Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

석탄회를 활용한 콘크리트의 성능에 관한 연구

조형근,양회진 호남대학교 산업기술연구소 1997 산업기술연구논문집 Vol.4 No.-

석탄화력발전과정이 부산물인 석탄회가 사용석탄량의 11∼57%로 생성됨에 따라 이의 처리비용 및 환경보전적 측면에서의 많은 문제점이 야기되고 있어 석탄회의 유효이용에 관한 연구가 절실하다. 따라서 본 연구에서는 석탄회를 콘크리트 혼화재로 재활용하기 위한 방안을 강구하고자 석탄회의 발생과정 및 종류, 물리적 및 화학적 특성, 재활용 현황등을 파악하고, 석탄회의 배합혼입률에 따른 콘크리트 재령별 압축강도 특성에 대한 실험연구를 수행하였다. During combustion of powdered coal in modern power plant, coal ash is produced by 11∼57% of resource coal. The coal ash requires a great deal of disposal expense and causes a number of probrems in environmental conservation. It is necessary that researches for utilization of fly ash are required as soon as possible. The goal of this study are to develop a methodology for the utilization of fly ash as a mineral admixture in concrete. This paper presents the performance of concrete using fly ash. Results of the experimental study indicates that fly ash concrete tend to reduce the early compressive strength up to 28 days, but improve the long term compressive strength.

淸代 前期의 活字印刷

曺炯鎭 한국문헌정보학회 1995 한국문헌정보학회지 Vol.29 No.-

The type printing of first Ch'ing dynasty term in China is worthy to be studied because the type printing during that period included metal type, wood type, and clay type as well as the development phase was similar to Chosun dynasty culturally and technologically. This paper studied typography during the first Ch'ing dynasty term, including Shunzhi(1662-1722), Yongaheng(1723-1735), Qianlong(1736-1795), Jiaqing(1796-1820) period. The main results of the study is as follows. 1. The main body of type printing was bookstore, lecture-hall, and individual as well as the royal court that is the centarl government. 2. The content of type edition covers classics, history, philosophy, and literary works. Specifically, even though Wuyingdienjuzhenban series is excluded, the content includes study of the classics, class of the history, class of the philosophy, literature works that include collection works and novel and government official bulletin. 3. The printing technique of bronze type was very popular in Beijing. Jiangsu, and Taiwan. It's scale and production technique was more elaborate than in Ming dynasty. 4. Wood type was very popular in Beijing, Jiangsu, Zhejiang, Anhui, Sichuan, and Fujian. In addition to wood type, chinese ware type was applied to book printing in Shandong, However, most of them were wood type and they were used after Qianlong period. 5. The production technique of type was skilled enough to present the fine view of a style of type. The typesetting technique was improved as much as woodblock printing. With regard to the making technology of Chinese ink, the light and darkness of chinese ink was not even sometimes. But, the technology was improved significantly when comparing with the failure experience of printing that chinese ink was not developed in early type invention. 6. In case that the book was printed in bookstore with the intention of profit and the number of book was large, the proofreading attitude was rough. However, overally, it was made correction carefully applying the various methods of proofreading. 7. The support of government made a great contribution in the area of all printing technology, including production, typesetting, and brushing of type

산업자본재 자산의 가치평가에 있어 신뢰도 함수의 적용

조진형,이도경,김상호 금오공과대학교 산업기술개발연구원 2001 産業技術開發硏究 Vol.17 No.-

Box-Cox model by HuIten and Wykoff and T-factor method by Elfar and Whelan, adopted the assumptions of the characteristics of capital assets, and are still widely used today even though their assumptions were weak. We improve the Box-Cox model by combining the existing economic efficiency and depreciation pattern, based on the efficiency curve of marginal productivity and reliability function. Thus, Rayleigh curve which has been used for the reliability of current capital assets was chosen as m efficiency curve. As a result, it was possible to classify the efficiency curves into 4 kinds rather than the existing 3, as well as the types of depreciation curves. In this paper, therefore, the power family of the Box-Cox model which was a non-linear regression model would be identified, by utilizing the reliability functions. In addition, Box-Cox model as a linear model to measure economic depredations. Based on these result it is easy to estimate economic depreciations as well as to test depreciation rates.

저장기간에 따른 일산화탄소 중독 혈액의 성분 변화

진홍용,조형상 중앙대부설한국의과학연구소 1984 한국의과학 Vol.16 No.4

Glass 용해로 공정의 안정화 검증 및 방안에 관한 연구

조진형,구자활 금오공과대학교 2006 論文集 Vol.27 No.-

As tools to improve productivity and quality, SPC(statistical process control) and Af'Ctautomatic process control) are used in the instrumental process. In process, we know that a statistical control-in is identified with a process of random variables being independently and identically distributedriid). It IS often difficult in practice to attain a statistical control-in because of systematic time series effects like autocorrelation. When the data are autocorrelated In a process, as the diagnosis, we can use ARIMA procedure. In this thesis, a procedure is introduced to diagnose and identify a statistical control-in/out using ARIMA.

비접촉 온도센서를 이용한 2차원 열화상 측정 시스템 개발

조용진, 임형민 忠北大學校 農業科學硏究所 2017 農業科學硏究 Vol.33 No.1

A thermal imaging system has been developed to measure the temperature on surface, using non-contact temperature sensor. Also, the developed system can monitor the temperature based on Zigbee communication for ubiquitous sensor network. The measurement of temperature was performed on the pot plant depending on the moving speed of frame. The optimal speed for frame movement was 1.4 m/ s. The developed system might provide as a basic study which predict the location of crops according to the difference of temperature between soil and crop.

성장기 어린이에서 상악 중절치 조기 상실 후 치조골 소실

나혜진,송제선,이제호,최형준,김성오,손흥규,최병재 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

어린이는 8-10세 경에 외상을 자주 받으며 구강 내에서는 상악 절치부가 호발하는 부위이다. 외상으로 인하여 상악 절치가 상실되면 어린이에게 합병증을 야기할 수 있으므로 가능한 한 상악 절치를 유지해야 하지만 조기 상실되는 경우가 있다. 상악 절치의 조기 상실로 인한 합병증으로는 심미적 문제나 치조골의 수직적 높이와 수평적 너비의 감소, 인접치의 경사, 악궁 장 경 감소 등이 있다. 그 중에서 치조골이 소실되면 보철적 수복 시에 기능성과 안정성, 심미적인 면에 영향을 준다. 이 증례는 외상으로 인하여 상악 중절치가 조기 상실된 9세 여아와 6세 남아에서 각각 5년 5개월, 3년 7개월 후의 치조골 소실 정도를 cone beam computed tomography와 진단 모형 상에서 관찰하였기에 보고하는 바이다. The anterior maxillary incisor is the most traumatized region in the mouth and trauma is frequent between the ages of 8-10. Traumatic loss of teeth, can lead to many complications in children. Thus, as possible to keep traumatic teeth, but if you need extractions There may be. Complications occur and early tooth loss is frequent. Complications of early loss of central incisors are esthetic compromise, loss of vertical and horizontal width, height, contour of alveolar bone, tilting of adjacent teeth, arch length loss. Alveolar bone loss may affect normal function and stability, and results in esthetic problem for future prosthesis restoration. The 9-year-old girl and 6-year-old boy got early loss of upper central incisor. The amount of alveolar bone resorption was measured using cone beam computed tomograph and cast analysis.

소아에서 발생한 골수이형성 증후군 2례

홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.

설계강우의 시간적 분포모형 적용성 연구

서진호,이상배,조흥제,민병형 東亞大學校 海洋資源硏究所 1995 硏究論文集 Vol.8 No.1

위천대표유역의 11녀간의 단독강우사상 3,550개를 선별하여 Yen-Chow의 삼각형 및 사다리꼴, Huff, Pilgrim-Cordery 및 Mononobe의 방법에 의한 지속시간별 설계강우의 시간적분포 특성치를 제시하였다. Yen-Chow 방법의 삼각형분포의 특성치 a 값은 0.44에서 0.50까지 분포하였고, 사다리꼴은 지속시간이 길어질수록 무차원 특성변수 h 의 값이 점차 커지는 경향을 나타내었다. Huff 4분기법에 의한 분석결과는 2구간 강우가 지배적이고 3구간 강우가 낮은 분포를 나타내었다. 또한 Pilgrim-Cordery 방법에서는 6시간까지는 점방위 강우형이고, 6시간이상은 점차 후방위로 변화하였다. Mononobe 방법은 시간별 강우량을 중앙집중형으로 나타내었다. 본 방법들의 적용성을 검토하기 위해 위천유역의 32개 관측 강우-유출자료를 이용하였고, 분석결과 Yen-Chow 방법의 삼각형분포가 비교적 재현성이 높게 나타났다. 이들 설계강우의 시간적분포모형들은 미계측유역의 유출해석에 중요한 수단을 제공할 것으로 판단된다. The historical data from 3,550 event storms during 11 years in Wi-stream basin have been used to investigate the statistical parameter of the time distribution for design storms by the method of Yen-Chow, Huff, Pilgrim-Cordery and Mononobe. The dimensionless value of triangular hyetograph, a , ranges from 0.44 to 0.50 and trapezoidal hyetograph, h , value increases as the duration time is getting longer in Yen-Chow method. In the Huff, the second-quartile storms occurred most frequently and third-quartile storms occurred most infrequently. In the Pilgrim-Cordery, the shapes for shorter than 6-hour durations are advanced tendency. However, for longer than 6-hour durations show delayed tendency. In the Mononobe, every one hour rainfall occured Centered Type. The application of these methods for each duration time was tested by using the observed rain-fall-runoff data of Wi-stream basin. As a result, the reappearance of hydrographs of triangular hyetograph by Yen-Chow method showed promising, and it was approved to be used for prediction of the ungaged basins.