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- 저자 : B. P. Malik (검색결과 4 건)
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Malik, Y.P.S.,Chakravarti, S.,Sharma, K.,Vaid, N.,Rajak, K.K.,Balamurugan, V.,Biswas, S.K.,Mondal, B.,Kataria, R.S.,Singh, R.K. Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.7
Toll-like receptors (TLRs) play an important role in the recognition of invading pathogens and the modulation of innate immune responses in mammals. The TLR4 and TLR7 are well known to recognize the bacterial lipopolysaccharide (LPS) and single stranded (ssRNA) ligands, respectively and play important role in host defense against Gram-negative bacteria and ssRNA viruses. In the present study, coding exon fragments of these two TLRs were identified, cloned, sequenced and analyzed in terms of insertion-deletion polymorphism, within bovine TLRs 4 and 7, thereby facilitating future TLR signaling and association studies relevant to bovine innate immunity. Comparative sequence analysis of TLR 4 exons revealed that this gene is more variable, particularly the coding frame (E3P1), while other parts showed percent identity of 95.7% to 100% at nucleotide and amino acid level, respectivley with other Bos indicus and Bos taurus breeds from different parts of the world. In comparison to TLR4, sequence analysis of TLR7 showed more conservation among different B. indicus and B. taurus breeds, except single point mutation at 324 nucleotide position (AAA to AAM) altering a single amino acid at 108 position (K to X). Percent identity of TLR7 sequences (all 3 exons) was between 99.2% to 100% at nucleotide and amino acid level, when compared with available sequence database of B. indicus and B. taurus. Simple Modular Architecture Research Tool (SMART) analysis showed variations in the exon fragments located in the Leucine Rich Repeat (LRR) region, which is responsible for binding with the microbial associated molecular patterns and further, downstream signaling to initiate anti-microbial response. Considering importance of TLR polymorphism in terms of innate immunity, further research is warranted.
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Evaluation of Crossbreeding Effects for Wool Traits in Sheep
Malik, B.S.,Singh, R.P. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.11
Crossbreeding effects for wool quality traits viz. greasy fleece weight (kg), staple length (cm), average fibre diameter (${\mu}$) and medulation percentage were estimated using the Dickerson's and Kinghorn's models. The data analyzed involved 15 genetic groups including Nali purebred, $F_1$'s of two and three breeds, $F_2$'s and reciprocal crossbred obtained from the crossing of Nali (N), Merino (M) and Corriedale (C) breeds during 1980-96. Nali and Corriedale breeds had non-significant negative additive genetic effects (Dickerson's model) on greasy fleece weight, while effects of Corriedale were negative for staple length only from both models. In general additive genetic effects of all three breeds were non-significant for all the wool traits except medulation percentage. Non significant heterotic and recombination effects (epistatic loss) were estimated from both models. However, the estimates of crossbreeding effects varied between the models both in magnitude as well as in direction barring few exceptions. Undesirable positive heterosis was found on medulation percentage for all types of combinations involving three breeds. Comparison of least squares means of various genetic groups revealed that both two breed and three breed crosses were superior to the Nali breed for all wool quality traits. Fibre diameter of MN crossbreds was significantly less than CN crossbreds. Results also indicated that as the inheritance of Nali breed in a cross is decreased, the medulation percentage decreases which is desirable. Inter se mating of crossbreds (two breed, three breed) has not resulted in a decline in the wool quality traits. These results indicate that the synthetic population derived from three breeds can be stabilized easily for wool traits as there may not be epistatic loss on subsequent inter se mating of crossbreds.
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Poonam Gaur,B. P. Malik,Dimple Sharma,Arun Gaur 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.2
The present work aims at the synthesis of Zinc-doped CdSe (Zn:CdSe) nanoparticles with average size near the Bohr radius by wet chemical method. The synthesized nanoparticles have been characterized by X-ray diffraction (XRD), UV-Vis spectrometer is used for the determination of bandgap and crystallite size is estimated using Debye–Scherrer formula and Brus equation. The nonlinear optical property that is excitonic nonlinear absorption and the wavelength dependence of nonlinear absorption has also been measured near the excitonic transitions involving the lowest electron state (1S) and one of the hole states 1S3/2(h). We observe the saturable absorption (SA), which can be described by a third-order and a fifth-order nonlinear process for Zn:CdSe nanocrystals. The irradiance and wavelength dependence of the excitonic nonlinearity are explained by two-level model. The calculations have been performed with the help of Z-scan experimental setup using Handy Compact Q-switched pulsed Nd:YAG laser (HYL-101 Quanta System).
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Genetic Variability and Bottleneck Analysis of Jakhrana Goats by Microsatellite DNA Fingerprinting
Dinesh Kumar,A. K. Pandey,S. P. S. Ahlawat,Geetu Malik,Rekha Sharma,Digpal Singh Gour,S. P. Dixit,N. K. Verma,R. A. K. Aggarwal,Neelam Gupta,B. N. Shahi,S. C. Gupta 한국유전학회 2005 Genes & Genomics Vol.27 No.3
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