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Che Yu Kuo,Kao Chin Chen,I Hui Lee,Huai-Hsuan Tseng,Nan Tsing Chiu,Po See Chen,Yen Kuang Yang,Wei Hung Chang 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.2
Objective: The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain. Methods: We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [123I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium. Results: The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability. Conclusion: OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.
Health and Income Variation – A Panel Data Study on the Developed and Less Developed Economies
I-MING CHIU,TETSUJI YAMADA,CHIA-CHING CHEN 한국국제경제학회 2011 International Economic Journal Vol.25 No.2
In this paper, human capital in the form of ‘health status’ is introduced into a neoclassical economic growth model as one of the main factors differentiating rich and poor countries. Various panel data models are used to examine how health and other growth factors affect average income in different countries. Our main empirical finding indicates that a one-year increase in life expectancy (the health status measure) raises GDP per capita by 0.5–0.9%. Based on this result, a baseline health status can be established to help poor countries achieve a targeted economic growth rate.
Sintering YAG:Ce phosphor ceramic layers onto glass substrates by CO2 laser for WLED applications
Chiu I-Chi,Nien Yung-Tang,Chen Pui-Jung 한국물리학회 2023 Current Applied Physics Vol.50 No.-
Cerium-doped yttrium aluminum garnet (YAG:Ce) phosphor layers were sintered onto glass using CO2 laser. The layer adhesion was found to depend on the spin coating thickness. The x-ray diffraction indicated the formation of YAG phase, with minor impurities of Y2SiO5 and Y4Al2O9. When the coating thickness was 65 μm, the laser beam reacted thoroughly with glass and YAG precursors, and a liquid phase was formed, producing a thin amorphous layer (~5 μm) on the surface grooves. However, when the thickness was increased to 170 μm, the laser beam could not penetrate to react entirely with YAG precursors, resulting in more raw residues and poor adhesion. The sintered YAG:Ce phosphor layers on glass were characterized via photoluminescence, presenting yellow emission with a thermal quench to 75% at 125 ◦C, which is comparable to that of the solid-state reacted YAG:Ce ceramics.
Three methods for studying coupled vibration in a multi flexible disk rotor system
YiJui Chiu,Xiao-Yun Li,Yi-Cheng Chen,Sheng-Rui Jian,Chia-Hao Yang,I-Hsiang Lin 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.11
This paper improved and developed Shaft-disk-blade (SDB) rotor system based on the previous studies of the authors in the last decade from Yang and Huang (2005) to Chiu et al. (2017). This paper also explored blade-bending, disk-transverse, and shaft-torsion coupling vibration of a multi flexible disk rotor system. Unlike the previous studies of the authors, this paper adopted three methods: (a) Assumed mode method (AMM), (b) Finite element method (FEM), and (c) experimental method. The first approach is the main method, and the two other methods are complementary. Results generated from the three methods were then compared and analyzed. Based on the previous definition of the authors, a flexible disk rotor system displays three types of coupling vibrations: Inter-blade, SDB, and diskblade modes. The system changes the rules of natural frequencies and mode shapes. This paper presents several interesting results. First, the author determined the change rules of the mode shapes and natural frequencies using the AMM, FEM (including three kinds of software), and the experimental method. Second, numerical calculation results also revealed that two phenomena regarding the distance of disk and flexible disk would be affected by the natural frequencies. Third, the experimental results would be explored in this paper. Last, the flexible disk could affect the system instability in the case study of rotation effects.
A fermentation strategy for production of recombinant protein subjected to plasmid instability
Shu-Jen Chen,Bo-Shun Ke,I-Chung Chiu 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.5
The appearance of plasmid-losing cells in a recombinant Escherichia coli culture was observed when the cell mass became doubled after induction, which corresponded to the timing of cell fission. Accordingly, a two-stage fermentation strategy capable of maintaining plasmid stability without selective pressure in a recombinant E. coli culture was proposed. In the first stage (cell growth stage), a high cell density culture was obtained by incubating the cells in the R medium. In the second stage (producing stage), the cells were devoted to producing the recombinant protein by introducing the fresh LB medium supplemented with isopropyl-β-D-thiogalactopyranoside (IPTG). It was necessary to prevent the doubling in the cell mass after induction; otherwise cell fission would occur and generate plasmid-losing cells. The present strategy is expected to be extensively applicable in recombinant E. coli cultures
E-beam lithography and electrodeposition fabrication of thick nanostructured devices
Lo, T N,Chen, Y T,Chiu, C W,Liu, C J,Wu, S R,Lin, I K,Su, C I,Chang, W D,Hwu, Y,Shew, B Y,Chiang, C C,Je, J H,Margaritondo, G Institute of Physics [etc.] 2007 Journal of Physics. D, Applied Physics Vol.40 No.10
<P>A nanofabrication approach based on advanced e-beam lithography and electrodeposition successfully produced high-resolution (≈40 nm line width) metal structures with high aspect ratio (>12) and high density. The combination of these characteristics is essential for hard-x-ray optical components such as zone plates, for x-ray lithography masks and for other devices.</P>