http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김동찬,김호겸,민창기,김태현,김용욱 경희대학교 디자인연구원 2003 예술· 디자인학연구 Vol.6 No.1
The purpose of this study is to design a basic draft of a monumental inscription with a poem of a peace for stirring up a peaceful mind. The inscription is expected to be a place for arousing a peaceful mind to visitors. Moreover, this place can be a place for culture and rest, which uplifts the image and phase of Kyunghee University to both.
Kim, Hwa,Oh, Seok-Jeong,Kwak, Hui-Chan,Kim, Jong-Kyu,Lim, Cheol-Hong,Yang, Jeong-Sun,Park, Kwangsik,Kim, Sang-Kyum,Lee, Moo-Yeol Taylor Francis 2012 Journal of toxicology and environmental health. Pa Vol.75 No.24
<P>Carbon black (CB) is an industrial chemical with high potential for human exposure. Although the relationship between exposure to particulate matter (PM) and cardiovascular disease is well documented, the risk of adverse cardiovascular effects attributed to CB particles has not been clearly characterized. This study was performed to (1) investigate the effects of CB on cardiovascular system and (2) identify the target tissue or potential biomarkers. Carbon black with a distinct particle size, N330 (ultrafine particle) and N990 (fine particle), was intratracheally instilled into rats at a doses of 1, 3, or 10 mg/kg. Measurements of thrombotic activity and determination of plasma homocysteine levels, cardiac functionality, and inflammatory responses were conducted at 24-h and 1-wk time points. Exposure to N330 accelerated platelet-dependent blood clotting at 10 mg/kg, the highest exposure tested. Unexpectedly, both N330 and N990 led to prolongation of activated partial thromboplastin time (aPTT), whereas these CB particles failed to affect prothrombin time (PT). N990 produced a significant elevation in the level of plasma homocysteine, a well-established etiological factor in cardiovascular diseases. Both N330 and N990 induced apparent inflammation in the lungs; however, both particles failed to initiate systemic inflammation. Neither CB particle produced observable cardiac symptoms as detected by electrocardiography. Taken together, data show CB exposure enhanced the cardiovascular risk by inducing hyperhomocysteinemia and platelet hyperactivity, although these effects may be variable depending on particle size and exposure duration. Homocysteine may be a potential biomarker for cardiovascular toxicity following CB exposure.</P>
IRF7 promotes glioma cell invasion by inhibiting AGO2 expression.
Kim, Jun-Kyum,Jin, Xiong,Ham, Seok Won,Lee, Seon Yong,Seo, Sunyoung,Kim, Sung-Chan,Kim, Sung-Hak,Kim, Hyunggee Saikon Pub. Co 2015 TUMOR BIOLOGY Vol.36 No.7
<P>Interferon regulatory factor 7 (IRF7) is the master transcription factor that plays a pivotal role in the transcriptional activation of type I interferon genes in the inflammatory response. Our previous study revealed that IRF7 is an important regulator of tumor progression via the expression of inflammatory cytokines in glioma. Here, we report that IRF7 promotes glioma invasion and confers resistance to both chemotherapy and radiotherapy by inhibiting expression of argonaute 2 (AGO2), a regulator of microRNA biogenesis. We found that IRF7 and AGO2 expression levels were negatively correlated in patients with glioblastoma multiforme. Ectopic IRF7 expression led to a reduction in AGO2 expression, while depletion of IRF7 resulted in increased AGO2 expression in the LN-229 glioma cell line. In an in vitro invasion assay, IRF7 overexpression enhanced glioma cell invasion. Furthermore, reconstitution of AGO2 expression in IRF7-overexpressing cells led to decreased cell invasion, whereas the reduced invasion due to IRF7 depletion was rescued by AGO2 depletion. In addition, IRF7 induced chemoresistance and radioresistance of glioma cells by diminishing AGO2 expression. Finally, AGO2 depletion alone was sufficient to accelerate glioma cell invasion in vitro and in vivo, indicating that AGO2 regulates cancer cell invasion. Taken together, our results indicate that IRF7 promotes glioma cell invasion and both chemoresistance and radioresistance through AGO2 inhibition.</P>
탄성응력파를 이용한 터널라이닝 배면의 비파괴 평가에 대한 실험적 연구
김문겸 ( Kim Moon-kyum ),이재영 ( Lee Jae-yung ),김병찬 ( Kim Byung-chan ) 한국구조물진단유지관리공학회 1998 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.2 No.1
In this study, the Impact-Echo Test, which is one of nondestructive tests(NDT), is proposed to predict the mechanical conditions behind tunnel lining, and the test method is to be improved, to be applied real object, and to be utilized in practical situations. A reduced tunnel model is made to perform the nondestructive model test, and the efficiency of the proposed test is investigated. Additionally, destructive test is carried out at the same routine to evaluate material properties, the elastic modulus and the compressional strength of concrete. The property values are compared with the values by nondestructive test. The NDT using the characteristics of the elastic stress waves can be used to estimate the material properties instead of destructive method. Finally, the modified Impact-Echo Test is more efficient tool for detecting the flaw behind concrete lining, for estimating the soundness of the whole structure. In the modified Impact-Echo Test, two transducers measure complex dynamic responses at the same time, and the responses provide informations of the void location. A systematic NDT system is needed for adaptation of the proposed method to practical problems, and the advances of the related fields make it possible to evaluate the stability of the tunnel structures.