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Recurrent Follicular Dendritic Cell Sarcoma of the Parotid Gland Imaged with 18F-FDG PET/CT
William Makis,EW Hudson,Brian Chiu 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.4
Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor with only 67 cases of head and neck FDCS reported in the literature. A 65-year-old female had a 6-cm follicular dendritic cell sarcoma resected from the left parotid gland with close margins. It recurred 1 year later as a 5-cm mass that was intensely [18F] fluoro-2-deoxy-D-glucose (18F-FDG) avid on positron emission tomography/computed tomography (PET/CT) and was re-excised. A follow-up PET/ CT did not show any metastatic disease. The use of 18F-FDG PET/CT in the management of FDCS warrants further research. We present the 18F-FDG PET/CT imaging findings of this rare tumor.
Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood
Williams, Jesse W.,Elvington, Andrew,Ivanov, Stoyan,Kessler, Skyler,Luehmann, Hannah,Baba, Osamu,Saunders, Brian T.,Kim, Ki-Wook,Johnson, Michael W.,Craft, Clarissa S.,Choi, Jae-Hoon,Sorci-Thomas, Mar Grune & Stratton 2017 Circulation research Vol.121 No.6
<P>Conclusions: Warm ambient temperature is, like UCP1 deficiency, atheroprotective, but the mechanisms of action differ. Thermoneutrality associates with reduced monocyte egress from the bone marrow in a UCP1-dependent manner in mice and likewise may also suppress blood monocyte counts in man.</P>
Synapsins differentially control dopamine and serotonin release.
Kile, Brian M,Guillot, Thomas S,Venton, B Jill,Wetsel, William C,Augustine, George J,Wightman, R Mark The Society 2010 The Journal of neuroscience Vol.30 No.29
<P>Synapsins are a family of synaptic vesicle proteins that are important for neurotransmitter release. Here we have used triple knock-out (TKO) mice lacking all three synapsin genes to determine the roles of synapsins in the release of two monoamine neurotransmitters, dopamine and serotonin. Serotonin release evoked by electrical stimulation was identical in substantia nigra pars reticulata slices prepared from TKO and wild-type mice. In contrast, release of dopamine in response to electrical stimulation was approximately doubled in striatum of TKO mice, both in vivo and in striatal slices, in comparison to wild-type controls. This was due to loss of synapsin III, because deletion of synapsin III alone was sufficient to increase dopamine release. Deletion of synapsins also increased the sensitivity of dopamine release to extracellular calcium ions. Although cocaine did not affect the release of serotonin from nigral tissue, this drug did enhance dopamine release. Cocaine-induced facilitation of dopamine release was a function of external calcium, an effect that was reduced in TKO mice. We conclude that synapsins play different roles in the control of release of dopamine and serotonin, with release of dopamine being negatively regulated by synapsins, specifically synapsin III, while serotonin release appears to be relatively independent of synapsins. These results provide further support for the concept that synapsin function in presynaptic terminals varies according to the neurotransmitter being released.</P>
논의를 강조한 탐구학습법에 따른 통합학급 초등학생의 단어 활용, 독해 및 쓰기 능력
박영근,윤세열,Brian Hand,William Therrien,Mack Shelley 한국특수교육학회 2013 특수교육학연구 Vol.48 No.2
The purpose of this study is to investigate the effects of argument-based inquiry approach for improving the literacy of students with special needs, and to introduce the Science Writing Heuristic as an argument-based inquiry approach. This study focused on how this approach influenced students' literacy such as vocabulary usage, reading comprehension, and writing skills. From the forty-eight public elementary schools in the Midwest of the U.S., twenty-four elementary schools were designated as the treatment group and the remaining as the control group. Students in the treatment group were immersed in a learning environment where there is strong emphasis on argumentation while those in the control group learned science in a traditional manner. Students' achievement levels were determined based on the mean scores of the state-standardized test in the Midwest. The findings indicated that the argument-based inquiry approach contributed to students' test performances on vocabulary usage, reading comprehension, and writing skills significantly better than the traditional approach. The argument-based inquiry approach emphasized dialogical interactions between students with special needs and students' active engagement in scientific inquiry. This approach provides meaningful learning experience through argumentation in science class, and would contribute to literacy education for students with special needs in Korean elementary school settings. 본 연구의 목적은 ‘논의를 강조한 탐구 학습법’이 초등학교 특수교육대상 학생들의 단어 활용, 독해, 쓰기능력에 미치는 효과를 분석하는데 있다. ‘논의를 강조한 탐구 학습법’ 은 특수교육 지원 요구를 가진 학생들이 또래와의 상호작용을 통하여 능동적으로 과학 탐구 활동에 참여할 수 있도록 돕는다. 본 연구의 목적을 위해서 미국 중부의 48개 일반 초등학교를 탐구적 과학 글쓰기 활동을 실시한 24개의 실험집단 학교와, 이 중재학습을 실시하지 않은 24개의 통제집단 학교로 나누고, 각 학교에서 통합교육을 받고 있는 특수교육대상 학생들을 대상으로 단어 활용, 독해, 쓰기능력 검사를 실시하였다. 연구결과, 논의를 강조한 탐구 학습법을 경험한 특수교육대상 학생들이 통제집단의 학생들보다 단어 활용, 독해, 쓰기 능력에 향상을 보인다. 우리나라 초등학교 ‘과학’ 수업 시간을 통해 논의를 강조한 탐구학습법을 활용하는 것이 특수교육지원 요구를 가진 학생들의 단어 활용, 독해, 쓰기능력 향상에 도움을 줄 수 있을 것이라고 기대한다.