肺炎 誘發菌의 生育을 抑制하는 韓藥材 探索에 關한 硏究

정병운,서운교,정지천,한영환 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

韓藥材 중 肺炎의 치료효과가 기대되는 淸熱化痰, 止咳平喘藥을 중심으로 23種의 藥材를 사용하여 肺炎을 유발하는 K. pneumoniae, S. pyogenes 및 S. pneumoniae 세균의 생육을 억제하는 藥材를 탐색하고, 탐색된 藥材의 추출물에 대한 세균의 最小生育抑制濃度를 측정하였다. 韓藥材의 水溶性 추출물 중 黃連, 胡黃蓮, 敗醬, 黃芩이 K. pneumoniae에서, 黃連이 S. pyogenes에 대해서 생육억제 효과가 있었으며, S. pneumoniae에 대한 比較沮止環의 直徑은 黃連, 鳥梅, 五味子, 黃芩이 우수하였으나 黃連 추출물 사용시 병원균 모두에서 生育沮止環의 크기가 가장 크게 나타났으며 對照群로 사용된 大腸菌과 枯草菌에서도 어느 정도의 抗細菌 효과를 볼 수 있었다. 에탄올 추출물에서는 敗醬, 黃芩, 五味子, 鳥梅가 K. pneumoniae 세균의 생육을 억제하였으며, S. pyogenes 세균은 黃連, 五味子, 鳥梅, 馬兜鈴찾, 黃芩에 의하여 생육이 억제되어 黃連은 水溶性 및 에탄올 溶解性 주출물에서 모두 우수한 抗細菌 효과를 보여주고 있다. 각 세균에 대한 最小生育沮止濃度(MIC)는 K. pneumoniae 세균일 경우 黃連 및 黃芩의 水溶性 추출물과 鳥梅 및 敗醬의 에탄올 溶解性 추출물이 유의성을 보였으며, S. pyogenes 세균은 黃連의 水溶性 및 에탄올 溶解性 추출물과 鳥梅의 에탄올 溶解性 추출물, S. pneumoniae 세균은 黃連과 鳥梅의 水溶性 및 에탄올 溶解性 주출물에서 유의성이 나타났다. 이상의 결과를 통하여 黃連, 五味子, 鳥梅, 黃芩, 胡黃蓮, 敗醬의 水溶性 및 에탄올 溶解性 추출물이 肺炎 誘發菌f K. pneumoniae, S. pyogenes, S. pneumoniae에 對하여 우수한 生育抑制 作用을 나타냄을 알 수 있었다. The various oriental herbal medicines, which have usually been used for treatment of reducing fever, purging intense heat and detoxication, were screened to determine the antibacterial activity and the minimal inhibitory concentration against pulmonary disease-causing Klebsiella pneumoniae, Streptococcus pyogenes, and Streptococcus pneumoniae. The results obtained were as follows: 1. Among the 23 oriental medicines tested, the water-soluble extracts of Coptis japonica, Scutellaria baicalensis and Picrorrhiza kurroca showed the antibacterial activity against K. pneumoniae and that of C. japonica against S. pyogenes. The antibacterial activities of C. japonica, Prunus mume, Schizandra chinesis, Scutellaria baicalensis were also found against S. pyogenes. When C. japonica was used, the high antibacterial activity was shown against Bacillus subtilis and other extracts showed a little activity against B. subtilis and E. coli as a control. 2. The ethanol-soluble extracts of Patrinia scabriosaefolia, P. mume, S. baicalensis, S. chinensis showed the antibacterial activity against K. pneumoniae and those of S. baicalensis, C. japonica, S. chinensis P. mume against S. pyogenes and S. pneumoniae. However, those extract showed a little antibacterial activity against B. subttilis and E. coli except for that the extract of C. japonica showed comparatively high growth inhibition of B. subtilis. 3. Among the medicinal herbs tested, the water- and ethanol extracts of C. japonica showed very extcellent antibacterial activity against the pathogenic bacteria and controls. 4. When the water-soluble extracts of C. japonica and S. baicalensis, minimal inhibitory concentrations (MICs) against K. pneumoniae were 10 ㎎/㎖ and 22 ㎎/㎖, respectively. The MICs of the ethanol-soluble extracts of P. mume and P. scabriosaefolia were 5 ㎎/㎖ and 20 ㎎/㎖, respectively. 5. For the MICs against S. pyogenes, C. japonica showed 15 ㎎/㎖ with the water-soluble extract and P. mume and C. japonica with the ethanol-souble extract did 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. 6. For the MICs against S. pneumoniae, C. japonica and P. mume with the water- and ethanol-souble extract showed 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. As a result, the highest antibacterial activity was found in the water- and ethanol-soluble extracts of C. Japonica against pulmonary disease-causing bacteria, K. pneumoniae, S. pyogenes, and S. pneumoniae. Also, the water- and ethanol-soluble extracts of S, chinensis, P. mume, S. baicalensis and P. kurrooa showed high antibacterial activities.

Chirospecific Synthesis of D-erythro- and L-threo-Sphinganines from Sugars

Jeong, Ill-Yun,Lee, Jin-Hwan,Lee, Byong-Won,Kim, Jin-Hyo,Park, Ki-Hun Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.5

D-erythro-sphinganine 1 and L-threo-sphinganine 2 have been prepared in the enantiomerically pure form by the chirospecific manner. Key intermediates, 2-amino-3-hydroxy-4-pentenoates 8 and 12, were obtained from L-glucono-1,5-lactone and L-gulonic acid g-lactone via a simultaneous dealkoxyhalogenation.

콘크리트 構造物의 龜裂發生 原因과 制御 및 對策에 관한 考察

鄭秉勳,鄭世煥 부천대학 1996 論文集 Vol.17 No.-

It is impossible completely to prevent cracking in concrete structures and its problems cannot be solved by one or two countermeasures as long as using concrete. The cracks in concrete spoil the outward appearance and lead to the deterioration of the watertightness and bring about the degradation of capability in the load carrying capacity and the durability in concrete structures. Therefore, it must be achieved to inclusively comprehend and to study for the causes of cracks. And also it is judged that the effective countermeasures for the control of cracks can be established by the continuous research for cracks and the study and the development of the new material which have the strong resistance for cracks. Above all, it is thought that the preparatory prevention against cracks is most important.

인천 지역 초등학교 학생에서 대기 오염물질의 농도와 알레르기 질환 유병률 및 폐기능과의 연관성

김정희 ( Jeong Hee Kim ),오성근 ( Sung Keun Oh ),성현우 ( Hyeon U Seong ),임대현 ( Dae Hyun Lim ),손병관 ( Byong Kwan Son ),김환철 ( Hwan Cheol Kim ),이지영 ( Ji Young Lee ),임종한 ( Jong Han Leem ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4

목적: 인천의 초등학교 학생을 대상으로 학교의 대기 오염물질 수준과 알레르기 질환 및 폐기능과의 연관성을 규명하고자 하였다. 방법: 인천 지역 11개 초등학교 2학년 학생 1,262명을 대상으로 하였다. 일산화탄소(CO), 이산화질소(NO2), 오존(O3), 아황산가스(SO2), 미세먼지(PM10)의 학교별 5년간 평균농도는 국립환경연구원의 자료를 바탕으로 지리정보체계를 이용해 추정하였다. 대기 오염물질 수준과 학생들의 알레르기 질환 유병률 및 폐기능의 연관성을 평가하기 위해 크게 두 가지 방법으로 나눈 군 학생간에 비교를 하였다. 학교에서 대기 오염물질 배출시설까지의 거리가 1 km 이상인 비인접학교와 1 km 이내인 인접학교로 나누어 두 군을 비교하였다. 또한, 각 대기 오염물질별 5년간 평균농도의 중간값을 기준으로 대기오염물질 농도가 상대적으로 높은 학교와 상대적으로 낮은 학교로 나누어 두 군을 비교하였다. 결과: 오존을 제외한 대기 오염물질 농도는 인접학교에서 비인접학교에 비해 유의하게 높았다. 인접학교 학생들은 1초간 노력성 호기량(FEV1)과 최대호기속도(PEF)가 비인접학교 학생들에 비해 유의하게 낮았고, `최근 일년간 숨이 차서 말하기 힘든 증상 경험`은 비인접학교 학생들보다 유의하게 많았다. 또한, 이 말하기 힘들어하는 증상은 NO2, SO2, PM10의 상대적 농도가 높은 군에서도 각각의 상대적 농도가 낮은 군에 비해 유의하게 많았다. PM10의 상대적 농도가 높은 군에서는 알레르기비염의 유병률이 상대적 농도가 낮은 군보다 유의하게 높았다. 결론: 학교의 대기 오염물질은 학생들의 알레르기 질환 특히, 알레르기비염의 유병률 증가와 폐기능 감소에 영향을 미치는 것으로 생각된다. Purpose: This study aimed to determine whether the standard clinical pathway based on evidence is applicable to pediatric asthma patients in the emergency room, and whether it is better for treatment effectiveness. Methods: The clinical pathway was applied to children who visited our emergency room due to acute asthma between January 1 and December 31, 2009. Medical records of the emergency room were reviewed to see if the clinical pathway was correctly applied. The patients were divided into 2 groups: those who the pathway was correctly applied and those who the pathway was incorrectly applied to (group B, n=41). Results: Acute asthma exacerbation occurred in 24 children (47%) in group A, while it occurred in 27 children (53%) in group B. The majority of patients in group B had moderate asthma exacerbation. The incorrect application of the clinical pathway and no use or insufficient use of inhaled anticholinergics was most frequently noted. The most common cause for the incorrect application of the clinical pathway was its misunderstanding of residents. The hospitalization rate was higher in group B than in group A. Conclusion: The application of the clinical pathway to pediatric asthma patients in the emergency room increased treatment effectiveness. However, training for the residents and intensive care for the patient with moderate asthma exacerbation are necessary for correct application of the clinical pathway. [Pediatr Allergy Respir Dis(Korea) 2010;20:264-276]

반슬림 폐단면 충전형 합성보의 휨성능 평가

임환택(Hwan Taek Lim),최병정(Byong Jeong Choi) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.3

U형 강재보를 근간으로 콘크리트 슬래브와 합성을 위하여 A형의 덮개형 강재앵커를 검토하여 AU합성보를 연구하였다. 이는 노출형의 H형강 강재보에 비해 내부 평면의 자율성을 높일 수 있고 공기 단축과 더불어 층고 절감이 가능하며 튜브구조로서 내부에 콘크리틀 충전하여 휨 강도과 휨 강성를 높였다. 본 연구에서는 AU합성보의 휨실험을 통해 성능을 평가하였다. 실험 결과, 하중 초기에 선형적으로 하중이 증가하면서 콘크리트 슬래브의 파괴에 의해 최대 강도에 도달하고 최대 내력의 85% 이상을 발휘하며 연성적 거동을 하였다. 또한, 덮개형 강재앵커를 통해 합성효과를 발휘하였으며 모든 실험체가 최대 내력에 도달할 때까지 완전 합성거동으로 안정적이었다. 그리고 U형 단면의 강판 두께를 증가시켰을 경우에도 휨 강도와 휨 강성이 증가하였고, U형 단면의 하부에 고강도 강판을 용접 부착하였을 경우에도 성능이 개선되었다. AU합성보의 휨강도는 건축구조기준에 따라 제안된 휨 강도식을 적용할 수 있을 것으로 판단되었다. AU-composite beam based on U-shaped steel beams and steel plate anchors of type A was developed. The composite beam reduced the height of the building floor and construction cost. In addition, it decreased the length of construction work, and improved the flexural strength and stiffness as a form of tubes. In this study, AU-composite beams were tested directly and their performance was evaluated through bending experiments. The strength of the specimens was increased initially by linear loads and reached a maximum strength due to destruction of the concrete slab. All of the experiments showed more than 85% of the maximum stress and performed gentle movement. In addition, there was good composite behavior with the steel plate anchor that had excellent composite effects and reached full strength until the maximum strength was reached. When the thickness of the steel plate was increase, the flexural stiffness and strength of the specimen were improved. Therefore, the flexural strength of AU-composite beams can be estimated using the flexural strength formula according to the KBC 2016.

각 부하 수준에서 최적조류계산을 활용한 조상설비 설치 위치 및 용량 산정 방안

조환희(Hwan-Hee Cho),배문성(Moon-Sung Bae),정진우(Jin-Woo Jeong),이병준(Byong-Jun Lee) 대한전기학회 2015 대한전기학회 학술대회 논문집 Vol.2015 No.7

Fracture mechanism and electromechanical behavior of chemical vapor deposited graphene on flexible substrate under tension

Lee, Jeong-Hwan,Jang, Dong-Won,Hong, Seong-Gu,Park, Byong Chon,Kim, Jae-Hyun,Jung, Hyun-June,Lee, Soon-Bok Elsevier 2017 Carbon Vol.118 No.-

<P>The electromechanical characteristics of chemical vapor deposited graphene transferred onto a polymeric substrate were investigated by conducting tensile tests in combination with electrical resistance measurement inside a scanning electron microscope. Our results showed that the unique interfacial adhesion character of the graphene/polymer substrate, where the graphene adheres to the substrate by weak van der Waals forces, gives rise to interfacial sliding in the region around the crack edge during tensile straining, causing a reduction in strain transfer from the substrate to the graphene, and this retards or restricts the growth of preformed cracks and promotes the nucleation of new cracks. Such a fracture mechanism (i.e., cracking mechanism) was closely associated with the electromechanical behavior, leading to a distinct threeestage feature, i.e., the stage I flat region, the stage II superlinear region and the stage III linear region, in the electrical resistance-strain curve. We demonstrated the validity of the suggested fracture mechanism and its correlation with the electromechanical characteristics by combining statistical analysis of the evolution of crack size distribution with strain, frictional force measurement and coupled thermaleelectrical finite element analysis. (C) 2017 Elsevier Ltd. All rights reserved.</P>

Implementation of Under Voltage Load Shedding for Fault Induced Delayed Voltage Recovery Phenomenon Alleviation

Yun-Hwan Lee,Bo-Hyun Park,Seung-Chan Oh,Byong-Jun Lee,Jeong-Hoon Shin,Tae-Kyun Kim 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.2

Significant penetration of induction motor loads into residential neighborhood and commercial regions of local transmission systems at least partially determine a vulnerability to a fault induced delayed voltage recovery (FIDVR) event. Highly concentrated induction motor loads with constant torque could stall in response to low voltages associated with system faults. FIDVR is caused by wide spread stalling of small HVAC units (residential air conditioner) during transmission level faults. An under voltage load shedding scheme (UVLS) can be an effective component in a strategy to manage FIDVR risk and limit the any potential disturbance. Under Voltage Load Shedding take advantage of the plan to recovery the voltage of the system by shedding the load ways to alleviation FIDVR.

도시형 자기부상열차 제3궤조 전차선로의 안전성 및 신뢰성 확보를 위한 인터페이스 정립 (The Organization of Interface for safety and reliability of Urban Maglev Third rail System)

민병찬(Byong-Chan Min),조상훈(Sang-Hoon Cho),허영태(Young-Tae Heo),홍두영(Du-Young Hong),김창환(Chang-Hwan Kim),정남철(Nam-Cheol Jeong) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.5

도시형 자기부상열차는 전자기력으로 레일에서 낮은 높이로 부상하여 운행되는 열차이다. 자기부상열차는 궤도와의 직접적인 접촉 없이 움직이기 때문에 소음이 적고 기계적 마찰에 의한 진동이 거의 발생하지 않는다. 또한 급곡선 주행이 가능하고 경사도가 높은 언덕지역도 쉽게 주행 할 수 있기 때문에 도심에서의 새로운 교통수단으로 주목받고 있다. 따라서 도시형 자기부상열차의 성공적인 실용화를 위하여 제3궤조 전차선로 설비와 인터페이스를 통하여 안전성과 신뢰성 확보는 필수 고려 사항중 하나이다. 특히 파워레일, 신축확장장치, 절연 구분장치, 지지금구와 같은 제3궤조 전차선로 설비는 내 부식성, 시공의 편의성 및 유지보수성을 고려하여 설치되어야 한다. 본 논문에서는 자기부상열차 시스템 구축을 위한 제3궤조 설비의 구성요소에 대한 인터페이스 항목을 분석하고 전차선로의 안전성을 높일 수 있는 시스템 엔지니어링 인터페이스 체계를 제시하고자 한다. 또한 제안하는 자기부상용 제3궤조 전차선로 시스템은 한국기계연구원내 시험을 통하여 시스템의 안전성을 증명하였으며, 시스템 구성품의 수명분석을 통해 제3궤조 전차선로 운영의 신뢰성을 향상시키고자 한다. The Maglev train is operated by levitating from a power of a large number of magnets and moving without direct contact to railway track so that reduces noise and vibration due to mechanical friction. Also, the Maglev passes sharp curves and steep hill without any difficulties. The Maglev has a potential to be an alternative transport system urban areas. For successful commercializing of Maglev, the organization of interface for safety and reliability of third rail system are one of the key considerations. Especially, the components of the third rail system, such as power rail, expansion joints, FRP section insulator, and supporter with epoxy insulator, should be durable, convenient for construction, and easy to maintenance. This paper analyzes the characteristics of the third rail system components and proposes organization of interface for system engineering. The operating tests of KIMM for the proposed third rail system verify the safety. Also, this paper analyzes the life cycle of the system components to improve the system reliability and evaluation.

Development of High Density Mammalian CellCulture system for the Production of Tissue-Type Plasminogen Activator

Park, Byong-Gon,Chun, Joo-Mi,Lee, Chang-Jin,Chun, Gie-Taek,Kim, Ik-Hwan,Jeong, Yeon-Ho The Korean Society for Biotechnology and Bioengine 2000 Biotechnology and Bioprocess Engineering Vol.5 No.2

A high cell density culture system for the anchorage dependent CHO cells was developed based on the combination of in removal of ammonium ion and microcarrier culture system, and semi-fed-batch feeding of glucose and glutamine was employed to the developed culture system. The glass bead was selected as an optimum microcarrier in terms of cell growth. An ammonium ion selective zeolite, Phillipsite-Gismondine, was packed in a dialysis menium ion. The semi-fed-batch operation was employer to the novel culture system for the high density cell culture, and the results showed the cell growth was improved by 32% and tPA productivity by 250%.