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UML diagram-driven test scenarios generation based on the temporal graph grammar
( Zhan Shi ),( Xiaoqin Zeng ),( Tingting Zhang ),( Lei Han ),( Ying Qian ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.7
Model-based software architecture verification and test scenarios generation are becoming more and more important in the software industry. Based on the existing temporal graph grammar, this paper proposes a new formalization method of the context-sensitive graph grammar for aiming at UML activity diagrams, which is called the UML Activity Graph Grammar, or UAGG. In the UAGG, there are new definitions and parsing algorithms. The proposed mechanisms are able to not only check the structural correctness of the UML activity diagram but also automatically generate the test scenario according to user constraints. Finally, a case study is discussed to illustrate how the UAGG and its algorithms work.
( Qiuhua Wang ),( Xiaoqin Ouyang ),( Jiacheng Zhan ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.7
With the rapid development of network, Intrusion Detection System(IDS) plays a more and more important role in network applications. Many data mining algorithms are used to build IDS. However, due to the advent of big data era, massive data are generated. When dealing with large-scale data sets, most data mining algorithms suffer from a high computational burden which makes IDS much less efficient. To build an efficient IDS over big data, we propose a classification algorithm based on data clustering and data reduction. In the training stage, the training data are divided into clusters with similar size by Mini Batch K-Means algorithm, meanwhile, the center of each cluster is used as its index. Then, we select representative instances for each cluster to perform the task of data reduction and use the clusters that consist of representative instances to build a K-Nearest Neighbor(KNN) detection model. In the detection stage, we sort clusters according to the distances between the test sample and cluster indexes, and obtain k nearest clusters where we find k nearest neighbors. Experimental results show that searching neighbors by cluster indexes reduces the computational complexity significantly, and classification with reduced data of representative instances not only improves the efficiency, but also maintains high accuracy.
Bone Morphogenetic Protein 9 Overexpression Reduces Osteosarcoma Cell Migration and Invasion
Zilan Lv,Ya-guang Weng,Dandan Yang,Jie Li,Min Hu,Min Luo,Xiaoqin Zhan,Peipei Song,Chen Liu,Huili Bai,Baolin Li,Yang Yang,Yingying Chen,Qiong Shi 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2
Transforming growth factor- (TGF-) is known to pro-mote tumor migration and invasion. Bone morphogenetic proteins (BMPs) are members of the TGF- family expressed in a variety of human carcinoma cell lines. The role of bone morphogenetic protein 9 (BMP9), the most powerful osteogenic factor, in osteosarcoma (OS) progression has not been fully clarified. The expression of BMP9 and its receptors in OS cell lines was analyzed by RT-PCR. We found that BMP9 and its receptors were expressed in OS cell lines. We further investigated the influence of BMP9 on the biological behaviors of OS cells. BMP9 overexpression in the OS cell lines 143B and MG63 inhibited in vitro cell migration and invasion. We further investigated the ex-pression of a panel of cancer-related genes and found that BMP9 overexpression increased the phosphorylation of Smad1/5/8 proteins, increased the expression of ID1, and reduced the expression and activity of matrix metalloproteinase 9 (MMP9) in OS cells. BMP9 silencing induced the opposite effects. We also found that BMP9 may not affect the chemokine (C-X-C motif) ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) axis to regulate the invasiveness and metastatic capacity of OS cells. Interestingly, CXCR4 was expressed in both 143B and MG63 cells, while CXCL12 was only detected in MG63 cells. Taken together, we hypothesize that BMP9 inhibits the migration and invasiveness of OS cells through a Smad-dependent pathway by downregulating the expression and activity of MMP9.