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건일로딘 정(미결정에토돌락 200 ㎎)에 대한 에토돌 정의 생물학적동등성
이정애,이윤영,조태섭,박영준,문병석,김호현,이예리,이희주,이경률 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
A bioequivalence of Etodol™ tablets (Yuhan corporation) and Kuhnillodine™ tablets (Kuhnil Pharm, Co., Ltd.) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 200 ㎎ dose of etodolac of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a 2×2 cross-over design. Concentrations of etodolac in human plasma were monitored by a high-performance liquid chromatography. AUCt (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed AUCt and C_(max). No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the AUCt ratio and the C_(max) ratio for Etodol™/Kuhnillodine™ were 1.01 - 1.10 and 0.87 - 1.06, respectively. This study demonstrated a bioequivalence of Etodol™ and Kuhnillodine™ with respect to the rate and extent of absorption.
Ye, Byoung Seok,Seo, Sang Won,Lee, Yunhwan,Kim, Seong Yoon,Choi, Seong Hye,Lee, Young Min,Kim, Do Hoon,Han, Hyun Jeong,Na, Duk L.,Kim, Eun-Joo S. Karger AG 2012 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.34 No.3
<P>Abstract</P><P><B><I>Background:</I></B> Amnestic mild cognitive impairment (aMCI) is regarded as a prodromal stage of Alzheimer’s disease (AD). Given that patients with early-onset AD (EOAD) and with late-onset AD (LOAD) are known to have different clinical courses, symptoms and neuroimaging findings, early-onset (EOMCI) and late-onset aMCI (LOMCI) might be expected to have similar differences as EOAD versus LOAD. <B><I>Methods:</I></B> Our study involving 425 patients with aMCI (124 EOMCI, 301 LOMCI), who were followed for around 1.5 years, and 958 normal control subjects (NC) investigated neuropsychological characteristics and prediction of progression to AD in patients with EOMCI versus LOMCI. Neuropsychological scores were compared between EOMCI, LOMCI and NC with analyses of covariance controlling age, gender, education and disease duration. The risk of AD conversion was evaluated by Cox proportional hazard analyses. <B><I>Results:</I></B> The baseline neuropsychological performances were comparable between EOMCI and LOMCI. Visuospatial memory for EOMCI and verbal memory scores for LOMCI were significant predictors of AD conversion. <B><I>Conclusion:</I></B> Our study indicates that EOMCI with visuospatial memory impairment, which implies underlying right predominant pathology, and LOMCI with poor verbal memory, which suggests underlying left predominant pathology, are individual conditions at an increased risk of conversion to AD.</P><P>Copyright © 2012 S. Karger AG, Basel</P>
Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia
Ye, Byoung Seok,Seo, Sang Won,Kim, Jung-Hyun,Kim, Geon Ha,Cho, Hanna,Noh, Young,Kim, Hee Jin,Yoon, Cindy W.,Woo, Sook-young,Kim, Sook Hui,Park, Hee Kyung,Kim, Sung Tae,Choe, Yearn Seong,Lee, Kyung Han Ovid Technologies (Wolters Kluwer) - American Acad 2015 Neurology Vol.85 No.19
Ye, Byoung Seok,Jeon, Seun,Yoon, Sohoon,Kang, Seong Woo,Baik, KyoungWon,Lee, Yoonju,Chung, Su Jin,Oh, Jungsu S,Moon, Hyojeong,Kim, Jae Seung,Lee, Phil Hyu,Sohn, Young Ho British Medical Association 2018 Journal of neurology, neurosurgery and psychiatry Vol.89 No.2
<P>Conclusions The results of this study suggested that accumbens atrophy and frontotemporal cortical thinning, especially frontal cortical thinning, independently contributed to neuropsychiatric symptoms in patients with PD, while DAT uptake did not affect the neuropsychiatric symptoms.</P>
Gastrectomy and nigrostriatal dopaminergic depletion in de novo Parkinson's disease
Chung, Seok Jong,Jeon, Seun,Yoo, Han Soo,Yoon, Jung Han,Lee, Jee Eun,Kim, Joong‐,Seok,Kim, Soo‐,Jong,Oh, Jungsu S.,Kim, Jae Seung,Ye, Byoung Seok,Sohn, Young H.,Lee, Phil Hyu John Wiley Sons, Inc. 2019 Movement disorders Vol.34 No.2
Temporarily Hidden Multi-Object Tracking for Visually Impaired
Ye-Jin Kim(김예진),Hyeon-Seok An(안현석),Byoung-Chol Chang(장병철),Jae-Hyuk Cha(차재혁) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6
Visually Impaired (VI) face challenges regarding situational awareness, particularly in ensuring pedestrian safety. One crucial aspect of obstacle avoidance is the continuous tracking of objects, including temporarily hidden objects (THO). They are objects that have been detected in few frames within the previous one second frame sequence. Existing object tracking methods do not effectively track THO. So, we propose a method that determines whether the currently detected object has been in the previous 20 frames based on their distance and feature similarity. This allows continuous tracking of THO, improving object tracking for VI.
White matter hyperintensities as a predictor of freezing of gait in Parkinson's disease
Chung, Seok Jong,Lee, Yang Hyun,Yoo, Han Soo,Oh, Jungsu S.,Kim, Jae Seung,Ye, Byoung Seok,Sohn, Young H.,Lee, Phil Hyu Elsevier 2019 Parkinsonism & related disorders Vol.66 No.-
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>To investigate the effect of white matter hyperintensities (WMH) on long-term motor outcomes in Parkinson's disease (PD).</P> <P><B>Methods</B></P> <P>We retrospectively reviewed medical records of 268 patients with de novo PD (follow-up > 3 years). According to the Clinical Research Center for Dementia of South Korea (CREDOS) WMH visual rating scale scores, the patients were divided into two groups: a PD group with minimal WMH (PD-WMH-; n = 198) and a PD group with moderate to severe WMH (PD-WMH+; n = 70). We compared longitudinal increases in doses of dopaminergic medications between the two groups using a mixed model. We also assessed the effects of WMH on the development of freezing of gait (FOG).</P> <P><B>Results</B></P> <P>Patients in the PD-WMH + group were older than those in the PD-WMH- group, and had more severe motor deficits and more severely decreased striatal dopamine transporter availability. The PD-WMH + group required higher doses of dopaminergic medications for symptom control, compared to the PD-WMH- group, over the follow-up period. After adjusting for age, sex, striatal dopamine transporter availability, and levodopa-equivalent dose, the PD-WMH + group showed a higher risk of developing FOG (HR, 3.29; 95% CI, 1.79–6.05; p < 0.001) than the PD-WMH- group.</P> <P><B>Conclusion</B></P> <P>This study demonstrates that WMH burden negatively affects the longitudinal requirement of dopaminergic medication and the development of FOG. These findings suggest that baseline WMH severity or volume may be a useful prognostic marker of motor outcomes in PD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The PD-WMH + group had more severe motor deficits than the PD-WMH- group at baseline. </LI> <LI> The PD-WMH + group exhibited more severely decreased striatal DAT availability. </LI> <LI> The PD-WMH + group required higher doses of PD medications over the follow-up period. </LI> <LI> The PD-WMH + group had a higher risk of developing FOG than the PD-WMH- group. </LI> <LI> Baseline WMH may be a useful prognostic marker for future motor disability in PD. </LI> </UL> </P>
Chung, Seok Jong,Yoo, Han Soo,Moon, Hyojeong,Oh, Jungsu S,Kim, Jae Seung,Park, Yong Hee,Hong, Jin Yong,Ye, Byoung Seok,Sohn, Young H,Lee, Phil Hyu British Medical Association 2018 Journal of neurology, neurosurgery and psychiatry Vol.89 No.2
<P>Conclusions These results suggest that a short exposure to the offending drugs before the development of parkinsonism would be associated with subtle nigrostriatal dopaminergic dysfunction in patients with DIP.</P>
Chung, Seok Jong,Park, Yeong-Hun,Yoo, Han Soo,Lee, Yang Hyun,Ye, Byoung Seok,Sohn, Young H.,Lee, Jong-Min,Lee, Phil Hyu Elsevier 2019 NEUROBIOLOGY OF AGING Vol.78 No.-
<P><B>Abstract</B></P> <P>This study aimed to investigate whether reversion to cognitively normal status (CogN) is related to a favorable cognitive prognosis in Parkinson's disease with mild cognitive impairment (PD-MCI). We recruited 217 patients with PD-MCI who underwent serial neuropsychological assessments 3–5 times (mean interval, 1.84 years). Thirty-six patients reverted to CogN (reverters) during follow-up, whereas the other 181 did not (nonreverters). We assessed the risk of cognitive worsening in PD-MCI reverters, nonreverters, and patients with PD-CogN (n = 88). In addition, we performed comparative analyses of comprehensive neuroimaging studies between the PD-MCI reverter (n = 17) and nonreverter (n = 34) subgroups. PD-MCI reverters had a lower risk of dementia conversion than nonreverters. In addition, PD-MCI reverters had similar risks of cognitive worsening with patients with PD-CogN. PD-MCI reverters exhibited greater cortical thickness in the right parahippocampal gyrus and less severely decreased functional connectivity in the default mode and executive control networks relative to nonreverters. Our results suggest that PD-MCI reverters have relatively preserved structural and functional integrity and a favorable cognitive prognosis compared with nonreverters.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cognitive profile of PD-MCI reverters was different from that of nonreverters. </LI> <LI> PD-MCI reverters had a lower risk of dementia conversion than nonreverters. </LI> <LI> PD-MCI reverters had a similar risk of cognitive worsening with patients with PD-CogN. </LI> <LI> PD-MCI reverters had less cortical thinning in the parahippocampus than nonreverters. </LI> <LI> PD-MCI reverters had preserved functional integrity relative to nonreverters. </LI> </UL> </P>