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RISS 인기검색어
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- 저자 : Bu Lihong (검색결과 2 건)
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Bu Lihong,Tu Ning,Wang Ke,Zhou Ying,Xie Xinli,Han Xingmin,Lin Huiqin,Feng Hongyan 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.1
Objective: To investigate the relationship between 18F-FDG PET/CT semi-quantitative parameters and the International Association for the Study of Lung Cancer, American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histopathologic classification, including histological subtypes, proliferation activity, and somatic mutations. Materials and Methods: This retrospective study included 419 patients (150 males, 269 females; median age, 59.0 years; age range, 23.0–84.0 years) who had undergone surgical removal of stage IA–IIIA lung adenocarcinoma and had preoperative PET/CT data of lung tumors. The maximum standardized uptake values (SUVmax), background-subtracted volume (BSV), and background-subtracted lesion activity (BSL) derived from PET/CT were measured. The IASLC/ATS/ERS subtypes, Ki67 score, and epidermal growth factor/anaplastic lymphoma kinase (EGFR/ALK) mutation status were evaluated. The PET/CT semiquantitative parameters were compared between the tumor subtypes using the Mann–Whitney U test or the Kruskal–Wallis test. The optimum cutoff values of the PET/CT semi-quantitative parameters for distinguishing the IASLC/ATS/ERS subtypes were calculated using receiver operating characteristic curve analysis. The correlation between the PET/CT semi-quantitative parameters and pathological parameters was analyzed using Spearman’s correlation. Statistical significance was set at p < 0.05. Results: SUVmax, BSV, and BSL values were significantly higher in invasive adenocarcinoma (IA) than in minimally IA (MIA), and the values were higher in MIA than in adenocarcinoma in situ (AIS) (all p < 0.05). Remarkably, an SUVmax of 0.90 and a BSL of 3.62 were shown to be the optimal cutoff values for differentiating MIA from AIS, manifesting as pure ground-glass nodules with 100% sensitivity and specificity. Metabolic-volumetric parameters (BSV and BSL) were better potential independent factors than metabolic parameters (SUVmax) in differentiating growth patterns. SUVmax and BSL, rather than BSV, were strongly or moderately correlated with Ki67 in most subtypes, except for the micropapillary and solid predominant groups. PET/CT parameters were not correlated with EGFR/ALK mutation status. Conclusion: As noninvasive surrogates, preoperative PET/CT semi-quantitative parameters could imply IASLC/ATS/ERS subtypes and Ki67 index and thus may contribute to improved management of precise surgery and postoperative adjuvant therapy.
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Edwin D. Lephart,Lihong Bu 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
Soy isoflavones, the most abundant phytoestrogens, are known as endocrine modulators and appear to be an ef-fective treatment in some women during perimenopause when symptoms such as hot flashes may be reduced. This study ex-amined the effects of dietary soy isoflavones on regulatory behaviors such as body weight, food and water intake, and skintail temperature by feeding male Long-Evans rats one of the three standard chows (Phyto-free, Phyto-200, and Phyto-600)containing approximately 1015 ppm, 200 ppm, and 600 ppm of isoflavones, respectively. In an apparent dose-dependentmanner, body weight was decreased as a function of increasing isoflavone levels in the diets. The average skin tail tempera-ture of Phyto-600-fed rats (25.5°C) was significantly lower than Phyto-free (27.5°C) values by approximately 2°C. The ratson the Phyto-200 diet (26.6°C) displayed a temperature in between the Phyto-free and Phyto-600 values. Similar to the bodyweight results, skin tail temperature was decreased in an apparent dose-dependent manner as a function of increasing isoflavoneconcentrations in the diets. These results suggest that consumption of soy isoflavones alters regulatory behaviors (such asbody weight and food and water intake) and skin temperature regulation that may help explain, in part, the beneficial effectsof soy isoflavones on obesity and hot flashes in humans.
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