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다수 객체 유지 기법을 이용한 항만 하역 장비 시뮬레이터 구현
구영철,김규환,김희연,이양민,이재기 東亞大學校附設 淸報技術硏究所 2006 情報技術硏究所論文誌 Vol.13 No.2
Nowadays there are going to be performed various researches about the operation and management of container terminals. By these researches, problems that arise in operation of container terminals are examined and solved. However the analysis of a port loading equipments actually wastes many time and much money. In these cases, the simulator is the most efficient means among related researches. Therefore this paper studied on a simulator for intelligent port handing equipments. The simulator divided loading courses into five steps and each step made in a module. The virtual port has many 3D objects and objects move each other independently. In this environment, the more 3D objects have, the more the simulator slows by dropping FPS. This problem is solved by the maintenance technique of many objects. Because It took many objects of a container box and guaranteed better FPS.
Killer 효모 Saccharomyces cerevisiae B15-1의 에탄올 발효특성
이창호,우철주,이종수,정기택,박희동 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3
정치배양에 의한 Saccharomyces cerevisiae B15-1의 에탄올 발효에 미치는 영향 인자와 초기 기질농도에 따른 발효 특성을 연구, 검토하여 에탄올 생성 최적 조건하에서 발효액중의 생성된 에탄올 농도, 균체 농도 및 당 농도와의 관계를 규명하고자 하였다. 에탄올 생성의 최적 조건은 배양 온도 30℃, 초기 pH 5.0이었으며, 에탄올 비생성 속도는 초기 기질농도가 150 g/l일 때 1.203 g-EtOH/g-cell·hr로서 가장 높게 나타났다. 에탄올 발효능은 기질농도가 150 g/l 이하에서는 거의 일정하였으나 200 g/l에서는 급격히 감소하였다. 최종 균체량과 최종 에탄올 생성량은 초기 기질의 농도가 증가함에 따라 증가하는 현상을 보였으나 그 증가율은 기질의 농도가 높을 수록 다소 감소하는 경향을 나타내었다. 초기 기질농도가 150 g/l 이하에서는 대부분이 발효에 의해 에탄올로 전환되었으나 200 g/l의 당을 사용한 경우에는 균체의 증식과 발효가 완료된 후에도 약 10.7 g/l의 기질이 에탄올로 전환되지 못하고 배지에 남아 있었다. 초기 기질 농도를 매개변수로 생성된 에탄올과 에탄올 수율을 조사한 결과 에탄올 수율은 초기 당농도가 증가할수록 급격히 감소하였으며, 초기 당농도가 일정한 경우 에탄올 생성량이 소량일 때는 에탄올의 생성량이 증가할수록 에탄올의 수율은 급격히 증가하다가 점차 완만한 증가현상을 보였으며 에탄올 생성량이 60 g/l 이상에서는 거의 일정하였다. Characteristics of ethanol fermentation were investigated during the stationary culture of a killer yeast, Saccharomyces cerevisiae B15-1. Specific ethanol production rate reached the maximum level, 1.203 g-EtOH/g-cell·hr, at 150 g/l of the initial glucose concentration. No big differences were obtained in ethanol fermentability based on the initial sugar concentration below 150 g/l. When 200 g/l of sugar was used, fermentability dropped significantly. Although the final cell mass and the amount of ethanol produced were increased, their increase rates were declined according to the increase of initial sugar concentration. It was found that most of the sugar used below 150 g/l of concentration could be changed to ethanol. However, when 200 g/l of sugar was used, some of them remained in the media even after increase of cell mass and fermentation stopped. The ethanol yield was decreased when initial sugar concentration was high, and were increased when the amount of ethanol produced was increased and finally reached the plateau over 60 g/l of ethanol concentration.
Cheol Gyun Kim,Won Kyong Kim,Narae Kim,Young Jin Pyung,Da-Jeong Park,Jeong-Cheol Lee,Chong-Su Cho,Hyuk Chu,Cheol-Heui Yun 대한면역학회 2023 Immune Network Vol.23 No.6
Scrub typhus, a mite-borne infectious disease, is caused by Orientia tsutsugamushi. Despite many attempts to develop a protective strategy, an effective preventive vaccine has not been developed. The identification of appropriate Ags that cover diverse antigenic strains and provide long-lasting immunity is a fundamental challenge in the development of a scrub typhus vaccine. We investigated whether this limitation could be overcome by harnessing the nanoparticle-forming polysorbitol transporter (PST) for an O. tsutsugamushi vaccine strategy. Two target proteins, 56-kDa type-specific Ag (TSA56) and surface cell Ag A (ScaA) were used as vaccine candidates. PST formed stable nano-size complexes with TSA56 (TSA56-PST) and ScaA (ScaA-PST); neither exhibited cytotoxicity. The formation of Ag-specific IgG2a, IgG2b, and IgA in mice was enhanced by intranasal vaccination with TSA56-PST or ScaA-PST. The vaccines containing PST induced Ag-specific proliferation of CD8+ and CD4+T cells. Furthermore, the vaccines containing PST improved the mouse survival against O. tsutsugamushi infection. Collectively, the present study indicated that PST could enhance both Ag-specific humoral immunity and T cell response, which are essential to effectively confer protective immunity against O. tsutsugamushi infection. These findings suggest that PST has potential for use in an intranasal vaccination strategy.
Numerical Study of an External Store Released from a Fighter aircraft
Cheol-Heui Han,Young-Hyun Yoon,Hwan-Kee Cho,Sang-Hyun Lee 한국전산유체공학회 2008 한국전산유체공학회 학술대회논문집 Vol.2008 No.-
The prediction of the separation trajectories of the external stores released from a military aircraft is an important task in the aircraft design area having the objective to define the operational and release envelopes. This paper presents the results obtained for store separation by employing commercial sorftwares, FLUENT and CFD-FASTRAN. FLUENT treats the rigid body motion by employing the remeshing scheme. CFD-FASTRAN uses the chimera(overset) grid and interpolations. It was found that, for the prediction of the trajectories and behavior of the stores separated from the wing, both codes shows the good agreement with the experimental results.
Enhancement of Immune Responses Elicited by Nanovaccines through a Cross-Presentation Pathway
Kim Cheol-Gyun,Lee Jeong-Cheol,Ju Do-Bin,Kim Seo-Kyung,Yun Cheol-Heui,조종수 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.3
Numerous studies have aimed to develop novel advanced vaccines, in part because traditional vaccines have been unsuccessful in preventing rapidly emerging and reemerging viral and bacterial infections. There is a need for an advanced vaccine delivery system to ensure the successful induction of humoral and cellular immune responses. In particular, the ability of nanovaccines to modulate intracellular antigen delivery by inducing exogenous antigens (loaded onto major histocompatibility complex class 1 molecules) in CD8+ T cells, the so-called cross-presentation pathway, has attracted a great deal of attention. Protection against viral and intracellular bacterial infections relies on cross-presentation. This review discusses the advantages, requirements, and preparation of nanovaccines, the cross-presentation mechanism, the several parameters affecting cross-presentation by nanovaccines, and future perspectives.