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Positivity properties of the bundle of logarithmic tensors on compact Kähler manifolds
Campana, Fré,dé,ric,Pă,un, Mihai London Mathematical Society 2016 Compositio mathematica Vol.152 No.11
<P>Let $X$ be a compact Kähler manifold, endowed with an effective reduced divisor $B=\sum Y_{k}$ having simple normal crossing support. We consider a closed form of $(1,1)$-type $\unicode[STIX]{x1D6FC}$ on $X$ whose corresponding class $\{\unicode[STIX]{x1D6FC}\}$ is nef, such that the class $c_{1}(K_{X}+B)+\{\unicode[STIX]{x1D6FC}\}\in H^{1,1}(X,\mathbb{R})$ is pseudo-effective. A particular case of the first result we establish in this short note states the following. Let $m$ be a positive integer, and let $L$ be a line bundle on $X$, such that there exists a generically injective morphism $L\rightarrow \bigotimes ^{m}T_{X}^{\star }\langle B\rangle$, where we denote by $T_{X}^{\star }\langle B\rangle$ the logarithmic cotangent bundle associated to the pair $(X,B)$. Then for any Kähler class $\{\unicode[STIX]{x1D714}\}$ on $X$, we have the inequality $$\begin{eqnarray}\displaystyle \int _{X}c_{1}(L)\wedge \{\unicode[STIX]{x1D714}\}^{n-1}\leqslant m\int _{X}(c_{1}(K_{X}+B)+\{\unicode[STIX]{x1D6FC}\})\wedge \{\unicode[STIX]{x1D714}\}^{n-1}.\end{eqnarray}$$ If $X$ is projective, then this result gives a generalization of a criterion due to Y. Miyaoka, concerning the generic semi-positivity: under the hypothesis above, let $Q$ be the quotient of $\bigotimes ^{m}T_{X}^{\star }\langle B\rangle$ by $L$. Then its degree on a generic complete intersection curve $C\subset X$ is bounded from below by $$\begin{eqnarray}\displaystyle \biggl(\frac{n^{m}-1}{n-1}-m\biggr)\int _{C}(c_{1}(K_{X}+B)+\{\unicode[STIX]{x1D6FC}\})-\frac{n^{m}-1}{n-1}\int _{C}\unicode[STIX]{x1D6FC}.\end{eqnarray}$$ As a consequence, we obtain a new proof of one of the main results of our previous work [F. Campana and M. Păun, <I>Orbifold generic semi-positivity: an application to families of canonically polarized manifolds</I>, Ann. Inst. Fourier (Grenoble) 65 (2015), 835-861].</P>
Parametric Analysis of Slamming Forces: Compressible and Incompressible Phases
Campana, E.F.,Carcaterra, A.,Ciappi, E.,Iafrati, A. The Society of Naval Architects of Korea 2000 Journal of ship and ocean technology Vol.4 No.1
The slamming force occurring in the free fall impact of cylindrical bodies on the water surface is analyzed in both compressible and incompressible stages. In the compressible phase the hydrodynamic analysis is carried on by the acoustic approximation, obtaining a closed form expression for the maximum impact force. The incompressible analysis is approached through and unsteady boundary element method to compute the free surface evolution and the slamming force on the body. A similar behavior seems to characterize the maximum slamming force versus a dimensionless mass parameter.
Campana, P.E.,Leduc, S.,Kim, M.,Olsson, A.,Zhang, J.,Liu, J.,Kraxner, F.,McCallum, I.,Li, H.,Yan, J. ELSEVIER 2017 APPLIED ENERGY -BARKING THEN OXFORD- Vol.185 No.2
<P>The results indicate that the photovoltaic water pumping systems provide high potential for improving forage productivity, contributing to meet the local demand. The optimal areas are highly sensitive to several environmental and economic parameters such as increased forage potential yield, forage management costs, forage water requirements, ground water depth, forage price and CO2 price. Most of the optimal areas are selected when the market forage price ranges from 300 to 500 $/tonne DM, indicating that the forage produced using PVWP technology for irrigation is already competitive compared to the imported forage. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Antimicrobial Activity of Two Propolis Samples Against Human Campylobacter jejuni
Raffaella Campana,Vania Patrone,Ingrid Tarsilla Maria Franzini,Giuseppe Diamantini,Emanuela Vittoria,Wally Baffone 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
The aim of this study was to analyze the antimicrobial activity of two ethanolic extracts of propolis (EEPs) and selected flavonoids against 16 Campylobacter jejuni clinical isolates and several Gram-positive and Gram-negative human pathogens. The antimicrobial activity of EEPs and flavonoids was evaluated by the agar well diffusion method. The EEPs inhibited the growth of C. jejuni, Enterobacter faecalis, and Staphylococcus aureus. The most active flavonoid was galangin, with the highest percentage of sensitivity among C. jejuni strains (68.8%); lower percentages of sensitivity were observed for quercetin (50%). The minimal inhibitory concentrations (MICs) of EEPs and flavonoids for C. jejuni isolates were determined by the agar dilution method. EEPs showed MIC values of 0.3125–0.156mg/mL for all C. jejuni strains; galangin and quercetin gave MICs ranging from 0.250 to 0.125mg/mL. Thus propolis preparations could be used as support to traditional therapy for Campylobacter infection, especially when the antibiotic agents show no activity against this microorganism.
Distal migration of a partially covered duodenal stent requiring emergency surgical extraction
Luca Giovanni Campana,Rebecca Fish,Owen Thomas Dickinson,Mairéad Geraldine McNamara,Sarah Theresa O’Dwyer,Hans-Ulrich Laasch 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.2
Duodenal stenting is an established alternative for the palliation of malignant gastric outlet obstruction (MGOO). Despite being relatively rare, stent migration remains an issue of concern. We present a case of duodenal stent displacement in a 71-year-old female with biliary and duodenal strictures secondary to pancreatic cancer. She presented with acute abdominal pain 10 days following the insertion of a 24-mm partially covered double-layer knitted device, which migrated to the ileocaecal junction. Since the priority was to minimise hospitalisation, we performed a laparotomy with extraction through an enterotomy combined with gastrojejunostomy to bypass the duodenum. The patient resumed oral intake on postoperative day 9 and tolerated a semi-solid diet for 3 months, until death. Despite continuous advances in enteral stent design, patient surveillance remains paramount. This report illustrates the complex decision-making around MGOO, addresses the management of stent migration, and highlights the role of surgery in simultaneously treating stent complications and palliating duodenal obstruction.
Distal migration of a partially covered duodenal stent requiring emergency surgical extraction
Luca Giovanni Campana,Rebecca Fish,Owen Thomas Dickinson,Mairéad Geraldine McNamara,Sarah Theresa O’Dwyer,Hans-Ulrich Laasch 소화기인터벤션의학회 2022 Gastrointestinal Intervention Vol.11 No.2
Duodenal stenting is an established alternative for the palliation of malignant gastric outlet obstruction (MGOO). Despite being relatively rare, stent migration remains an issue of concern. We present a case of duodenal stent displacement in a 71-year-old female with biliary and duodenal strictures secondary to pancreatic cancer. She presented with acute abdominal pain 10 days following the insertion of a 24-mm partially covered double-layer knitted device, which migrated to the ileocaecal junction. Since the priority was to minimise hospitalisation, we performed a laparotomy with extraction through an enterotomy combined with gastrojejunostomy to bypass the duodenum. The patient resumed oral intake on postoperative day 9 and tolerated a semi-solid diet for 3 months, until death. Despite continuous advances in enteral stent design, patient surveillance remains paramount. This report illustrates the complex decision-making around MGOO, addresses the management of stent migration, and highlights the role of surgery in simultaneously treating stent complications and palliating duodenal obstruction.
Patching continuous-time signals using high-gain observers and 3rd order splines
Jesus A. Meda-Campana 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
In real-time applications, due to disturbances or problems inherent to the measurement systems, portions of the measured signal are lost or distorted. Thus, in those cases when the control goal is to track measured signals in real-time, the continuity and smoothness of the closed-loop system may be compromised. To minimize this problem, in this work, a method to patch the continuous-time signal is proposed. The approach, based on high-gain observers and third-order splines, allows taking into account not only the initial and the ending points of the missing part of the signal but the corresponding derivatives as well. As a result, a smooth signal is obtained. To illustrate the validity of the approach, a sufficiently complex signal, named the first state of the Lorenz attractor is reconstructed in the numerical experiments.
Expansion and Activation of Natural Killer Cells for Cancer Immunotherapy
조덕,Dario Campana 대한진단검사의학회 2009 Annals of Laboratory Medicine Vol.29 No.2
Natural killer (NK) cells can kill a wide range of cancer cells and are a promising tool for cell therapy of cancer. NK cells cytotoxicity is regulated by a balance between stimulatory and inhibitory signals. Interleukin-2 is known to increase NK cell cytotoxicity. Although many cytokines have been studied in efforts to induce durable NK cell expansions, most reports indicate a rather modest effect and the requirement for additional stimuli. We found that contact with the K562 myeloid leukemia cell line, genetically modified to express a membrane-bound form of interleukin-15 and the ligand for the costimulatory molecule 4-1BB, induced vigorous expansion of NK cells from peripheral blood. Based on these findings, we developed a method for large-scale clinical-grade expansion of NK cells. This method is currently used to expand allogeneic NK cells for infusion in patients with leukemia and solid tumors. We here summarize methods for expansion and activation of NK cells from human peripheral blood mononuclear cells as well as clinical-scale methods to produce NK cells for immunotherapy under Current Good Manufacturing Practices (cGMP) conditions.