는 물에 대한 역학 조사 및 바이러스 검사 등이 필요할 것으로 생각한다. This study was performed to evaluate the clinical features of aseptic meningitis in Pohang City in 1997 and its relationship to drinking water. We reviewed the clinical records of 78 aseptic meningitis patients who had been admitted to Dongguk University Pohang Hospital, and investigated the drinking water of patients by telephone survey. The results were as follows: 1) The ratio of male to female was 1.23:1. 2) The aseptic meningitis occurred in children of all age groups, but was most prevalent in 5-6year old children. 3) All the cases developed from May to October, but they showed two peaks in June and September. 4) Fever was the most common clinical manifestation(96.2%), followed by vomiting(89.7%), headache(84.6%), neck rigidity(73.1%), pharyngeal injection(71.8%), and anorexia(52.6%). 5) On admission leukocytosis(WBC > 10,000/㎣) on peripheral blood was showed in 64.5%, and increased erythrocyte sedimentation rate(≥ 20 mm/h) in 29.0%, and increased C-reactive protein(≥ 0.5 mg/dl) in 84.1%. 6) On CSF examination, leukocyte count was in the range of 13 to 860/㎣ (mean 241.2/㎣), protein in the range of 0 to 253 mg/dl(mean 78.4 mg/dl), and glucose in the range of 35 to 115 mg/dl(mean 70.8 mg/dl). 7) There was no case who developed any complication. 8) On the telephone survey about the drinking water, we were able to do the survey in 46 cases, raw underground water was used in 13 cases(23.8%), boiled underground water in 11 cases(23.9%), raw tap water in 2 cases(4.3%), and boiled tap water in 20 cases(43.5%). We could not identify the close relationship between the drinking water and aseptic meningitis because of the small sample size, the absence of control group, and the difficulties in the study of past event. Epidemiologic and virologic studies of drinking water will be necessary.

DS-CDMA의 수용 능력에 관한 연구

조경구,나현식 湖南大學校 情報通信硏究所 1999 정보통신연구 Vol.9 No.-

본 연구에서는 전력제어가 정확하며 해당 셀에서 가입자 수가 균일하다는 가정하에 단일셀에서 CDMA와 FDMA, TDMA 간의 가입자 수를 비교하였다. 다른 기술들이 결합되지 않은 순수한 CDMA의 가입자 수용능력은 단일 셀이 다중 셀에서 FDMA, TDMA와 큰 차이가 없으나, 음성활성화계수(VAC)와 섹터화 안테나 등 간섭 신호를 감소시키는 기술이 결합된 경우는 상대적으로 많은 이득이 있는 것으로 나타났다. In this paper, radio capacity between CDMA and FDMA, TDMA in a single cell under an accurate power control was compared. The pure CDMA has no significant capacity difference over FDMA, TDMA. However, with interference reduction techniques, sectored antenna and voice activity factor combined CDMA shows the greater performance on capacity than FDMA, TDMA regardless data rates.