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- 저자 : Bajgai, Madhab Prasad (검색결과 41 건)
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Bajgai, Madhab Prasad,Aryal, Santosh,Bhattarai, Shanta Raj,Bahadur, K. C. Remant,Kim, Kawn-Woo,Kim, Hak Yong Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of applied polymer science Vol.108 No.3
<P>The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, M<SUB>w</SUB> = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci 2008</P>
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Bajgai, Madhab Prasad,Aryal, Santosh,Parajuli, Daman Chandra,Khil, Myung-Seob,Lee, Duck Rae,Kim, Hak Yong Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.111 No.3
<P>Brush copolymers composed of methoxy poly(ethylene glycol) (MPEG) and poly(ϵ-caprolactone) (PCL) have been synthesized by the ring-opening polymerization of ϵ-caprolactone initiated by hydroxyl function of thermally esterified MPEG-citrate in presence of stannous octoate. Citric acid (CA) acts as spacer between brush-like MPEG and the long chain of PCL. Existence of hydrophobic domains as cores of the micelles were characterized by <SUP>1</SUP>H NMR spectroscopy and further confirmed with fluorescence technique using pyrene as a probe. Critical micelle concentration (CMC) of the synthesized copolymer decreased from 0.019 to 0.0031 mg/mL on increasing the fraction of PCL. Along with the physicochemical study, the brush copolymers were explored for the preparation of nanoparticles by nanoprecipitation technique. The morphology and geometry of micelles were investigated by using DLS, AFM, and TEM. Hydrodyanamic dimensions of micelles were around 118 and 178 nm with the core size of 8–10 nm, which further aggregated to form secondary micelle of 60–90 nm. Such assembled polymeric micelles with its flexible dendritic MPEG corona could hold a promise for the immobilization (encapsulation) of hydrophobic drugs and subsequently promote sustained release so that it can be a good vehicle for anti-cancer drug deliverance. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>
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Johny Bajgai,Cheol-Su Kim,Ailyn Fadriquela,Rahima Begum,Xingyu Jing,Dong Heui Kim,Soo-Ki Kim,Kyu-Jae Lee 한국물학회 2019 한국물학회지 Vol.7 No.1
Atopic dermatitis (AD) is chronic relapsing skin inflammatory allergic disease characterized by a complex pathogenesis including skin barrier dysfunction, immune-redox disturbances and pruritus. Topical treatment medications such as corticosteroids, calcineurin inhibitors, T-cell inhibitors were used in AD but these agents may have some potential side-effects. Therefore, many researchers explored abundant numbers of alternative therapies by using natural products and mineral compounds related with its antioxidant and immunomodulator effects to minimize toxicity and adverse-effects. In the present study, we investigated the effects of mineral complex material patch (MCM) treatment on AD-like lesions in 2, 4-dinitrochlorobenzene (DNCB)-induced hairless mice. Animals were divided into four groups; normal control, negative control (DNCB Only), DNCB+ Tacrolimus (PC) and DNCB+MCM patch to evaluate its therapeutic effect on DNCB-induced AD. Our results showed that MCM patch improved the skin dermatitis by significantly increasing the skin barrier strength, score and moisture level and decreasing the transepidermal water loss as compared to DNCB only group. In line, ROS level, inflammatory, Th1 and Th2 cytokines were decreased with MCM treatment whereas nitric oxide level and total anti-oxidant enzyme activities were significantly enhanced as compared to DNCB only and NC groups. Moreover, total IgE level was significantly increased in DNCB only group and decreased in PC and MCM treated group. Taken together, our findings suggest that MCM may potentially protect against AD lesional skin via regulation of skin barrier function and immune-redox response. However, further studies are needed to explain the detail molecular mechanism of MCM effect.
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Johny Bajgai,Md. Habibur Rahman,Ailyn Fadriquela,Subham Sharma,Dong-Heui Kim,Seong-Hoon Goh,In-Soo You,Yun-Su Na,Nam-Kyu Kong,Soo-Ki Kim,Cheol-Su Kim,Kyu-Jae Lee 한국물학회 2020 한국물학회지 Vol.8 No.1
Various neurodegenerative diseases including dementia and cognitive dysfunction pathogenesis are caused due to oxidative stress. Several studies have proved that molecular hydrogen (H2) acts as a therapeutic and preventive anti-oxidant, however, H2 effect on dementia is poorly documented. In the present study, we investigated the effects of H2 inhalation on trimethyltin (TMT)-induced memory dysfunction in the C57BL/6 mice. For this, mice were intraperitoneally injected a single dosage of TMT 2.6 mg/kg body weight. The subjects were randomly divided into the following groups: normal control without TMT induction, TMT only as a negative control (TMT injection + saline administration), positive control group [TMT injection + lithium chloride (50 mg/kg body weight) injection], H2-2wk group [TMT injection + H2 gas inhalation (once a day for 30 min for 2 weeks) and H2-4wk group [TMT injection + H2 gas inhalation (once a day for 30 min for 4 weeks). As a result, TMT-exposed mice showed symptoms such as tremor, seizure and aggressive behavior. Meanwhile, H2-treated groups after TMT treatment showed significantly increased spatial cognition abilities in the Y-maze test. Likewise, the level of the oxidative stress markers such as ROS, NO and MDA were found to be decreased in H2-2wk and H2-4wk groups as compared to the TMT only group in both serum and brain lysate, coherently, antioxidant enzymatic activities were increased in H2-2wk and H2-4wk groups compared to TMT only group. Moreover, H2 showed prevention effect of neuronal apoptosis through the suppression of apoptotic signaling molecules such as BAX, and cleaved caspase-7. Overall, H2 inhalation exhibited memory enhancing activity and decreased the oxidative stress markers and suppressed apoptotic signaling molecules on TMT-inducd mice. Therefore, H2 might be one of candidates for repairing dementia and neuro-degenerative diseases which shows symptoms such as dysfunction of learning, memory and cognition. However further studies are needed to clarify this notion.
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Johny Bajgai,Eun-Sook Jeong,Ailyn Fadriquela,Dong-Heui Kim,Cheol-Su Kim,Soo-Ki Kim,Kyu-Jae Lee 한국물학회 2019 한국물학회지 Vol.7 No.1
Alcohol-induced hangover and liver diseases are considered as a cause of serious health morbidity, mortality and socio-economic burden worldwide. In recent years, many researchers explored abundant numbers of natural products related with hepatoprotective effect against oxidative damage. In this study we investigated the protective effects of urushiol-free enzyme-treated lacquer tree (Rhus verniciflua sap) extract (ELTE) on alcohol-induced in Sprague Dawley (SD) rat model. Rats were randomly divided into 3 groups; negative control without treatment (NeC), positive control group (PC) treated with anti-hangover drink (Condition), and experimental group orally treated with urushiol-free ELTE. Experimental materials were administered to each SD rat accordingly 25 mg/kg for 5 d via gavage. At 5th day after treatment of experimental materials, each group received a dose of ethanol (4 g/kg body weight) and blood serum sample was assessed after 1 h and 5 h to investigate immune-redox and hangover markers. Our results showed blood lymphocytes levels were significantly lower in ELTE group than NeC group. Likewise, ROS generation was significantly reduced in ELTE group as compared to all other groups. In line, alcohol concentration in blood was significantly reduced in PC and ELTE groups as compared with NeC group. Collectively, our results suggest that urushiol-free ELTE might be an excellent potential candidate against acute alcohol-induced hangover relief and liver protection.
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Johny Bajgai,Jeong Eunsook,Cheol Su Kim,Ailyn Fadriquela,Dong-Heui Kim,Kyu-Jae Lee 한국물학회 2019 한국물학회지 Vol.7 No.1
Hydrogen water (HW) which is produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on dementia that is associated with cognitive impairment and memory loss, is poorly documented. In the present study, we investigated the drinking effects of hydrogen water on dementia patient for prevention through oxidative stress and immuno redox mechanism. Dementia patients were administered with HW and purified water (PW) for 6 months. Further, we evaluated hydrogen water effect on the cognitive impairment by checking the serum concentration of Alzheimer's disease (AD) biomarkers [Amyloid β (Aβ) 40, Aβ 42 and tau], inflammatory cytokines such as IL-1β, IL-6, IL-13, TNF-α, IL-10 and IL-4, Th1/Th2 cytokines such as IL-2, IFN-γ, IL-12p70 and IL-5, reactive oxygen species (ROS), and nitric oxide (NO) levels. We found that HW treatment significantly decreased the serum level of Aβ 40 after 6 mon of treatment. In parallel, inflammatory cytokines were significantly inhibited in experimental group compared to control group. In line, Th1/Th2 cytokines were significantly decreased in HW than PW group. Furthermore, oxidative stress markers such as ROS and nitric oxide level were decreased in HW treated group than PW control group. Overall our clinical results strongly recommended that drinking hydrogen water might be a promising preventative approach for age-related neurodegenerative disease like dementia and have an enormous impact on future healthcare for the elderly patients. This might be the first note on the clinical application of drinking HW on the serum of dementia patients.
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Application of New Concept Disinfectant, Huureka®, On Livestock Farming
Johny Bajgai,Cheol-Su Kim,Md. Habibur Rahman,Ailyn Fadriquela,Trinh Thi Thuy,Soon-Bong Song,Kyu-Jae Lee 한국물학회 2020 한국물학회지 Vol.8 No.1
Hypochlorous acid (HOCl) water was initially developed in Japan in 1987 and its antimicrobial property was reported in 1992. HOCl water is used globally to improve public health and recently started to use in agriculture. It is generated through a process called electrolysis. General property of HOCl water is low in pH, a high oxidation-reduction potential, high available chlorine concentration and high dissolved oxygen. The property of HOCl water depends on the parameters such as concentration of the ingredient NaCl and HCl, voltage, and electrolyte flow rate used in the electrolysis process. Recently, mixing type of HOCl generation without electrolysis, hydrogen-mineral HOCl (HM-HOCl), was developed and started to be used in agriculture due to several advantages such as easy production of high-concentration and high-capacity HOCl, long-lasting HOCl concentration, low level of harmful material and easy handling. Several experiments revealed that HM-HOCl is more available than electrolyzed HOCl to apply to various fields such as organic farming without pesticide, aquaculture and fish farming, and livestock breeding. It is very useful for decreasing stink in cattle shed, preventing viral disease of fishes, and decreasing mortality rate and increasing growth rate of broiler chickens by drinking the high concentration HOCl water (free active chlorine 50 ppm). The results of HM-HOCl usage was satisfied by farmers and governmental institutions of Korea. Therefore, we would like to introduce HM-HOCl, a new concept of disinfectant, and expand its usage in sustainable development in agriculture and rural environment.
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High Mineral Spring Water Promotes Skin Injury Healing in Hairless Mice
Johny Bajgai,Kyu Jae Lee 한국물학회 2017 한국물학회지 Vol.6 No.1
Wounds are common prevalent clinical problem found in day to day life. Although numerous studies have been conducted in this field but only few studies address about the mineral effect on wound healing process. To explore the therapeutic effect of the high mineral spring water (HMW) on the wound healing process, we carried out an animal injury model for that female SKH-1 mice were divided into five groups: normal control (NC, n=10), untreated control (NT, n=10), 100 % Pure HMW (PHMW, n=10) group, 10% HMW experimental (DHMW, n=10) and two round wounds (approximately 5 mm in diameter) total of 6 round wounds were punched into each side of the superior region of the posterior extremity by biopsy puncher to each mouse. We found that HMW spraying led to an enhanced healing speed compared to untreated control group. Reactive oxygen species was suppressed in both PHMW and DHMW group compared to NT group. Collectively, our results provide the evidence that HMW might be beneficial for the treatment of skin wound injury.
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