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( Cheng-maw Ho ),( Shu-li Ho ),( Chia-tung Shun ),( Po-huang Lee ),( Ya-hui Chen ),( Chin-sung Chien ),( Hui-ling Chen ),( Rey-heng Hu ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Primary liver progenitor cell cancer is a rare disease entity without definite evidence and characterization. Current nomenclature of primary liver cancer with prominent progenitor features is not comprehensive. This study was aimed to investigate the existence of this kind of primary liver cancer and characterize it immunohistopathologically based on the emerging understanding of cancer stem cell pathobiology. Methods: Surgical specimens from primary liver cancer which posed diagnostic difficulty fitting within current WHO classification of combined hepatocellular-cholangiocellular carcinoma with stem-cell features according to the growth morphology and its suggested immunohistochemical features, were stained with antibodies against well-defined markers of progenitor cells, stemness, and differentiation toward hepatocytes or cholangiocytes. Comparative interpretation of images was processed considering the histological morphology and characteristic markers. Results: The primary liver cancer consisted of CD24+ cancer progenitor cells and CD90+ mesenchymal stromal cells, which were intimately mixed. CD24+ cancer cells demonstrated bi-directional trends of differentiation: bile ductule transformation (cytokeratin 19+, epithelial cell adhesion molecule [EpCAM]+, neural cell adhesion molecule [NCAM]+, CD133+, and delta-like 1 homolog [DLK1]+); and trabecular or nested cell clusters toward hepatic lineage (hepatocyte nuclear factor-4 alpha [HNF-4α]+, Hep Par1+ and negative for CK19, EpCAM, CD133, and DLK1). Moderate lymphocyte (mostly CD4+ and CD8+ T cells) infiltrated in the CD90+ cancer- associated stroma. Conclusions: We provided the corroboration that liver progenitor cells can form primary liver cancer, not just presented as few side population of cancer stem cells. Its existence might pose significance for future stem cell therapeutic intervention targeting liver diseases, albeit the disease is rare.
Performance of adding waste glass and sewage sludge to reservoir-sediment aggregates
Ing-Jia Chiou,Chin-Ho Chen,Chia-Ling Lin 사단법인 한국계산역학회 2014 Computers and Concrete, An International Journal Vol.13 No.1
Accumulated annual reservoir sedimentation in Taiwan was 14.6 million m3 in 2010, seriously endangering reservoir safety and the water supply. In addition, the sintering temperature of reservoir-sediment aggregates (RSAs) is very high, and very energy consuming consequently. Therefore, to explore the effects of admixtures on sintering behavior and performance of the aggregates, two different admixtures are blended, waste-glass and municipal sewage sludge, into reservoir sediment to make artificial aggregates. Experimental results show that the lightweight characteristics of waste-glass/reservoir-sediment aggregates (WGRSAs) are more significant than those of sewage sludge/reservoir-sediment aggregates (SSRSAs). Moreover, as sintering temperature increases, the specific gravity of WGRSAs drops more apparently. The optimum sintering temperature of pure reservoir-sediment aggregates (PRSAs), SSRSAs, and WGRSAs was 1150°C, 1100°C, and 1050°C, respectively. The PRSAs are normal weight with better strength; the WGRSAs are lightweight and energy-saving; and the SSRSAs are lightweight with normal strength.
Genetic Algorithm for Shortest Driving Time in Intelligent Transportation Systems
Chu-Hsing Lin,Jung-Chun Liu,Chia-Han Ho,Jui-Ling Yu,Wei-Shen Lai 보안공학연구지원센터 2009 International Journal of Hybrid Information Techno Vol.2 No.1
The route guidance system, which provides driving advice based on traffic information about an origin and a destination, has become very popular along with the advancement of handheld devices and the global position system. Since the accuracy and efficiency of route guidance depend on the accuracy of the traffic conditions, the route guidance system needs to include more variables in calculation, such as real time traffic flows and allowable vehicle speeds. As variables considered by the route guidance system increase, the cost to compute multiplies. Since handheld devices have limited resources, it is not feasible to use them to compute the exact optimal solutions in real time systems by some well-known algorithm, such as the Dijkstra’s algorithm, which is usually used to find the shortest path with a map of reasonable numbers of vertices. To solve this problem, we propose to use the genetic algorithm to alleviate the rising computational cost. We use the genetic algorithm to find the shortest time in driving with diverse scenarios of real traffic conditions and varying vehicle speeds. The effectiveness of the genetic algorithm is clearly demonstrated when applied on a real map of modern city with very large vertex numbers.
CEO Overconfidence or Private Information: Evidence from U.S. Property-Liability Insurance Companies
Sangyong Han,Gene C. Lai,Chia-Ling Ho 한국재무학회 2020 한국재무학회 학술대회 Vol.2020 No.08
This paper uses conventional measures of CEO overconfidence: option holdings-based and net stock purchase-based measures to examine the impact of CEOs who hold firm-specific risk on insurer’s risk-taking and firm performance in U.S. publicly traded property-liability insurance companies. We find that two CEO overconfidence measures are negatively associated with insurer’s risk-taking and positively related to firm performance. We also provide evidence that CEOs who maintain high exposure to firm-specific risk exploit their private information to time stock-option exercises in an effort to increase the cash payout from these exercises. Our overall results indicate that CEOs who have private information on their firms’ future earnings maximize their personal profits by postponing option exercises or buying additional stocks, and that they tend to take a lower risk to protect their personal wealth in property-liability insurance firms. Therefore, our findings suggest that it may not be CEO overconfidence, but rather the private information and the intention to control the company’s risk that drive our results.
Anomaly Detection Using LibSVM Training Tools
Jung-Chun Liu,Chu-Hsing Lin,Jui-Ling Yu,Wei-Shen Lai,Chia-Han Ho 보안공학연구지원센터 2008 International Journal of Security and Its Applicat Vol.2 No.4
Intrusion detection is the means to identify the intrusive behaviors and provide useful information to intruded systems to respond fast and to avoid or reduce damages. In recent years, learning machine technology is often used as a detection method in anomaly detection. In this research, we use support vector machine as a learning method for anomaly detection, and use LibSVM as the support vector machine tool. By using this tool, we get rid of numerous and complex operations and do not have to use external tools for finding parameters as needed by using other algorithms such as the genetic algorithm. Experimental results show that high average detection rates and low average false positive rates in anomaly detection are achieved by our proposed approach.
Lin, Chin-Wen,Yang, Jeng-Huh,Chu, Hsien-Pin,Su, Ho-Ping,Chen, Hsiao-Ling,Huang, Chia-Cheong Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.3
The physiochemical properties and interactions between porcine blood and waxy rice were determined. Addition of calcium chloride (0.15%) improved acceptability of blood cake and increased the gelatinization degree of waxy rice. The water-holding capacity of porcine blood gel (blood/water=60/40, v/v), extent of absorption and gelatinization of waxy rice, and scanning electron microscopy showed that blood protein matrix and waxy rice are competitors for holding water in the cooking procedure. Non-haem iron content increased linearly (R=0.95) when heating temperature rose. The presence of blood proteins caused increasing of peak temperature (Tp) of gelatinization in differential scanning calorimetric thermal gram, The microstnlcture of plasma proteins and haemoglobin appeared continuous changes, and interacted with surface of waxy rice flour in terms of network and mosaic form, respectively. The electrophoretic patterns revealed an interaction between plasma proteins and waxy rice glutelin and haemoglobin when heated could be found at temperatures above $60^{\circ}C$.