Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells

Lee, A-Hyeong,Oh, Kyung-Taek,Baik, Hye-Jung,Lee, Bo-Reum,Oh, Young-Taik,Lee, Don-Haeng,Lee, Eun-Seong Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.8

In this study, wormorm-like polymeric micelles were construted from poly(L-lactic acid)-b-poly(ethyelen glycol) (PLLA-b-PEG) block copolymers via worm-like (or cylindrical) self- assembly that consisted of a relatively long PLLA block ($M_n$ 7K Daltons) at the core and a relatively short PEG block ($M_n$ 2K Daltons) as the shell. Several cancer-targeting moieties (such as folate, cobalamin, and cyclic arginine-glycine-aspartic (RGD) peptide) were chemically coupled with the succinylated or maleimided PEG block of PLLA-b-PEG to act as a cancer cell-specific targeting ligand for breast cancer. The worm-like micelles with muplite cancer cell-specific ligands proved to be successful in recognizing different breast cancer cells at once. This has the potential to aid in cancer-specific drug delivery and to be used as an effective treatment for breast cancer.

β-In2S3 as water splitting photoanodes: promise and challenges

Bo Reum Lee,Ho Won Jang 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.2

As the interest in sustainable energy production increases, water splitting through semiconductor materials to convert solarenergy directly to hydrogen energy has been extensively reported to date. Recently, the III–VI group chalcogenide semiconductorshave received great attention for narrow-gap photoelectrochemical (PEC) water splitting electrodes. Among themetal sulfides, beta indium sulfide (β-In2S3) shows remarkable properties for photoelectrodes such as high photoelectricsensitivity, high photoconductivity, large photoelectric conversion yield, low toxicity, high absorption coefficient, efficientcharge separation, moderate charge transport, appropriate band position, and narrow band gap. Most of its unique propertiescome from the defective spinel crystal structure. Despite the superior advantages, there is a serious problem of photocorrosioninduced by accumulated holes on the surface of the electrodes during the photocatalytic reaction under illumination whichreduces the PEC properties. Herein, we review overall physicochemical and optoelectronic properties of β-In2S3, regardlessof pros and cons, followed by the discussion of assorted strategies to further improve the PEC activities.

Dual-color FISH karyotype analysis of Cassia tora L. using 5S and 45S rDNA probes

Bo Reum Park,Jee Hee Lee,Sang-Ho Kang,Jeong-Hoon Lee,Byoung Ohg Ahn,Chun-Gun Park,Young-Sup Ahn,Seon-Woo Cha,Yoon-Jung Hwang,Hyun Hee Kim 한국약용작물학회 2014 한국약용작물학회 학술대회논문집 Vol.2014 No.2

A novel pH-responsive polysaccharidic ionic complex for proapoptotic <small>D</small>-(KLAKLAK)₂ peptide delivery

Lee, Bo Reum,Oh, Kyung Taek,Oh, Young Taik,Baik, Hye Jung,Park, So Young,Youn, Yu Seok,Lee, Eun Seong Royal Society of Chemistry 2011 Chemical communications Vol.47 No.13

<P>We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as ‘GCS-<I>g</I>-DMA’ hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites <I>via</I> a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.</P> <P>Graphic Abstract</P><P>Charge-switching ionic nanocomplexes allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc03590d'> </P>

Dual-color FISH karyotype analysis of Cassia tora L. using 5S and 45S rDNA probes

Bo Reum Park,Jee Hee Lee,Sang-Ho Kang,Jeong-Hoon Lee,Byoung Ohg Ahn,Chun-Gun Park,Young-Sup Ahn,Seon-Woo Cha,Yoon-Jung Hwang,Hyun Hee Kim 한국약용작물학회 2014 한국약용작물학술대회 발표집 Vol.2014 No.10

Interfacial engineering of In2O3/In2S3 heterojunction photoanodes for photoelectrochemical water oxidation

Bo Reum Lee,Sungkyun Choi,Woo Seok Cheon,Jin Wook Yang,Mi Gyoung Lee,So Hyeon Park,Ho Won Jang 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.4

Photoelectrochemical (PEC) water splitting is one of the critical energy conversion techniques to prepare for future energydemands. Among the various trials to construct effective water splitting semiconductor photoelectrodes, In2O3/In2S3 heterostructurescan be promising candidates for their advantageous properties in solar water oxidation. Herein, we synthesizedIn2O3nanorods on FTO substrate through a direct glancing angle deposition method. Subsequently, the In2S3layer wasconformally coated on In2O3nanorods through facile chemical bath deposition. As synthesized photoanodes of In2O3/In2S3form type II junction, leading to considerable cathodic onset potential shift with the increased photocurrent density comparedto pristine samples. To further enhance PEC properties, the interficial engineering strategies of the Co ion doping and thedeposition of ultra-thin Al2O3film were carried out. Co ion could facilitate the charge transfer in photoanodes through theincreased surface area, and the 2 nm Al2O3layer coated above the photoanode effectively worked as the passivation layer tostabilize the photoanodes in alkaline electrolytes environments. This work would contribute to developing efficient photoanodesthrough various nanoscale engineering strategies.

The historical review and value of Cheon.Ha.Tae.Pyeong(天.下.太.平) Jamu(字舞) in Korea and China

( Bo-reum Lee ) 한국무용연구학회 2021 한국무용연구회 국제학술발표논문집 Vol.2021 No.-

거울을 활용한 미러링 코칭이 자유형 스트로킹 변화에 미치는 영향

이보람(Lee, Bo-Ram),윤소미(Yun, Somi),정아름(Jung, Ah-Reum),이윤빈(Lee, Yun Bin),이희진(Lee, Hee Jin),이대택(Lee, Dae Daek) 한국웰니스학회 2020 한국웰니스학회지 Vol.15 No.4

본 연구는 자유형 스트로크를 교정하기 위해 수영장 바닥 거울을 사용한 코칭이 효과적인지 분석하는데 목적이 있다, 1년 이상 수영 강습을 받은 성인 30명을 무작위로 Mirror group(MG)과 No mirror group(NMG)으로 나누어 실시하였다. MG(men=12, 32.25±8.2 yrs, 175±5.5 ㎝, 70.9±9.2 ㎏; women=3, 37.6±13.7 yrs, 160.0±3.4 ㎝, 55.6±3.5 ㎏), NMG(men=7, 28.7±6.1 yrs, 176.2±3.7 ㎝, 72.4±14.4 ㎏; women=8, 38.8±14.6 yrs, 162.1±4.4 ㎝, 54.1±7.3 ㎏)은 2.43 m x 4.57 m x 1.37 m 크기의 인공 수조에서 자유형 1분을 실시하였다. 거울제공 여부와 시간의 상호작용이 스트로크 기준점과의 차이에 미치는 효과는 1차 검사에서 NMG: 6.0±3.982 ㎝, MG: 7.67±3.266 ㎝로 집단 간 차이가 1.67 ㎝인 반면, 2차 검사결과 NMG: 5.07±3.788 ㎝, MG: 2.47±3.502 ㎝ 로 집단 간 차이가 2.6 cm 로 나타나 통계적으로 유의하였다(F=20.627, p<.001). 거울 제공 여부와 시간에 따른 스트로크 빈도에 대한 분산분석 결과, 피드백 종류와 1차, 2차 검사의 상호작용이 스트로크 빈도에 미치는 효과는 1차 결과 NMG: 57.67±6.821 score, MG: 60.73±7.294 score에서 2차 결과 NMG: 56.33±6.586 score, MG: 53.67±5.447 score로 통계적으로 유의한 차이가 있는 것으로 나타났다(F=24.807, p<.001). 거울 제공 여부와 사전사후 검사 따른 스트로크 시간에 대한 분산분석을 실시한 결과, 피드백 종류와 1차, 2차 검사의 상호작용이 스트로크 시간에 미치는 효과는 1차 NMG: 2.04±.208 sec, MG: 2.05±.250sec에서 2차 NMG: 2.15±.287 sec, MG: 2.39±.307 sec로 통계적으로 유의한 차이가 나타났다(F=10.813, p<.01). This study analyzed whether coaching recreational swimmers using pool bottom mirror for correcting front crawl stroke is effective in achieving an intended stroke. Thirty adults who enrolled swimming lessons for more than 1 year participated and were randomly divided into two groups; mirror group (MG: 12 men; 32.3±8.2 yrs, 175.0±5.5 ㎝, 70.9±9.2 ㎏: 3 women; 37.6±13.7 yrs, 160.0±3.4 ㎝, 55.6±3.5 ㎏) and control group (CG: 7 men; 28.7±6.1 yrs, 176.2±3.7 ㎝, 72.4±14.4 ㎏: 8 women; 38.8±14.6 yrs, 162.1±4.4 ㎝, 54.1±7.3 ㎏). They performed front crawl twice in a swimming flume (2.43 × 4.57 × 1.37 meter) at their chosen speed (pace of 87.9±4.2 for men, 102.7±4.7 sec/100 meter for women). Their stroke was video recorded by an underwater camera (xnb-6001, Samsung, Korea) and dry land camera (gnd-6020R, Samsung, Korea). After their first trial and recording, individual stroke was evaluated and verbal feedback was given for correction targeting full arm range stroking. During second trial, MG had a mirror (81 × 151 ㎝) installed under the bottom of flume so that they could check their stroke. CG did not use mirror during second trial. An image analyzer (Dartfish, Swiss) was used to analyze the distance between reference point (RP: where fingertip was reached over Vastus lateralis during standing till on land) and fingertip as well as stroke time (time between left hand immersion cycle). Stroke frequency was counted cycles of both arms. Two trials were compared. The distance between RP and fingertip was 7.7±3.3 and 2.5±3.5 ㎝ in MG in 1st and 2nd trial, respectively (p<0.001) while it was 6.0±4.0 and 5.1±3.8 ㎝ in CG. The stroke frequency was 60.7±7.3 in MG and 57.7±6.8 freq/min in CG at 1st trial. It was decreased to 53.7±5.4 in MG (p<0.001), but not in CG (56.3±6.6 freq/min). The stroke time was increased from 2.1±0.3 to 2.4±0.3 sec in MG (p<0.01), but it was not changed in CG (2.1±0.2 vs. 2.2±0.3 sec)(F=10.813, p<.01).

한국 일무의 연구동향과 성과

이보름 ( Lee Bo-reum ),김기화 ( Kim Ki-hwa ) 한국무용연구학회 2018 한국무용연구 Vol.36 No.1

본 연구는 종묘일무를 비롯한 문묘일무 및 그 밖의 한국 일무를 대상으로 1968년부터 2017년까지 발표된 논문들을 조사하여 연구 동향을 살펴보고 그 성과를 논의 하였다. 선행 연구의 동향과 성과를 규명하는 것은 무용학의 발전 동향을 파악하여 후속 연구 과제를 수행하는데 매우 유용하며 자료사적 차원에서도 그 필요성을 찾을 수 있다. 1968년 일무를 주제로 처음 발표된 논문을 시작으로 2017년까지의 논문을 10년 주기로 기간을 선정하여 전체 5기로 나누어 조사하였다. 연구는 년차별, 주제별 동향을 살펴보고 이를 바탕으로 일무연구의 성과를 분석하였다. 연구결과 한국 일무 연구는 총 50년의 연구 기간 중 최근 20년 동안 양적이나 내용적으로 급성장하였음을 알 수 있었다. 총 102편의 연구가 이루어졌고, 이중 학위논문이 31편으로 전체연구 대비 30.4%의 연구 흐름을 보였고, 학술논문이 전체 연구 대비 71편으로 69.6%의 연구 흐름을 보였다. 연구 성과는 양적인 면에서 제5기부터 제4기, 제3기, 제2기, 제1기의 역순으로 높게 나타나고 있음을 알 수 있었다. 연구 주제별 양적동향은 철학/미학/무용사가 가장 많은 연구 성과를 보였고, 다음으로 무용보/움직임 분석, 기타(개괄 및 콘텐츠), 이론/비평의 순으로 성과를 보였다. 가장 미비한 성과를 보인주제는 심리학(치료), 사회학/인류학, 교육 등으로 각 1편의 연구 성과만을 보였다. 일무연구 50년의 성과는 폭넓은 연구주제로의 확산, 중점과제의 심화, 광대한 사료의 체계화, 사료를 통한 객관적 논점의 제시, 학파 성립의 가능성 제고 등을 통해 후속연구를 이끌어 내거나 심화 시키는 등 학문적 성과를 거두며 무용학 발전에 기여하였다고 할 수 있다. This study investigated the research trends of 1968 to 2017 and examined the results of the study. To identify trends and achievements of previous studies, it is very useful to understand the trends of development of dancers and to carry out the follow - up research tasks. Starting with the research published in the first journals related to daily work in 1968, the period was selected every 10 years until 2017, and the period was divided into five periods. The results of the study were analyzed based on the annual trends and thematic trends. As a result of the research, it was found that the Korean workplace study has grown rapidly both quantitatively and contentually during the last 20 years. Work-related research has achieved academic achievements such as spreading to a wide range of research topics, intensifying focus tasks, systematizing vast feeds, presenting objective points through feed, and enhancing the possibility of establishing schools.

문묘석전제례 홀기(笏記)의 사적(史的) 고찰을 통한 일무절차의 변화양상

이보름 ( Lee Bo-reum ) 한국무용연구학회 2021 한국무용연구 Vol.39 No.3

본 연구는 문묘제례 홀기의 사적(史的) 고찰을 통해 일무절차의 변화양상을 살펴봄으로써 문묘일무의 올바른 계승과 현대적 수용의 가치를 밝히는데 목적이 있다. 이에 문헌별 문묘제례 의식을 분류하여 일무절차를 살펴보고, 의식별로 그 양상을 파악하여 특징을 도출하였다. 문헌별로 문묘제례는 총 15개의 의식으로 분류되며 이 중 총 4개의 의식에서 일무의 절차가 진행되었다. 일무는 임금이 주관하는 석전에서만 문무와 무무가 모두 추어졌으며 왕세자·왕세손·유사가 주관하는 석전에서는 문무만 추어졌고 무무는 무무원이 춤추는 자리에 입장하지만 춤은 추어지지 않았던 것으로 보인다. 본 연구를 통해 전통적인 교육기관에서 행해지는 제례의식과 일무의 역사ㆍ문화적 가치를 되새겨 보고 예악전통의 구조를 밝히어 현대문화 속에 살아있는 유가 예악 문화로 계승해 나아가는데 기여 할 수 있을 것이다. 또한 잠재되어 있는 제례의식 및 고대무용 복원연구의 기초가 될 수 있을 것이라 기대한다. The aspect and characteristic of ilmu process structure is investigated which change and development was made according to the change of period by understanding the process structure of Korean munmyojerye ceremony and ilmu and studying the relationship centering the literature recorded the courtesy and procedure of Joseon Dynasty in this study. The procedure of munmyoilmu has been inherited without big change according to the time flows through the literature because it was structuralized as designated regulation and rules and formalities in the munmyojerye ceremony different with folk dance has presence and improvisation. It is impossible to know how much the munmyoilmu demonstrated actually, however, the fact that the existence is maintained until so far proves that the historic nature, legitimacy and artistry is a living culture in our life. It is expected that historical and cultural value of Confucianism is meditated and can contribute to inherit and develop it as the custom of Confucianism ceremony music culture living in modern culture by finding out the structure of ceremony music tradition by this study.