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- 저자 : Andrzej Bartke (검색결과 5 건)
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Bartke Andrzej,Brannan Savannah,Hascup Erin,Hascup Kevin,Darcy Justin 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.2
Aging is strongly related to energy metabolism, but the underlying processes and mechanisms are complex and incompletely understood. Restricting energy intake and reducing metabolic rate can slow the rate of aging and extend longevity, implying a reciprocal relationship between energy metabolism and life expectancy. However, increased energy expenditure has also been associated with improved health and longer life. In both experimental animals and humans, reduced body temperature has been related to extended longevity. However, recent findings on the function of thermogenic (brown or beige) adipose tissue produced intense interest in increasing the amount of energy expended for thermogenesis to prevent and/or treat obesity, improve metabolic health, and extend life. Evidence available to-date indicates that increasing adipose tissue thermogenesis by pharmacologic, environmental, or genetic interventions can indeed produce significant metabolic benefits, which are associated with improved chances for healthy aging and long life.
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Growth Hormone and Aging: Updated Review
Andrzej Bartke 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.1
Role of growth hormone (GH) in mammalian aging is actively explored in clinical, epidemiological, and experimental stud-ies. The age-related decline in GH levels is variously interpreted as a symptom of neuroendocrine aging, as one of causes of altered body composition and other unwelcome symptoms of aging, or as a mechanism of natural protection from cancer and other chronic diseases. Absence of GH signals due to mutations affecting anterior pituitary development, GH secretion, or GH receptors produces an impressive extension of longevity in laboratory mice. Extension of healthspan in these animals and analysis of survival curves suggest that in the absence of GH, aging is slowed down or delayed. The corresponding endo-crine syndromes in the human have no consistent impact on longevity, but are associated with remarkable protection from age-related disease. Moreover, survival to extremely old age has been associated with reduced somatotropic (GH and insu-lin-like growth factor-1) signaling in women and men. In both humans and mice, elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing acceleration of aging. The widely advertised potential of GH as an anti-aging agent attracted much interest. However, results obtained thus far have been disappointing with few documented benefits and many troublesome side effects. Possible utility of GH in the treatment of sarcopenia and frailty remains to be explored.
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Growth Hormone and Aging: New Findings
Bartke Andrzej,Hascup Erin,Hascup Kevin,Masternak Michal M. 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.3
Complex relationships between growth hormone (GH) signaling and mammalian aging continue to attract attention of many investigators. Recent results include evidence that the impact of GH on genome maintenance (DNA damage and repair) is drastically different in normal as compared to cancer cells, consistent with GH promoting aging and cancer progression. Impact of GH on DNA methylation was studied as a possible mechanism linking actions of GH during early life to the trajec-tory of aging. Animals with reduced or enhanced GH signaling and novel animals with adipocyte-specific deletion of GH receptors were used to elucidate the effects of GH on white and brown adipose tissue, including the impact of this hormone on lipolysis, fibrosis, and thermogenesis. Effects of GH on adipose tissue related to lipid and energy metabolism emerge as mechanistic links between GH, healthspan, and lifespan. Treatment of healthy men with a combination of GH, dehydroepi-androsterone, and metformin was reported to restore thymus function and reduce epigenetic age. Studies of human subjects with deficiency of GH or GH receptors and studies of mice with the same endocrine syndromes identified several pheno-typic changes related (positively or negatively) to the previously reported predisposition to healthy aging. Results of these and other recent studies advance present understanding of the mechanisms by which GH influences aging and longevity and of the trade-offs involved.
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William Banz,Jennifer Hickey,Andrzej Bartke,Todd Winters,Nancy Henry 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
The objective of this study was to determine the effect of soy-based diets on mammary tumors in female can-cer-prone mice. Transgenic virgin female mice expressing human pituitary growth hormone and their respective phenotypi-cally normal littermates were fed a diet containing either casein (C), low-isoflavone soy protein (LIS), or high-isoflavone soyprotein (HIS). Indices of tumor development were measured throughout the study. Both days from birth until death and dayson diet until death were increased [by 20% (P. .01) and 19% (P. .02), respectively] in the LIS group when compared withthe C group. Both intervals were increased also (by 16% and 17%, respectively; P. .05) in the HIS group when comparedwith the C group. Days from birth to first tumor were increased by 7% (P. .05), as was days on diet to first tumor by 5%(P. .05), in the LIS group when compared with the C group. First-onset number of tumors was decreased (P. .02) by 41%and 34% in the LIS and C groups, respectively, when compared with the HIS group. Final onset of tumors was decreased(P. .05) by 44% and 9% in the LIS and HIS groups, respectively, when compared with the C group. Total area of final tu-mors was decreased (P. .05) by 30% in the LIS group when compared with the C group. Taken cumulatively, these datasuggest that a diet rich in soy protein may provide protective benefits regarding tumor development in female cancer-pronemice. Furthermore, some bioactive compounds in the HIS diet appeared to confound the soy protein-induced beneficial effects.
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