잠김 금속판을 이용한 대퇴골 전자하 골절의 치료 : 압박 고 나사와 비교

손현철, 김용민, 김동수, 최의성, 박경진, 조병기, 박지강, 배승환 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

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원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

라미부딘 내성 만성 B형 간염 환자에서의 아데포비어의 치료 효과

이지숙,장리라,이상욱,한병훈,윤병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Backgrounds/Aims : Adefovir dipivoxil(ADV) has been shown to be effective against lamivudine resistant strain of hepatitis B virus. But continuation of lamivudine therapy or switching to Adefovir dipivoxil in patients with viral breakthrough after long term lamivudine therapy are controversial. To find efficacy of adefovir dipivoxil, we retrospectively assessed clinical course after lamivudine resistance in patients who changed adefovir dipivoxil and continued lamivudine therapy. Methods : 58 patients with lamivudine resistant HBV mutants after at least 6 months of lamivudine treatment were included in this study. 24 of the 58 patients were treated with ADV and rest of them were continued the lamivudine therapy after lamivudine resistance. The continuous lamivudine treatment group (n=34) was divided into two groups according to ALT count (ALT≧40, n=19 vs ALT<40, n=16) The clinical course and the biochemical and virological response of the switching adefovir group were compared with those of continuing lamivudine group. HBV genotypes and YMDD mutation site was anaylzed by TRUGENE HBV Genotyping. Results : At twelve months, the levels of median serum HBV DNA and ALT was decreased and albumin was improved significantly(P<0.01) in adefovir switching group compared with lamivudine sustained group, especially ALT was elevated more than 40. There is no significant differences between adefovir switching group and lamivudine sustained group (ALT<40, n=15). This study showed that adefovir dipivoxil reduces HBV replication and improves not only biochemical markers of disease activity, but also liver function. HBV genotypes of 58 patients were all C and rtM204I/V mutant was the most common. Conclusion : This study provides an evidence that adefovir dipivoxil can be effective in the treatment of lamivudine-resistant HBV mutants, especially ALT elevated.

환율전가와 수출가격

오지영,유병철 東亞大學校 2002 東亞論叢 Vol.39 No.-

This paper studies the relationship between exchanges rates and export. We also investigate the asymmetry effect of exchange rates on export price using Korean quarterly data from 1990 to 1999. We found the strong evidence for asymmetry effect and estimated the degree of exchage rates pass through.

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.

Polyvinylfluorocinnamate 광배향막 표면에서의 액정배향에 관한 연구

이병현,함성근,임지철,송기국 慶熙大學校 材料科學技術硏究所 1997 材料科學技術硏究論集 Vol.10 No.-

광배향에 의하여 액정의 방향자가 유도되는 메카니즘을 이해하기 위하여 광반응성 고분자인 polyvinylfluorocinnamate의 UV 조사에 따른 구조변화를 FTIR과 UV/Vis spectroscopy를 이용하여 조사하였다. 선편광이 된 UV를 등방성의 고분자 필름에 조사하여 필름 내에 광학적 anisotropy가 형성되는 것을 확인하였고 이러한 배향막의 anisotropy에 의하여 액정의 방향자가 결정되는 것을 알 수 있었다. 광조사에 의하여 UV의 편광방향과 수직으로 늘어서게 된 분자 사슬내의 group들이 분산력에 의하여 액정분자의 배향을 조사된 UV의 편광방향과 수직인 방향으로 유도하는 것이다. In order to understand the induction mechanism of the liquid crystal director, structural changes of photosensitive polyvinylfluorocinnamate with UV irradiation were investigated using FTIR and UV/Vis spectroscopy. It was found that optical anisotropy was induced in the film by irradiation of linearly polarized UV light onto the isotropic polymer film, and such anisotropy in the film determined the direction of the liquid crystal director. The groups in the polymer, which are preferentially aligned perpendicular to the polarization direction after the UV exposure, induce liquid crystal alignment perpendicular to the polarization direction of UV via dispersive intermolecular interactions.

레이더를 이용한 콘크리트의 두께 측정과 유효 측정범위 설정에 관한 연구

임홍철,이지훈,손병오 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.4

콘크리트 구조물의 성능평가 방법의 하나로 최근 들어 레이더가 널리 쓰이고 있다. 콘크리트 구조물 적용에 대한 레이더법의 발전을 위해서는, 콘크리트의 전자기적 재료 특성과 레이더의 작동원리를 이해하고, 활용하는 체계적인 연구노력이 필요하다. 본 논문에서는 레이더법의 유효 측정범위 설정과 레이더를 이용한 콘크리트의 두께측정 방법을 제시하고, 레이더 측정을 통한 콘크리트의 유전상수 계산 방법을 제안한다. 실험에서는 900mm (길이) × 600mm (폭)에 두께 50mm, 100mm, 150mm, 200mm, 250mm의 콘크리트 시편 5개를 사용하였다.

출생 전 스트레스와 감금 스트레스가 흰쥐 편도복합체 별아교세포에 미치는 영향 : I. 별아교세포의 세포체에 미치는 영향

이지용,최병영,김동희,정원석,조병필,양영철 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3

신경계통의 가소성은 신경세포의 변화에 의해 이루어질 뿐 아니라 신경아교세포의 변화에 의해서도 이루어진다. 신경아교세포 중 별아교세포는 신경세포의 기능을 조절하므로 정상적인 뇌의 기능을 유지하는데 매우 중요하다. 뇌에서 편도복합체는 위험 혹은 유해한 일련의 감각정보를 받아들이는 구역으로 받아들인 일련의 이와 같은 정보를 통합하고 변환시켜 공포라는 감정을 만들어낸다. 이런 과정은 편도복합체 신경세포에서 분비되는 신경전달물질의 균형변화에 의해 이루어지며, 신경전달물질의 조절에 별아교세포가 관여하므로 본 연구에서는 출생 전 스트레스와 성장 후에 받은 스트레스가 편도복합체 별아교세포의 세포체에 어떤 영향을 미치는지 조사하였다. 이를 위해 흰쥐를 스트레스를 받지 않은 대조군 (CON), 성장 후 스트레스를 받은 군(CONR), 출생 전 스트레스를 받은 군(PNS), 출생 전 스트레스와 성장 후 스트레스를 모두 받은 군 (PNSR)으로 구분하였다. 별아교세포는 GFAP 항체를 이용한 면역조직화학 염색을 시행하여 확인하였으며, methylene blue/azure II로 대조 염색하였다. Neurolucida 프로그램을 이용하여 계측한 별아교세포의 세포체는 일부 편도복합체 신경핵에서 출생 전 스트레스를 받은 PNS군이 대조군에 비하여 면적이 증가하였으며, 이런 경향은 출생전 스트레스를 받고 다시 성장 후 스트레스를 받은 PNSR군에서 더욱 증가하였다. 따라서 흰쥐의 편도복합체에 분포하는 별아교세포는 스트레스에 영향을 받아 비대해지는 경향을 보인 것으로 나타났으며, 출생 전 스트레스가 성장 후에도 영향을 미치는것으로 사료된다. The plasticity of nervous system is generated not only due to changes in neurons but also due to changes in neuroglial cells. Astrocyte is important for maintaining the normal brain function and controlling the neuronal functions. The amygdala receives an array of important sensory information of danger signals. This information is further transduced and integrated to produce the highly adaptive emotion, fear. In this study, morphometric changes in the cell bodies of astrocytes in the amygdala, induced by prenatal stress and restraint stress were examined. For this purpose, rats were classified into 4 groups; control group (CON), only restraint-stressed (starting on P90 for 3 days) group (CONR), prenatally-stressed group (PNS), and prenatally and restraint (on P90 for 3 days) stressed group (PNSR). Astrocytes were verified with anti-GFAP immunohistochemistry, counter stained with methylene blue/azure II and were examined using the Neurolucida. Results showed that astrocytes in the amygdala of PNS rats had significantly larger cell bodies than did CON rats and this was enhanced further by restraint stress. Thus this data showed that hypertrophy of the astrocytic cell bodies of amygdala complex is induced by prenatal and restraint stress.

도금공정 크롬시료 분석을 위한 Microwave Oven Digestion/Atomic Absorption Spectrophotometry 방법의 정확도 및 정밀도 평가

이병규,이지태,신용철 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.1

The purpose of this study was to evaluate the analytical accuracy and precision of microwave oven digestion/atomi absorption spectrophotometry (AAS) for analyzing airborne chromium collected on mixed cellulose ester membrane (M filter from the work environment, and to compare the accuracy and the precision with those of the National Institute for Occupational Safety and Health (NIOSH) Metho? #7024 hot plate digestion/AAS method. For this study, field air sample pairs were collected from a electroplating process, and spiked samples in a laboratory were prepared and using these samples. Two digestion methods were comp? and evaluated in terms of recovery rate and bias as indices of accuracy and coefficient of variation as a index of precision. The results and conclusions are as follows. In spiked samples, the accuracies (% mean recoveries) of h? plate/AAS and microwave oven/AAS method were 97.19? 97.1%, respectively, and the precisions (pooled respectively, and the precisions (pooled coefficient of variance, CV_pooled) 6.93% and 3.88%, respectively. The biases of hot plate an? microwave oven methods were 4.56 - 14.7% and 2.2 - 7.? respectively. There was no statistically significant difference between hot plate and microwave oven methods recovery rates of spiked sample (p>0.05). Also, no statistically significant difference was shown among the concentrations of air samples determined by two method(p>0.05). In conclusion, microwave oven/AAS method h? excellent accuracy and precision, and advantages such as time-saving and simple procedure in comparison with th? classical NIOSH method. Therefore, this method can be use? widely to analyze airborne chromium collected on MCE filter from the work environments.

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.