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Kim, Yu J.,Kim, Ju‐,Young,Yoon, Jin Y.,Kyung, Sun Y.,Lee, Sang P.,Jeong, Sung H.,Moon, Chanil,Park, Jeong‐,Woong Blackwell Publishing Ltd 2011 Basic & clinical pharmacology & toxicology Vol.109 No.1
<P><B>Abstract: </B> Cigarette smoking is the principal cause of chronic obstructive pulmonary disease (COPD), especially emphysema, which is characterized by alveolar wall destruction and airspace enlargement. Apoptosis of lung structural cells is involved in the pathogenesis of COPD. Xanthine derivatives (aminophylline or theophylline) have been used for the treatment of COPD as a bronchodilator. But the effects of xanthine derivatives on apoptosis of the lung structural cells remain poorly understood, even though it is known that theophylline protects against ultraviolet irradiation–induced cell death in corneal epithelial cells. This study was designed to determine whether aminophylline would protect against cigarette smoke extract (CSE)–induced apoptosis in lung fibroblasts. We demonstrated that aminophylline protected against apoptosis of MRC‐5 cells at a relatively lower therapeutic range (10 μg/ml), resulting in a significant increase in cell viability occurring at 20% concentration after 8‐hr exposure. Annexin staining decreased from 68 ± 4% of the control to 12 ± 2% of aminophylline (10 μg/ml) pre‐treatment after 20% CSE exposure for 12 hr (<I>p </I><<I> </I>0.05). Aminophylline decreased caspase 3 and 8 activities and nuclear condensation or fragmentation in MRC‐5 cells after exposure to 20% CSE for 12 hr compared with control and high levels of aminophylline (>50 μg/ml) pre‐treatment. These findings suggest that aminophylline protected apoptosis of MRC‐5 cells through the inactivation of caspases 3 and 8 and could be an effective agent to reduce cigarette smoking–induced lung structural cell apoptosis.</P>
Expression of Nesfatin-1/NUCB2 and Its Binding Site in Mouse Testis and Epididymis
Jinhee Kim,Hyunsook Kim,Sumin Kim,Hyejin Yang,Hyunhae Cho,Supyong Hwang,Chanil Moon,양현원 한국발생생물학회 2011 발생과 생식 Vol.15 No.3
Nesfatin-1/NUCB2, which is secreted from the brain, is known to control appetite and energy metabolism. Recent studies have been shown that nesfatin-1/NUCB2 was expressed not only in the brain, but it was also expressed in the gastric organs and adipose tissue. However, little is known about the expression of nesfatin-1/NUCB2 in the male reproductive system. Therefore, we examined whether the nesfatin-1/NUCB2 and its binding site exists in the male reproductive organs. Nesfatin-1/NUCB2 mRNA and protein were detected in the mouse testis and epididymis by PCR and Western blot analysis. As a result of the immunohistochemistry staining, the nesfatin-1 protein was localized at the interstitial cells and Leydig cells in the testis. Nesfatin-1 binding sites were also displayed at boundary cells in the tunica albuginea. Furthermore, in order to examine if the expression of nesfatin-1/NUCB2 mRNA in the testis and epididymis were affected by gonadotropin, its mRNA expression was analyzed after PMSG administration into mice. NUCB2 mRNA expression levels were increased in both of the testis and epididymis after PMSG administration. These results demonstrated for the first time that nesfatin-1 and its binding site were expressed in the mouse testis and epididymis. In addition,nesfatin-1/NUCB2 mRNA expression was controlled by gonadotropin, suggesting a possible role of nesfatin-1 in the male reproductive organs as a local regulator. Due to this, further study is needed to elucidate the functions of nesfatin-1 on the male reproductive system.
분자동력학을 이용한 나노 리소그래피 공정의 결정립계의 변형 거동 연구
김찬일(Chanil Kim),현상일(Sangil Hyun),김영석(Youngsuk Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
Large-scale molecular dynamics simulations are performed to verify the deformation characteristics of grain boundaries in nanolithography process. The copper substrate made of 200,000 atoms is constructed by two grains in different crystal orientations using dynamic relaxation method. The grain boundary is located in the middle of the substrate with 45~135 degree angles. The plowing tip is made of diamond-like-carbon atoms in a variety of shapes. In the simulations, the generation, propagation, and accumulation of dislocations are observed inside the substrate. From the numerical results, we address the dynamic behavior of the grain boundaries as well as the frictional characteristics in terms of the morphology of initial grain boundaries.
Enumeration of CD34-positive Stem Cells Using the ADAMII Image-based Fluorescence Cell Counter
Yu, Haein,Yoo, Jaeeun,Hwang, Jung Sil,Kim, Mikyung,Bae, Kyung Hee,Jekarl, Dong Wook,Oh, Jong Hyun,Lee, Ji Yeon,Han, Sunmi,Chung, Chanil,Kim, Myungshin,Kim, Yonggoo Korean Society for Laboratory Medicine (KAMJE) 2019 Annals of Laboratory Medicine Vol.39 No.4
Chanil Park,Seok-Woo Son,Jung-Hoon Kim 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.4
The nature of the vertical motion responsible for the summertime heavy rainfall events (HREs) in Korea is quantitatively examined. By compositing 318 HREs in June – September 1979 – 2018, it is found that the synoptic conditions of the HREs are typically characterized by a developing surface cyclone with a southwesterly low-level jet, and a well-defined upper-level jet streak and trough. This baroclinic environment allows for well-organized vertical motion over Korea at the east of the upper-level trough and the equatorward side of the upper-level jet entrance. The relative importance of dynamic and diabatic forcings in driving the vertical motion is quantified by solving the quasi-geostrophic omega equation. It turns out that the dynamic forcing, defined as Q-vector convergence, is comparable to the diabatic forcing in the developing stage of the HREs. The diabatic forcing, however, becomes more important in the mature stage as latent heating rapidly increases. The decomposition of Q-vector into the transverse (cross-isentropic) and shear wise (along-isentropic) components reveals that the dynamic uplift is largely caused by the shear wise Q-vector convergence which is closely related to the developing trough in the upper-to-middle troposphere on the west of the HREs. This result indicates that the HREs in Korea are organized by the baroclinic trough coupled to moist processes. The thermally-direct secondary circulation at the entrance region of the upper-level jet, which has been highlighted in the literature, plays a relatively minor role.
Kim, Eunseon,Jung, Chanil,Han, Jonghun,Her, Namguk,Min Park, Chang,Son, Ahjeong,Yoon, Yeomin Taylor Francis 2016 Desalination and Water Treatment Vol.57 No.57
<P>Commercially available powdered activated carbon (PAC) and activated biochar (produced in the laboratory), combined with kaolinite, were used to determine the adsorption of a beta-blocker (atenolol, ATN) and sunscreen compounds (benzophenone, BZP; and benzotriazole, BZT); a hypothesis was made that the presence of kaolinite would increase the adsorption of those target compounds. Various synthetic solutions were prepared by altering the pH, background ions, ionic strength, and glucose/humic acid content to mimic various natural water conditions. The removal efficiency of biochar-kaolinite was higher than that of PAC-kaolinite, presumably because the relatively high surface area and pore volume of biochar resulted in a higher adsorption capacity for the target compounds. Removal of the compounds in the absence of kaolinite followed the order BZP>ATN>BZT (a (mg/g); Langmuir maximum adsorption capacities were as follows: 85.0, 20.6, and 15.6 for PAC, and 125, 37.5, and 25.9 for biochar, respectively). An increase in the pH from 3.5 to 10.5 decreased the adsorption of ATN, BZP, and BZT by 14.5, 2.1, and 14.4%, respectively, by biochar-kaolinite. Additionally, an increase in background ions and their ionic strength, using NaCl, Na2SO4, and CaCl2, increased the adsorption of the target compounds slightly, by 2.0-6.6%, depending on the target compound. Overall, biochar had a higher adsorption capacity for all chemicals tested compared with PAC, suggesting that biochar derived from loblolly pine chip may be a promising sorbent for water/wastewater treatment and environmental applications.</P>