강건 실험계획법을 이용한 열화자료의 분석

서순근,하천수 한국품질경영학회 2004 품질경영학회지 Vol.32 No.1

The reliability of the product can be improved by making the product less sensitive to noises. Especially, it is important to make products robust against various noise factors encountered in production and field environments. In this paper, the phenomenon of degradation assumes a simple random coefficient degradation model to present analysis procedures of degradation data for robust experimental design. To alleviate weak points of previous studies, such as Taguchi's, Wasserman's, and pseudo failure time methods, novel techniques for analysis of degradation data using the cross array that regards amount of degradation as a dynamic characteristic for time are proposed. Analysis approach for degradation data using robust experimental design are classified by assumptions on parametric or nonparametric degradation rate(or slope). Also, a simulation study demonstrates the superiority of proposed methods over some previous works.

불확정 모형하에서 가속수명시험의 최적 설계

서순근,하천수,김갑석 한국품질경영학회 2001 품질경영학회지 Vol.29 No.3

This paper presents new compromise ALT plan which is applied to situations that true relationship between stress and parameters is not known exactly. The assumed failure distribution of this study is one of location-scale family, i. e., exponential, Weibull, and lognormal distributions which have been ones of the popular choices of failure distributions. The method of applying the stress is constant, and the censoring mechanism is Type I censoring. Compared with existing compromise plans under true simple linear model in terms of statistical efficiency, the efficiency of new compromise plan is better than the corresponding other compromise ones in most cases. For case when true model is quadratic, this plan can be used without any severe loss in statistical efficiency. The proposed new compromise ALT plan is illustrated with a numerical example and sensitivity analyses are conducted to study effects of pre-estimates of design parameters.

Dynamic characteristics of a planetary gear system based on contact status of the tooth surface

Ruibo Chen,Jianxing Zhou,Wenlei Sun 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.1

Studies on the planetary gear have attracted considerable attention because of its advantages, such as compactness, large torque-toweight ratio, vibrations, and high efficiency, which have resulted in its wide applications in industry, wind turbine, national defense, and aerospace fields. We have established a novel dynamic model of the planetary gear transmission by using Newton’s theory, in which some key factors such as time-variant meshing stiffness, phase relationships, and tooth contact characteristics are considered. The influences of gear axial tipping, operating conditions, and the meshing phase on the contact characteristics and the dynamic characteristics were researched systematically. It was found that the contact area of the tooth surface was moved due to the axial gear tipping, which obviously affected the meshing stiffness. With the increase in the inclination angle of the sun gear, the meshing stiffness decreases, which produces an evident influence on the high natural frequency in the planetary transmission system. In terms of the dynamic characteristics of the system, the component of rotating frequency appeared in the dynamic meshing force of the sun gear and the planetary gear. Moreover, the floating track of the center wheel varied significantly and exhibited an oval distribution as the inclination angle of the sun gear changed. When the inclination angle of the sun gear increased, the rotating frequency component increased significantly, but the other meshing frequency components remained unchanged; meanwhile, the deformation of the floating track also increased. If the inclination angle of the sun gear changes, the vibration state of the system and the collision impact could become more serious, and the lifetime of the planetary transmission system will reduce. Furthermore, when the load was increased, we found that the gear-tooth contact zone transformed from line contact to surface contact, the meshing stiffness increased, the effect of high natural frequency on the planetary transmission system became more evident, but its low-order natural frequency remained stable. With regard to the dynamic characteristics of the system, the components of the major frequency at the external gearing remained unchanged, but the rotation frequency of the sun gear and the meshing frequency amplitude increased linearly with the increase in load. In conclusion, the variation in the meshing stiffness of the planetary gear system had minor impact on the low-order natural frequency, but had a significant impact on the high natural frequency of the planetary transmission system due to the phase variation of the gear.

Proteomic analysis of amino acid metabolism differences between wild and cultivated Panax ginseng

Sun, Hang,Liu, Fangbing,Sun, Liwei,Liu, Jianzeng,Wang, Manying,Chen, Xuenan,Xu, Xiaohao,Ma, Rui,Feng, Kai,Jiang, Rui The Korean Society of Ginseng 2016 Journal of Ginseng Research Vol.40 No.2

Background: The present study aimed to compare the relative abundance of proteins and amino acid metabolites to explore the mechanisms underlying the difference between wild and cultivated ginseng (Panax ginseng Meyer) at the amino acid level. Methods: Two-dimensional polyacrylamide gel electrophoresis and isobaric tags for relative and absolute quantitation were used to identify the differential abundance of proteins between wild and cultivated ginseng. Total amino acids in wild and cultivated ginseng were compared using an automated amino acid analyzer. The activities of amino acid metabolism-related enzymes and the contents of intermediate metabolites between wild and cultivated ginseng were measured using enzyme-linked immunosorbent assay and spectrophotometric methods. Results: Our results showed that the contents of 14 types of amino acids were higher in wild ginseng compared with cultivated ginseng. The amino acid metabolism-related enzymes and their derivatives, such as glutamate decarboxylase and S-adenosylmethionine, all had high levels of accumulation in wild ginseng. The accumulation of sulfur amino acid synthesis-related proteins, such as methionine synthase, was also higher in wild ginseng. In addition, glycolysis and tricarboxylic acid cycle-related enzymes as well as their intermediates had high levels of accumulation in wild ginseng. Conclusion: This study elucidates the differences in amino acids between wild and cultivated ginseng. These results will provide a reference for further studies on the medicinal functions of wild ginseng.

Parthenolide-Induced Apoptosis, Autophagy and Suppression of Proliferation in HepG2 Cells

Sun, Jing,Zhang, Chan,Bao, Yong-Li,Wu, Yin,Chen, Zhong-Liang,Yu, Chun-Lei,Huang, Yan-Xin,Sun, Ying,Zheng, Li-Hua,Wang, Xue,Li, Yu-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

Purpose: To investigate the anticancer effects and underlying mechanisms of parthenolide on HepG2 human hepatocellular carcinoma cells. Materials and Methods: Cell viability was assessed by MTT assay and cell apoptosis through DAPI, TUNEL staining and Western blotting. Monodansylcadaverin(MDC) and AO staining were used to detect cell autophagy. Cell proliferation was assessed by Ki67 immunofluorescence staining. Results: Parthenolide induced growth inhibition in HepG2 cells. DAPI and TUNEL staining showed that parthenolide could increase the number of apoptotic nuclei, while reducing the expression of the anti-apoptotic protein Bcl-2 and elevating the expression of related proteins, like p53, Bax, cleaved caspase9 and cleaved caspase3. Parthenolide could induce autophagy in HepG2 cells and inhibited the expression of proliferation-related gene, Ki-67. Conclusions: Parthenolide can exert anti-cancer effects by inducing cell apoptosis, activating autophagy and inhibiting cell proliferation.

Expression of Neurotrophin 4 and Its Receptor Tyrosine Kinase B in Reproductive Tissues during the Follicular and Luteal Phases in Cows

Sun, Yongfeng,Li, Chunjin,Sun, Yanling,Chen, Lu,Liu, Zhuo,Ma, Yonghe,Wang, Chunqiang,Zhang, Wei,Zhou, Xu Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.3

The neurotrophins, required for the survival and differentiation of the nervous system, are known to be important for the development of the reproductive tissues. However, the signals initiating the growth of follicles, gamete development, and transport and the development of zygote in the reproductive system of cows remain ambiguous. The purpose of the present study was to identify the transcripts and proteins of Neurotrophin 4 (NT4) and its receptor tyrosine kinase B (TrkB) in bovine reproductive tissues. The transcripts and immunoreactivity of NT4 and TrkB proteins were detected by reverse transcription polymerase chain reaction and western blot analysis. Using immunohistochemistry, the specific immunoreactivity of NT4 and TrkB were detected in the oocytes of primordial follicles and in the growing primary follicles. The NT4 and TrkB immunoreactivity was predominantly observed in granulosa cells, cumulus granulosa cells, cumulus oocyte complexes, theca cells of mature follicles, as well as in the oviduct epithelial cells, uterine gland cell, and epithelium cells of the uterus during the follicular and luteal phases in cows. Expressions of NT4 and TrkB mRNAs were not significantly different among the ovary, oviduct, and uterus of the follicular phase. For the luteal phase, the expression of NT4 mRNA in the ovary was significantly higher than that in the oviduct and uterus, and the expression of TrkB mRNA in the oviduct was significantly higher than that in the ovary and uterus, as determined by fluorescence quantitative reverse transcription polymerase chain reaction. The expression of NT4 mRNA was significantly higher than that of TrkB mRNA in the ovary and uterus, whereas NT4 mRNA expression was lower than that of TrkB mRNA in the oviduct during the luteal phase. The present study hypothesizes that NT4 participates in the regulation of both gonads and extra-gonadal reproductive tissues in cows.

China Consensus Document on Allergy Diagnostics

Chen Hao,Li Jing,Cheng Lei,Gao Zhongshan,Lin Xiaoping,Zhu Rongfei,Yang Lin,Tao Ailin,Hong Haiyu,Tang Wei,Guo Yinshi,Huang Huaiqiu,Sun Jinlyu,Lai He,Lei Cheng,Liu Guanghui,Xiang Li,Chen Zhuanggui,Ma Ha 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.2

The prevalence of allergic diseases has increased dramatically in recent years in China, affecting the quality of life in 40% of the population. The identification of allergens is the key to the diagnosis of allergic diseases. Presently, several methods of allergy diagnostics are available in China, but they have not been standardized. Additionally, cross-sensitization and co-sensitization make allergy diagnostics even more complicated. Based on 4 aspects of allergic disease (mechanism, diagnosis procedures, allergen detection in vivo and in vitro as well as the distribution map of the most important airborne allergens in China) and by referring to the consensus of the European Society of Allergy and Clinical Immunology, the World Allergy Organization, and the important literature on allergy diagnostics in China in recent years, we drafted this consensus of allergy diagnostics with Chinese characteristics. It aims to standardize the diagnostic methods of allergens and provides a reference for health care givers. The current document was prepared by a panel of experts from the main stream of professional allergy associations in China.

Study on the Linkage Effect between China and South Korea Stock Market

Sun Jian quan,Sun Xiao lin,Chen Xiao long 한국유통과학회 2017 KODISA ICBE (International Conference on Business Vol.2017 No.-

As the trend of the world financial integration gradually strengthen, the research of the relationship between different stock markets mean a lot to improve the capital markets. The purpose of this article is to explore the linkage effect of market between China and South Korea. There is no evidence to prove that the five variables on behalf of the Chinese stock market have any relationship with KOSPI200 index by the granger causality test. There is no co-integration relationship between two markets by using co integration test to explore the long-term stable equilibrium relationship between China and South Korea stock markets. Therefore there is no significant relationship between China and South Korea market.

Active mass damper control for cable stayed bridge under construction: an experimental study

Chen, Hao,Sun, Zhi,Sun, Limin Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.38 No.2

A cable stayed bridge under construction has low structural damping and is not as stable as the completed bridge. Control countermeasures, such as the installation of energy dissipating devices, are thus required. In this study, the general procedure and key issues on adopting an active control device, the active mass damper (AMD), for vibration control of cable stayed bridges under construction were studied. Taking a typical cable stayed bridge as the prototype structure; a lab-scale test structure was designed and fabricated firstly. A baseline FEM model was then setup and updated according to the modal parameters measured from vibration test on the structure. A numerical study to simulate the bridge-AMD control system was conducted and an efficient LQG-based controller was designed. Based on that, an experimental implementation of AMD control of the transverse vibration of the bridge model was performed. The results from numerical simulation and experimental study verified that the AMD-based active control was feasible and efficient for reducing dynamic responses of a complex structural system. Moreover, the discussion made in this study clarified some critical problems which should be addressed for the practical implementation of AMD control on real cable-stayed bridges.

Performance of an innovative gravity-driven micro-filtration technology for roof rainwater treatment

Chen Shiguang,Sun Hongwei,Chen Qiuli 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.6

Rainwater harvesting has become an important strategy to achieve the goal of sustainable development in urban areas. The latest emerged gravity driven micro-filtration technology can effectively reduce turbidity and bacteria to a very low level but still have disadvantages of low removal of dissolved organic substances and low permeate flux. An innovative gravity driven micro-filtration technique using ceramic flat sheet membrane as filter module was established and introduced to the treatment of rainwater that was harvested from a typical official building in GuangZhou, South China. The performance of this process has been evaluated in terms of pollutants (e.g. pH, turbidity, total dissolved solids (TDS), CODcr, NH₃-N, DOC,UV254, total Coliforms and E.coli) removal efficiency, and the permeate flux profiles. Results shows that the removal rates of turbidity, TDS, CODcr, NH₃-N, DOC,UV254, Coliforms and E.coli were 92.2%, 91.9%, 65.5%, 42.6%, 76.9%, 61%, 96.9% and 95.5%, respectively. The GDM system can run continuously for 60 days without back washing, and the permeate flux stabilized at 22~45 L/(m<SUP>2</SUP>·h) under a constant water head of 20 kPa. Experimental results demonstrated that the GDM system employing a ceramic flat membrane can significantly improve the organics removal in rainwater.