통합적 지적정보를 이용한 지가정보시스템 구축

황창섭,임인섭,최석근 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.2

This study focused on construction of the land price information system which can efficiently, scientifically, and accurately manage the individual announced land price. The system is adapted to the test area(Kakyung-dong, Chongju city), whose master plan is being made. As a result, it is concluded that can improve the efficiency and accuracy of land price management. Also, users can easily use it without professional knowledge since if offer convenient user environment. Furthermore, it can rapidly search character and classification of land sue-zoning, the present condition of land price and so on. And it can cause the improvement of good quality service for people by issuing accurately and rapidly documents related to a city plan.

폐결핵치료 중인 환자에서 Rifampicin에 의해 유발된 위막성 대장염 2예

김봉진,권균홍,임창섭,김자영,홍정범,옥미선,배용목,김지연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Pseudomembranous colitis (PMC) is a disease caused by Clostridium difficile proliferation. The causative drugs are clindamycin, third-generation cephalosporins, flouroquinolone and so on. Rifampicin has been reported as a cause of PMC in the 1980s, and the frequency of PMC is increasing because rifampicin is a first line drug for anti-tuberculosis therapy. Two patients were recently admitted to our hospital due to watery diarrhea for 1 month and they were diagnosed with PMC by sigmoidoscopy. Their onset age were 74, 72 years old and latent period of symptoms were 60, 129 days, respectively. In one case, the patient displayed coexisting hypertension and diabetes. The clinical symptoms improved after discontinuing the rifampicin and then administering oral metronidazole. We report here on two cases presumed to be rifampicin-induced PMC.

체외충격파 쇄석술 시행 후 5년 뒤 발생한 요관 협착 및 농신장 1예

이현승,권균홍,조용건,김봉진,임창섭,김자영,허동,임학 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

A 40-years-old woman was admitted to this hospital with flank pain and high grade fever for 2 weeks. As a matter of her past history, extracorporeal shock wave lithotripsy (ESWL) was performed for treatment of renal stones 5 years ago. Her abdominal CT findings were hydronephrosis with pyonephrosis and renal stones. Antibiotics administered for 5 days had no effects on her symptom improvement. A right ureteral stricture was noticed by ultrasonography follow up. We inserted double J stent and continued antibiotics therapy for 10 days, and then her fever was disappeared and flank pain was improved. ESWL is one of the most important treatment of renal and ureteral stone. However, its complications should not be negligible including bleeding, pain, ureteral obstruction, infection and so on. Complications of ESWL can be divided into acute and chronic courses. When we treat pyelonephritis patient with past history of ESWL, possibility of ureteral stricture must also be considered. In this study we report a case of pyelonephritis caused by ureteral stricture, possibly as a chronic complication of ESWL performed 5 years earlier

Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma

Lim, Sun Min,Choi, Jae Woo,Hong, Min Hee,Jung, Dongmin,Lee, Chang Young,Park, Seong Yong,Shim, Hyo Sup,Sheen, Seungsoo,Kwak, Kyeong Im,Kang, Dae Ryong,Cho, Byoung Chul,Kim, Hye Ryun Elsevier 2019 Lung cancer Vol.131 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Radon, a natural radiation, is the leading environmental cause of lung cancer in never-smokers. However, the radon exposure impact on the mutational landscape and tumor mutation burden (TMB) of lung cancer in never-smokers has not been explored. The aim of this study was to investigate the mutational landscape of lung adenocarcinoma in never-smokers who were exposed to various degrees of residential radon.</P> <P><B>Materials and methods</B></P> <P>To investigate the effect of indoor radon exposure, we estimated the cumulative exposure to indoor radon in each house of patients with lung cancer with a never-smoking history. Patients with at least 2 year-duration of residence before the diagnosis of lung adenocarcinoma were included. Patients were subgrouped based on the median radon exposure level (48 Bq/m<SUP>3</SUP>): radon-high <I>vs.</I> radon-low and targeted sequencing of tumor and matched blood were performed in all patients.</P> <P><B>Results</B></P> <P>Among 41 patients with lung adenocarcinoma, the TMB was significantly higher in the radon-high group than it was in the radon-low group (mean 4.94 <I>vs</I>. 2.6 mutations/Mb, <I>P</I> = 0.01). The recurrence rates between radon-high and radon-low group did not differ significantly. Mutational signatures of radon-high tumors showed features associated with inactivity of the base excision repair and DNA replication machineries. The analysis of tumor evolutionary trajectories also suggested a series of mutagenesis induced by radon exposure. In addition, radon-high tumors revealed a significant protein-protein interaction of genes involved in DNA damage and repair (<I>P</I> < 0.001).</P> <P><B>Conclusions</B></P> <P>Indoor radon exposure increased the TMB in never-smoker patients with lung adenocarcinoma and their mutational signature was associated with defective DNA mismatch repair.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Radon is the leading environmental cause of lung cancer in never-smokers. </LI> <LI> We investigated the mutational landscape in never-smokers who were exposed to residential radon. </LI> <LI> Indoor radon exposure increased tumor mutation burden. </LI> </UL> </P>

Long Term Treatment Results and Prognostic Factors of Hilar Cholangiocarcinoma

Chang Sup Lim,Jin-Young Jang,Seung Eun Lee,Mee Joo Kang,Sun-Whe Kim 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.3

The Implication of Cytogenetic Alterations in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm Identified by Fluorescence <i>In Situ</i> Hybridization and Their Potential Diagnostic Utility

Chang-Sup Lim,Kyongok Im,Dong Soon Lee,Wooil Kwon,Jae Ri Kim,Youngmin Han,Sun-Whe Kim,Jin-Young Jang 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4

Background/Aims: We investigated chromosomal aberrations in patients with pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) by fluorescence in situ hybridization (FISH) to identify cytogenetic changes and molecular markers that may be useful for preoperative diagnosis. Methods: Tissue samples from 48 PDAC and 17 IPMN patients were investigated by FISH analysis using probes targeting chromosomes 7q, 17p, 18q, 20q, and 21q and the pericentromeric region of chromosome 18 (CEP18). Results: The PDAC samples harbored 17p deletion (95.8%), 18q deletion (83.3%), CEP18 deletion (81.2%), 20q gain (81.2%), 21q deletion (77.1%), and 7q gain (70.8%). The IPMN samples had 17p deletion (94.1%), CEP18 deletion (94.1%), 21q deletion (70.6%), 18q deletion (58.8%), 20q gain (58.8%), and 7q gain (58.8%). A significant difference in CEP18 gain was identified between the PDAC and IPMN groups (p=0.029). Detection of 17p or 18q deletion had the highest diagnostic accuracy (80.0%) for PDAC. Conclusions: Chromosomal alterations were frequently identified in both PDAC and IPMN with similar patterns. CEP18 gain and 17p and 18q deletions might be involved in the later stages of PDAC tumorigenesis. Chromosome 17p and 18q deletions might be excellent diagnostic markers.

Comparison of Various Methods of Vessel Ligation

Chang-Sup Lim,Jin-Young Jang,Mee Joo Kang,Seung Eun Lee,Sun-Whe Kim 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.4

Analysis of Results after Liver Resection for Metastasis from Non-Colorectal and Non-Endocrine Tumors

( Chang-sup Lim ),( Hyo-sin Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Liver metastasis from colorecal cancer and endocrine organs relatively well researched and reported. However, there have been few reports on outcome of liver metastasis from noncolorectal and non endocrinee organs. In this study, we evaluate the prgosnostic factor among the patient who underwent hepatic resection with noncolorectal nonendocrine liver metastasis. Methods: The overall study period was September 2005 - July 2015. A total of 23 patients were selected from the two different hospital database and included in the analysis Patients and tumors characteristics were reported. Overall survival and subgroup analyses based on different characteristics were performed Results: Them Mean age of the patients was 57.9 ± 11.5 years. Male was 15 (65.2%) and female 8 (34.8%) Primary malignancies distribution resulted as follows: Genitourinary 7 (30.4%) Gastrointestinal 6 (26.1%) Pancreatic cancer 3 (13.0%) Lung cance 2 (8.7%) Breast cancer 2 (8.7%) CBD cancer 1 (4.3%) Melanoma 1 (4.3%) and Nasopharyngeal cancer 1 (4.3%) The overall survival rates at 1, 3, 5 years, were 68.5%, 38.0% and 19.0% respectively .Presence of Neoajuvant treatment and recurrence after hepatic resection were significant different between Death and Survival groups (21.4% vs 77.8%, P < 0.05), (78.6% vs 22.2%, P <0.05) and Overal survival rate was high in the patients with Neoajuvant treatment (1, 3 and 5yr: 88.9%, 77.8% and 51.9% vs 53.8%, 23.1% and 0 % P < 0.05) Conclusions: Neoajuvant treatemnt could have survival benefit in the patient of noncolorectal nonendocrine liver metastasis

지방육종형성 동물모델에서 123I-15-(p-iodophenyl)-3-R , S-methylpentadecanoic acid ( BMIPP ) 의 생체분포와 생체영상

최창운(Chang Woon Choi),임상무(Sang Moo Lim),이태섭(Tae Sup Lee),서용섭(Yong Sup Suh),우광선,정위섭(Wee Sup Chung),임수정(Soo Jung Lim),오옥두(Ok Doo Awh) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.5

N/A Purpose: 123I-labeled fatty acids have been used in the evaluation of regional myocardial energy metabolism. This study aimed to evaluate the usefulness of 123I-BMIPP as a liposarcorna-imaging agent. Materials and Methods: We compared in vitro uptakes between liposarcoma(SW872) and glioma(9L) cell lines, and examined biodistribution and in vivo images of 123I-BMIPP in liposarcoma-bearing nude mice. Cold-BMIPP was labeled with 123I using Cu2+ as catalyst. After purification by Sep-pak, radiochemical purity was determined by TLC. We compared cellular uptake between glioma and liposarcoma after incubation of 5, 10, 15, 30, 60, 120, and 180 mins with culture medium containing I-BMIPP. The difference in biodistribution was determined between non-feeding (water only) group for 18 hr and feeding group in normal mice (n=6/group) at 0.5, 2, and 24 hr. In liposarcoma-bearing nude mice model, liposarcoma, SW872, cell lines were injected subcutaneously into the left thigh of nude mice. The biodistribution of 123I-BMIPP was evaluated at 0.5, 2, and 24 hr (n=5 / group) and in vivo image of 123I-BMIPP was obtained with gamma camera at 2 and 24 hr in liposarcorna-bearing nude mice. Results: Radiolabeling yield and radiochemical purity were 95% and above 99%, respectively. SW872 cell line showed more increased uptake than 9L with 1.5 times at 180 mins. The clearance of 'I-BMIPP in various tissues was more delayed in the non-feeding group than in the feeding group, especially at delayed time (24 hr) in normal mice, and the major excreting organ was the gastrointestinal tract. In liposarcoma-bearing nude mice, tumor/blood ratio of 123I-BMIPP was 0.94, 0.75, and 1.38 and tumor/muscle ratio was 0.66, 1.53, and 1.11 at 0.5, 2, and 24hr, respectively. 123I-BMIPP was selectively localized in liposarcoma at 24 hr image. Conclusions: These results suggest that 123I-BMIPP can be used as a liposarcoma-imaging agent. (Korean J Nucl Med 200135:324-333)

간내결석증의 최근 치료경험 및 장기 치료성적 분석

임창섭(Chang-Sup Lim),장진영(Jin-Young Jang),이승은(Seung Eun Lee),강미주(Mee Joo Kang),김선회(Sun-Whe Kim) 한국간담췌외과학회 2010 한국간담췌외과학회지 Vol.14 No.1

Purpose: Treatment of hepatolithiasis is difficult because of the high recurrence rate, and the long-term outcome is not satisfactory. We reviewed clinical outcomes to determine the optimal treatment modalities for hepatolithiasis. Methods: Between 1981 and 2005, 648 patients with hepatolithiasis were treated at our institute. Changing patterns of treatment modalities and outcomes were analyzed for the periods: 1st (1981∼1985; n=159), 2nd (1986∼1990; n=100), 3rd (1991∼1995; n=111), 4th (1996∼2000; n=141), and 5th (2001∼2005; n=137). Clearance and recurrence rates according to the treatment modalities and associated malignancies were analyzed in patients for the most recent 10 years. Results: During the past 25 years, hepatectomy as a treatment for hepatholithiasis has increased in frequency and become the major treatment modality in the recent 10 years, while choledocholithotomy and drainage procedures have decreased in frequency. With improvement in operative clearance and post-operative lithotripsy, the final clearance rate improved from 79.0% to 91.3%. In the most recent 10 years, the final clearance rate of hepatectomy, choledocholithotomy, cholangioenterostomy, and PTCS was 97.1%, 82.0%, 78.8%, and 100%, respectively, and the recurrence rate was 34.7%, 15.4%, 17.0%, and 42.9%, respectively. Twenty-six patients (47.2%) had recurrences within 2 years, and 12 patients (21.8%) had recurrences after 5 years. Cholangiocarcinomas occurred in 10 patients (3.6%). The diagnosis of cholangiocarcinoma was established pre-operatively in 2 patients, post-operatively in 4 patients, and during the follow-up period in 4 patients. Conclusion: In the treatment of hepatolithiasis, hepatectomy has a high clearance rate and a low recurrence rate. To reduce the recurrence rate, complete stone clearance without residual stones seems to be of utmost importance. Suspicion of malignancy and long-term follow-up are needed in the management of patients with hepatolithiasis.