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Bocui Song,Guoren Huang,Ying Xiong,Jingbo Liu,Linli Xu,Zhenning Wang,Gen Li,Jing Lu,Shuang Guan 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.11
The aim of this study was to evaluate the effect of salidroside on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 macrophages and related anti-inflammatory mechanism. PGE2 production was measured by enzyme-linked immunosorbent assay (ELISA); NO production was tested by Griess reagent. Inducible nitric oxidesynthase (iNOS) and COX-2 were determined by RT-PCR and Western blot analysis; IjB and P-IjB protein express were detected by Western blot analysis; cytosolic free Ca2+ ([Ca2 + ]i)was measured by a fluorescent microscope. The data showed salidroside inhibited LPS-induced NO and PGE2 production and reduced iNOS and COX-2 protein expression in RAW 264.7 macrophages. Consistent with these observations, salidroside inhibited LPS-induced cytosolic free Ca2 + concentration ([Ca2 +]i) elevation. In addition, we further investigated signal transduction mechanisms and found that the activation of NF-jBwas suppressed by salidroside in a dose-dependent manner. These results suggest that salidroside suppresses NO and PGE2 production by inhibiting iNOS and COX-2 protein expression, level of [Ca2 + ]i, and activation of NF-jB signal transduction pathway.
Functional Roles of Exosomes in Allergic Contact Dermatitis
Song Bocui,Chen Qian,Li Yuqi,Zhan Shuang,Zhao Rui,Shen Xue,Liu Min,Tong Chunyu 한국미생물·생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.12
Allergic contact dermatitis (ACD) is an allergen-specific T-cell-mediated inflammatory response, albeit with unclear pathogenesis. Exosomes are nanoscale extracellular vesicles secreted by several cell types and widely distributed in various biological fluids. Exosomes affect the occurrence and development of ACD through immunoregulation among other ways. Nevertheless, the role of exosomes in ACD warrants further clarification. This review examines the progress of research into exosomes and their involvement in the pathogenesis, diagnosis, and treatment of ACD and provides ideas for exploring new diagnostic and treatment methods for this disease.