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Wegener 씨 육아종 증례보고 1예 : A Case Report
정선관,임형근,정은택,노병석,김창근,원종진 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
Wegener's granulomatosis is characterized by necrotizing and granulomatous disease which involves upper, lower respiratory tract and kidney. The basic pathophysiologic mechanism of Wegener's granulomatosis is still unknown. We report a case of Wegener's granulomatosis which involved lung and pleura and was diagnosed by clinical symptoms, radiologic findings and anti-neutrophilic cytoplasmic autoantibodies.
불소 투여에 의한 흰쥐 경골의 골단판과 골간단의 전자현미경적 연구
장병수,임도선 東南保健大學 2002 論文集-東南保健大學 Vol.20 No.2
The purpose of this investigation was to study the initial effects of fluoride on bone resorption in the distal tibial epiphyseal plate and adjacent metaphyseal bone from young male rat given drinking water including 300ppm fluoride using by scanning electron microscopy. The tibia revealed an increase in the portion of mature hypertrophied cells of the epiphyseal plates as compared with normal control. The lacunae of rat which administered of fluoride, varied considerably in shape and size. and were arranged irregular forms. In the metaphysis of tibia, the cancellous bone was reduced and the network of trabeculae was sparsely distributed. The trabeculae were thin and evetually disppeared toward the center of the diaphysis. Mineralized bone treated with fluoride were markedly reduce. The surfaces of tibia were rough and irregular. The result of this study indicate that much dose of fluoride on bone include an inhibition of resorption in the epiphyseal plate and structural alternation of a metaphyseal trabecular bone.
법랑질형성 동안에 흰쥐 절치의 법랑모세포에 관한 현미경적 연구
장병수,임도선 東南保健大學 1999 論文集-東南保健大學 Vol.17 No.2
The aim of the present study was to examine in detail, both at light and electron microscopical levels, the morphological variations in ameloblast of the fetal rat incisor enamel organ. Rats were started on distilled water at the beginning of pregnancy. The pups were sacrificed 11 days after delivery and the animals were perfused intravascularly with glutaraldehyde and the incisors were removed. To examine on the ultrastructure of the ameloblast, the study employed primary light microscopy but electron microscopy was used to clarify some of the light microscopic findings. Longitudinal sections through the incisors of a show continuous layer of ameloblasts on the labial surface of the teeth. This layer contains the entire sequence of developmental stages in enamel production. The ameloblast layer was divided into three main zones: 1)Presecretory zone, region of ameloblasts facing pulp. 2)Secretory zone, region of inner and outer enamel secretion. 3)Maturation zone, region of reduced ameloblasts. In particularly, the present study has shown that two distinctively different types of ameloblasts appear in the enamel organ during enamel maturation in the rat incisors. These two types have been designated ruffle-ended ameloblasts(rAB) and smooth-ended ameloblasts(sAB).
메뚜기(Euprepocnemis shirakii Bolivar) 위심세포의 미세구조
余聖文,張炳秀,李成燦,林道善 단국대학교 1993 論文集 Vol.27 No.-
In Euprepocnemis shirakii Bolivar, the pericardial cells are arranged sparsely on each lateral side of the dorsal vessel. The basal lamina of the cell is about 70nm in diameter and functionally adapted for selective filtering of foreign materials from the hemolymph. Cytoplasm of the pericardial cell is structurally divided into two portions. The one is cortex area which consists with labyrinthine channel invaginated into cytoplasm, coated vesicles and α-vacuoles. The other is endoplasm which composed of nucleus, β-vacuoles and γ-vacuoles. The entrance of the labyrinthine canal fromed by invagination of the plasma membrane is junctioned by several membraneous diaphragm folding. So, we guess the membraneous diaphragm be involved in selective absorption of foreign material. Many coated vesicles are formed by pinocytosis of the labyrinthine canal, And these vesicles are then assembled to be α-vacuoles, β-vacuoles, which is present in the outskirts of the endoplasm, have two-folded outer membrane and been stuffed with electron-dense materials. γ-vacuoles consist with one membrane and have mid-electron dense materials in the membrane.
홍완성,장병수,임도선,박상옥,여성문 韓國電子顯微鏡學會 2000 Applied microscopy Vol.30 No.1
성인 남성의 모발에서 정상 모간과 자연상태에서 손상된 모간의 외부형태와 미세구조적 변화를 광학현미경과 주사 및 투과전자현미경으로 관찰하였다. 정상 모간은 모소피층, 모피질, 모수질 등의 3부분으로 구성되어 있었다. 모소피층은 5-7개의 모소피세포들이 중첩되어 모피질과 모수질을 둘러싸고 있고, 길게 신장되어 모피질을 둘러싸고 있는 소피세포의 두께는 약 0.4㎛로 확인되었다. 또한, 이들 세포사이에는 약 25㎛의 세포사이 막복합체가 관찰되었다. 모피질은 잘 발달되어 각질화세포(cornified cell)들로 치밀하게 채워져 있었고, 각질화세포는 직경 약 0.5-0.8㎛인 구형 또는 타원형외 macrofibril로 구성되어 있었으며, 이들은 약 8nm 두께의 가는 microfibri이 동심원상의 규칙적인 형태로 배열되어 있었다. 그리고 macrofibril 사이에는 약 0.5㎛크기의 직경을 가진 구형의 melanin과립들이 고르게 산재되어 관찰되었다. 모수질은 공기가 채워져 있었고, 직경이 약 16㎛의 구형의 형태로 모간의 전체 직경에 1/5 정도를 차지하고 있었다. 풍화에 의해 손상된 모간은 모소피층이 박리되어 있었으며, 모피질세포의 세포질도 손상되어 melanin과립들이 표면에 노출되어 있는 것이 확인되었다. 조직표본상에서 모소피층의 박리과정은 모소피 사이에 공포가 형성되고, 이어서 모소피의 가장자리가 떨어져 나가고, 박리되지 않은 부위는 절단되었다. 모소피가 탈락되어 모피질이 노출된 부위에서는 각질화세포내에 존재하는 macrofibri이 각각 분리되고, 인접원 macrofibril 사이에 공기가 채워지게 되어 오간의 풍화과정은 더욱 촉진되었다. 그리고 노출된 macrofibril 사이에서 탈락 직전의 melanin 과립들이 산재되어 관찰되었다. The morphological changes in normal and weathering hair shafts of the human scalp were investigated by using the transmission and scanning electron microscopes. The hair shaft composed of cuticular layer, cortex and medulla. The surface of normal hairs are smooth and covered by imbricated cuticular scales. The cuticular layer consists of five to seven cuticle cells. These cells, which are flat and thin, measuring about 100 ㎛ long and 0.4 ㎛ thick, appears intercellular membrane complex in diameter 25 nm. The cortex composed of melanin granules and cornified cells, which multicomponent concentric microfibrils in diameter about 8 nm give rise to macrofibrils in diameter 0.5 ㎛ to 0.8 ㎛ encased in limiting membrane. The melanin granules are spherical shaped about 0.5 ㎛ in size and scattered between macrofibrils. The medulla in the normal hairs are 16 ㎛ in diameter centrally region of cortex. Normal hair shafts undergo progressive degenerative changes due to a variety of environmental insults. In the initial weathering process of hair, the cuticular scales became irregularly raised and broken, and then cuticle cells formed cytoplasmic vacuolation, following dissociated intercellular membrane complex, ultimately entirely lost and nuded cortex. Occasionally, transverse fissures were seen at hair shafts indicating that the hairs were deteriorated Complete removal of the cuticular layer in the heavily damaged cortex portions appeared splitting of the cortical cell into its macrofibrils and scattering of melanin granules.