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RISS 인기검색어
- 검색키워드
- 저자 : Byon Hyoung-joo (검색결과 5 건)
- 무료
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Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells
Mi-Hyoung Kim,Yun-Young Byon,Eun-Ju Ko,Jie-Young Song,Yeon-Sook Yun,Taekyun Shin,Hong-Gu Joo 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Ginsan, a Panax ginseng polysaccharide that contains glucopyranoside and fructofuranoside, has immunomodulatory effects. Although several biologic studies of ginsan have been performed, its effects on dendritic cells (DCs), which are antigen-presenting cells of the immune system, have not been studied. We investigated the immunomodulatory effects of ginsan on DCs. Ginsan had little effect on DC viability, even when used at high concentrations. Ginsan markedly increased the levels of production by DCs of IL-12 and TNF-Ձ, as measured by ELISA. To examine the maturation-inducing activity of ginsan, we measured the surface expression levels of the maturation markers MHC class II and CD86 (B7.2) on DCs. It is interesting that ginsan profoundly enhanced the expression of CD86 on DC surfaces, whereas it increased that of MHC class II only marginally. In <sup>3</sup>H-thymidine incorporation assays, ginsan-treated DCs stimulated significantly higher proliferation of allogeneic CD4<sup>+</sup> T lymphocytes than did medium-treated DCs. Taken together, our data demonstrate that ginsan stimulates DCs by inducing maturation. Because DCs are critical antigen-presenting cells in immune responses, this study provides valuable information on the activities of ginsan.
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Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells
Kim, Mi-Hyoung,Byon, Yun-Young,Ko, Eun-Ju,Song, Jie-Young,Yun, Yeon-Sook,Shin, Taek-Yun,Joo, Hong-Gu The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Ginsan, a Panax ginseng polysaccharide that contains glucopyranoside and fructofuranoside, has immunomodulatory effects. Although several biologic studies of ginsan have been performed, its effects on dendritic cells (DCs), which are antigen-presenting cells of the immune system, have not been studied. We investigated the immunomodulatory effects of ginsan on DCs. Ginsan had little effect on DC viability, even when used at high concentrations. Ginsan markedly increased the levels of production by DCs of IL-12 and TNF-${\alpha}$, as measured by ELISA. To examine the maturation-inducing activity of ginsan, we measured the surface expression levels of the maturation markers MHC class II and CD86 (B7.2) on DCs. It is interesting that ginsan profoundly enhanced the expression of CD86 on DC surfaces, whereas it increased that of MHC class II only marginally. In $^3H$-thymidine incorporation assays, ginsan-treated DCs stimulated significantly higher proliferation of allogeneic $CD4^+$ T lymphocytes than did medium-treated DCs. Taken together, our data demonstrate that ginsan stimulates DCs by inducing maturation. Because DCs are critical antigen-presenting cells in immune responses, this study provides valuable information on the activities of ginsan.
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Radioprotective effects of an acidic polysaccharide of Panaxginseng on bone marrow cells
Hong-Gu Joo,Hyun-Ji Kim,Mi-Hyoung Kim,Yun-Young Byon,Jae Woo Park,Youngheun Jee 대한수의학회 2007 JOURNAL OF VETERINARY SCIENCE Vol.8 No.1
An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the detailed mechanism was not fully elucidated. This study examined the effects of APG on bone marrow cells (BMs). The phenotypical and functional changes in APG-treated BMs after gamma radiation were studied. The benefit of APG on BMs damaged by gamma radiation was determined by measuring the cell viability. Using 2 different assays, a pretreatment with APG significantly increased the viability of BMs against gamma radiation. APG-treated BMs had a significantly higher amount of IL-12, which is a major cytokine for immune responses, compared with the medium-treated BMs. The expression of MHC class II molecules of APG-treated BMs was also increased, and APG-treated BMs showed significantly higher levels of allogeneic CD4+ T lymphocyte proliferation. Furthermore, APG-treated mice had a larger number of BMs after gamma radiation than the control mice, and the BMs of APG-treated mice were successfully cultured into dendritic cells, which are the representative antigenpresenting cells. Overall, this study shows that APG alters the phenotype of BMs, increases the viability and alloreactivity of BMs after gamma radiation both in vitro and in vivo. Therefore, APG may be a good candidate radioprotective agent for BMs.
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Yun-Young Byon,Mi-Hyoung Kim,Eun-Sook Yoo,Kyu-Kye Hwang,Youngheun Jee,Taekyun Shin,Hong-Gu Joo 대한수의학회 2008 Journal of Veterinary Science Vol.9 No.4
Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study, we investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan, we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information, useful in the field of radiotherapy.
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MUD 기반 수신기의 채널 추정을 위한 주 경로 선택 알고리즘
변형주,서인권,김영록,Byon Hyoung-joo,Seo In-kwon,Kim Younglok 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.5C
다중 사용자 검출 기법을 기반으로 하는 무선 통신 수신기는 단일 사용자 검출 기법에 비해 더욱 정확한 채널 추정을 필요로 한다. 추정 채널 계수 중에서 잡음 성분만을 포함하는 계수를 제거함으로써 더욱 정확한 채널 응답을 추정해 내기 위한 방법으로 주 경로를 선택하는 기법이 있다. 일반적으로 주 경로를 선택하기 위해서는 잡음과 간섭의 전력을 먼저 추정한 후에 그 값과 상대적인 문턱값을 기준으로 하여 신호의 유무를 판단하는 기법이 사용된다. 본 논문에서 제안된 적응적 주 경로 선택 기법은 문턱값 기법을 반복적으로 수행하며 각 반복 단계에서 계산된 오차로 반복 지속 여부를 판단하기 때문에 반복 횟수가 채널 환경에 따라서 적응적으로 변화한다. 제안된 기법의 반복에 의한 처리 속도 지연은 상대적으로 무시할 수 있을 정도로 작고, 하드웨어 복잡성의 증가가 거의 없이 보다 정확한 잡음 전력의 추정치를 얻을 수 있는 장점을 갖고 있다. 제안된 기법의 다중 사용자 기반 3GPP TDD 환경에서의 실험 결과는 BER 성능의 향상을 보이지는 않지만 잡음 및 간섭 전력 추정의 오류는 $10\%$정도이며 이는 최대 $50\%$의 오류를 갖는 일반적인 방법에 비해 현저히 낮다. The multiuser detection (MUD) based wireless receiver requires more accurate channel estimation than the single user detection (SUD) schemes such as Rake receiver, and hence the post processing is required for MUD to clean up the estimated channel coefficients by eliminating the noise only coefficients. The adaptive post processing method is proposed in order to provide more accurate channel responses and the power level of the background noise and interferences at the cost of the negligible processing delay compared to the conventional method based on the threshold test with the threshold value relative to the noise variance. The simulations are performed in 3GPP-TDD mode environment. The results show that the noise estimation error of the proposed method is maximum $10\%$, which is much smaller than $50\%$ maximum error of the conventional method.
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