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RISS 인기검색어
- 검색키워드
- 저자 : Baolin Hu (검색결과 5 건)
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Stability analysis of bimodular pin-ended slender rod
Wenjuan Yao,Jianwei Ma,Baolin Hu 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.4
Many novel materials, developed in recent years, have obvious properties with different modulus of elasticity in tension and compression. The ratio of their tensile modulus to compressive modulus is as high as five times. Nowadays, it has become a new trend to study the mechanical properties of these bimodular materials. At the present stage, there are extensive studies related to the strength analysis of bimodular structures, but the investigation of the buckling stability problem of bimodular rods seems to cover new ground. In this article, a semi-analytical method is proposed to acquire the buckling critical load of bimodular slender rod. By introducing non-dimensional parameters, the position of neutral axis of the bimodular rod in the critical state can be determined. Then by combining the phased integration method, the deflection differential equation of bimodular pin-ended slender rod is deduced. In addition, the buckling critical load is obtained by solving this equation. An example, which is conducted by comparing the calculation results between the three of the methods including the laboratory tests, numerical simulation method and the method we developed here, shows that the method proposed in the present work is reliable to use. Furthermore, the influence of bimodular characteristics on the stability is discussed and analyzed.
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Stability analysis of bimodular pin-ended slender rod
Yao, Wenjuan,Ma, Jianwei,Hu, Baolin Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.4
Many novel materials, developed in recent years, have obvious properties with different modulus of elasticity in tension and compression. The ratio of their tensile modulus to compressive modulus is as high as five times. Nowadays, it has become a new trend to study the mechanical properties of these bimodular materials. At the present stage, there are extensive studies related to the strength analysis of bimodular structures, but the investigation of the buckling stability problem of bimodular rods seems to cover new ground. In this article, a semi-analytical method is proposed to acquire the buckling critical load of bimodular slender rod. By introducing non-dimensional parameters, the position of neutral axis of the bimodular rod in the critical state can be determined. Then by combining the phased integration method, the deflection differential equation of bimodular pin-ended slender rod is deduced. In addition, the buckling critical load is obtained by solving this equation. An example, which is conducted by comparing the calculation results between the three of the methods including the laboratory tests, numerical simulation method and the method we developed here, shows that the method proposed in the present work is reliable to use. Furthermore, the influence of bimodular characteristics on the stability is discussed and analyzed.
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Daofei Tang,Changhong Wang,Baolin Hu,Kun Wang,Chengtao Ma 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.3
Regular borehole sampling and laboratory tests have a long process, many disturbances and the risk of large errors. Hence, it is difficult to quickly and accurately obtain the geotechnical parameters in scientific calculations. The Cone Penetration Test (CPT) is an in-situ testing technique with a wide range of applications and high data quality. However, CPT data (cone resistance, qc, and sleeve friction, fs) cannot be directly converted into geotechnical parameters. The fundamental reason is the lack of mathematical-physical methods that establish the relationship between geotechnical parameters and CPT data. This study proposes a stochastic discrete-continuum coupling method to calibrate the geotechnical parameters. The deterministic and stochastic relationship between CPT data and geotechnical parameters is established. Firstly, the macroscopic and microscopic constitutive models are introduced. Secondly, a Bayesian sampling algorithm based on the Markov chain Monte-Carlo (MCMC) method is combined with the coupling mechanism. Finally, two examples verify the rationality of the stochastic discrete-continuum coupling method. CPT data of Ottawa 20 − 30 sand is used as the research objective, the prediction results are compared with the real results through numerical calculation, and effectiveness of the deterministic discrete-continuum coupling method is verified. Then, based on the coupling numerical model, the shallow bearing stratum in Shanghai, namely ② 1 silty clay, is taken as an example, and the geotechnical parameters are calibrated. The predicted values of CPT data based on the posterior distributions are closer to the measurements than the prior reconnaissance information. In the engineering practice, the mechanism and statistics between the geotechnical parameters and CPT data are revealed, it provides a new idea for calibrating geotechnical parameters.
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Bone Morphogenetic Protein 9 Overexpression Reduces Osteosarcoma Cell Migration and Invasion
Zilan Lv,Ya-guang Weng,Dandan Yang,Jie Li,Min Hu,Min Luo,Xiaoqin Zhan,Peipei Song,Chen Liu,Huili Bai,Baolin Li,Yang Yang,Yingying Chen,Qiong Shi 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2
Transforming growth factor- (TGF-) is known to pro-mote tumor migration and invasion. Bone morphogenetic proteins (BMPs) are members of the TGF- family expressed in a variety of human carcinoma cell lines. The role of bone morphogenetic protein 9 (BMP9), the most powerful osteogenic factor, in osteosarcoma (OS) progression has not been fully clarified. The expression of BMP9 and its receptors in OS cell lines was analyzed by RT-PCR. We found that BMP9 and its receptors were expressed in OS cell lines. We further investigated the influence of BMP9 on the biological behaviors of OS cells. BMP9 overexpression in the OS cell lines 143B and MG63 inhibited in vitro cell migration and invasion. We further investigated the ex-pression of a panel of cancer-related genes and found that BMP9 overexpression increased the phosphorylation of Smad1/5/8 proteins, increased the expression of ID1, and reduced the expression and activity of matrix metalloproteinase 9 (MMP9) in OS cells. BMP9 silencing induced the opposite effects. We also found that BMP9 may not affect the chemokine (C-X-C motif) ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) axis to regulate the invasiveness and metastatic capacity of OS cells. Interestingly, CXCR4 was expressed in both 143B and MG63 cells, while CXCL12 was only detected in MG63 cells. Taken together, we hypothesize that BMP9 inhibits the migration and invasiveness of OS cells through a Smad-dependent pathway by downregulating the expression and activity of MMP9.
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