입원환자 낙상예방 프로그램에서 근력운동의 효과: 낙상 고위험군 노인환자를 중심으로

이현옥 ( Hyun-ok Lee ),이병화 ( Byung-hwa Lee ),이창희 ( Chang-hee Lee ) 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.4

Objectives: The purpose of this study is to analyze the changes in the indices of body muscle strength, the indices of muscle strength associated with physical balance, and index of the pain relief between the intervention group who performed the muscle strength exercise and control group who not performed the muscle strength exercise. The study period was from September 7, 2016 to May 12, 2017, and it was conducted after receiving Institutional Review Board approval. Methods: Among 40 participants who were recruited in this study, the final analysis subjects were a total of 39 people, excluding the one people who dropped out during the 2-week. For analysis, the changes were compared with baseline and after two weeks by comparing three types of body muscle strength indices, four types of physical balance indices, and one type of pain relief index. Finally, we analyzed whether there is a difference between the groups in the each changes. Results: In the body muscle strength index change analysis, the change of muscle mass relative to weight was not statistically significant, but the difference between the groups regard to change was statistically significant (p<0.05). The lower body strength and the bone mineral were statistically significant in both the intervention and control group, but the difference between the groups regard to change was not statistically significant. In the index of muscle strength associated with physical balance change analysis, the intervention group showed improvement much higher in the right arm, left arm, right leg, and left leg of muscle mass than the control group. Also, the muscle mass of the right arm and the left arm was statistically significant in the analysis of the difference between the groups regard to change (p<0.05). Analysis of changes in pain relief index showed that the intervention group showed significantly improvement higher than the control group, and the difference between the groups regard to change was statistically significant (p<0.05). Conclusions: In the elderly patients in the hospital where the fall prevention program was provided, it was concluded that the intervention group higher improved the muscle strength associated with physical balance and the pain relief compared with the control group.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

악관절 강직증의 치험례

현영옥,강창희,노양호,천영두,김신헌,이희원 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

Temporomandibular ankylosis is defined as a situation in which the condyle is fused to the fossa by bone or fibrous tissue. Conditons such as trauma, infection, or systemic disease may predispose to various types of ankylosis, bringing about different levels of limitation in mandibular movement. Most patients with temporomandibular ankylosis are associated with limitation of maximal mouth opening, deviation of the chin toward the affected side, impaired occlusion, chronic pain, compromised oral hygiene, severe facial asymmetry & impeded mandibular molar eruption occurring in childhood. Several techniques to release ankylosis have been described in the literature, showing variable and often unsatisfactory results. The most frequently used operations are gap arthroplasty, interpositional arthroplasty, and exicision and joint reconstruction with autogenous or alloplastic materials. We have managed the two patients of TMJ ankylosis. They had previously TMJ surgery and we treated with gap arthroplasty & active physial therapy. We have obtained favorable results and report these cases with literatures review.

CLOSED LOCK 증례에 대한 악관절 세정술의 임상적 연구

현영옥,강창희,노양호,천영두,이희원 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

Purpose : To evaluate the efficacy of arthrocentesis for treatment of closed lock. Material : 42 patients were diagnosed to closed lock by physical, radiographic examriation and undergone arthrocentesis. All patients have a pain and mouth opening limitation on affected site. Method : Arthrocentesis was done under conscious sedation and local infiltration anesthesia, normal saline and some steroid was injected on upper compartment of tempormandibular joint. After pumping and lavage, manual reduction procedure of anterially displaced disc was done. All the patients wear an anterior repositioning splint just after arthrocentesis. The result of arthrocentesis was assessed by pain and difference of mouth opening. Result : Difference of mouth opening after arthrocentesis was improved to 18.85mm and pain was gradually decreased. All patients were worn stabilization type splint after mean 1.84 months. 6 patients had relapse of mouth opening limitation so done arthrocentesis again and delivered good results.

흰쥐 췌장을 지배하는 운동 및 감각신경세포체의 표지부위

이창현,정순용,차영옥,정승호,송창호,이무삼 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.6

소프트웨어 프로세스 개선을 위한 형상관리 프로세스 프레임워크의 개발

장옥현;이병걸 서울여자대학교 컴퓨터과학연구소 2004 정보기술논문지 Vol.2 No.-

많은 소프트웨어 조직에서 형상관리 활동 수행을 통한 소프트웨어 제품의 품질향상 및 프로세스 개선을 위해 노력하고 있다. 그러나 현실적으로 형상관리에 소요되는 높은 비용과 체계적인 방법론 및 절차의 부재로 인하여 기대한 효과를 제대 로 얻지 못하고 있다. 본 논문에서는 기존의 형상관리 이슈들을 분석하고 재정의하여 다양한 형태의 소프트웨어 조직에서 조직의 특성에 맞게 형상관리 프로세스를 재구성하거나 변경할 수 있는 형상관리 프로세스 프레임워크를 제안한다. 제안하는 프레임워크는 CMM이나 SPICE와 같은 프로세스 표준에도 부합하도록 구성함으로써 조직의 소프트웨어 프로세스 개선에 직접 활용될 수 있도록 하였다. Many software organizations are pouring every effort in configuration management to improve their software process and thus to enhance the qualities of their software products. But it is still not feasible to have configuration management function effectively in organizations process improvement due to its high cost with implementation and the absence of the systematic methodology and procedures. This paper analyzes and reclassifies the existing configuration management issues, and proposes a framework to reorganize and customize the known configuration activities. The framework enables software organizations customize their configuration management to be consistent with organization's process environment and characteristics. The framework is also constructed to be compliance with such assessment standards as CMM or SPICE and thus can be practically used in improving organizations other software process areas.

감염 조절용 차단막의 두께가 광중합기의 중합광에 미치는 영향

장훈상,이석련,홍성옥,류현욱,송창규,민경산 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.5

연구목적: 본 연구는 감염 조절용 차단막을 여러 겹으로 사용했을 때 광중합기의 광강도와 파장, light diffusion 등에 미치는 영향에 대해 조사하였다. 연구 재료 및 방법: 감염 조절용 차단막은 투명 랩 (크린랩)을 사용하였고 광중합기는 할로겐 광중합기 (Optilux 360)와 LED 광중합기 (Elipar FreeLight 2)를 사용하였다. 차단막을 1겹, 2겹, 4겹, 8겹으로 광중합기의 광섬유말단을 감싸고 휴대용 광강도 측정기 (Cure Rite)로 광중합기의 광강도를 측정하였다. 광중합기를 주문제작한 optical breadboard에 고정시킨 후 휴대용 spectroradiometer (CS-1000)를 이용하여 광중합기의 파장을 측정하였고, DSLR (Nikon D70s)을 이용하여 광중합기의 light diffusion을 사진 촬영하였다. 결과: 광강도 측정 결과는 차단막의 두께가 증가할수록 광강도가 유의하게 감소하였으나 할로겐 광중합기에서 1겹과 2겹 사이에는 유의차가 없었으며, 4겹 이상의 차단막을 투과할 때 광강도가 더 많이 감소하였다. 여러 겹의 차단막을 투과한 광중합기의 전체적인 파장 형태와 peak wavelength의 변화는 관찰되지 않았다. Light diffusion 사진 촬영 시, LED 광중합기에서는 차단막의 두께가 미치는 영향이 없었으나 할로겐 광중합기에서는 차단막을 4겹 사용했을 때부터 중합광이 조사되는 각도가 감소하기 시작하여 8겹 사용했을 때 통계적으로 유의하게 감소하는 것을 볼 수 있었다 (p < 0.05). 결론: 광중합형 복합레진을 광중합할 경우 감염 조절용 차단막이 찢어지는 경우를 대비하여 1겹으로 사용하기 보다는 2겹으로 사용하는 것이 환자간의 교차감염을 예방하는데 유리할 것으로 사료된다. Objectives: This study investigated the effect of infection control barrier thickness on power density, wavelength, and light diffusion of light curing units. Materials and Methods: Infection control barrier (Cleanwrap) in one-fold, two-fold, four-fold, and eightfold, and a halogen light curing unit (Optilux 360) and a light emitting diode (LED) light curing unit (Elipar FreeLight 2) were used in this study. Power density of light curing units with infection control barriers covering the fiberoptic bundle was measured with a hand held dental radiometer (Cure Rite). Wavelength of light curing units fixed on a custom made optical breadboard was measured with a portable spectroradiometer (CS-1000). Light diffusion of light curing units was photographed with DSLR (Nikon D70s) as above. Results: Power density decreased significantly as the layer thickness of the infection control barrier increased, except the one-fold and two-fold in halogen light curing unit. Especially, when the barrier was four-fold and more in the halogen light curing unit, the decrease of power density was more prominent. The wavelength of light curing units was not affected by the barriers and almost no change was detected in the peak wavelength. Light diffusion of LED light curing unit was not affected by barriers, however, halogen light curing unit showed decrease in light diffusion angle when the barrier was four-fold and statistically different decrease when the barrier was eight-fold (p < 0.05). Conclusions: It could be assumed that the infection control barriers should be used as two-fold rather than one-fold to prevent tearing of the barriers and subsequent cross contamination between the patients.

放射線照射에 의한 濟州産 鹽乾옥돔의 貯藏性向上에 관한 硏究

金洙賢,鄭昌朝,趙韓玉,金在河 제주대학교 방사능이용연구소 1985 연구보고 Vol.1 No.-

濟州産 鹽乾옥돔(yellow sea bream ; Branchiostegus japonicus japonicus)을 Vinyl 眞空包裝 0, 0.5, 1.0, 1.5 및 2.0Mrad 水準으로 放射線 照射후 室溫과 冷藏으로 60日間 貯藏하여 鹽乾옥돔의 理化學的變化 및 官能檢査를 수행하였다. 貯藏期間中 總菌數는 放射線 照射水準이 높아짐에 따라 抑制되고 있었으며, 放射線照射와 冷藏處理가 더욱 效果的이었다. TMA의 增加率은 高線量水準에서 적었으며 2.0Mrad水準은 도리어 貯藏初期에 비하여 末期에 이르러 TMA의 含量을 減少시켰다. TMAO의 減少率은 貯藏條件에 관계없이 照射後 20日傾부터는 急激한 減少現象을 나타내었다. Total nitrogen의 減少는 無照射區에서 가장 컸으며, 照射水準이 높아짐에 따라 變化의 폭은 적었다. VBN含量은 各 處理區 모두 D30에서 顯著한 增加를 보이고 있었으며, 放射線處理에 따라 多少 抑制되었다. 放射線照査와 室溫貯藏區에서는 20日까지, 放射線照査 및 冷藏處理區에서는 40日까지 鹽乾옥돔의 鮮度를 유지시킬 수가 있었다. 組織變化, 總菌數, 腐敗 등 要因을 考慮할 때 鹽乾옥돔의 貯藏性向上을 위해서는 1.0Mrad가 適正水準으로 推定되었다. Salted dry yellow sea bream were vaccum packed in a plastic bags and irradiated at differents levels (0.0.5, 1.0, 1.5 and 20 Mrad) using ?? source. The irradiated samples were stored at room temperature and 5℃. Physical and chemical properties were examined during storage. The total bacterial count was depressed according to level of irradiation applied. It was noted that cold storage after irrdiation was more effective than room temperature. TMA contents slowly increased with higher dosage rates up to 1.5 Mrad but there was a gradual decrease of TMA at the 2.0 Mrad level.It was observed that there was a rapid decrease of TMAO 20 days after irradiation irrespective of storage temperature. The reduction of total nitrogen content was highest in the control but to a lesser degree when irradiation was applied. VBN content increased in all treatments 30 days after irradiation but it was also noted that there was a tendency toward depression of VBN by irradiation. The shelf life of salted dry sea bream was extended by 20 days with irradiation plus room temperature, and by 40 days with irradiation plus cold storage. To extend shelf life of salted dry sea bream, the most effective dosage rate was 1.0 Mrad based on tenderness, bacterial count and rancidity.

혈청이 마우스 간 세포주 BNL CL.2의 Nitric Oxide 생성에 미치는 영향

유지창,정헌택,김유현,진효상,김신무,배현옥 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1

마우스 간 세포주인 BNL CL.2의 시험관내 배양에서 혈청과 IFN-γ가 세포주의 nitric oxide(NO) 생성과 세포 손상에 미치는 영향을 알아보기 위한 실험을 하였다. 혈청이 공급된 배양에서 IFN-γ에 의한 세포 생존율은 거의 변동이 없었으나, 혈청을 제거한 배양에서는 약 65%의 생존율이 유지되었으며, NO 생성 억제제인 N -monomethy-L-arginine (NMA)의 첨가는 농도 의존적으로 세포의 생존율을 감소시켰다. 혈청이 제거된 BNL CL.2세포주는 IFN-γ단독 처리에서도 NO 를 생성할 수 있었으며, IFN-γ와 lipopolysaccharide (LPS)의 복합 처리는 세포주의 NO 생성을 상승적으로 증가시켰다. 또한 protein tyrosine kinase (PTK) inhibitor인 herbimycin A와 genistein에 의해서 NO 생성이 억제되어 PTK의 활성이 혈청이 고갈된 BNL CL.2 세포에서 NO의 생성에 중요한 역할을 담당하고 있기 때문으로 판단된다. IFN-γ의 독성은 혈청을 제거시킬 때 NO 생성 억제제에 상승적으로 간 세포를 손상시키며, 이때 NO가 IFN-γ에 의해 유도된 손상을 어느 정도 억제시키는 것을 알 수 있었다. Nitric oxide (NO) plays an important role in immunologic defense, and influences upon the functioning of secretory tissues and cells. It also exhibits cytotoxic/cytostatic activity as one of major operating effectors of the cellular immunity system. We investigated the effects of serum on the cell damages and NO production in the mouse liver cell line BNL CL.2 to establish the role of NO. We observed that, when BNL CL.2 cells were cultured in serum-free medium, they were induced to cell damage by the stimulation of IFN-γalone or IFN-γplus LPS. Serumstarved cells showed large amount of nitrite accumulation and NO synthase (NOS) expression in response to IFN-γalone in dose-and time-dependent manners, but serum-supplied cells did not. The production of NO was blocked by protein tyrosine kinase (PTK) inhibitors, genistein and herbimycin. These results suggest that the deprivation of serum in the BNL CL.2 cell culture medium might primed with the cells to produce NO when the cells are triggered by IFN-γ and the involvement of PTK signal transduction pathway in the expression of NOS gene in murine hepatocytes.

放射線照射에 의한 柑橘貯藏에 관한 硏究

鄭昌朝,趙漢玉,金洙賢,金在河 제주대학교 방사능이용연구소 1985 연구보고 Vol.1 No.-

柑橘의 貯藏性 向上을 爲한 ?? 線 照射가 濟州産 溫洲柑橘에 미치는 影響을 調査하였다. 溫洲柑橘 4個 系統을 10,000Ci, ?? 線源을 利用 0, 50, 100, 150Krad水準으로 照射하여 92日間 半地下式 貯藏庫에 貯藏, 調査한 結果를 要約하면 아래와 같다. 1. 貯藏終了時까지의 柑橘 累積腐敗率은 中生系인 米澤(T₂) 74.32%, 早生溫洲(T₁) 69.67%, 中晩生系林溫洲(T₃) 61.79%와 晩生系 靑島(T₄)가 64.33%였다. 反面 서울地域의 腐敗率은 D-72에서 T₁; 28%, T₃; 25% 및 T₄; 24%로 濟州地域에 比해 越等히 낮았다. 柑橘의 腐敗는 貯藏初期에 徐徐히 增加하나 照射後 59日부터는 急激히 上昇하기 始作하였다. 腐敗率과 柑橘系統 사이에는 高度의 相關關係가 있었으며 貯藏性은 T₃와 T₄가 가장 우수하였다 ??. 高放射線 照射水準(100, 150Krad)은 貯藏中期까지 柑橘貯藏에 效果가 있었으나 照射 76日 以後에는 對照區와 差가 없었다. 2. 放射線 照射는 貯藏期間中 柑橘의 酸度를 減少 시켰으며 平均 酸度는 T₁; 1.01%, T₃; 1.01%, T₄; 0.84% 및 T₂; 0.77%로 柑橘系統 및 照射線量間에는 高度(P<0.01)의 有意差가 認定되었다. 3. 모든 處理區에서 還元糖과 全糖含量은 增加하고 있었으나 統計的 有意性은 없었고 50Krad照射區에서만은 對照區에 比해 有意的(P<0.01)으로 減少하고 있었다. 糖度는 T₁,T₄가 T₂, T₃에 比하여 높았으며 高線量水準(100, 150Krad)에서 Control에 比해 有意的인 減少가 있었다(P<0.01). Ascorbine 酸含量은 모든 處理區에서 貯藏時期가 經過됨에 따라 減少하였으며 高照射線量水準에서 對照區에 比해 有意的인 減少가 있었다(P<0.01). A study was conducted to evaluate the effect of ?? irradiation on the preservation of Satsuma mandarin in Cheju Island. Four varieties (S. m. early, S. m. Komezawa, S. m. Hayashi and S. m. Aoshima) were irradiated using 10,000 Ci, ?? ray with dosages of 0, 50, 100 and 150Krad. During 92 days of storage the effects of irradiation on mandarin properties were as follows; 1. At the end of storage period the accumulated fruit rotting percentage were S. m. Komezawa (T₂); 74.32%, S. m. early (T₁); 69.67%, S. m. aoshima (T₄); 64.33% and S. m. Hayashi (T₃); 61.79%. The rottings steadily increased from the early stage of storage and rapid spoilage continued after 59 days of irradiation. A high correlation existed between fruit rotting and varieties (T₃; Y=0.78x-15.30, T₄; Y=0.79x-12.29, T₁; Y=0.93x-9.01 and T₂; Y=0.79x-13.49). High dosages (100 and 150 Krad) improved fruit preservation during the mid storage stage. However 76 days after high dose irradiation there was no significant difference a rotting between irradiated fruit and the control. 2. Irradiation decreased acidity of fruit during storage (P<0.01). The mean acidities of examined varieties were T₁; 1.01%, T₃; 1.01%, T₄; 0.84% and T₂; 0.77%. A significant differences were observed in acidity between varieties and dosages (P<0.01). 3. With one exception in all treatments, the increase in free and total sugar content was not statistically significant. The exception was the 50 Krad treatment where the total sugar content decreased. T₁and T₄showed slightly higher value of Brix than T₂and T₃and were significantly (P<0.01) decreased by higher dosage. The ascorbic acid content in all treatments decreased with length of storage and also decreased significantly with a higher dosage.