Phosphorus Removal in Pilot Plant Using Biofilm Filter Process from Farm Wastewater

Shin, Sung-Euy,Choi, Du-Bok,Lee, Choon-Boem,Cha, Wol-Suk The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.4

Various environmental conditions affecting total phosphorus removal from farm wastewater in a biofilm filter process were investigated using loess balls and Chromobacterium LEE-38 at a pilot plant. When Chromobacterium LEE-38 was used, the removal efficiency of total phosphorous was approximately 10- or 5-fold higher than that of Acinetobacter CHA-2-14 or Acinetobacter CHA-4-5, respectively. When a loess ball of $11{\sim}14mm$ manufactured at a $960^{\circ}C$ calcining temperature was used, the removal efficiency of total phosphorous was 90.0%. When 70% of the volume fraction was used, the maximum efficiency of total phosphorus removal was 93.1%. Notably, when the initial pH was in the range of 6.0 to 8.0, the maximum removal efficiency of total phosphorus was obtained after 30 days. When the operating temperature was in the range of 30 to $55^{\circ}C$, the maximum removal efficiencies of total phosphorus, 95.6 to 94.6%, were obtained. On the other hand, at operating temperatures below $20^{\circ}C$ or above $40^{\circ}C$, the removal efficiency of total phosphorous decreased. Among the various processes, biofilm filter process A gave the highest removal efficiency of 96.4%. Pilot tests of total phosphorus removal using farm wastewater from the biofilm filter process A were carried out for 60 days under optimal conditions. When Acinetobacter sp. Lee-11 was used, the average removal efficiency in the p-adsorption area was only 32.5%, and the removal efficiencies of chemical oxygen demand (COD) and biological oxygen demand (BOD) were 56.7 and 62.5%, respectively. On the other hand, when Chromobacterium LEE-38 was used, the average removal efficiency was 95.1%, and the removal efficiencies of COD and BOD were 91.3 and 93.2%, respectively.

Gender-related Differences in Management of Nonvalvular Atrial Fibrillation in an Asian Population

Lee, Jung Myung,Kim, Tae-Hoon,Cha, Myung-Jin,Park, Junbeom,Park, Jin-Kyu,Kang, Ki-Woon,Shim, Jaemin,Uhm, Jae-Sun,Kim, Jun,Park, Hyung Wook,Lee, Young Soo,Choi, Eue-Keun,Kim, Chang-Soo,Joung, Boyoung,K The Korean Society of Cardiology 2018 Korean Circulation Journal Vol.48 No.6

<P><B>Background and Objectives</B></P><P>Gender-related differences in health care utilization for atrial fibrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations.</P><P><B>Methods</B></P><P>The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed.</P><P><B>Results</B></P><P>A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA<SUB>2</SUB>DS<SUB>2</SUB>-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and non-vitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufficient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001).</P><P><B>Conclusions</B></P><P>Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufficient NOAC dosing was common in both sex, it was significantly more frequent in women.</P>

A cephalometric study on the velopharyngeal changes after maxillary protraction

Lee, Nam-Ki,Cha, Bong-Kuen 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

이 연구의 목적은 훼이스마스크로 상악 전방견인치료를 받은 성장기 골격성 Ⅲ급 부정교합자 25명(남 10, 여 15, 평균나이 9.9세)에서 단기간의 정적인 구개범인두 변화를 측모두부방사선 계측사진상에서 선 계측, 각도 계측 및 비율 계측을 시행하여 평가하는 것이다. 경구개 평면각의 변화량은 maxillary depth 또는 N perp to A의 변화량과 음의 상관관계를 보였다(p <0.01). 경 연구개 각의 증가는 유의성이 있었으며, 이는 경구개 평면각의 변화보다 연구개 평면각의 변화의 영향을 더 받았다(p <0.001). 연조직 과 경조직 비인두 깊이의 증가는 유의성이 있었으며 (p <0.001), 이들의 변화량과 연구개 평면각의 변화량간에는 양의 상관관계를 보였다(p <0.05). 경구개 길이의 증가는 유의성이 있었으며 (p <0.001), 이는 연조직 비인두 깊이의 증량과 음의 상관관계를 보였다(p <0.05). Need 비율 S (C)의 증가는 유의성이 있었으나 (p <0.001), 이러한 증가는 이전 연구에서 보고된 Need 비율 S (C)의 정상범위 내에 있었다. 이 연구로 상악골의 전방견인 후에 정적인 구개범인두 부위에 변화가 있을지라도 구개범인두의 적격성이 유지됨을 알 수 있었다. The purpose of this study was to investigate cephalometrically the short term static velopharyngeal changes in 25 patients (10 boys and 15 girls, aged from 5 years 9 months to 12 years 10 months in the beginning of treatment) with skeletal Class Ⅲ malocclusions who underwent nonsurgical maxillary protraction therapy with a facemask The linear, angular and ratio measurements were made on lateral cephalograms. Only the change in hard palatal plane angle was negatively correlated with the change in maxillary depth or N-perp to A (p < 0.01). The change in velar angle showed a statistically significant increase (p < 0.001). This change was influenced more by the soft palatal plane angle than by the hard palatal plane angle (p < 0.001). The changes in soft tissue nasopharyngeal depth and hard tissue nasopharyngeal depth showed statistically significant increases (p < 0.001). Correlations between the changes in soft tissue (or hard tissue) nasopharyngeal depth and the change in soft palatal plane angle were significant (p < 0.05). The increase in hard palate length was statistically significant (p < 0.001). The change in hard palate length was negatively correlated with the change in soft tissue nasopharyngeal depth (p < 0.05). The change in need ratio S (C) showed a statistically significant increase (p < 0.001). But this difference was within the normal range reported by previous studies. These findings indicate that the velopharyngeal competence was maintained even if the anatomical condition of the static velopharyngeal area were changed after maxillary protraction.

Prevalence of Non-valvular Atrial Fibrillation Based on Geographical Distribution and Socioeconomic Status in the Entire Korean Population

Lee, So-Ryoung,Choi, Eue-Keun,Han, Kyungdo,Cha, Myung-Jin,Oh, Seil The Korean Society of Cardiology 2018 Korean Circulation Journal Vol.48 No.7

<P><B>Background and Objectives</B></P><P>Prevalence of atrial fibrillation (AF) varies based on geographical location and socioeconomic status. We aimed to evaluate the prevalence of AF and utilization of antithrombotic therapy based on geographical regions and income levels in the entire Korean population.</P><P><B>Methods</B></P><P>We performed a cross-sectional analysis of Korean adults (aged ≥20 years) using the 2015 National Health Insurance Service database (n=41,505,679). The study population was stratified into 17 geographical regions and 21 income levels.</P><P><B>Results</B></P><P>We identified 276,842 patients diagnosed with AF. Overall prevalence of AF in suburban/rural regions was significantly higher than that observed in urban regions (0.72% vs. 0.61%, respectively, p<0.001). Elderly patients (age ≥75 years) showed a higher prevalence of AF and comorbidities related to AF development showed a higher prevalence among the population residing in suburban/rural regions. Among AF patients with a CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score ≥2, oral anticoagulation (OAC) therapy utilization was lower in the suburban/rural regions than that observed in the urban regions (48.2% vs. 51.8%, respectively, p<0.001). The relationship between income levels and AF prevalence showed a J-shaped curve. The OAC prescription rate showed a positive correlation with income levels. Non-vitamin K antagonist oral anticoagulants tended to be more commonly prescribed among the higher income groups.</P><P><B>Conclusions</B></P><P>Geographical location of residence and income levels were closely associated with the prevalence of AF and antithrombotic therapy utilization. This information may provide further insights for more effective surveillance of AF and stroke prevention for improved clinical outcomes.</P>

Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA₂DS₂-VASc score in the entire Korean population

Lee, So-Ryoung,Choi, Eue-Keun,Han, Kyung-Do,Cha, Myung-Jin,Oh, Seil Elsevier 2017 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.236 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Data on the epidemiology of atrial fibrillation (AF) and temporal trends are not well established in the Korean population. We aimed to estimate the incidence and prevalence of AF in Korea between 2008 and 2015.</P> <P><B>Methods</B></P> <P>Using the National Health Insurance Service database, we analyzed as a nationwide cohort the entire Korean adult population from 2008 to 2015 (<I>n</I> =41,505,679 in 2015). AF was identified by using diagnostic codes.</P> <P><B>Results</B></P> <P>During an 8-year period representing 314,311,360 person-years of follow-up, 496,341 individuals were newly diagnosed with AF. The incidence of AF increased to >1.12-fold as follows: from 15.34 to 17.14 per 10,000 person-years (<I>p</I> <0.001). We also found a 1.68-fold increase in the prevalence of AF, from 0.46% in 2008 to 0.67% in 2015 (<I>p</I> <0.001). The incidence and prevalence of AF increased with advancing age. The median age of the AF patients increased from 68 to 71years (<I>p</I> <0.001). The prevalence of diabetes and heart failure in AF subjects increased (<I>p</I> <0.001). The percentage of patients with a CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score of ≥2, who were strongly recommended for anticoagulation treatment, increased from 80.2% to 86.8% (<I>p</I> <0.001).</P> <P><B>Conclusion</B></P> <P>The incidence and prevalence of AF gradually increased from 2008 to 2015. The proportion of AF patients who were candidates for anticoagulation therapy also significantly increased owing to population aging and increasing comorbidities (i.e., heart failure and diabetes). These findings may provide a framework to understand the actual disease burden and establish the optimal management strategy for AF.</P>

Therapeutic Effect of Dioctahedral Smectite on Diarrhea Caused by E. coli and Salmonella in Calves

Hu Jang Lee1,3*, Chun-Nam Cha, Yeo-Eun Lee, Hyunju Choi, Joon-Seob Shin, Suk Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

The objectives of the current study were to evaluate the therapeutic effect of dioctahedral smectite (smectite) against calf diarrhea caused by pathogenic E. coli and/or Salmonella typhimurium. In this study, 20 calves (aged 2~3 months) with diarrhea were used for evaluation of the efficacy of smectite on calf diarrhea with 20% smectite suspension in PBS. Calves received 10 ml smectite suspension three times per day after feeding, and fecal samples were collected at the gate of treatment and on the first, second, third, fourth, and fifth day after administration. On the fifth day after treatment with smectite suspension, the diarrhea index showed a significant decrease in the treated group, compared to the control group (P<0.001). The number of pathogenic E. coli in feces of the treated group was significantly decreased, compared to each control group from the second day after treatment (P<0.001), and that of Salmonella typhimurium was significantly decreased from the first day after treatment (P<0.05). According to the results of the current study, 20% smectite suspension had a therapeutic effect on diarrhea caused by E. coli and/or Salmonella in calves.

P*TIME: 실시간 엔터프라이즈의 고성능 트랜잭션 처리를 위한 메모리 중심의 경량 DBMS

차상균(Sang K. Cha1),송창빈(Changbin Song),권근주(Keunjoo Kwon),이용식(Yongsik Lee),김기홍(Kihong Kim),이동헌(Dongheun Lee),이주창(Juchang Lee),황상용(Sangyong Hwang),노재윤(Jaeyun Noh),권용식(Yongsik Kwon),윤용식(Yongsik Yoon) 한국정보과학회 데이터베이스 소사이어티 2003 데이타베이스 연구 Vol.19 No.4

Comparative occurrence of ischemic stroke with the rhythm versus rate control strategy in a national prospective cohort of atrial fibrillation

( Jae Guk Kim ),( Young Soo Lee ),( Ki-woon Kang ),( Eue-keun Choi ),( Myung-jin Cha ),( Jung-myung Lee ),( Jin-bae Kim ),( Junbeom Park ),( Jin-kyu Park ),( Tae-hoon Kim ),( Jae-sun Uhm ),( Jaemin Sh 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1

Background/Aims: Comparative occurrence of ischemic stroke for rhythm versus rate control strategy in patients with non-valvular atrial fibrillation (NVAF) is still inconclusive. The purpose of this study was to investigate whether the rhythm control strategy is associated with a lower risk of ischemic stroke compared to the rate control strategy in NVAF patients. Methods: The CODE-AF registry prospectively enrolled 6,280 consecutive patients who were treated for NVAF at 10 tertiary referral centers in South Korea. Of these, 2,513 NVAF patients (age, 67 ± 10 years; male, 61.8%) were clinically followed up for over 1-year and divided into rate and rhythm control groups. Results: Those treated with the rhythm control strategy were younger and had less proportions of underlying disease compared to those treated with the rate control strategy. After the propensity matching analysis, those treated with the rhythm control strategy had similar baseline characteristics including the CHA₂DS₂-VASC score compared to those treated with the rate control strategy. The rate of oral anticoagulation, all bleeding, and hospitalization were also similarly between the two groups. The incidence rate of ischemic stroke in the rhythm control group was significantly lower than in the rate control group (0.7 vs. 6.9 per 1,000 person-years, p = 0.011). Conclusions: The rhythm control strategy demonstrated a beneficial effect to lower the risk of ischemic stroke during a 1-year follow-up compared to the rate control strategy.

가평 전주이씨묘 출토복식 고찰

최연우,박윤미,김윤경,김지희,박양희,이선우,차서연,편나영,황혜남,Choi, Yeon Woo,Park, Yoon Mee,Kim, Yoon Gyung,Kim, Ji Hee,Park, Yang Hee,Lee, Seon U,Cha, Seo Yeon,Pyeon, Na Young,Hwang, Hye Nam 한국의류학회 2017 한국의류학회지 Vol.41 No.5

In 1995, the costumes were restored in an unknown woman's tomb at the Jeonju Lee's family cemetery in Gapyeong, Gyeonggi-Do, and there are currently nine items remaining. In this study, we first introduced these 9 relics to academia and analyzed the morphological characteristics of the costumes. We also estimated the time and person of burial compared with costumes unearthed from other burials. Jeogories (short jacket) are all four items. One of these items was unusual in shape, and the upper part of the seop (gusset) was wrinkled and shaped. This type of Jeogori appears only till the 1520s in other tombs. There are also two skirts, one of which is characterized by a superimposed pattern. The top and bottom / middle part of the skirt were rolled up, and the skirt, which was double-rolled up in this way, was first discovered. An analysis of the shape of Jeogori and skirt indicated that the person buried in the Jeonju Lee's family tomb was believed to have survived until the early 16th century. Based on these estimated periods, as a result of looking at the genealogy of Jeonju Lee's family, it was concluded that the tomb was probably a woman named Lee Geum Myeong (李金命) born in the mid-15C and died between the late 15C and the early 16C.

Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study

Choi, You-Jung,Choi, Eue-Keun,Han, Kyung-Do,Jung, Jin-Hyung,Park, Jiesuck,Lee, Euijae,Choe, Wonseok,Lee, So-Ryoung,Cha, Myung-Jin,Lim, Woo-Hyun,Oh, Seil Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.273 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period.</P> <P><B>Methods</B></P> <P>Using the Korean National Health Insurance Services database, we identified patients diagnosed with HCM from the entire Korean population between 2005 and 2015. The annual prevalence and incidence of AF and stroke in HCM patients were estimated.</P> <P><B>Results</B></P> <P>The prevalence of AF in HCM patients has gradually increased to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. The incidence of AF ranged from 4.1 to 5.5%, a similar trend was observed for each year in HCM patients. The prevalence of stroke in HCM patients was approximately 10%, while that in HCM patients with AF was about 20%. During 8741 person-years, AF-related stroke occurred in 257 subjects among 2309 HCM patients with new-onset AF. The overall incidence rate of AF-associated stroke was 2.94 per 100 person-years. In subgroup analysis, the incidence rate of AF-associated stroke was 1.49 per 100 person-years in the under 45 year-old group and 1.48 per 100 person-years in the group with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point in HCM patients.</P> <P><B>Conclusions</B></P> <P>The prevalence of AF in HCM patients gradually increased over 10 years. The annual risk of AF-associated stroke in HCM was over 1% even in younger patients and those with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point, which provide evidence to support the prevention of stroke in HCM patients with AF.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This is the first largest nationwide study on hypertrophic cardiomyopathy (HCM), a rare myocardial disease in Korea. </LI> <LI> The prevalence of AF in HCM patients gradually increases to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. </LI> <LI> The annual incidence of AF in HMC patients was about 5%, and higher in female and the elderly. </LI> <LI> The prevalence of stroke in HCM patients with AF was about 20%, which were more than twice that in overall HCM patients. </LI> <LI> The risk of AF-related stroke in HCM patients was >1% per person-year even in younger patients or low CHA<SUB>2</SUB>DS<SUB>2</SUB>­VAS<SUB>C</SUB> score. </LI> </UL> </P>