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A Family of Single-Stage Single-Switch PV MICs with Steep Conversion Gain
Ching-Ming Lai,Yi-Hung Liao 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
In this paper, a family of single-stage single-switch photovoltaic (PV) module integrated converters (MICs) with steep voltage conversion gain capability and galvanic isolation is presented. As an illustration, the new MIC topology based on the isolated-type single-ended primary-inductor converter (Sepic) with coupled inductor is analyzed and developed. Moreover, a fast maximum power point tracking (MPPT) strategy with linear current control is adapted in the proposed SEPIC-type PV MIC. Finally, a speciation of single-phase 150W prototype is constructed, and experimental results indeed verify the effectiveness of the proposed converter.
Lam, Simon Ching,Chong, Andy Chun Yin,Chung, Jessie Yuk Seng,Lam, Ming Yee,Chan, Lai Man,Shum, Cho Yee,Wong, Eliza Yi Ni,Mok, Yat Man,Lam, Ming Tat,Chan, Man Man,Tong, Ka Ying,Chu, Oi Lee,Siu, Fong Ki 한국성인간호학회 2020 성인간호학회지 Vol.32 No.1
Purpose: This study aimed to establish the translation adequacy and examine the psychometric properties of FaceMask Use Scale (FMUS). Methods: This methodological study employed a cross-sectional design with repeatedmeasures. Phase 1 examined the equivalence and relevance of English and Chinese versions of FMUS. Phase2 examined the internal consistency, stability and construct validity. Different sample batches (213 universitystudents and 971 general public) were used appropriately for psychometric testing. The 2-phase data were collectedbetween January and April 2017. Results: In Phase 1, the semantic equivalence and relevance (item- and scale-levelcontent-validity-index=100%) was satisfactory. Furthermore, from 133 paired test-retest responses, the quadraticweighted kappa (.53~.73, p<.001) and Intraclass Correlation Coefficient (ICC=.81) between the English andChinese version of FMUS were satisfactory. In Phase 2, FMUS demonstrated satisfactory internal consistency(Cronbach’s ⍺=.80~.81; corrected item-total correlation coefficients=.46~.67) and two-week test-retest stability(ICC=.84). The known-groups method (t=3.08, p<.001), exploratory (71.10% of total variance in two-factor model)and confirmatory factory analysis (x2/df=4.02, Root Mean Square Residual=.03, Root Mean Square Error ofApproximation=.06, Goodness of Fit Index=.99, Comparative Fit Index=.99) were all satisfactory for establishingthe construct validity. Conclusion: The FMUS has an equivalence Chinese and English versions, satisfactoryreliability and validity for measuring the practice of face mask use. This poses clinical and research implications forthose community health nurses who works on respiratory protection. Further research should be conducted on the‘negligent practice’ of FMU.
Chyong-Huey Lai,Elizabeth Vallikad,Hao Lin,Lan-Yan Yang,Shih-Ming Jung,Hsueh-Erh Liu,Yu-Che Ou,Hung-Hsueh Chou,Cheng-Tao Lin,Huei-Jean Huang,Kuan-Gen Huang,Jiantai Qiu,Yao-Ching Hung,Tzu-I Wu,Wei-Yang 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.1
Objectives: An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer. Methods: Between 2007 and 2014, 45 newly-diagnosed ovarian cancer patients were enrolled after complete remission and randomized (1:1) to arm A (4-weekly carboplatin area under the curve 4 and pegylated liposomal doxorubicin [PLD] 30 mg/m2, n=24) for 6 cycles or arm B (observation, n=21). The primary end-point was PFS. A post hoc translational study was conducted to deep sequence BRCA/homologous recombination deficiency (HRD) genes, because BRCA/HRD mutations (BRCA/HRDm) are known to be associated with better prognosis. Results: Enrollment was slow, accrual was closed when 7+ years had passed. With a median follow-up of 88.9 months, the median PFS was significantly better in arm A (55.5 months) than arm B (9.2 months) (hazard ratio [HR]=0.40; 95% confidence interval [CI]=0.19–0.87; p=0.020), yet the median overall survival was not significantly different in arm A (not reached) than arm B (95.1 months) (p=0.148). Overall grade 3/4 adverse events were more frequent in arm A than arm B (60.9% vs 0.0%) (p<0.001). Quality of life was generally not significantly different. Distribution of BRCA1/2m or BRCA/HRDm was not significantly biased between the two arms. Wild-type BRCA/non-HRD subgroup seemed to fare better with maintenance therapy (HR=0.35; 95% CI=0.11–1.18; p=0.091). Conclusions: Despite limitations in small sample size, it suggests that maintenance carboplatin-PLD chemotherapy could improve PFS in advanced ovarian cancer.
Chlorophyll-Related Compounds Inhibit Cell Adhesion and Inflammation in Human Aortic Cells
Kuan-Hung Lin,Ching-Yun Hsu,Ya-Ping Huang,Jun-You Lai,Wen-Bin Hsieh,Meng-Yuan Huang,Chi-Ming Yang,Pi-Yu Chao 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.10
The objectives of this study were to investigate the effects of chlorophyll-related compounds (CRCs) and chlorophyll (Chl) a + b on inflammation in human aortic endothelial cells. Adhesion molecule expression and interleukin (IL)-8, nuclear factor (NF)-jB p65 protein, and NF-jB and activator protein (AP)-1 DNA binding were assessed. The effects of CRCs on inflammatory signaling pathways of signal transducers and activators of transcription 3 (STAT3) and mothers against decapentaplegic homolog 4, respectively induced by IL-6 and transforming growth factor (TGF)-b, in human aortic smooth muscle cells cultured in vitro were also investigated. HAECs were pretreated with 10 lM of CRCs, Chl a + b, and aspirin (Asp) for 18 h followed by tumor necrosis factor (TNF)-a (2 ng/mL) for 6 h, and U937 cell adhesion was determined. TNF-a–induced monocyte-endothelial cell adhesion was significantly inhibited by CRCs. Moreover, CRCs and Chl a + b significantly attenuated vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and IL-8 expressions. Treatments also significantly decreased in NF-jB expression, DNA binding, and AP-1 DNA binding by CRCs and Asp. Thus, CRCs exert anti-inflammatory effects through modulation of NF-jB and AP-1 signaling. Ten micromoles of CRCs and Asp upregulated the expression of mothers against decapentaplegic homolog 4 (Drosophila) (SMAD4) in the TGF-b receptor signaling pathway, and SMAD3/4 transcription activity was also increased. Ten micromoles of CRCs were able to potently inhibit STAT3-binding activity by repressing IL-6–induced STAT3 expression. Our results provide a potential mechanism that explains the anti-inflammatory activities of these CRCs.
Newly-Constructed Single-Phase Multistring Multilevel Inverter for Fuel-Cell Microgrid
Yi-Hung Liao,Ching-Ming Lai 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
The objective of this paper is to construct a novel transformerless five-level multistring inverter topology for fuel-cell microgrid system. In this study, a high step-up converter is introduced as a front-end stage to improve the conversion efficiency of conventional boost converters and to stabilize the output DC voltage of various DERs such as PV and fuel cell modules for use with the simplified multilevel inverter. The simplified multilevel inverter requires only six active switches instead of the eight required in the conventional H-bridge cascaded multilevel inverter. In addition, two active switches are operated under line frequency. The presented multistring inverter offers strong advantages such as improved output waveforms, smaller filter size, and lower EMI and THD. Experimental results show the effectiveness of the proposed solution.