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Andrzej S., Rybak,Andrzej M., Woyda-Ploszczyca The Korean Society of Phycology 2022 ALGAE Vol.37 No.4
The red alga Compsopogon caeruleus can generally be found in tropical and subtropical waters worldwide. In addition to its natural habitats, this species may be found in waters that receive abnormally hot water, e.g., from powerhouses. To date, the presence of C. caeruleus has not been observed in thermally polluted lacustrine ecosystems in Poland, which has a moderate climate. The thalli of this red alga were found growing on Vallisneria spiralis in Lichenskie Lake. Importantly, this paper presents a previously unknown relationship between the temperature (20, 25, 30, 35, and 40℃) and oxygen requirements of C. caeruleus (based on ex situ measurements of O<sub>2</sub> consumption by thalli). Surprisingly, 35℃ can be the optimum temperature for C. caeruleus, and this temperature is higher than the values reported by some previous thermal analyses by approximately 10℃. Additionally, we reviewed and mapped the distribution of this nonnative and mesophilic red alga in natural / seminatural water ecosystems in Europe. Finally, we propose that the occurrence of C. caeruleus mature thalli can be a novel, simple and easy-to-recognize bioindicator of artificially and permanently heated waters in moderate climate zones by a regular discharge of postindustrial water.
Andrzej M. Wrzesien,Duoc T. Phan,James B.P. Lim,Hieng-Ho Lau,Iman Hajirasouliha,Cher Siang Tan 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2
Cold-formed steel (CFS) portal frames can be a viable alternative to conventional hot-rolled steel portal frames. They are commonly used for low-rise commercial, light industrial and agricultural buildings. In this paper, the effect of stressed-skin action on the optimum design of CFS portal frames is investigated by conducting a minimum cost design optimisation on a building of span of 6 m, height-to-eaves of 3 m and frame spacing of 3 m; the effect of different number of bays are considered. For the purpose of this study, it is assumed that gables are rigid.The effect of stressed-skin action is larger for“square-shaped” buildings (i.e. when the span and length are the same on plan) and decreases as more bays are added(i.e. as the building becomes more “rectangular-shaped” on plan). The results of the minimum cost optimisation indicate that if stressed-skin action is taken into account, the cost of the internal frame can be reduced by around half for “square-shaped” buildings. It should be noted that this is a minimum cost optimisation, which is not the same as a minimum weight optimisation. It is also shown that a safe design of internal frames could be obtained by ignoring wind loads (i.e. designing the frame only for gravity loads),but this is limited to buildings having a “square-shape”.
OGLE-2005-BLG-071Lb, THE MOST MASSIVE M DWARF PLANETARY COMPANION?
Dong, Subo,Gould, Andrew,Udalski, Andrzej,Anderson, Jay,Christie, G. W.,Gaudi, B. S.,Jaroszyń,ski, M.,Kubiak, M.,Szymań,ski, M. K.,Pietrzyń,ski, G.,Soszyń,ski, I.,Szewczyk, O.,Ulac IOP Publishing 2009 The Astrophysical journal Vol.695 No.2
Monika M. Karpin´ ska,Joanna Matysiak,Andrzej Niewiadomy 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.10
One-pot synthesis of new biologically active 4-(1H-benzimidazol-2-yl)benzene-l,3-diols has been developed. The compounds were prepared by the reaction of aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethione]s with benzene-l,2-diamines. Their structures were identified using elemental, IR, lH-NMR, and mass spectra analyses. The developed method offers short reaction times, relatively large-scale synthesis, easy and quick isolation of the products, and good yields. The cytotoxicity in vitro against the 4 human cancer cell lines: SW707 (rectal), HCV29T (bladder), A549 (lung), and T47D (breast) was determined. The antiproliferative properties of some compounds studies were stronger than those of cisplatin, which was used as a comparator drug.
Growth Hormone and Aging: New Findings
Bartke Andrzej,Hascup Erin,Hascup Kevin,Masternak Michal M. 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.3
Complex relationships between growth hormone (GH) signaling and mammalian aging continue to attract attention of many investigators. Recent results include evidence that the impact of GH on genome maintenance (DNA damage and repair) is drastically different in normal as compared to cancer cells, consistent with GH promoting aging and cancer progression. Impact of GH on DNA methylation was studied as a possible mechanism linking actions of GH during early life to the trajec-tory of aging. Animals with reduced or enhanced GH signaling and novel animals with adipocyte-specific deletion of GH receptors were used to elucidate the effects of GH on white and brown adipose tissue, including the impact of this hormone on lipolysis, fibrosis, and thermogenesis. Effects of GH on adipose tissue related to lipid and energy metabolism emerge as mechanistic links between GH, healthspan, and lifespan. Treatment of healthy men with a combination of GH, dehydroepi-androsterone, and metformin was reported to restore thymus function and reduce epigenetic age. Studies of human subjects with deficiency of GH or GH receptors and studies of mice with the same endocrine syndromes identified several pheno-typic changes related (positively or negatively) to the previously reported predisposition to healthy aging. Results of these and other recent studies advance present understanding of the mechanisms by which GH influences aging and longevity and of the trade-offs involved.
Zadlo, Andrzej,Burke, Janice M.,Sarna, Tadeusz Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.6
Melanin is usually considered a photoprotective pigment and antioxidant agent, but it is unclear how melanosomes protect pigmented cells against oxidative stress induced by light and whether aging modulates its photoprotective function, particularly in long-lived post-mitotic cells such as the retinal pigment epithelium (RPE). To address these issues, we analyzed the effects of untreated and experimentally photobleached melanosomes from cow RPE on the peroxidation of liposomal lipids induced by irradiation with intense visible light or by a rose Bengal photosensitized reaction. Photobleached melanosomes were used as a model of photo-aged pigment granules, and the progress of lipid peroxidation was monitored by electron spin resonance (EPR) oximetry and the iodometric determination of lipid hydroperoxides. We observed that while untreated melanosomes inhibited the rose Bengal induced peroxidation of lipids only moderately, partially photobleached melanosomes had very little effect on this process. Untreated melanosomes also inhibited peroxidation of liposomal lipids induced by intense visible light; however, the inhibitory effect markedly changed with the irradiation time. On the other hand, partially photobleached pigment granules accelerated the photoinduced peroxidation of lipids. The observed effects illustrate the limited efficiency of melanin within granules to scavenge and quench reactive oxygen species randomly generated by photosensitized reactions. The photosensitizing ability of photobleached melanosomes may arise from their capacity to photogenerate hydrogen peroxide. Collectively, our data indicate that natural melanin is only a moderately efficient photoprotective pigment, which upon photoaging may lose its antioxidant efficiency and even become a photosensitizer.