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자궁경부에 발생한 원발성 세포독성 T-세포 림프종 1예 : A case report
김지혜,곽재용,임창열 대한내과학회 2003 대한내과학회지 Vol.65 No.4
악성 림프종에서 자궁 경부로의 전이는 드물지 않지만 자궁 경부의 원발성 림프종은 드물다. 우연히 건강검진에서 발견하게된 병기 IE로 진단된 자궁경부의 T-세포 림프종 1 예를 보고하고 올바른 진단과 분류가 이루어지면 적절한 치료를 할 수 있고 이로 인해 성공적인 예후를 보일 수 있음을 강조한다. Non-Hodgkin's lymphoma can involve the gynecologic tract, most often as a manifestatiion of systemic involvement. Primary lymphomas of the female genital tract are rare. Most involve the cervix rather than the uterine corpus. All of those previously reported have been B-cell lymphomas, with the exception of several case reports. Primary T-cell lymphoma of the uterine cervix is rare. We describe a rare case of primary cytotoxic T-cell lymphoma of the uterine cervix, Ann Arbor stage IE in a 55-year-old woman. The tumor, incidentally disclosed at gynecological examination, appeared as diffuse cervical enlargement with mucosal erosion. A biopsy was taken and showed diffuse infiltration of variable sized lymphoma cells. Neoplastic cells were positive for LCA, CD3, TIA-1 and consistent with cytotoxic T-cell lymphoma. She was treated with 3 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisolone(CHOP). After chemotherapy, the patient was treated by pelvic external radiation therapy. At present, the patient is well and disease-free.
김소리,곽재용,임창열 대한내과학회 2004 대한내과학회지 Vol.66 No.3
저자들은 좌측 음낭 부종을 주소로 내원한 17세 남자 환자에서 고환주위에 발생한 IRS 분류 group Ⅰ, IRS-Ⅳ에 따른 stage 1, 저 위험군의 태생기성 횡문근육종을 서혜부 절개를 통한 근치적 고환 적출술 및 음낭 절제술 후 1년여에 걸쳐 매 9주 마다 5차까지의 VA 항암화학요법으로 치료 완료하였고, 치료 중 추적검사한 복부 컴퓨터 단층 촬영상 진행 소견이나 전이 소견 관찰되지 않았으며, 항암화학요법 종료 후 6개월 후 추적검사 예정으로 현재 항암화학요법 종료 후 4개월까지 특이소견 관찰되지 않고 있다. This paratesticular rhabdomyosarcoma is more frequent in children than in adult. Paratesticular rhabdomyosarcoma accounts for approximately 7% of all rhabdomyosarcomas and is the most common soft tissue sarcoma in childhood, with an annual incidence of four to seven cases per million. The rhabdomyosarcoma originated from paratedsticular region is considered to have a good prognosis in comparison with othe rhabdomyosarcomas, despite of the high frequency of retroperitoneal lymph node invasion. this superficial site allows rapid diagnosis and consequently often complete resection of the tumor. The multidisciplinary treatment of paratesticular rhabdomyosarcoma has improved control of the disease with a 2-year survival of 80%. Especially, The outcome for patients with localized paratesticular rhabdomyosarcoma is excellent with the use of the new regimen rather than traditional regimen composed of alkylating agent: an alkylating-free and anthracycline-free regimen is adequate treatment for low-risk patients. We report a case of paratesticular rhabdomyosarcoma of embryonal type in a 17-year-old male who presented left scrotal swelling without tenderness. The diagnosis was confirmed by biopsy. After left radical orchiectomy and hemiscrotectomy, he received VA (Vincristine/Actinomycin-D) chemotherapy.
Choi, Youn Seon,Kim, Su Hyun,Kim, Jun Suk,Lee, Juneyoung,Kang, Jin Hyoung,Kim, Sam Yong,Kim, Si Young,Kim, Chul Soo,Song, Hong Suk,Lim, Ho Yeong,Yim, Chang Yeol,Chung, Ik Joo,Cho, Goon Jae,Lee, Myung Elsevier 2006 Journal of pain and symptom management Vol.31 No.6
<P><B>Abstract</B></P><P>Appropriate pain assessment is very important for managing cancer pain. This study was designed to evaluate the utility of the Korean Cancer Pain Assessment Tool (KCPAT) by assessing changes in the management of cancer pain. The changes in pain intensity, the pattern of drug prescriptions, and the patients' satisfaction with pain control were analyzed after using the KCPAT. The results indicated that pain medicine prescriptions were changed in 194 (51.5%) cases after using the KCPAT, and 69.5% of these changes were affected by the KCPAT. After using the KCPAT, pain intensity as assessed by the Visual Analogue Scale (VAS, 0–10cm) decreased (4.31±2.35 vs. 3.60±2.45, <I>P</I><0.0001), and the presence of associated symptoms and psychosocial items was significantly reduced. The patients' satisfaction with pain control was improved. Forty-four physicians (89.8%) thought that the KCPAT was useful. The KCPAT improved patients' satisfaction with pain control and was a useful tool for evaluating and managing cancer pain.</P>
Cascade 기형위 , 위하수 , 과민성 장 증후군을 동반한 만성위염 환자에서 공복시 혈청 gastrin 치의 변동
임창열(Chang Yeol Yim),홍보희(Bok Hee Hong),이용구(Yong Koo Lee),권철(Cheol Kwon),안득수(Keuk Soo Ahn) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.1
N/A Chronic gastritis associated with nonspecific gastrointestinal symptoms is cne of the most. Common diseases, especially in Korea. But the etiology, clinicopathologic correlations, course and prognosis of the disease remain obscure. we observed the age and sex distribution, associated disease, symptomatology and fasting serum gastrin level in 77 patients composed of 28 cases of chronic gastritis without any othor anatomic and functional abnormality, 24 cases of chronic gastritis with cascade stomach, 20 cases of chronic gastritis with gastric ptosis and 5 cases of chronic gastritis with irritable bowel syndrome, who were treated from March 1982 to September 1982 at Jeonbug Naticnal University Hospital. The results were as follosws: 1. The ratios of male to female were 13 to 15 in chronic gastritis without any other abnormality, 17 to 7 in chronic gastritis with cascade stomach, 3 to 17 in chronic gastritis with gastric ptosis and 2 to 3 in chronic gastritis with irritable bowel syndrome. In all 7 patient, the ratio was 35 to 42. 2. The mean age of all 77 patients was 41.55+-1.22(mean+-S.E.) years and the most prevalent age group was fifth decade of life in all four groups of patients. 3, Sixteen(20.8%) of the 77 patients had associated diseases which were pulmonary tuberculosis(4 cases), clonorchiasis(3 cases), arthritis(3 cases), allergic skin diseases,(3 cases), toxic goiter (1 case), cirrhosis of the liver (1 case) and hypertension(1 case). In 2 cases, the nonspecific gastrointestinal syrnptoms developed after adrninistration of herbs. In sympatology, the most common symptom was postprandial epigastric distress which was complained in 60 of the 77 patients. The next common symptonis in descending order were postprandial epigastric fullness, epigasrtic hunger pain, dry mouth, belching, bitter taste, nausea, meteorism, lower abdominal pain, constipation and diarrhea. The fasting serum gatrin levels of the patients with chronic gastritis without ariy other abnorma!.ty, chron!c gastrit!s rvith cascade stornach and chrcnic gastritis with irritable tcwel syndro me were significantly lover than that of normal controls. But the fasting eerim gastrin levels of the patients with chronic gastritis with gastric ptosis revealed no sipnificant diffcrence compared with that of normal controls
임창열 ( Chang Yeol Yim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.4
Nitric oxide (NO) is emerging as a potential anti-cancer agent to overcome tumor cell resistance to conventional therapeutic agents. NO is a short-life molecule produced from L-arginine by the nitric oxide synthase (NOS). There are three isoforms of the enzyme: neuronal NOS (nNOS or NOS1), inducible NOS (iNOS or NOS2), and endothelial NOS (eNOS or NOS3). Each of these isoforms may be expressed in a variety of cell types. The actions of NO are highly variable in oncology revealing both sides of the spectrum as an anti-neoplastic versus a pro-neoplastic agent. The final activity of NO is dependent on its working microenvironment, including the type of cell exposed to NO, the redox state of the reaction, as well as the final intracellular concentration and the duration of exposure to NO. NO donors mimic continuous production of NO in a wide range of time intervals (seconds to days). Thus, multiple biological and (pro-versus anti-) neoplastic responses are elicited from NO donors depending on the half-life and the type of cell exposed to the compound. This paper is a review of the current knowledge of various roles of NO in cancer. (Korean J Med 78:430-436, 2010)