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Changpeng Cai,Qiangang Zheng,Yong Wang,Haibo Zhang,Fengyong Sun 한국항공우주학회 2023 International Journal of Aeronautical and Space Sc Vol.24 No.2
The acceleration performance of aero-engine is an important guarantee to realize the rapid maneuvering of aircraft. The sharp change of inlet temperature of turbine caused by acceleration process poses a great challenge to the service life of high pressure turbine guide vane, and then influences engine life. How to reach a compromise between the acceleration performance and service life is one of the troublesome issues in the design and research of aero-engine control system. To handle this problem, this paper proposes an engine acceleration control method with variable outlet bleed of compressor considering the life of high pressure turbine guide vane. SQP algorithm is adopted to take into account the mechanical thermal fatigue life of turbine guide and the shortest acceleration time as the optimization objectives. In the acceleration process, the outlet bleed of compressor is adjusted to shorten the acceleration time. The simulation results demonstrate that compared with the conventional acceleration control method, the variable bleed acceleration control can decrease the acceleration time by 10%. While considering the service life of high pressure turbine guide vane, on the premise of the same acceleration time as the conventional method, the temperature gradient of high pressure turbine guide vane is reduced by 50%, the number of safe life cycles increase by 24%, and the service life of high pressure turbine guide vane is effectively enhanced.
Qian Zhang,Changpeng Hu,Jingbin Huang,Wuyi Liu,Wenjing Lai,Faning Leng,Qin Tang,Yali Liu,Qing Wang,Min Zhou,Fangfang Sheng,Guobing Li,Rong Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of themidbrain and the striatum and is an important pathologic basis of Parkinson’s disease (PD). Recent research has shownthat dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission plays a crucial role in dopaminergicnerve cell apoptosis. However, the upstream regulatory mechanism remains unclear. Our study showed that Drp1knockdown inhibited aberrant mitochondrial fission and apoptosis. Importantly, we found that ROCK1 was activated inan MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1dephosphorylation/activation. Our in vivo study confirmed that Y-27632 significantly improved symptoms in a PDmouse model by inhibiting Drp1-mediated aberrant mitochondrial fission and apoptosis. Collectively, our findingssuggest an important molecular mechanism of PD pathogenesis involving ROCK1-regulated dopaminergic nerve cellapoptosis via the activation of Drp1-induced aberrant mitochondrial fission.
Solution Method and Application Verification of the K-curve as a Highway Transition Curve
Bing-hong Pan,Changpeng Wen,Kaiming Wang,Changjiang Liu,Linqi Chen 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7
Because of the singular form and low flexibility of the clothoid as a highway transition curve in highway horizontal alignment, the K-curve, whose ratio of the chord-tangent angle to the tangential angle at any point is fixed, was proposed in a previous work, including the corresponding parametric equations and basic characteristics, and its high flexibility and various shapes were proved. Here, the application and verification of the K-curve in highway alignment is further studied. The solution methods of the K-curve for different connections are given. Through theoretical calculations and specific real-world examples, the geometric positions and lateral forces of the K-curve and the clothoid under different connection conditions are compared. The results show that the difference between the K-curve and clothoid in the above two aspects under a straight line-to-circle connection is greater than that under a circle-to-circle connection as an egg curve, and although the lateral force coefficient of the K-curve is smaller than that of the clothoid, the K-curve suffers from rapid change in the lateral force coefficient and a higher lateral acceleration change rate. Finally, the application conditions of the K-curve for highway alignment design are given with consideration of the centrifugal acceleration change rate.
Huan Liu,Dan Zhao,Changpeng Zhang,Minghao Li,Shijie Zhang,Xincai Xiao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-
The novel nanozyme has been used in the detection field as biosensor, but has also been employed in newfields like antibacterial and inhibiting of biofilm growth applications. This paper reports the rapid preparationof the nanozyme PS-CDs-MnO2 with oxidase activity by using PS-CDs as reducing agent to reduceKMnO4. The mechanisms of positive electrical property of PS-CDs-MnO2 and the single linear oxygen(1O2) have promised the broad-spectrum antibacterial ability and high efficiency in eliminating bacteria,with 48 h long-term antibacterial effect. The minimum inhibitory concentration (MIC) againstStaphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and Pseudomonasaeruginosa (P. aeruginosa) at 7.50 lg/mL, 60 lg/mL, 15 lg/mL and 60 lg/mL, respectively. The preparedPS-CDs-MnO2 could effectively inhibit the formation of S. aureus biofilm at the concentration of 10 lg/mL. The visually sensitive and selective sensing platform based on PS-CDs-MnO2-TMB was established, andrealized the colorimetric detection of tiopronin (TPN) with a detection range at 285.71 nM–14.28 lMand detection limit at 6.30 nM. This research provides a good theoretical and practical basis for the preparationof oxidase nanozyme and its application in detection, antibacterial and inhibition of biofilm formationfields.
Long, Zhi,Gao, Liqin,Li, Yankai,Kang, Baotao,Lee, Jin Yong,Ge, Junjie,Liu, Changpeng,Ma, Shuhua,Jin, Zhao,Ai, Hongqi American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.44
<P>The self-assembly powder (SAP) with varying Nafion content was synthesized and characterized by XRD, XPS, HRTEM, and mapping. It is observed that the oxygen from oxygen functional groups transfers to the surface of Pt and generate PtO during the process of self-assembly with the mechanism of micro galvanic cell, where Pt, carbon black, and Nafion act as the anode, cathode and electrolyte, respectively. The appearance of PtO on the surface of Pt leads to a turnover of Nafion structure, and therefore more hydrophilic sulfonic groups directly contact with Pt, and thus the triple-phase boundary (TPB) has been expanded.</P>