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- 저자 : Chao You (검색결과 51 건)
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Chao Li,Linchang Miao,Quan You,Lijian Lei,Xiaodong Liang,Junjie Wang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.12
The structural expanded polystyrene (EPS) concrete (above 35 MPa) has the potential to be used as metro track bed to reduce and isolate vibration, but its bond behavior is still unclear. This inhibits its application because it is often used in combination with reinforcing bar. In this paper, a class of structural EPS concrete (above 35 MPa) was developed. Based on this, a series of pull-out tests were conducted and the bond behavior of deformed bars in these structural EPS concretes was investigated. In addition, effects of rebar bond length and rebar diameter were analyzed in detail. Experimental results indicate that the structural EPS concrete suffers splitting failure more easily than the conventional concrete (CC). Increase of EPS replacement, rebar bond length or rebar diameter tends to cause the splitting failure of structural EPS concrete. Moreover, with increase of EPS replacement, the failure process is less explosive and more gradual. The stress-slip relationships of the most specimens show three stages, namely linear ascending, non-linear progression, and descending stages. The bond strength of structural EPS concrete is found depended linearly on the power function of its compressive strength, relative cover thickness (c/d) and relative rebar bond length (L/d), respectively. Accordingly, a bond strength prediction model was formulated, and it can precisely predict the bond strength of deformed bars in structural EPS concrete, specimens failing in splitting or splitting-pull out modes, and no fiber added. The results can provide reference for the design of structural EPS concrete.
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Copper Particle Effect on the Breakdown Strength of Insulating Oil at Combined AC and DC Voltage
You-Yuan Wang,Yuan-Long Li,Chao Wei,Jing Zhang,Xi Li 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
Converter transformer is the key equipment of high voltage direct current transmission system. The solid suspending particles originating from the process of installation and operation of converter transformer have significant influence on the insulation performance of transformer oil, especially in presence of DC component in applied voltage. Under high electric field, the particles easily lead to partial discharge and breakdown of insulating oil. This paper investigated copper particle effect on the breakdown voltage of transformer oil at combined AC and DC voltage. A simulation model with single copper particle was established to interpret the particle effect on the breakdown strength of insulating oil. The experimental and simulation results showed that the particles distort the electric field. The breakdown voltage of insulating oil contaminated with copper particle decreases with the increase of particle number, and the breakdown voltage and the logarithm of particle number approximately satisfy the linear relationship. With the increase of the DC component in applied voltage, the breakdown voltage of contaminated insulating oil decreases. The simulation results show that the particle collides with the electrode more frequently with more DC component contained in the applied voltage, which will trigger more discharge and decrease the breakdown voltage of insulating oil.
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You Qian,Bai Ding-xi,Wu Chen-xi,Chen Huan,Hou Chao-ming,Gao Jing 한국간호과학회 2022 Asian Nursing Research Vol.16 No.5
Purpose: Despite the high prevalence of postdialysis fatigue (PDF) in maintenance hemodialysis patients, no meta-analysis on the prevalence and risk factors of PDF has yet been published. This study aimed to identify the prevalence of PDF and explore its related factors. Methods: PubMed, Embase, CENTRAL, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the four Chinese databases (National Knowledge Infrastructure [CNKI], Chinese Biomedical Literature database [SinoMed], Wanfang Digital Periodicals [WANFANG], and Chinese Science and Technology Periodicals [VIP] database) were searched from inception up to July 2022. This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The articles were independently searched by two reviewers, and the relevant data were extracted. The Agency for Healthcare Research and Quality was used to assess the quality of the included studies. Results: Thirteen articles with 2,118 participants were included. The pooled prevalence was 60.0%. The meta-analysis results revealed that the ultrafiltration volume, mean arterial pressure after dialysis, and good sleep quality were potentially associated with PDF, whereas only good sleep quality (odds ratio 0.24, 95% confidence interval 0.19e0.30) was significantly associated with PDF. Conclusion: PDF is common in maintenance hemodialysis patients, which is related to the ultrafiltration volume, sleep quality, and mean arterial pressure after dialysis. However, the mechanism underlying the risk factors and PDF remains unknown. Further research is warranted to investigate the risk factors, intervention, treatment, and mechanism in maintenance hemodialysis patients.
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Design and synthesis of novel androgen receptor antagonists via molecular modeling
( Chao Zhao ),( You Hee Choi ),( Daulat Bikram Khadka ),( Yifeng Jin ),( Kwang-youl Lee ),( Won-jea Cho ) 전남대학교 약품개발연구소 2016 약품개발연구지 Vol.25 No.-
Several androgen receptor (AR) antagonists are clinically prescribed to treat prostate cancer. Unfortunately, many patients become resistant to the existing AR antagonists. To overcome this, a novel AR antagonist candidate called DIMN was discovered by our research group in 2013. In order to develop compounds with improved potency, we designed novel DIMN derivatives based on a docking study and substituted carbons with heteroatom moieties. Encouraging in vitro results for compounds 1b, 1c, 1e, 3c, and 4c proved that the new design was successful. Among the newly synthesized compounds. 1e exhib-ited the strongest inhibitory effect on LNCaP cell growth (IC-<sub>50</sub>=0.35 μm) and also acted as a competitive AR antagonist with selectivity over the estrogen receptor (ER) and the glucocorticoid receptor (GR). A docking study of compound 1e fully supported these biological results. Compound 1e is considered to be a novel, potent and AR-specific antagonist for treating prostate cancer. Thus, our study successfully applied molecular modeling and bioisosteric replacement for hit optimization. The methods here provide a guide for future development of drug candidates through structure-based drug discovery and chemical Modifications. ⓒ 2015 Elsevier Ltd. All rights reserved.
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You-Ping Wang,Chao-Hong Ma,Ru-Hai Li 한국차학회 2015 한국차학회지 Vol.- No.S
Arthropod insects are important pests that feed on leaves and young shoots often causing 10 to 20% loss in tea yield. Evaluation of the effect of major cultural practice such as pruning on the ecological aspect of the arthropod insects and their natural enemies is essential to develop a sound IPM program for organic tea plantation. The impac of summer pruning in mid-May on the arthropod communities was investigated with 3 different pruning intensities,i.e. light, heavy, and no pruning, in Hubei organic tea plantation. Light summer pruning had significant impact on the species and number of tea bush insect pests and their natural enemies within 1 month after pruning, and it lasted by2 months. Heavy pruning had greater impacts. Light pruning postponed the first peak in occurrence of Empoasca vitis (Gothe) for 20 days and the peak of Acaphylla theae Watt for 30 days. Heavy pruning postponed the first peak of Empoasca vitis (Gothe) for 25 days, and completely avoided the damage on tea bush from Acaphylla theae Watt. difference in diversity indices and the ratio of ‘natural enemies/insect pests’ of the arthropod communities on tea bushes by 3 and 4 months after pruning, respectively. The results suggest that light pruning can be used to control insect pests in organic tea plantations with the effect lasting for two months. Heavy pruning had a better control of insect pests than light pruning, but it is hardly to recommend without confirming the balance among sustainability of tea bush vigor in growth and tea yield in the following year, population of natural enemies and the efficacy of insect pest control. The optimum intensity of pruning may differ by individual tea plantation as the age and vigor of tea bush, soil fertility and management of tea bush nutrition differ by each tea plantation.
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Copper Particle Effect on the Breakdown Strength of Insulating Oil at Combined AC and DC Voltage
Wang, You-Yuan,Li, Yuan-Long,Wei, Chao,Zhang, Jing,Li, Xi The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
Converter transformer is the key equipment of high voltage direct current transmission system. The solid suspending particles originating from the process of installation and operation of converter transformer have significant influence on the insulation performance of transformer oil, especially in presence of DC component in applied voltage. Under high electric field, the particles easily lead to partial discharge and breakdown of insulating oil. This paper investigated copper particle effect on the breakdown voltage of transformer oil at combined AC and DC voltage. A simulation model with single copper particle was established to interpret the particle effect on the breakdown strength of insulating oil. The experimental and simulation results showed that the particles distort the electric field. The breakdown voltage of insulating oil contaminated with copper particle decreases with the increase of particle number, and the breakdown voltage and the logarithm of particle number approximately satisfy the linear relationship. With the increase of the DC component in applied voltage, the breakdown voltage of contaminated insulating oil decreases. The simulation results show that the particle collides with the electrode more frequently with more DC component contained in the applied voltage, which will trigger more discharge and decrease the breakdown voltage of insulating oil.
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Fuqiang You,Chao Wang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.1
This article studies the fault estimation problem of linear systems with unkown state time-varying delay. A new PD learning observer (LO) is proposed to realize the simultaneous estimation of system states and actuator fault. Furthermore, the time-delay dependence criterion of the existence of the proposed observer is given through the technique of linear matrix inequalites (LMIs). Because the mismatch between the original system and the observer system in the time delay term has a bad influence on the fault estimation, the H∞ performance index is introduced. At the same time, the problem of sensor fault estimation based on PD learning observer for time-delay systems is studied. Finally, three simulation examples are used to prove the effectiveness of the proposed method.
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Making Line Undercut Structure by Incremental Laser Shock Forming
Shuxin You,Xiangying Wang,Zhong Ji,Chao Zheng,Guofang Zhang,Ren Liu 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.8
A novel technology to plastically deform line undercut structures by pulsed laser, named as incremental laser shock forming (ILSF) of sheet metal, is presented in this paper and is investigated by experiments and numerical simulations. The deformation of a line undercut structure can be considered as the accumulation of several point undercuts, the shape evolution during ILSF of copper foils was observed, and the thickness distribution on a cross-section was measured. The influences of laser energy E, forming height H, and laser spot overlap rate η on the process were studied and a process window was established to avoid deformation failure. The results show that the plastic deformation at η = 0% is less uniform and more vulnerable than that at η = 50%. Three typical failure modes were concluded and discussed. Finite element method simulation was conducted to verify the feasibility of forming line undercut structure by ILSF, and to analyze its deformation mechanism.
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