Prediction of the Duration to Next Admission for an Acute Affective Episode in Patients with Bipolar I Disorder

Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.

On-line Error-matching Measurement and Compensation Method for a Precision Machining Production Line

Shih-Ming Wang,Chun-Yi Lee,Hariyanto Gunawan,Chin-Cheng Yeh 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.2

When producing a matching part for good mating with its counterpart (assembly part), good matching accuracy between the matching part and assembly part is highly required. The matching errors are influenced by not only the errors of the matching part but also the errors of the assembly part. Because the errors of an assembly part could be different from others, it is very difficult to have very good mating accuracy, if the manufacturing of a matching part does not take the actual errors of the assembly into account. Furthermore, it will need additional off -line assembly mating tests to find a good mating pair. This study proposes an error-matching compensation method to solve the not-good-mating problem for manufacturing assembly modules with good matching accuracy. In this method, the actual errors of an assembly part are directly in-line measured and used to compensate the machining process of a matching part so that a dedicated part with the good mating condition can be on-line made for the error-measured assembly part. In addition to having better matching accuracy, this method also provides advantages of high production efficiency and cost saving, because it will not need the off -line mating test to find good mating pairs. This method also includes a function of in-line auto-generation of error compensation NC programs to support continuous production. In this study, error analysis of two mating types (planar mating and triangle mating) were explored and discussed. The Human–Machine Interface was built with the use of C# language. Finally, machining experiments with in-line measurements were conducted to verify the proposed method. The experimental results have shown the feasibility and effectiveness of the proposed method.

Applying Interactive Genetic Algorithms to Disassembly Sequence Planning

Shih-Chen Lee,Hwai-En Tseng,Chien-Cheng Chang,Yu-Ming Huang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.4

In addition to garbage sorting and resource recycling, green design should be a fundamental method for solving environmentalproblems, and design for disassembly is an important foundation of green design. This study focuses on providingquantitative assessment methods for designers’ reference. This study proposes interactive genetic algorithms to solve theproblem of disassembly sequence planning. First, the disassembly factor is measured by the fuzzy scoring procedure method,and then the genetic algorithm is used to select the optimal sequence. With the penalty value provided from the process, areference is provided for the revised design. Finally, examples are discussed to demonstrate that the proposed approach isa feasible method.

Efficiency Measurement of Selected International Ports using Aggregated Performance Index

( Ming Tao Chou ),( Hsuan Shih Lee ) 한국해운물류학회(구 한국해운학회) 2004 해운물류연구 Vol.41 No.-

In this paper, we propose the Aggregated Performance Index method. This study applies Aggregated Performance Index to provide an efficiency measurement for international ports. The Aggregated Performance Index technique is powerful in resolving the measurement of port efficiency and ranking of port, because Aggregated Performance Index has been applied to analyze the relative efficiency of decision-making units (DMUs) in a set of multiple inputs and multiple outputs, and don`t require an explicit a priori determination of relationships between outputs and inputs. Using multidimensional scaling (MD5) process, we adjustment and present an alternative that is theoretically and practically superior to the most common methods proposed in the past papers, especially in the D MUs measure field. This method overcomes the problem of Data Envelopment Analysis method which can neither rank efficiency of ports nor show the real efficiency distance of DMUs. Thus, the Aggregated Performance Index method is useful in wide array of Australian and other international ports` ranking. Finally this Aggregated Performance Index method is applied to the ranking of 16 international ports. As a result, five ports, the port of Melbourne, the port of Osaka, the port of Zeebrugge, the port of Brisbane, and the port of Fremantle are found to be the most inefficient ports. Six other international ports, the port of Tanjung Priok, the port of Hamburg, the port of Sydney, the port of Tilbury, the port of Yokohama, and the port of La Spezia, which are found to be efficient ports. The port of Singapore, the port of Hong Kong, the port of Felixstowe, the port of Rotterdam, and the port of Keelung are found to be the most efficient ports.

Efficiency measurement of selected international ports using aggregated performance index

CHOU Ming-tao,LEE Hsuan-shih 한국해운물류학회 2004 해운물류연구 Vol.43 No.-

In this paper, we propose the Aggregated Performance Index method. This study applies Aggregated Performance Index to provide an efficiency measurement for international ports. The Aggregated Performance Index technique is powerful in resolving the measurement of port efficiency and ranking of port, because Aggregated Performance Index has been applied to analyze the relative efficiency of decision-making units (DMUs) in a set of multiple inputs and multiple outputs, and don't require an explicit a priori determination of relationships between outputs and inputs. Using multidimensional scaling (MDS) process, we adjustment and present an alternative that is theoretically and practically superior to the most common methods proposed in the past papers, especially in the DMUs measure field. This method overcomes the problem of Data Envelopment Analysis method which can neither rank efficiency of ports nor show the real efficiency distance of DMUs. Thus, the Aggregated Performance Index method is useful in wide array of Australian and other international ports' ranking.Finally this Aggregated Performance Index method is applied to the ranking of 16 international ports. As a result, five ports, the port of Melbourne, the port of Osaka, the port of Zeebrugge, the port of Brisbane, and the port of Fremantle are found to be the most inefficient ports. Six other international ports, the port of Tanjung Priok, the port of Hamburg, the port of Sydney, the port of Tilbury, the port of Yokohama, and the port of La Spezia, which are found to be efficient ports. The port of Singapore, the port of Hong Kong, the port of Felixstowe, the port of Rotterdam, and the port of Keelung are found to be the most efficient ports.

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.

Effect of dietary supplementation of Bacillus subtilis TLRI 211-1 on laying performance, egg quality and blood characteristics of Leghorn layers

Tsai Ming-Yang,Shih Bor-Ling,Liaw Ren-Bao,Chen Wen-Tsen,Lee Tsung-Yu,Hung Hsi-Wen,Hung Kuo-Hsiang,Lin Yih-Fwu 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.4

Objective: TLRI 211-1 is a novel Bacillus subtilis strain. This experiment was to investigate dietary supplementation of TLRI 211-1 on laying performance, egg quality and blood characteristics of layers. Methods: One hundred and twenty 65-wk-old Leghorn layers were divided into four treatment groups for 8 weeks experiment. Each treatment had three replicates. The basal diet was formulated as control group with crude protein 17% and metabolizable energy 2,850 kcal/kg and supplemented with TLRI 211-1 0.1%, 0.3%, and commercial Bacillus amyloliquefaciens 0.1% as treatment 2, 3 and 4 groups, respectively. Both TLRI 211-1 and commercial Bacillus amyloliquefaciens were adjusted to contain 1×109 colony-forming unit (CFU)/mL (g), hence the 0.1% supplemental level was 1×109 CFU/kg. Results: The results showed that TLRI 211-1 0.3% and commercial B. amyloliquefaciens groups had higher weight gain than the other groups; TLRI 211-1 0.1% group had better feed to eggs conversion ratio than the control and commercial B. amyloliquefaciens groups (p<0.05). Bacillus subtilis supplementation increased yolk weight (p<0.05). In egg quality during storage, TLRI 211-1 0.1% had higher breaking strength than the control group at the second week of storage (p<0.05). At the third week of storage, TLRI 211-1 0.3% had higher Haugh unit (p<0.05). Hens fed diets supplemented with TLRI 211-1 0.3% significantly decreased blood triglyceride levels and increased blood calcium levels (p< 0.05). TLRI 211-1 0.3% group had lower H2S (p<0.05) and hence had less unpleasant odor in excreta of hens. Conclusion: In conclusion, supplementation with 0.1% TLRI 211-1 can significantly improve feed to eggs conversion ratio. TLRI 211-1 supplementation also can maintain eggs at their optimum quality level during storage. The study showed that B. subtilis TLRI 211-1 can be used as feed additives for improving egg production performance and egg quality.

Can Elderly Patients with Severe Mitral Regurgitation Benefit from Trans-catheter Mitral Valve Repair?

Ching-Wei Lee,Shih-Hsien Sung,Wei-Ming Huang,Yi-Lin Tsai,Hsiang-Yao Chen,Chiao-Po Hsu,Chun-Che Shih,Kuo-Piao Chung 대한심장학회 2019 Korean Circulation Journal Vol.49 No.6

Background and ObjectivesAge is a traditional risk factor for open-heart surgery. The efficacy and safety of transcatheter edge-to-edge mitral valve repair, using MitraClip (Abbott Vascular), has been demonstrated in patients with severe mitral regurgitation (MR). Since octogenarians or older patients are usually deferred to receive open-heart surgery, the main interest of this study is to elucidate the procedural safety and long-term clinical impact of MitraClip in elderly patients. MethodsPatients with symptomatic severe MR were evaluated by the heart team. For those with high or prohibitive surgical risks, transcatheter mitral valve repair was performed in hybrid operation room. Transthoracic echocardiography (TTE), blood tests, and six-minute walk test (6MWT) were performed before, 1-month, 6-months, and 1 year after index procedure. ResultsA total of 46 consecutive patients receiving MitraClip procedure were enrolled. Nineteen patients (84.2±4.0 years) were over 80-year-old and 27 (73.4±11.1 years) were younger than 80. Compare to baseline, the significant reduction in MR severity was achieved after the procedure and sustained. All the patients benefited from significant improvement in New York Heart Association functional class. The 6-minute walk test (6MWT) increased from 259±114 to 319±92 meters (p=0.03) at 1 year. The overall 1-year survival rate was 80% in the elderly and 88% in those <80 years, p=0.590. Baseline 6MWT was a predictor for all-cause mortality (odds ratio, 0.99; 95% confidence interval, 0.982–0.999; p=0.026) after the MitraClip procedure. ConclusionsTrans-catheter edge-to-edge mitral valve repairs are safe and have positive clinical impact in subjects with severe MR, even in advanced age.

Toward understanding of subscriber behabioral intention and risk assessment in adopting 3G value-added services from the secured handset enabler

Ke-Hwa Lee,Ming-Yu Zhang,Shih-Chih Chen 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

Up to today, the third generation (3G) mobil services don’t perform as well as expectation than its business forecast a decade ago. Limited handset capability and availability are the one of roof causes to put the blame on operators’ optimistic 3G business model and overlook to subscriber behavioral intentions in various personal concerns. Secured handset enabler (SHE) comprises a series of remote software-controlled mechanism to protect the personal sensitive data and messages that stored in the Smartphone or PDA when the mobile device is mis-placed, lost, or stolen. This study discusses the possible alignment in innovating 3G value-added services (VAS) foundation toward understanding subscriber behavioral intentions and risk assessment. In the proposed modelling elements, perceived usefulness, perceived ease-of-use, subjective norms, and perceived behavioral, control directly influence the behavioral intention through mediation of attitude. The C-TAM-TPB model was utilized to examine those collected data from 233 interviewers in their perceptions of SHE application. Overall, the results revealed that the effect of satisfaction was significant importance, but those usefulness, subjective norms, and perceived behavioral control did not influence directly an individual’s continuance intentions. Moreover, perceived usefulness and perceived ease-of-use had influence indirectly the continuance intentions through mediation of satisfaction. The implications of this study were also discussed in this paper.

An Improvement on Robust H<SUB>∞</SUB> Control for Uncertain Continuous-Time Descriptor Systems

Hung-Jen Lee,Shih-Wei Kau,Yung-Sheng Liu,Chun-Hsiung Fang,Jian-Liung Chen,Ming-Hung Tsai,Li Lee 대한전기학회 2006 International Journal of Control, Automation, and Vol.4 No.3

This paper proposes a new approach to solve robust H∞ control problems for uncertain continuous-time descriptor systems. Necessary and sufficient conditions for robust H∞ control analysis and design are derived and expressed in terms of a set of LMIs. In the proposed approach, the uncertainties are allowed to appear in all system matrices. Furthermore, a couple of assumptions that are required in earlier design methods are not needed anymore in the present one. The derived conditions also include several interesting results existing in the literature as special cases.